LOCUS       NM_001100829            8891 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 170B (TMEM170B), mRNA.
ACCESSION   NM_001100829
VERSION     NM_001100829.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8891)
  AUTHORS   Kang,C., Duo,Y., Zheng,L., Zhao,N., Wang,J., Liu,Z., Qiu,L. and
            Bi,F.
  TITLE     CAFs-derived exosomes promote the development of cervical cancer by
            regulating miR-18a-5p-TMEM170B signaling axis
  JOURNAL   Biochem Biophys Res Commun 694, 149403 (2024)
   PUBMED   38147699
  REMARK    GeneRIF: CAFs-derived exosomes promote the development of cervical
            cancer by regulating miR-18a-5p-TMEM170B signaling axis.
REFERENCE   2  (bases 1 to 8891)
  AUTHORS   Li,M., Han,Y., Zhou,H., Li,X., Lin,C., Zhang,E., Chi,X., Hu,J. and
            Xu,H.
  TITLE     Transmembrane protein 170B is a novel breast tumorigenesis
            suppressor gene that inhibits the Wnt/beta-catenin pathway
  JOURNAL   Cell Death Dis 9 (2), 91 (2018)
   PUBMED   29367600
  REMARK    GeneRIF: these results highlight TMEM170B as a novel tumor
            suppressor target in association with the beta-catenin pathway.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL357518.15, DB092520.1 and BE670213.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001100829.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.80081.1,
                                           SRR1803615.488209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379426.2/ ENSP00000368737.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-478               AL357518.15        7247-7724
            479-547             DB092520.1         14-82
            548-611             DB092520.1         84-147
            612-637             DB092520.1         149-174
            638-1010            DB092520.1         176-548
            1011-8853           AL357518.15        45142-52984
            8854-8891           BE670213.1         4-41                c
FEATURES             Location/Qualifiers
     source          1..8891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.2"
     gene            1..8891
                     /gene="TMEM170B"
                     /note="transmembrane protein 170B"
                     /db_xref="GeneID:100113407"
                     /db_xref="HGNC:HGNC:34244"
     exon            1..626
                     /gene="TMEM170B"
                     /inference="alignment:Splign:2.1.0"
     CDS             530..928
                     /gene="TMEM170B"
                     /codon_start=1
                     /product="transmembrane protein 170B"
                     /protein_id="NP_001094299.1"
                     /db_xref="CCDS:CCDS43425.1"
                     /db_xref="GeneID:100113407"
                     /db_xref="HGNC:HGNC:34244"
                     /translation="MKAEGGDHSMINLSVQQVLSLWAHGTVLRNLTEMWYWIFLWALF
                     SSLFVHGAAGVLMFVMLQRHRQGRVISVIAVSIGFLASVTGAMITSAAVAGIYRVAGK
                     NMAPLEALVWGVGQTVLTLIISFSRILATL"
     exon            627..797
                     /gene="TMEM170B"
                     /inference="alignment:Splign:2.1.0"
     exon            798..8891
                     /gene="TMEM170B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4151..4156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM170B"
                     /note="hexamer: AAGAAA"
     polyA_site      4170
                     /gene="TMEM170B"
     regulatory      8867..8872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM170B"
                     /note="hexamer: AATAAA"
     polyA_site      8891
                     /gene="TMEM170B"
                     /note="major polyA site"
ORIGIN      
        1 cctcgagtgt cggcgacccg agggcgggca ggcgggcggc aggtgccgcc gcagcctctg
       61 gctggtcccg cgtctccgtc ctccggcggc gatgagctgg gccctgtcgg gggctgcacc
      121 tgccggctgc ccatcagcac cggcctcctg gcgtgacctc ggcctcctcg cgtgtccagt
      181 ccccgcggcg cggcgctgcc cctgagaggg agcggcggcg gcctcctccg ccccgagtcc
      241 tcgctcgggg gccgcgcgag gacggcgccc ggccccctcc cctccttcct ccgtccgccg
      301 tcctcaatgt ctccccggcg gggagggggc tgcctgggag acacgctgag cggccccccc
      361 acggaggccc tccggctgca gcagcagcag cgcccggccc ggcgtcccgc agcctccacc
      421 agcggcggcg gcctggagga gccgcgcacc cgccgccgcc ccccgagcct cgcagccgcc
      481 gccgccgccc ggcacccgag gagagggcgg cgggcgcccc tcggggaaga tgaaggcgga
      541 ggggggcgac cactccatga tcaacctgtc ggtgcagcag gtcctgagcc tctgggccca
      601 cgggacggtg ctgaggaacc tcacggagat gtggtactgg atcttcctct gggctctctt
      661 ctcttctctg tttgtccatg gtgctgcagg agtgttgatg tttgtgatgc tgcagaggca
      721 taggcaggga agagtcatct ctgtcattgc agtcagcatt ggatttctgg cttctgtaac
      781 tggagcgatg attaccagtg cagcagtagc gggcatttac agagtagctg ggaagaacat
      841 ggcccctttg gaagcgctgg tatggggcgt tggacagact gtactgacat taatcatctc
      901 cttttcaagg atcctcgcta cactttgagg tttctgtggg aatgtcttac ttcacataag
      961 gaaacagatg tacagattcc ctgaaaacgg cattgttaac aagtggaaat gaaattgtgc
     1021 aagaatgtgg actgagcagg tcaaagcata aggaagacct tgagctgtgt ggaaggattg
     1081 ccctctggtg ttcaagtgat tgcactaccg cactgcacct tatgtgcctc tgtctcaggc
     1141 aaggtgcatt aagacactat gtaaagttac aagaaaaagc accttgttta gctgcctatc
     1201 aggttaacat tggtgttgaa atcatcgttc ctaacagtgt tatgttaagt tacagggacg
     1261 ttttgaggta ttgatatatg tgccaaactc ttttcttttt gttaacattg atcatgtgac
     1321 aatttgcaag tgtagatgta gctgagtgct gtgaacatat ttgacatgaa ttcaggtaat
     1381 gtactaagat ttttgttcgg taacactaaa tcccgtatga gtgctaaata ctgaattgtt
     1441 taatatgaga gaaattattt ggtttttaat gttgcgcgtt tctgggattt agggcttcaa
     1501 tatgtttagg tattattgtt atttaattga tgtggaagat aagtcttctt aactgaagac
     1561 tagctcaact gttttaagaa ctcagagtag ctctataggg tgcatacttt tcaccaactt
     1621 aagtaacacc cttttaatag cttctctcat gcatccatat tctgtttata caaattcaga
     1681 aacttgaagg gtcatacaca ttgattgtag tttgtgcgtc ataaaaatgt aatttgaaga
     1741 ttttcttaaa aatttttgta agaaaaaagt ctgaaatgca tgttgcattc tttgaccctt
     1801 ctaaagaaag tttttgcctt gtatctcatg gacaaaacat ctttataact agtatctcag
     1861 tgggattgta ttacgtgttg catatatctt gatttttgac aaaacataaa cagtctttca
     1921 ttctggagta ttaactgttt ttagagactg gcctaaatta ggctctggaa ataaagacct
     1981 catttgtaga aataagtaac aagtaagtta tataggaaga gtaatgaact attttacttt
     2041 ggacatgtgg caacatcata attttgctaa gtaaaaattg gggaatatag tagataattt
     2101 taaaatttgg caattagtct cagcatatca atgcagtact gagcgtgtat tagagtaatt
     2161 cagttgttca gttcttgatt tatgatatga agttatgatt taagtttagt agaagaatct
     2221 gtgagggcat atagcaaaag tggaaatgtc ctttatataa aacattttaa gaggttctgg
     2281 caatacgtaa ttgtaagagt ataggaagta gggttgaact ggtctcctaa tgagattttt
     2341 tttggcacca gatacaatta taatgtgcta actcaaagga gacattgcag agaatatgaa
     2401 gttaaggata atccaaaaat aacctggtag ccttgctgtt taatccaatt tgctataaaa
     2461 gtaggccttt gttatattac attcaaattt aagaactttg ttacccatac cactttttct
     2521 ctatccagaa gcagagtata tccacaactt accaatgaga agttggagag gcagtacttt
     2581 tctcagtatg gaagccaatt tgggagattt actaacactg gcttggaaat ttgttttaaa
     2641 aaaataataa gcaactatgc atggatcttt gaagtaaatc ttaaaattga ttatttttat
     2701 tatgtacagg cctgaaattg ttttcatgtg ttctttatat tcctgatgtt tttacaaatt
     2761 aaatttaggc ataacttttc caagtcaatc tgattttttc ttttctgcca gacttgaatt
     2821 gtgttcttct tttactttgg ctattctgtc aataatttaa agcattcgta ttcttccaga
     2881 ggaattacca atagcatgtg gaaattgttt cagatctcca gaatgaatac ttattttaac
     2941 atatgtttat tttatgattt aagaaagtta tggtaaagta atatggagca tgattcataa
     3001 tccaaaatta acaagaaaat aacttggata cattaaatgt actaatgtgt ggaccaaaga
     3061 gatttaaact attgttttta ctctagaatg aaagtataat tgaacggtta ataattagtt
     3121 tgtagagtgt cctgcagtta ttatcaagtt gctttacatt atcaattgtg tgtgtatgtg
     3181 tatactttta attttagggg ttatttttgg tttctttgct gttttcagtt atttccattg
     3241 agattttgtg caactgtctc tcttttgatg ttttgagatg cagttgaata gtttgagttt
     3301 gtgaattgtc ttaatagcta tttatatgct gaaattttta aaaagttagt agctttccta
     3361 tagacacaag aaatgtttaa tgatatatat acacacacgt atatatcatt atataggtat
     3421 atagagagct gctatatatg aatacagtct acttggaaag ctttttttca gtgaacactt
     3481 tcatgttcta gtggaaaatt tgttcagtgt aatgatcttt taaataggtt tgaggatgtt
     3541 tgaaaatttt gaattttggg aaaattttct tcacttaata gagctggaga cccttgtttg
     3601 ggacatgaca aaagtcctta ttgatgtatt tgggttatat actttgttaa aattcgtatg
     3661 tgatttagca gtacattttc ttcgtgacaa atgcaagaag ggagggagga tcctctatag
     3721 tggacactcc tttatttaaa aaatgtttaa taaaatattg tttatagtga aatcagctcc
     3781 ccaaagaagg aactcctaca tgcccaaact aattacagtt gaacatactg attaaaaatg
     3841 ccatagatca cagctagtca ggaggcctca aataaactgc aaataatgct taaaacttta
     3901 aaagaaggag aaccagcagt cttccgaacc atgggacagt tccaaggtaa tagcctacct
     3961 tgcctaggat aagtgaagtc ctaaatgatg gctatcttca gggcctggag cagaattatt
     4021 ctttagatct taatgtttac caaacagtgt tacagtttgt tacccaatat actttcttag
     4081 tatttgcagc atacatttca ctgctcaaaa aagtataagg gttttgtttg tactttaaat
     4141 gagagaaata aagaaatgag ttggcctgta tatcttgtat ttgtgatatg agcaacggga
     4201 taatttgaaa tcacagaatg ttgtgggaaa ggtctttaaa gaacctctaa tgaagaaaat
     4261 gtggctgcca cattgatgta cctaggctgc cactcataca gcaaataatt ctattttgta
     4321 aacacttcgt gtggatccac tatgtaaagt gctctaccaa gtattttctc tagtaagaag
     4381 tacaagaatt accaagatgg aattctttac cttgagtaca ccaagagcta gcaagatgat
     4441 ttttaaatcc taaaaagttt gggacaacat tttgcttcct gattttagtt gagagttagc
     4501 ctgttatccc tccaaattct cattttcctg gttcatccac taaatagaat ttccataact
     4561 gagatatcat ggctgtgaca tagtgaagag aatacgagac tccaagccag caacacagat
     4621 tgaattaaga ctctgtcact tgtcaacttt ttgaccttga gcaaatcact taacttctct
     4681 gagcctcagt tcatactccg taaaatgtga ctaatacctc atgtagttat tgtgaggatt
     4741 acgtgagatt gtttatgaat ggcaaagcag tatgtatttc acagtaaatg atcaactgat
     4801 agtctctaga atttttttaa attacatttt gcaattgcat taccaattga atatgttgtt
     4861 ttgtaaaatt catcaatttt gtttcatttc tatattttcc ttacatatgc tttaggaaag
     4921 aaactaaaaa cgttttctta taatcttgct tcatctcctt ttcacttttt ctttttaaaa
     4981 tcagcagatc tttaagaacc ttttgtgaat tggtggtggt ggaaatggcc agtgcaagca
     5041 ggattaaatt aggagttctg ttgaccactg gttaaaatag gaaaagggta gagaggtagt
     5101 cagccttgac tcccttatct attcccactt acttcccttg gattcattca gccatgttga
     5161 tttattgact ttctgctatt tgctaattat tcttcttgaa aagtaagagc gatatataac
     5221 ccttcagtct tctatatgtc tgtttcttct gccggccctg ggcccttggc tctacagtgt
     5281 agtgccaatt ctgtagaaaa atagaacgat attcagtgtc taccaagttc tttcttccac
     5341 aggccaaggg tgcttaagcc ctagctgtta ttttgtttct tttatttatt tattttttga
     5401 gacggagttt cgctcttgtt gcccaggctg cagtgcaatg gcatgatctc agctcaccgc
     5461 aacctctgcc tcccaggttc aagcgattct ccttcctcag cctcccgagt agctgggatt
     5521 acaggcgtgc accaccatgc ctggccagtt ttgtattttt agtagagaca gatttctcta
     5581 tgttggtcag gctggtctca aactcccgac ctcaagggat ccacccacct tggcctccca
     5641 aagtgctggg attacaggtg taagctgccg tgcccagcct attttttttt aacttcaaat
     5701 actattattt taaatttatg ttcattatgt aattcaggga gtaacgatgc ctggagcaat
     5761 ttctgaaata ttctcaaacc acttcactct tgacactaca gatttttctc tcagtctcaa
     5821 tcagaatctc tgcagtcatt atttgttttt aagatgtgag ggacgaggaa aattactgaa
     5881 gaaattctag cagatttcga ttgcagagaa atttggtaac actttttggg taactgggta
     5941 aattactatt tcttttaata atcgggtgaa actctgaatt gttaaaacgg accaataatc
     6001 aaatggtttt ataatctttc ttaacttccc gtccttgtta taacatcttg gaagaagact
     6061 cttcaggata aaaaggatat tatttgatta aaaattatag catttggaga ggtaacacac
     6121 aaaaacaaaa acatatttga caaagcgccc tacatcctgt gttttgttag gactagaaac
     6181 tatactggat gagtatgtat actgcatgtt tacacatgct gtgtttcttt atatgtgagg
     6241 cttcactgac caccgtgcat tttgaaattg tattgcattt tgtgtgtgtg tgtggtgaca
     6301 ggtttgctct tctcacttaa ggagctctgg tctgtgtagg cagtacagtg ttgttaggga
     6361 ggttgctgaa ttatctaaaa atgtatccat gaatttgggg gaaataatgc ttaatatctg
     6421 aagtattttc agtaaatgtg gagatatatc agataatact tttaaattag tggaaacaca
     6481 tttctgagtg aactgagcta tgaactataa tcatctcttc ccctgagttt agggaagttg
     6541 ttttcacatt ctttacattt attgcacata tactgaactt acataataac tcttccctga
     6601 ttttgagaac gaatttagca atttcctaaa aatcttcctc ctctttccat acagatgtcg
     6661 tatgttatag tttaaacata tgtacaattt gttgatagaa tccaaggagc tggtttagga
     6721 aagaatactc ttaaccccta cagttatgca gctctaatct tactgaaaag taaatacttt
     6781 aggcaagtca ggagagcatg aacctcatac atacattttt acgattatgt actgcaccca
     6841 catgtatcta ctcttggtag taacatgact ccaccctttt tgggaatgta tttaggtgga
     6901 taactgaaac ggaaaagcag tttgacacaa atacacagaa agaggaattg cggtgcataa
     6961 tcaatcgtct gagtcccata actgtaacac tttttctctt ataaattggt agttcctaaa
     7021 aatcaccact ttaaaaattt tattctgtct tgctgaatta agcagaaatc acttttttta
     7081 gagccttgtt taaaggaacg ttaactcgag agtactactg atgatgacgc ttctcttgtt
     7141 tttaaagtat ttacacatca ttgttaagta tttttggaat ggaacatttt aaagttttct
     7201 ccatagaaag caacatagtg gcacttgttg agtaaatgat cataaaaatg acttgctttt
     7261 aatagcagat gagttgatag tttaactgtt gacactttct taatgttttt gatgttggat
     7321 gcatttacaa tggaagaatt tttttgaaag atttggccct ctcaccaata cacacattca
     7381 gacttgagct gcacgcattt agatgaacaa ataggaaatt cacggtattt tttgttttag
     7441 ccatccaaaa ttcataggat tctaccaaaa atattagccc ctgactctag ttattctgag
     7501 atgagggaat caactttatc ttgaaagtta actagctaaa atgtctttat ttaaatagca
     7561 aaaatatagt ttacctgaca agtattaaaa gtctcacttt caaattgtgt taactctcag
     7621 accactgatg aatcttttgg taaatcacag gcagatttta aaagctaaat gaagccttag
     7681 tgccttgaaa gttaagatac ttgtgcaaaa tggatttagc aagattcagg attggcacca
     7741 gtgagttggc tagatacaca tcaccagtga ctgggaattc aaagtttaga aagcctaacg
     7801 aatagtagct actaacttca tatggttcaa tgtaaatcag ttacttagtc attgactgtg
     7861 acagatgaca gctactttca ctatattttc atgatgtggt atttttctct attttttctt
     7921 tttccaagta tgaaatggaa aaaaatgtag ttaagaaaat taagtgtgag actttaaaat
     7981 ttagttttgt tgtaaactag agattctagt gaacagtgtt agttttatac tgtagtacag
     8041 ggcacacact ttaaccttta gaaatatgtt taccatcagg gatttatttt tactatagaa
     8101 atactaaatg tactgtgaag cttaaagaca ggagaataaa tgttggaggg gtaatacaca
     8161 aaaacaaagg catatttgat gaagtaccct gtgttatgtg aacacaattt ccccttctgt
     8221 taagactata aactatatga gtatgtgtac tgcatgttta cataaaacag tttaattttg
     8281 aaggattatt ttaaaaacta tgtttatata taatacctaa caagctgtaa atattgtata
     8341 ttattgattt ttaattttat ataagcaatt ttttatttcc caattcatgt acaaatctca
     8401 ttatgtatat agcataattt cctggagaac acaaattttg cagtgaattt taagtaattt
     8461 taattgcagt aagcatcagt ttagcctaga gatgttgatc tttattttaa attatttttc
     8521 accattctca ttttcttcaa agggcagcaa taaacatatg caagttattt ttaattatag
     8581 aaagtaggtc tacaaagata agatctaggt tccaattcat tgctttaagg aaaagatgca
     8641 caattactat cattcagtgt ctaatcacag gaccatttct gaggtccaca tgtggctctc
     8701 ctctttgtaa tatacagggt gaactcttta ctgatacaca caagacaact gttaaaaagt
     8761 gaatccagca cttaaatgtc attacacaga atttattgga ttaaaaattt gtaatataca
     8821 gtattttaat aaagtttctg tattcaattt catgcactta tatataaata aacctgtctt
     8881 tgaaagcttt a
//
