LOCUS       NM_001161342            1241 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 171 (TMEM171), transcript
            variant 2, mRNA.
ACCESSION   NM_001161342
VERSION     NM_001161342.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1241)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1241)
  AUTHORS   Kottgen,A., Albrecht,E., Teumer,A., Vitart,V., Krumsiek,J.,
            Hundertmark,C., Pistis,G., Ruggiero,D., O'Seaghdha,C.M., Haller,T.,
            Yang,Q., Tanaka,T., Johnson,A.D., Kutalik,Z., Smith,A.V., Shi,J.,
            Struchalin,M., Middelberg,R.P., Brown,M.J., Gaffo,A.L., Pirastu,N.,
            Li,G., Hayward,C., Zemunik,T., Huffman,J., Yengo,L., Zhao,J.H.,
            Demirkan,A., Feitosa,M.F., Liu,X., Malerba,G., Lopez,L.M., van der
            Harst,P., Li,X., Kleber,M.E., Hicks,A.A., Nolte,I.M., Johansson,A.,
            Murgia,F., Wild,S.H., Bakker,S.J., Peden,J.F., Dehghan,A.,
            Steri,M., Tenesa,A., Lagou,V., Salo,P., Mangino,M., Rose,L.M.,
            Lehtimaki,T., Woodward,O.M., Okada,Y., Tin,A., Muller,C.,
            Oldmeadow,C., Putku,M., Czamara,D., Kraft,P., Frogheri,L.,
            Thun,G.A., Grotevendt,A., Gislason,G.K., Harris,T.B., Launer,L.J.,
            McArdle,P., Shuldiner,A.R., Boerwinkle,E., Coresh,J., Schmidt,H.,
            Schallert,M., Martin,N.G., Montgomery,G.W., Kubo,M., Nakamura,Y.,
            Tanaka,T., Munroe,P.B., Samani,N.J., Jacobs,D.R. Jr., Liu,K.,
            D'Adamo,P., Ulivi,S., Rotter,J.I., Psaty,B.M., Vollenweider,P.,
            Waeber,G., Campbell,S., Devuyst,O., Navarro,P., Kolcic,I.,
            Hastie,N., Balkau,B., Froguel,P., Esko,T., Salumets,A., Khaw,K.T.,
            Langenberg,C., Wareham,N.J., Isaacs,A., Kraja,A., Zhang,Q.,
            Wild,P.S., Scott,R.J., Holliday,E.G., Org,E., Viigimaa,M.,
            Bandinelli,S., Metter,J.E., Lupo,A., Trabetti,E., Sorice,R.,
            Doring,A., Lattka,E., Strauch,K., Theis,F., Waldenberger,M.,
            Wichmann,H.E., Davies,G., Gow,A.J., Bruinenberg,M., Stolk,R.P.,
            Kooner,J.S., Zhang,W., Winkelmann,B.R., Boehm,B.O., Lucae,S.,
            Penninx,B.W., Smit,J.H., Curhan,G., Mudgal,P., Plenge,R.M.,
            Portas,L., Persico,I., Kirin,M., Wilson,J.F., Mateo Leach,I., van
            Gilst,W.H., Goel,A., Ongen,H., Hofman,A., Rivadeneira,F.,
            Uitterlinden,A.G., Imboden,M., von Eckardstein,A., Cucca,F.,
            Nagaraja,R., Piras,M.G., Nauck,M., Schurmann,C., Budde,K.,
            Ernst,F., Farrington,S.M., Theodoratou,E., Prokopenko,I.,
            Stumvoll,M., Jula,A., Perola,M., Salomaa,V., Shin,S.Y.,
            Spector,T.D., Sala,C., Ridker,P.M., Kahonen,M., Viikari,J.,
            Hengstenberg,C., Nelson,C.P., Meschia,J.F., Nalls,M.A., Sharma,P.,
            Singleton,A.B., Kamatani,N., Zeller,T., Burnier,M., Attia,J.,
            Laan,M., Klopp,N., Hillege,H.L., Kloiber,S., Choi,H., Pirastu,M.,
            Tore,S., Probst-Hensch,N.M., Volzke,H., Gudnason,V., Parsa,A.,
            Schmidt,R., Whitfield,J.B., Fornage,M., Gasparini,P.,
            Siscovick,D.S., Polasek,O., Campbell,H., Rudan,I., Bouatia-Naji,N.,
            Metspalu,A., Loos,R.J., van Duijn,C.M., Borecki,I.B., Ferrucci,L.,
            Gambaro,G., Deary,I.J., Wolffenbuttel,B.H., Chambers,J.C., Marz,W.,
            Pramstaller,P.P., Snieder,H., Gyllensten,U., Wright,A.F., Navis,G.,
            Watkins,H., Witteman,J.C., Sanna,S., Schipf,S., Dunlop,M.G.,
            Tonjes,A., Ripatti,S., Soranzo,N., Toniolo,D., Chasman,D.I.,
            Raitakari,O., Kao,W.H., Ciullo,M., Fox,C.S., Caulfield,M.,
            Bochud,M. and Gieger,C.
  CONSRTM   LifeLines Cohort Study; CARDIoGRAM Consortium; DIAGRAM Consortium;
            ICBP Consortium; MAGIC Consortium
  TITLE     Genome-wide association analyses identify 18 new loci associated
            with serum urate concentrations
  JOURNAL   Nat Genet 45 (2), 145-154 (2013)
   PUBMED   23263486
REFERENCE   3  (bases 1 to 1241)
  AUTHORS   Okada,Y., Sim,X., Go,M.J., Wu,J.Y., Gu,D., Takeuchi,F.,
            Takahashi,A., Maeda,S., Tsunoda,T., Chen,P., Lim,S.C., Wong,T.Y.,
            Liu,J., Young,T.L., Aung,T., Seielstad,M., Teo,Y.Y., Kim,Y.J.,
            Lee,J.Y., Han,B.G., Kang,D., Chen,C.H., Tsai,F.J., Chang,L.C.,
            Fann,S.J., Mei,H., Rao,D.C., Hixson,J.E., Chen,S., Katsuya,T.,
            Isono,M., Ogihara,T., Chambers,J.C., Zhang,W., Kooner,J.S.,
            Albrecht,E., Yamamoto,K., Kubo,M., Nakamura,Y., Kamatani,N.,
            Kato,N., He,J., Chen,Y.T., Cho,Y.S., Tai,E.S. and Tanaka,T.
  CONSRTM   KidneyGen Consortium; CKDGen Consortium; GUGC consortium
  TITLE     Meta-analysis identifies multiple loci associated with kidney
            function-related traits in east Asian populations
  JOURNAL   Nat Genet 44 (8), 904-909 (2012)
   PUBMED   22797727
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1241)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN261444.1, AC116345.2, KF457920.1, BC035310.1 and DB334050.1.
            
            On May 31, 2019 this sequence version replaced NM_001161342.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter isoform (2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138516.8514.1, DRR138523.400876.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               CN261444.1         18-273
            257-272             AC116345.2         25812-25827
            273-400             KF457920.1         1-128
            401-1153            BC035310.1         256-1008
            1154-1160           AC116345.2         34094-34100
            1161-1241           DB334050.1         9-89                c
FEATURES             Location/Qualifiers
     source          1..1241
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..1241
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /note="transmembrane protein 171"
                     /db_xref="GeneID:134285"
                     /db_xref="HGNC:HGNC:27031"
     exon            1..122
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            123..830
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1162
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     proline-rich protein PRP2"
                     /codon_start=1
                     /product="transmembrane protein 171 isoform 2"
                     /protein_id="NP_001154814.1"
                     /db_xref="CCDS:CCDS54869.1"
                     /db_xref="GeneID:134285"
                     /db_xref="HGNC:HGNC:27031"
                     /translation="MSPAAAAEPDGDQQDRHVSKLIFCFFVFGAVLLCVGVLLSIFGF
                     QACQYKPLPDCPMVLKVAGPACAVVGLGAVILARSRAQLQLRAGLQRGQQMDPDRAFI
                     CGESRQFAQCLIFGFLFLTSGMLISVLGIWVPGCGSNWAQEPLNETDTGDSEPRMCGF
                     LSLQIMGPLIVLVGLCFFVVAHVKKRNTLNAGQDASEREEGQIQIMEPVQVTVGDSVI
                     IFPPPPPPYFPESSASAVAESPGTNSLLPNENPPSYYSIFNYGTPTSEGAASERDCES
                     IYTISGTNSSSEASHTPHLPSELPPRYEEKENAAATFLPLSSEPSPP"
     exon            831..972
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1241
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1223..1228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /note="hexamer: AATAAA"
     polyA_site      1241
                     /gene="TMEM171"
                     /gene_synonym="PRP2"
                     /note="major polyA site"
ORIGIN      
        1 aggacgcgcg gtgggtaggg tgcagggcgg ccggcgcagc cgaggccgcg tgcggaggcg
       61 gacgccgcgc ccagccagtg cccacagcag cgcggtcagc caggcgccgg acccagcttc
      121 agagctgctg aaatcttgga gggaagaaaa cacatcccac cctgcctccg ggaaggggcc
      181 tctcctggac atgtctcctg cagctgctgc tgagccagat ggggaccagc aggacagaca
      241 cgtcagcaaa ctcatcttct gcttctttgt cttcggcgcc gtcttgttgt gtgtgggagt
      301 cctgctctcc atctttgggt tccaggcatg ccaatataag cccctcccag actgccccat
      361 ggtgctcaag gtggcggggc ctgcatgtgc cgtggttggg cttggggctg tgatcctggc
      421 ccgctcccgg gcgcaacttc agctccgtgc agggctgcag agaggtcagc agatggaccc
      481 cgaccgagcc ttcatctgtg gagagagccg ccagtttgcc cagtgcctta tctttgggtt
      541 tctgttcttg acaagcggca tgctcatcag cgtcctgggc atttgggtcc ctggatgtgg
      601 ctccaactgg gcgcaggaac cgctaaacga gacagacact ggcgactcag agccccggat
      661 gtgtgggttc ctttctctgc agatcatggg gcccttgatt gtgcttgtgg gattgtgttt
      721 cttcgtggtt gcccatgtta agaagagaaa cacgctgaat gctggccagg atgcctctga
      781 gagagaagag ggacagatcc agattatgga gcctgtccag gtcactgtag gtgactcggt
      841 aataatattt ccaccccctc caccacctta ctttcctgaa tcttcagctt ctgcggtcgc
      901 tgagagtcct ggaactaaca gtctgcttcc gaatgaaaac cccccttcat attacagtat
      961 tttcaactat gggaccccaa cttcagaggg tgcagcctct gaaagagact gtgaatctat
     1021 atataccatt tctgggacga attcatcttc tgaggcctca cacactccac atcttccatc
     1081 tgaattgcct cctagatatg aagaaaaaga aaatgctgca gctacattct tgcctctatc
     1141 ttctgagcct tccccaccgt aaactatgga ctctagttca gttttatatg caatggatca
     1201 ctattttatt taattttttt taaataaaaa atacaatagc a
//
