LOCUS       NM_198276               1654 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 17 (TMEM17), mRNA.
ACCESSION   NM_198276 XM_117267
VERSION     NM_198276.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1654)
  AUTHORS   Wang,S., Zhou,Q., Yan,S., Liu,C., Li,F., Feng,D. and He,M.
  TITLE     TMEM17 Promotes Tumor Progression in Glioblastoma by Activating the
            PI3K/AKT Pathway
  JOURNAL   Front Biosci (Landmark Ed) 29 (8), 285 (2024)
   PUBMED   39206901
  REMARK    GeneRIF: TMEM17 Promotes Tumor Progression in Glioblastoma by
            Activating the PI3K/AKT Pathway.
REFERENCE   2  (bases 1 to 1654)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1654)
  AUTHORS   Zhang,X., Zhang,Y., Miao,Y., Zhou,H., Jiang,G. and Wang,E.
  TITLE     TMEM17 depresses invasion and metastasis in lung cancer cells via
            ERK signaling pathway
  JOURNAL   Oncotarget 8 (41), 70685-70694 (2017)
   PUBMED   29050311
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1654)
  AUTHORS   Li,C., Jensen,V.L., Park,K., Kennedy,J., Garcia-Gonzalo,F.R.,
            Romani,M., De Mori,R., Bruel,A.L., Gaillard,D., Doray,B., Lopez,E.,
            Riviere,J.B., Faivre,L., Thauvin-Robinet,C., Reiter,J.F.,
            Blacque,O.E., Valente,E.M. and Leroux,M.R.
  TITLE     MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary
            Transition Zone
  JOURNAL   PLoS Biol 14 (3), e1002416 (2016)
   PUBMED   26982032
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1654)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   6  (bases 1 to 1654)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR760587.1, BC047439.1 and AC093159.3.
            
            On Nov 22, 2018 this sequence version replaced NM_198276.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1113291.1,
                                           SRR5189667.224371.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267775 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335390.6/ ENSP00000335094.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-501               DR760587.1         312-812
            502-1259            BC047439.1         648-1405
            1260-1651           AC093159.3         184714-185105       c
            1652-1654           AC093159.3         184711-184713       c
FEATURES             Location/Qualifiers
     source          1..1654
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p15"
     gene            1..1654
                     /gene="TMEM17"
                     /note="transmembrane protein 17"
                     /db_xref="GeneID:200728"
                     /db_xref="HGNC:HGNC:26623"
                     /db_xref="MIM:614950"
     exon            1..166
                     /gene="TMEM17"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..663
                     /gene="TMEM17"
                     /codon_start=1
                     /product="transmembrane protein 17"
                     /protein_id="NP_938017.2"
                     /db_xref="CCDS:CCDS1871.1"
                     /db_xref="GeneID:200728"
                     /db_xref="HGNC:HGNC:26623"
                     /db_xref="MIM:614950"
                     /translation="MELPDPVRQRLGNFSRAVFSDSNRTGPESNEGPENEMVSSLALQ
                     MSLYFNTYYFPLWWVSSIMMLHMKYSILPDYYKFIVITVIILITLIEAIRLYLGYVGN
                     LQEKVPELAGFWLLSLLLQLPLILFLLFNEGLTNLPLEKAIHIIFTLFLAFQVVAAFL
                     TLRKMVNQLAVRFHLQDFDRLSANRGDMRRMRSCIEEI"
     exon            167..270
                     /gene="TMEM17"
                     /inference="alignment:Splign:2.1.0"
     exon            271..384
                     /gene="TMEM17"
                     /inference="alignment:Splign:2.1.0"
     exon            385..1654
                     /gene="TMEM17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1627..1632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM17"
                     /note="hexamer: ATTAAA"
     polyA_site      1654
                     /gene="TMEM17"
                     /note="major polyA site"
ORIGIN      
        1 acggagcctc ggagcgcccg cagactagcc cgtgtctgag ggggtgaggg atactgaggc
       61 ccaggcatgg agctgccgga tccggtgcgc cagcggctgg gaaacttcag ccgggccgtg
      121 ttcagtgatt ccaatcggac cggtccagag tccaatgagg gtccggaaaa tgaaatggtc
      181 tccagtttgg cactgcagat gtcactttat tttaatacct actatttccc actgtggtgg
      241 gtgagcagca ttatgatgct tcacatgaag tattcaatct tacctgacta ctacaaattc
      301 attgtgatca ctgttatcat cctaataacc ttaattgaag ccatccggtt gtatctgggc
      361 tacgtgggta acctacagga gaaggttcct gagttggctg gcttttggct tttgagcctt
      421 ctattgcagt tacctttaat tcttttcttg ctctttaatg aaggcctaac aaatctgccc
      481 ttggaaaaag cgatacatat catcttcact ctcttccttg ctttccaagt tgttgcagca
      541 tttcttacct taaggaaaat ggttaatcag ttggcagttc gtttccacct ccaagacttt
      601 gaccggctct ctgcaaacag aggagacatg agaaggatga ggtcatgtat agaagagatc
      661 tgatccagtg ttgttgagtg aaaatctgac agatcattct agagactgta agagttagga
      721 aaatatcaga gctctgagaa aagggacaaa gcaagtgttt tgaattgtat atgctctcac
      781 tctgaaattc caaggttggg ggcaatgatg aaactttgta cagtatatga aacagtatat
      841 taaccctaaa acctagatgt tgtccacctg atgccaaatt tcttaatttt ttttgatgtt
      901 gttgtctttt tcaggagtgt agaaatctat gtattggtgg ttgtcatttg ccagctctct
      961 cgtagcattt ctggttagaa tctttaacta gagatgtata catttcttta aaacttgttg
     1021 gttatccatg tcttgtctgt acatatgacc atgtttcttg acatggaaat accagtcagt
     1081 gttcctatgt atttgtctat atttgtaaac caagagaccg gctgggtgtg gtggctcacg
     1141 cctgtaatcc cagcactttg ggaggccgag gtgggcagat catgaggtca gaagatcgag
     1201 accatcctgg ctaacacggt gaaacccagc ctctactaaa aatacaaaaa aaaaaaaaat
     1261 tagctaggcg tggttgcagg cacctgtagt cccagctact tgggaggctg aggcaggaga
     1321 atggtgtgaa cccaggaggc agagcttgca gtgagccgag atcaagccac tgtactccat
     1381 cctgggtgac agagcaagac tccatctcaa aaaaataaat aaataaaaaa taaaacaaga
     1441 gaccaaattt tcatgtctgc tagggttaaa ttctaaccct aatattagct gttatactga
     1501 gatgaagaag aaaacaggtg gattgccttg gtatttagga aatatttttg ttataaaatt
     1561 acaactttca taaaaccata ttcagtattt gtaatggtgg tatacaaaat gcttttacaa
     1621 taaattatta aatatttaag gtatcagcag caaa
//
