LOCUS       NM_020141               2769 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 167B (TMEM167B), transcript
            variant 1, mRNA.
ACCESSION   NM_020141
VERSION     NM_020141.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2769)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2769)
  AUTHORS   Wendler,F., Gillingham,A.K., Sinka,R., Rosa-Ferreira,C.,
            Gordon,D.E., Franch-Marro,X., Peden,A.A., Vincent,J.P. and Munro,S.
  TITLE     A genome-wide RNA interference screen identifies two novel
            components of the metazoan secretory pathway
  JOURNAL   EMBO J 29 (2), 304-314 (2010)
   PUBMED   19942856
REFERENCE   3  (bases 1 to 2769)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356488.22 and BC008739.2.
            
            On Jun 2, 2019 this sequence version replaced NM_020141.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067116.1, AK075191.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338272.9/ ENSP00000342148.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL356488.22        13400-13416
            18-2767             BC008739.2         1-2750
            2768-2769           AL356488.22        19569-19570
FEATURES             Location/Qualifiers
     source          1..2769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..2769
                     /gene="TMEM167B"
                     /gene_synonym="AD-020; C1orf119"
                     /note="transmembrane protein 167B"
                     /db_xref="GeneID:56900"
                     /db_xref="HGNC:HGNC:30187"
     exon            1..119
                     /gene="TMEM167B"
                     /gene_synonym="AD-020; C1orf119"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..334
                     /gene="TMEM167B"
                     /gene_synonym="AD-020; C1orf119"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein kish-B"
                     /codon_start=1
                     /product="protein kish-B isoform 1 precursor"
                     /protein_id="NP_064526.1"
                     /db_xref="CCDS:CCDS30789.1"
                     /db_xref="GeneID:56900"
                     /db_xref="HGNC:HGNC:30187"
                     /translation="MTNVYSLDGILVFGLLFVCTCAYFKKVPRLKTWLLSEKKGVWGV
                     FYKAAVIGTRLHAAVAIACVVMAFYVLFIK"
     exon            120..251
                     /gene="TMEM167B"
                     /gene_synonym="AD-020; C1orf119"
                     /inference="alignment:Splign:2.1.0"
     exon            252..2769
                     /gene="TMEM167B"
                     /gene_synonym="AD-020; C1orf119"
                     /inference="alignment:Splign:2.1.0"
     regulatory      614..619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM167B"
                     /gene_synonym="AD-020; C1orf119"
                     /note="hexamer: ATTACA"
     polyA_site      636
                     /gene="TMEM167B"
                     /gene_synonym="AD-020; C1orf119"
                     /note="major polyA site"
     regulatory      2748..2753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM167B"
                     /gene_synonym="AD-020; C1orf119"
                     /note="hexamer: AATAAA"
     polyA_site      2769
                     /gene="TMEM167B"
                     /gene_synonym="AD-020; C1orf119"
                     /note="major polyA site"
ORIGIN      
        1 cttccagtca cctcggcccg gatcgggaag tgtcaagcgg gcgctccccc atctccgccg
       61 ctattaccac tgaacccgga ccccctaccc aggtccaggg ccagccgcca tgacgaacgt
      121 gtactccttg gatgggattc tggtgtttgg tttgctcttt gtttgcacct gtgcctactt
      181 caagaaagta cctcgtctca aaacctggct gctatcagag aagaagggtg tttggggtgt
      241 gttttacaaa gccgctgtga ttggaaccag gctgcatgct gctgtggcaa ttgcttgtgt
      301 tgtaatggcc ttttacgtcc tgtttataaa atgaattcca aagcacccaa gtcatcaact
      361 gccaaccaag gggacgggga tgaagaacct gttggagacc tgaacccagt gtaggagagt
      421 tcagctgaaa tcatcggtcc ccaggatgac accacagcat ctgcccctgc tatatgtggg
      481 gaaaactcat ggtcacgaac attatttatg cttcagggga ctacagaaag ccagcttcct
      541 ttgatctatg tgtaaatcag tccttggcag agtgcatata atgtccggat aaattacacc
      601 cctcggtgat aagattacat acctccttca taaaaacctg tcatcctgtt ttgttcttca
      661 gctcctcatc aggatctttt caaactgagg ctcattaggg aaggaactag gctgtgttca
      721 gacttctttt gaagagagag aattttcaag acttcttttc actctttgat ttggatctgg
      781 caaattgggg aggggatgct gggtgggaaa cagttatgaa atgccaagaa attctttggc
      841 tttagaaatt tatctttcat gtacccatcc gggaacataa aagagaggca tagtgctcat
      901 tgcaaaaaga gaacagatga agtagctgtg ttatgtgctg gtatcttgag agttttgcca
      961 agaaaatctg ggcctacata aaatttgaga attatctgtg tgatgagacc agaaagcagt
     1021 ggcttagaca agaaaaaatc tttctgttca ccagtatcct caaatggaga cttcacttga
     1081 tcagatggta tatgaaaaat gaatcaacta ttgctatttc gtaaaacctt tttatatttt
     1141 ctaaatttac ttagtgctaa atactgttac tcagttttaa atgccacgac taggggaaaa
     1201 agaaactatt gaagaaataa ttgtttagta tatttgcagt tggggtagaa gaaagaaatc
     1261 tagtatattg attcatatac tagtaaattc atctagtata agaacttgtg atgttagatt
     1321 gaagttttgt catcttataa aagacaacaa acttattttc tgtttaagtc tgagtgttat
     1381 ggcaattttt agttgattac ttatttttct tagccaaatt ttaattttct tcatattgca
     1441 ttgctcttta gttgtctctg gaaattctat ttactttaag gacatgagaa attcaaatga
     1501 gagaagttgc tgatattcat cagtgtgttt ggacagttca tagggtccac aaatcaaatg
     1561 aggttgtttc ctgaagtaga agaaaacaga actttgcaat tgatactgaa gtactttgcc
     1621 atggagttag taactcctga gcagaccatt ttagatggct cagcatttgg caggaagact
     1681 tctccattcc ctgcttatat ctatggaagg atcagctgtt ggatgtctag aacttctcta
     1741 tttaaaaaaa aagagtaggt ctaaaattaa attattataa gcaagcatag acatgggtct
     1801 tccagttgaa ttgtccatta ccgtaaaact taatggtgga caagttagct gtggttgatt
     1861 cctgtgtggc agtaaattgt cttctgtctg cttactccaa ataataaaag ctgctaggaa
     1921 gtttagattt tgaaataggc agtttaatgc tttgagggtt tctagaaata cagaaagtca
     1981 tcaagtaaac actgcatgtc taatcatctc agagttgtgg ctgttatctc ttcaggaatt
     2041 ggtccacagg gtaaatttca acaattcata cgttttccat tgtcatttct gaggaccttt
     2101 gagatgagag aaaggaaatc tagtggaaca ggaaagagag ttacaccttg tgggtgtgag
     2161 tttgggacct gttggcagaa gggaatgtca ctccctggaa acaggttcag catgtttgca
     2221 cttgttattt tgtagcttta atgatttttg ttttctaata gggcaaatgt ctctaagctt
     2281 ggtgtttaga gctgcttcat attttaaact agttccattc cacagttcta gttcaaacca
     2341 gtttttacag cctcctgggt gggtcgtctt gacccaaact cttgtgttgt tacattttga
     2401 gaggttttca taccagaatg taccaaaaag tgcacaaggt aaaggtaatt tacagccaga
     2461 aacaaatata catttgtttc atttcttgac tttccctaag cagataagca gaaacttgtt
     2521 taactcatta ctttgtttga tgtgtcttac atatttttga ctaaaagtta tagaatgtta
     2581 ttcctctggg ggaatctttt acaggtggag gaatggggat agcagtattg cctcagattc
     2641 aaactggcat caccataaac cctgtaggcc agggtggaat gaagtcagct cctttttata
     2701 gttgaaatac aattttttat tcaccattgt ctgcacaaat ccttgaaaat aaaccttttt
     2761 ttccctaca
//
