LOCUS       NM_174909               4528 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 167A (TMEM167A), mRNA.
ACCESSION   NM_174909
VERSION     NM_174909.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4528)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4528)
  AUTHORS   Portela,M., Segura-Collar,B., Argudo,I., Saiz,A., Gargini,R.,
            Sanchez-Gomez,P. and Casas-Tinto,S.
  TITLE     Oncogenic dependence of glioma cells on kish/TMEM167A regulation of
            vesicular trafficking
  JOURNAL   Glia 67 (2), 404-417 (2019)
   PUBMED   30506943
  REMARK    GeneRIF: DISCUSSION The results presented here show that
            kish/TMEM167A, a protein associated with vesicle transport and
            secretion,also is necessary for glioma growth, both in human cell
            xenografts and Drosophila models.
REFERENCE   3  (bases 1 to 4528)
  AUTHORS   Goldstein,J.I., Jarskog,L.F., Hilliard,C., Alfirevic,A., Duncan,L.,
            Fourches,D., Huang,H., Lek,M., Neale,B.M., Ripke,S., Shianna,K.,
            Szatkiewicz,J.P., Tropsha,A., van den Oord,E.J., Cascorbi,I.,
            Dettling,M., Gazit,E., Goff,D.C., Holden,A.L., Kelly,D.L.,
            Malhotra,A.K., Nielsen,J., Pirmohamed,M., Rujescu,D., Werge,T.,
            Levy,D.L., Josiassen,R.C., Kennedy,J.L., Lieberman,J.A., Daly,M.J.
            and Sullivan,P.F.
  TITLE     Clozapine-induced agranulocytosis is associated with rare HLA-DQB1
            and HLA-B alleles
  JOURNAL   Nat Commun 5, 4757 (2014)
   PUBMED   25187353
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4528)
  AUTHORS   Ramos,Y.F., Metrustry,S., Arden,N., Bay-Jensen,A.C., Beekman,M., de
            Craen,A.J., Cupples,L.A., Esko,T., Evangelou,E., Felson,D.T.,
            Hart,D.J., Ioannidis,J.P., Karsdal,M., Kloppenburg,M., Lafeber,F.,
            Metspalu,A., Panoutsopoulou,K., Slagboom,P.E., Spector,T.D., van
            Spil,E.W., Uitterlinden,A.G., Zhu,Y., Valdes,A.M., van Meurs,J.B.
            and Meulenbelt,I.
  CONSRTM   arcOGEN Consortium; TreatOA Collaborators
  TITLE     Meta-analysis identifies loci affecting levels of the potential
            osteoarthritis biomarkers sCOMP and uCTX-II with genome wide
            significance
  JOURNAL   J Med Genet 51 (9), 596-604 (2014)
   PUBMED   25057126
REFERENCE   5  (bases 1 to 4528)
  AUTHORS   Wendler,F., Gillingham,A.K., Sinka,R., Rosa-Ferreira,C.,
            Gordon,D.E., Franch-Marro,X., Peden,A.A., Vincent,J.P. and Munro,S.
  TITLE     A genome-wide RNA interference screen identifies two novel
            components of the metazoan secretory pathway
  JOURNAL   EMBO J 29 (2), 304-314 (2010)
   PUBMED   19942856
REFERENCE   6  (bases 1 to 4528)
  AUTHORS   Moretto,A., Bertolazzi,M., Capodicasa,E., Peraica,M.,
            Richardson,R.J., Scapellato,M.L. and Lotti,M.
  TITLE     Phenylmethanesulfonyl fluoride elicits and intensifies the clinical
            expression of neuropathic insults
  JOURNAL   Arch Toxicol 66 (1), 67-72 (1992)
   PUBMED   1316117
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA100343.1, BC107575.1, BX647979.1 and AI799606.1.
            
            On Nov 23, 2018 this sequence version replaced NM_174909.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.6970.1,
                                           SRR1803613.185923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000502346.2/ ENSP00000424707.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DA100343.1         103-136
            35-1207             BC107575.1         5-1177
            1208-4525           BX647979.1         1167-4484
            4526-4528           AI799606.1         23-25               c
FEATURES             Location/Qualifiers
     source          1..4528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.2"
     gene            1..4528
                     /gene="TMEM167A"
                     /gene_synonym="kish; TMEM167"
                     /note="transmembrane protein 167A"
                     /db_xref="GeneID:153339"
                     /db_xref="HGNC:HGNC:28330"
                     /db_xref="MIM:620000"
     exon            1..74
                     /gene="TMEM167A"
                     /gene_synonym="kish; TMEM167"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..290
                     /gene="TMEM167A"
                     /gene_synonym="kish; TMEM167"
                     /EC_number="3.6.5.4"
                     /note="transmembrane protein 167; protein kish-A"
                     /codon_start=1
                     /product="protein kish-A precursor"
                     /protein_id="NP_777569.1"
                     /db_xref="CCDS:CCDS34198.1"
                     /db_xref="GeneID:153339"
                     /db_xref="HGNC:HGNC:28330"
                     /db_xref="MIM:620000"
                     /translation="MSAIFNFQSLLTVILLLICTCAYIRSLAPSLLDRNKTGLLGIFW
                     KCARIGERKSPYVAVCCIVMAFSILFIQ"
     exon            75..184
                     /gene="TMEM167A"
                     /gene_synonym="kish; TMEM167"
                     /inference="alignment:Splign:2.1.0"
     exon            185..219
                     /gene="TMEM167A"
                     /gene_synonym="kish; TMEM167"
                     /inference="alignment:Splign:2.1.0"
     exon            220..4528
                     /gene="TMEM167A"
                     /gene_synonym="kish; TMEM167"
                     /inference="alignment:Splign:2.1.0"
     regulatory      691..696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM167A"
                     /gene_synonym="kish; TMEM167"
                     /note="hexamer: ATTAAA"
     polyA_site      718
                     /gene="TMEM167A"
                     /gene_synonym="kish; TMEM167"
     regulatory      4504..4509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM167A"
                     /gene_synonym="kish; TMEM167"
                     /note="hexamer: AATAAA"
     polyA_site      4528
                     /gene="TMEM167A"
                     /gene_synonym="kish; TMEM167"
                     /note="major polyA site"
ORIGIN      
        1 agacgggaca tgcagcctct tccgcctgag ccccggaagg gtgatgtggc tgcggcatcg
       61 ccggcctcgc tatgtctgcc attttcaatt ttcagagtct attgactgta atcttgctgc
      121 ttatatgtac ctgtgcttat attcgatcct tggcacccag cctcctggac agaaataaaa
      181 ctggattgtt gggtatattt tggaagtgtg ccagaattgg tgaacggaag agtccttatg
      241 ttgcagtatg ctgtatagta atggccttca gcatcctctt catacagtag ctggggaaaa
      301 tgccagaatg tagttgccat cagatttgat tgtgaacaag gactgactgc agaaaataat
      361 ggaaaggatg tttaactctt ttatctccga acattgaatg agataaattt ccagatgctg
      421 ttctctattt taatgttatt ggaccaatgt tctgtataaa caattaagat gtaaccattt
      481 aatagtctgt aacaatcaac ctcagtactg tcactacaat attacattct gcaaatgtta
      541 ttctgttgta tcagatacaa aattttagtg aggtatctct aaggcacata gtagaaaaca
      601 aaattggtta attactcaag ttcctttcac tgtgatttgg aaatgattta atctttatag
      661 aatgagaacc ttttttggac tagctttttt attaaaatgg ctcaatttgt gttgataagg
      721 attgcattaa tatttaatag tgcttgcttt tcctctgggc acaccatttt gatcattaac
      781 cagagtacct ctactcttag caaactctag tttatgacaa gtatttaaaa tatttaaaac
      841 aagcttatgc agttcttaag gacgaaggta aatgagatgt aacttaaaaa tagtattggg
      901 aaaatgttga tagttaacat tagtggattt agactagcca aatgacatag taggctctga
      961 aacatcttgt caagtatatg tattttgtgc atgaattttt gctggaaagc tgtctttctc
     1021 tgaaaaacac aacgttctta gaatgaaaag aacaattata aaataattat cctatatgtg
     1081 tttttcattc tttttagtgt catggcttca aaaatgaaac atttatttta attgccgtaa
     1141 aggaactgta tttttgtttt gttttttaac acagcacttt aaatccagtt tgtgttttgt
     1201 caacttgaac tggaatctct tttgttactt tggaggtgat aaatagtttt caaatctgct
     1261 gatttgtata ctgtggcaca agtatctttg aactttgata gtgaaaggag accttcaaca
     1321 atttttagtc taggcgagag gaatattagg aatgtgactt ctaaatttta caatagagca
     1381 gttattttaa ggtcatggtt aacatttctt aaggttcaac taaaattcag ttaaaatttc
     1441 agagctacga ggaacttaaa tcttagctaa aaattacctg ttgtagatag tattaattag
     1501 attgtttgca gctattaatt catcataaag ataaaatgaa gaaactctcc ctttttttaa
     1561 acaaaaaaaa ttatttctag attaataggc tagtagttat ttctgcagaa acaacgtatg
     1621 gaactgaaag ccacctattt ttattttaga ctaatttaaa ccacttggaa tggattctag
     1681 gaaacatctt aagcttgtgt gttgcctgtg gtggtttttt gtttgggggt gttttttggt
     1741 tttggtttga ttttctgtat tttgttatct ggggattttt tgtttgtttg ttttggtttg
     1801 gttttggttt tatatttttg gcatgtctat ggcagttaaa agtggtatat tttgctttag
     1861 atagggaatc aggttataat cattgttctt cctctaaact gcctcttggg ctttacatca
     1921 ggtcaaggat ttttagggtt tctcaaaaat aggattcttg tcagtgtatg catgctgagt
     1981 aagtcacctt tctggctcta atttctgggt ggccatctgt tgtccagctc tgctgccaac
     2041 tggactttcc gaaagccatg tcaactaatt ttttatatgc taagacaaat cgaatatgaa
     2101 aagaggaaga atattctaga tattctaaga catttcttaa tttggcatct cagaggaggt
     2161 aggtggaaag taaaggaaga gataattttg ggggaaaatt tgtggaaaca tacaaaacgt
     2221 tttgctttgt atagatgcta aacagagtgg gaggcagcat atttgtaaca acaaccattc
     2281 tgaccttttg aaacacaagc ttttggagaa gtcagggaga gacacagtat gaataaaagc
     2341 aattaacatt ttctttaatg tatatttttc aaagaggacc acggaatcct gttctctaac
     2401 ccaaggggca gtgtaggtgg ttttaagccc acagaatatt gagatatttc tcttgtggtt
     2461 ttggtggggt ggtgggatgc agaaggttat taaagatcaa tttaagcatc agatagacta
     2521 tcccttttat ttttttaact tttaggttca ggggtacatg tgcaggttgt tatataggta
     2581 aactcatgtc aagtggtttt gttgtacaga ttattttgtc acccaggtgc taagcctagt
     2641 acccagtagt tattttccct gctcttctcc ctcctcccac cctccaccct caagtaggcc
     2701 ccagtgtctg ttgttccttt ctttgtgtcc ttgagttctc atcatttagc tcctacttct
     2761 aaatgagaac atgtatttgg ttttctgttc tgtgttagtt tgctaaggat aatggcctcc
     2821 agctcagatg gaatatctct atcatataga cctgttgtta cagggcagga tcggatgatg
     2881 gacactgaag tcctcagctt gctaagttca gttgctctcc ctagcctcct tttggcttca
     2941 gagtcttttg attccatcta tcctggtatt ttttgtgtgc tgatgtttag ttctggattg
     3001 gcttcagctg tgctaatagg aagggcgttg tcttttcaag caatcttaaa aggtggtcaa
     3061 tcaaaaggcc agagtctgaa tcccttctgt ggcttaaata atttgaggat caagtccagt
     3121 gtcttgttaa tccctgttct actgtgccag acactatctt gaatgctttt atatgttcag
     3181 gttcaaaatc gctctttcat accaggggat gatagtaacg tgtaacttgc aatagattcc
     3241 ttcatcttag taataagatg atcagtctag ttaggacaaa atagagattg aataaattaa
     3301 cttttccaag tttacagagt aaaaatgagc agatctctgc ctggttttgt gaaaaagagt
     3361 tagcactggt aaatagaata tttctactcc tacaccattc tttcagtata tcatcactga
     3421 agacaggaag ataggcacac agattcttcc tcgtagtaat tcatagtgca ctaggtgaaa
     3481 gagatgaagt atgtattaaa agtacaatgt gatggcattt attattcaga taatcccagg
     3541 attctagaag aaaataaaga agagtgacag ttcagttagg gtgtgaactt ccagaggagc
     3601 actgcttaag ctgaacttga gagcattgtg caaaagcaca gtagtctgtt aagaactaga
     3661 aataacctag cttgtgccac ttcgggagta ttaagacata agcctagaaa ggtaggcaaa
     3721 ggttagatct tagactgtct tgtatttttc tcattcctgt tgattaccta cctcaaaatt
     3781 gaatatgttt ttcctcctgc ctaacacaaa actactcaag ggcagaaatt taaattcttc
     3841 cttggtgtat gtgcaaagaa ggttgaatat attcatgcct accttatttt ggactaggaa
     3901 tacagtagta tactttccga agacttgcct gaatagtata taaggtggag gcaactgact
     3961 agttaggtca gtatttttag aaactcttaa tagctcatac tcttgatacc aaaagcagcc
     4021 ctgattgtta aagcacacac ctgcacaaga agcagtgatg gttgcattta catttcctgg
     4081 gtgcacaaaa aaaaattctc aaaaagcaag gacttacgct ttttgcaaag cctttgagaa
     4141 gttactggat cataggaagc ttataacaag aatggaagat tcttaaataa ctcactttct
     4201 ttggtatcca gtaacagtag atgttcaaaa tatgtagctg attaatacca gcattgtgaa
     4261 cgctgtacaa ccttgtggtt attactaagc aagttactac tagcttctga aaagtagctt
     4321 cataattaat gttatttata cactgccttc catgactttt actttgccct aagctaatct
     4381 ccaaaatctg aaatgctact ccaatatcag aaaaaaaggg ggaggtggaa ttatatttcc
     4441 tgtgatttta agagtacaga gaatcatgca catctctgat tagttcatat atgtctagtg
     4501 tgtaataaaa gtcaagatga actctcaa
//
