LOCUS       NM_145254               5028 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens transmembrane protein 170A (TMEM170A), transcript
            variant 1, mRNA.
ACCESSION   NM_145254
VERSION     NM_145254.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5028)
  AUTHORS   Christodoulou,A., Santarella-Mellwig,R., Santama,N. and Mattaj,I.W.
  TITLE     Transmembrane protein TMEM170A is a newly discovered regulator of
            ER and nuclear envelope morphogenesis in human cells
  JOURNAL   J Cell Sci 129 (8), 1552-1565 (2016)
   PUBMED   26906412
  REMARK    GeneRIF: this paper shows that that downregulation of TMEM170A
            specifically induces tubular endoplasmic reticulum formation,
            whereas overexpression of TMEM170A induces endoplasmic reticulum
            sheet formation.
REFERENCE   2  (bases 1 to 5028)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   3  (bases 1 to 5028)
  AUTHORS   Gertow,K., Sennblad,B., Strawbridge,R.J., Ohrvik,J., Zabaneh,D.,
            Shah,S., Veglia,F., Fava,C., Kavousi,M., McLachlan,S., Kivimaki,M.,
            Bolton,J.L., Folkersen,L., Gigante,B., Leander,K., Vikstrom,M.,
            Larsson,M., Silveira,A., Deanfield,J., Voight,B.F., Fontanillas,P.,
            Sabater-Lleal,M., Colombo,G.I., Kumari,M., Langenberg,C.,
            Wareham,N.J., Uitterlinden,A.G., Gabrielsen,A., Hedin,U.,
            Franco-Cereceda,A., Nyyssonen,K., Rauramaa,R., Tuomainen,T.P.,
            Savonen,K., Smit,A.J., Giral,P., Mannarino,E., Robertson,C.M.,
            Talmud,P.J., Hedblad,B., Hofman,A., Erdmann,J., Reilly,M.P.,
            O'Donnell,C.J., Farrall,M., Clarke,R., Franzosi,M.G., Seedorf,U.,
            Syvanen,A.C., Hansson,G.K., Eriksson,P., Samani,N.J., Watkins,H.,
            Price,J.F., Hingorani,A.D., Melander,O., Witteman,J.C.,
            Baldassarre,D., Tremoli,E., de Faire,U., Humphries,S.E. and
            Hamsten,A.
  TITLE     Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant
            of carotid intima-media thickness and coronary artery disease risk
  JOURNAL   Circ Cardiovasc Genet 5 (6), 656-665 (2012)
   PUBMED   23152477
  REMARK    GeneRIF: This study identified rs4888378 in the
            BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of
            carotid intima-media thickness and coronary artery disease risk.
REFERENCE   4  (bases 1 to 5028)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK311919.1 and AC009163.6.
            
            On Nov 22, 2018 this sequence version replaced NM_145254.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.236162.1,
                                           SRR1803611.36984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162946, SAMN03267757
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000561878.2/ ENSP00000454404.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               AK311919.1         10-533
            525-5028            AC009163.6         57339-61842         c
FEATURES             Location/Qualifiers
     source          1..5028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..5028
                     /gene="TMEM170A"
                     /gene_synonym="TMEM170"
                     /note="transmembrane protein 170A"
                     /db_xref="GeneID:124491"
                     /db_xref="HGNC:HGNC:29577"
                     /db_xref="MIM:620630"
     exon            1..222
                     /gene="TMEM170A"
                     /gene_synonym="TMEM170"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..524
                     /gene="TMEM170A"
                     /gene_synonym="TMEM170"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 170"
                     /codon_start=1
                     /product="transmembrane protein 170A isoform 1"
                     /protein_id="NP_660297.1"
                     /db_xref="CCDS:CCDS10917.1"
                     /db_xref="GeneID:124491"
                     /db_xref="HGNC:HGNC:29577"
                     /db_xref="MIM:620630"
                     /translation="MEREGSGGSGGSAGLLQQILSLKVVPRVGNGTLCPNSTSLCSFP
                     EMWYGVFLWALVSSLFFHVPAGLLALFTLRHHKYGRFMSVSILLMGIVGPITAGILTS
                     AAIAGVYRAAGKEMIPFEALTLGTGQTFCVLVVSFLRILATL"
     exon            223..393
                     /gene="TMEM170A"
                     /gene_synonym="TMEM170"
                     /inference="alignment:Splign:2.1.0"
     exon            394..5028
                     /gene="TMEM170A"
                     /gene_synonym="TMEM170"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4820..4825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM170A"
                     /gene_synonym="TMEM170"
                     /note="hexamer: AATAAA"
     polyA_site      4844
                     /gene="TMEM170A"
                     /gene_synonym="TMEM170"
                     /note="major polyA site"
     regulatory      4892..4897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM170A"
                     /gene_synonym="TMEM170"
                     /note="hexamer: AATAAA"
     polyA_site      4931
                     /gene="TMEM170A"
                     /gene_synonym="TMEM170"
     regulatory      5005..5010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM170A"
                     /gene_synonym="TMEM170"
                     /note="hexamer: ATTAAA"
     polyA_site      5028
                     /gene="TMEM170A"
                     /gene_synonym="TMEM170"
ORIGIN      
        1 gacgctgagg cggcgagggt gagtcggcgc cggccgctac cgcacttcgg gcgctcgtcc
       61 ctcatttctc tgtggtgaat ggcgacggga tggagcgcga ggggagcggc ggcagcggcg
      121 ggtcggccgg gctcctgcag cagatcctga gcctgaaggt tgtgccgcgg gtgggcaacg
      181 ggaccctgtg ccccaactct acttccctct gctccttccc agagatgtgg tatggtgtat
      241 tcctgtgggc actggtgtct tctctcttct ttcatgtccc tgctggatta ctggccctct
      301 tcaccctcag acatcacaaa tatggtaggt tcatgtctgt aagcatcctg ttgatgggca
      361 tcgtgggacc aattactgct ggaatcttga caagtgcagc tattgctgga gtttaccgag
      421 cagcagggaa ggaaatgata ccatttgaag ccctcacact gggcactgga cagacatttt
      481 gcgtcttggt ggtctccttt ttacggattt tagctactct atagcataca tccttatgct
      541 gagatgttga acttaaactt tatggaatcc tccaaaagaa tacattatgg agtgtagtgt
      601 tttcttagtt cttcaaaggg aagcaacttg gatgaacagg aacatgaagg acaacacatc
      661 tcagcctttt cttcattttg aagctcctag aattgaagac ttatgtggac tcctattgtt
      721 ctcaaccaaa acaagtcttt tggctttctt ttttgtagat atttgattta agcagttttc
      781 atgtgtacct ttacccaagc caagtcaaca gtgtctctgg ggtggcatcc tttgcactga
      841 aatttacagt attctgtgag atgtcgcata ttttgaagaa accgtggaag atactggttt
      901 atttcaaatg agcagagtat gttgtattaa aatcttatct aatcttgatt aaaatttggc
      961 aaactctttt ctttgctaca tcttagtgac aataaatgcc aaataggttt tggttgagta
     1021 tagttttgaa aacaaatttg gtgaaataaa gcaggaaaaa aaatttaagt ataactcaag
     1081 tagtggcttt ggttccactg tttataaata aaaagtagat aacaatgaat aatgtgacat
     1141 tttctggaca actgtcttga cttctgatta agatatttta agagatgtga atttgttatt
     1201 ttgtatgttt tatcaaaata agctagctaa tttagacttt ttagattttc tgtaccacct
     1261 ttccctatca cttttaattc tcttaatttt atttcattta attggaaaca tacataccct
     1321 attaaatggc ttgagttgga aattttaagc cagatttgtt tggacattga ggcacacata
     1381 agatacttta ggcattctgt catagttttt cttagtgact ttggtatact aatgaccctt
     1441 gagaaactat agaagtgcat ctgaaactag agttagtggt tattgatttt ttagcttaat
     1501 gtgtttacct agtggtaact cttcagccca cttttacagt attgggtatc aactcccaga
     1561 aagtgcctaa agtttaatgt tcagatatgt acccactctc ccctttacat ttttattcaa
     1621 aagaatttat atctttaaag agatttaaat atcaagagtt tttttaaaac ttaattttag
     1681 ctatttaaat ttttattcta ctgcctaact ttctttttca ttaaaaggcc tgaaaactgt
     1741 gactctttga gagggaaaga atcgcagaaa ttaagtattt aatgtgatcc tttccaccta
     1801 aactgttttg tatggaatac aatcagtgtg gtggtagtgg tggtggttat ctgcaaaata
     1861 gtttctggtg attaaatctg actttttttt ttttttttct tttaaatgag acggagcctc
     1921 actgtgttgc ccaggctgga gtgcagtggt gcaatctcag ctcactccaa cctctgccac
     1981 ccgggttcaa gcgattctcc tgcctcagtt tcctgagtag ctgggattac aggcacctgc
     2041 caccgtgccc ggctaatttt tgtattttta gtagagatag gtttcaccat cttgcccagg
     2101 ctggtcttga actcctgacc ttgtgatcca cccgcctcgg cctcccaaag tgctgggatt
     2161 acaggcgtga gccaccgcgc ctggccataa atctgacatc tttaaaggaa agttttcatt
     2221 gtgagattaa ggcttaacag cccatgaggt catatacaca tgaacgtatc tattccattt
     2281 aaagcaatac acactctggc ttctgattaa aaatagccag gaggagagtc tctgaatcta
     2341 ctgtgattct ggagtctgcc caatttggaa aaaaaaaaaa aagaaaaaag tcaggaggac
     2401 caatttgcca gggaaactca tagaaaagaa ttacaaagag atcacaaaaa ctggacatat
     2461 tcttttgact aattagacca cttatggctg ggcgcagtgg ctcacaccta taatcccagc
     2521 actttgggag gtcgatgtgg gaggattgct tgagcccaag agttcaagac tggcctgggc
     2581 aacatagtga gaccttgtct ctactacaaa ataaaaaaaa attagctggg cgtggcctca
     2641 gctacccaag aggctaaagt gggaggatca cttgtgcctg ggaggttcag gctgctgtga
     2701 gccgagacca cgccactgaa ctccagctta ggccacaggg caagaccctg tcttaaaata
     2761 atattactaa ttttggtaat taacttatca aaactatagt gacatataca cgggcagaaa
     2821 cttataagta gagttgtaat gcagccaaat attcttacaa attccctaac aagaagctca
     2881 aatctttctc acaggcaaat tgtaaaaatt ctagtttttt gtttaaagag ctgtgatttt
     2941 caaaagtatc ccttcagttt aagaaatctg gggaattggt aacttttctt atgggaaatg
     3001 attgccatca tctctactga aggatgcctc ttactgaaaa atgtcttttg aaggagttct
     3061 tgcctaaagc attctttgga tgtaatttca tacactaaac atatagacca gtagttagtg
     3121 ggcccctcct cttaaacagt aacttttgaa gtactgatac atgattaaaa tgttagatat
     3181 ttttcactgg agctaagact taaaattagg gcattttgaa aggtgtattt gtttctgttt
     3241 cttgtttgat atattttggt tatctactct tttaaaaaac taaacgtata aaaggtatct
     3301 tcaaattact gagtgtttca tccatcccag taggtgaagt attctccagt gaataaatct
     3361 atatatatat atagatttta aatagcttga gcggtgtagc ttgaaatgtt ttcagggaaa
     3421 gactatttga atcataagga atagctttga ttttcttttt tatgtctcaa atatagaatt
     3481 atttgggggt ggtcactcag atggaagaat attggcaatt gtgttgaaca ttttacctta
     3541 tatagttttg agaatttttg ccaaaaactg atttcttaga aatatcctcc cccagctgtg
     3601 ctttggtttt ttggtttttt tgttttgaga cggagtcttg ctctgtcgcc caggctggag
     3661 tgcagtggca tgatctcggc tcactgcaag ctctgcctcc cgggttcacg ccattctcct
     3721 gcctcagcct cccgagtagc tgggactacg gacgtccacc accatgccca gctaattttt
     3781 tgtattttta gtagagacgg ggtttcaccg tgttagccag gatggtctca atctcctgac
     3841 ccgcctccac ctcccaaagt gctgggatta caggcatgag ccaccacacc cggcctctgc
     3901 tttgtttttt aaaaaaaaag aaatgcaaga gagggaggga ggcagcctcc tgaccataaa
     3961 agctgatttc ttgatttttt tttctttttt ttttgaaatg gagtcttgct ctgtctccaa
     4021 ggctggagtg cagtggcatg gtctcagctc actgcagcct ccgtttcctg ggttcaagtg
     4081 attgtcctgc cttggccgct gagtagctag gattactggc acccgccaca aggcccagct
     4141 aatttttgta tttttagtag agacagggtt tgattatgtt ggacaggctg gtctcaaact
     4201 cctgacttca agtgatccac ccgcctcggc ctcccaacgt gatgggacta tagacatgag
     4261 ccatcatgct tggccttctt gattcttgaa tacggggttt tgaggtgaaa gcatttcatg
     4321 aaaacttaag ttcatacaca agagcatcat gaatattcta aaagaggtat ctgtgctttt
     4381 tttgtgacca caaaatatta cttcttatga aatgtttaca ctaggtgagg aaaagttcat
     4441 taattacctt taaaccgttc cttatttttt ttaagatttt aaattgtatt ttggcttttg
     4501 cctccagtat cctttctggt tgctctggtt tgaattaagt tcctattatg ctgcagcaca
     4561 tatcaacctt ccctaagtaa ccatttcctg gaatgtgaag catcggtgcc attagcagac
     4621 catatgcaga aatgtcgtgt acttgcattt cttttttgtg cactctataa ggctggttgt
     4681 gactcagatc agcttaactt tttatattat gttatttcac taactgctac agtcaaaatg
     4741 atcaaatctt tgtacaatag aaaattattt aaattttatt tttctactga catttctaat
     4801 tctagtgtaa atgtttatca ataaaaaatt actttcaatt ctgagttgga attatatttc
     4861 tttttggtgg ctaatgagtt taatcttttg taataaaatt gacttcagtt ttcatttttt
     4921 aaataactta atatctagca tgtgtaactt tttttatgtt ctacttctta ctaatttatg
     4981 ataaaattct tgttcaaagt tgtgattaaa ccgtacttaa catgtgaa
//
