LOCUS       NM_032227               5570 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens transmembrane protein 164 (TMEM164), transcript
            variant 2, mRNA.
ACCESSION   NM_032227
VERSION     NM_032227.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5570)
  AUTHORS   Su,Y., Li,L., Chen,J. and Gao,C.
  TITLE     TMEM164 promotes ferroptosis by selectively mediating
            ATG5-dependent autophagosome formation to inhibit the progression
            of LUAD
  JOURNAL   Autoimmunity 57 (1), 2410192 (2024)
   PUBMED   39392409
  REMARK    GeneRIF: TMEM164 promotes ferroptosis by selectively mediating
            ATG5-dependent autophagosome formation to inhibit the progression
            of LUAD.
REFERENCE   2  (bases 1 to 5570)
  AUTHORS   Reed,A., Ware,T., Li,H., Fernando Bazan,J. and Cravatt,B.F.
  TITLE     TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether
            phospholipids
  JOURNAL   Nat Chem Biol 19 (3), 378-388 (2023)
   PUBMED   36782012
REFERENCE   3  (bases 1 to 5570)
  AUTHORS   Liu,J., Liu,Y., Wang,Y., Li,C., Xie,Y., Klionsky,D.J., Kang,R. and
            Tang,D.
  TITLE     TMEM164 is a new determinant of autophagy-dependent ferroptosis
  JOURNAL   Autophagy 19 (3), 945-956 (2023)
   PUBMED   35947500
REFERENCE   4  (bases 1 to 5570)
  AUTHORS   Poreau,B., Ramond,F., Harbuz,R., Satre,V., Barro,C., Vettier,C.,
            Adouard,V., Thevenon,J., Jouk,P.S., Coutton,C., Touraine,R. and
            Dieterich,K.
  TITLE     Xq22.3q23 microdeletion harboring TMEM164 and AMMECR1 genes: Two
            case reports confirming a recognizable phenotype with short
            stature, midface hypoplasia, intellectual delay, and elliptocytosis
  JOURNAL   Am J Med Genet A 179 (4), 650-654 (2019)
   PUBMED   30737907
  REMARK    GeneRIF: Xq22.3q23 microdeletion harboring TMEM164 and AMMECR1
            genes are associated with Alport syndrome, intellectual disability,
            midface hypoplasia, and elliptocytosis.
REFERENCE   5  (bases 1 to 5570)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP295095.1, BC085605.1, AL359079.15 and BU681952.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032227.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085605.1, SRR7346977.2745819.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372068.7/ ENSP00000361138.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BP295095.1         1-20
            21-1328             BC085605.1         1-1308
            1329-5036           AL359079.15        40018-43725         c
            5037-5570           BU681952.1         15-548              c
FEATURES             Location/Qualifiers
     source          1..5570
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..5570
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /note="transmembrane protein 164"
                     /db_xref="GeneID:84187"
                     /db_xref="HGNC:HGNC:26217"
     exon            1..65
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     exon            66..729
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1233
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /note="isoform b is encoded by transcript variant 2;
                     RP13-360B22.2; arachidonoyl ether phospholipid synthase"
                     /codon_start=1
                     /product="transmembrane protein 164 isoform b"
                     /protein_id="NP_115603.2"
                     /db_xref="CCDS:CCDS14550.2"
                     /db_xref="GeneID:84187"
                     /db_xref="HGNC:HGNC:26217"
                     /translation="MSRYSYQSLLDWLYGGVDPSFAGNGGPDCAAFLSWQQRLLESVV
                     VLTLALLEILVALRHILRQTKEDGRGSPGSQPEQVTQRPEEGKESLSKNLLLVALCLT
                     FGVEVGFKFATKTVIYLLNPCHLVTMMHIFLLACPPCRGAIVVFKLQMHMLNGALLAL
                     LFPVVNTRLLPFELEIYYIQHVMLYVVPIYLLWKGGAYTPEPLSSFRWALLSTGLMFF
                     YHFSVLQILGLVTEVNLNNMLCPAISDPFYGPWYRIWASGHQTLMTMTHGKLVILFSY
                     MAGPLCKYLLDLLRLPAKKID"
     exon            730..779
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     exon            780..846
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     exon            847..925
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1026
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..5570
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5419..5424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /note="hexamer: AATAAA"
     polyA_site      5456
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
     regulatory      5552..5557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /note="hexamer: ATTAAA"
     polyA_site      5570
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /note="major polyA site"
ORIGIN      
        1 gaagttgcta gctgggggca gagacggcca cgcggttgca ggagtaagag atccctctgt
       61 ggcgaattgg ccaacggctc ctttcaaccc tgcctcgttg gtggccactg gagaagcgcg
      121 gggggctccc ccagacagcc gtggggacaa gttagagcca gcactttacc ccgggccttg
      181 cgtgtagctt cccctcccct actctcggtg ccctggtgtc tggagggggg ttgtgggggt
      241 gtgcccgcct tacatggtcc accacccggg caaccctctg ggcttgtgtt ccatctcact
      301 cttgcttcct gtactgtggt caaggggaac cactgcatca tgtcccggta tagctaccag
      361 agtctcctgg actggctcta tgggggcgtg gaccccagtt ttgcaggcaa tgggggcccc
      421 gactgtgctg ccttcctctc ttggcagcag cggctgctgg aaagtgtggt ggtcctgacc
      481 ctggctctgt tggagatcct ggtggccctg cggcacatcc tgaggcagac gaaggaggac
      541 ggtaggggta gccctggcag ccagccagag caggtgaccc agcggccaga ggaaggcaag
      601 gagagcctga gcaagaatct gctcttagta gccctgtgcc tgaccttcgg ggtggaggtg
      661 ggctttaagt tcgccaccaa gaccgtcatc tacctgctca acccctgtca cctggtcacc
      721 atgatgcata tctttctcct ggcctgccct ccatgtcggg gagctatcgt cgtcttcaag
      781 ctacagatgc acatgttgaa tggagctctt ctggcattgc tgtttcctgt ggtaaacact
      841 cggctgctcc cctttgaatt ggagatttac tacattcagc atgttatgct ctacgtggta
      901 cccatctacc tgctttggaa aggaggtgct tacactccag agcccctcag cagtttccgg
      961 tgggctcttc tctcaactgg cctcatgttc ttttatcact tcagcgtctt gcagatcctc
     1021 ggcctggtca ccgaagtgaa tttgaacaac atgctgtgtc cggccatctc agacccattc
     1081 tacggcccct ggtatcgcat ctgggcctcg ggacaccaga ctctcatgac catgacccac
     1141 gggaagctgg tcatcctgtt ctcatacatg gctgggccct tgtgtaaata tctgctggat
     1201 ttgctccggc ttccagccaa gaaaatagac tgaaggtgct tatttttttt ttttttcctc
     1261 cctgaggaag caagtcgtga cttgacttgg agaacaccca gttcttgata aaatcatggg
     1321 agagggcagt aggatgtttg gtgtatttct ttttcctcct ttctgtccct ttcttctacc
     1381 actcttcctt tcccagctct tccccctacg atgtctcctt gagcctgggg tgtagtgctg
     1441 ggcgctggat tttcctcctt ccctttggct ctctctctgc tcctagtggc cttacatggg
     1501 gagattgcag tgagcggctc tttcactctg cttgtcggtg ctttaacaac agctggttga
     1561 ggagaaaggg aacaacaagt agtagttctt ttggcatcga agcaatgaga ttgggttgtg
     1621 tttcatttct ccactgccag ggacctccag gcttatgctg gcgtcccatt tagtctccag
     1681 cacagccctt accacggggg actgaggcct tgtttctata ccagcggcaa gcccagagcc
     1741 gagggatttc acagctcgtg gtcaagacag aaccagccag attctggtca ctggtgtccc
     1801 atgactcaaa gtaaacagcc aaccagccac tccctccagg atgctgcctg gggtgggagg
     1861 tgagagcacc acccagccca agggctagat tccattgaga gggttggaga tctattgcaa
     1921 tgacaaatcc aaagtgaaga gggtcaagat atatacagta ctaggccaga ccctgtgtaa
     1981 gttctgcctg tgagagttga gaactgatgc atatcccaat cagaagtgag cacagaaaac
     2041 tgtgatttga atcatacact ctgttttagg aaaatgttga taatagatac cattttaatc
     2101 ttgagtgccc cttaaatgtg ttccctctcc ctttccctct ccccccaccc ctccccctcc
     2161 cccctccctc cctctttccc tctctcaggc agcttcaggg aagaatgagc tggaattggc
     2221 tggttggttg gtttttgagt ttggagaatc ctcgcatcag ggcccatttc tggaagattc
     2281 tgtagatctg tttcttggtt ttacagggcc agtgttgttt ccctagggcc agatttcttc
     2341 agtgtatcca cactcagtgc tgaattgttt aatgtggggg acatcacgtc ctcctcatcc
     2401 tgtctacccc caaatcccat gtctaggttg aaagggggct gccaaagaat taagtcctca
     2461 tgggtggagg ttcaggtgct ccacaaggag gagcttttgt tgaaggactt cagctcagtt
     2521 atgcacggac ctcaagcagg caggaagtgg ctgggcattg ctgactccac attgactccc
     2581 actaggaaca gatttgctta agaacagaaa agctcatttg gtgattttgt ctgatgagcc
     2641 tcccttcccc tgtcccactc taggcaacac agttgaccta gaccagttcc agtatttcca
     2701 gtttgaccgt gtttgaccta cactgagctt cggtgcctca gtggtcataa ttttagcaag
     2761 tggacctata ggaagcaacc ctgggaggga ccgtccttct gcagaggcct gcgggcattg
     2821 aggctatcaa tccccagggc ttggggagca ggaggggagg gcaccaagtg ctcttactct
     2881 cctgagctcc ttttgatgcg taagctttgt ttttggccct ctttgaaggc agggccaaac
     2941 ttttcttagt gcctctcacc ttagggtggc cctccaggga aggtgctcct tgaatggctg
     3001 gattggccct gcccaccgtc aaactgctac atgtaggaat agctgatgag gaaatacaca
     3061 aggcctcagt gccccttggc ctctttacaa aaggagaagt tggaagggga ttgtgggagg
     3121 agcccctggg ggcctggtct gtcctccacc agaacttgga gttgctgcca gcagaggatc
     3181 tgtgcctcag ctgaagacta gctccggaat gtcatagggg tgtgactgtg taggccttct
     3241 cctcctcctc gtttctgtgg catggcacag gttgcctggt tgctcgagcc ttccccatgt
     3301 tgacatcctc cacaagcttg cctttgctct gtctacagct tagtacccca ttctggaggg
     3361 cactttctgg tgcttggaag gagagaagaa agcaaaagcc acatgcctgg catggccaag
     3421 ccagagacag atccacctgt cagaggaagg aagaagtaaa gggggcatgc agggcttttg
     3481 ggggccagat tggctcagaa acatgtaggt caaaagaata gagggggccc agtctatagg
     3541 cttcacaagg agccatggcc tgtatttggg gcattgggga gcataaggca tctgaactgg
     3601 tccagatctc actcttatct tgggccaagc caacgtggag agaagcaacc caaccagact
     3661 cttggcagcc tgccttacag ggtagcccac cttatagggt agccctcata tctgccctgt
     3721 gccggccctc tactgcccca gctttggtac aggagtgagg gagaagctgg agcttgcaca
     3781 cccagtggcc agtggggctg tcttcccagc tcctcctcag ggctttcctg tcagtgccaa
     3841 gccagttccc cagccaggtt tccgtgtgcc atttgccagc gtgtgggagc tctgcgcgtg
     3901 tgtgagggtg tttgtagaag agggcagttt cctttcaaat ggccttagga agggaaaaga
     3961 gtactccctc cagcccctag gtagccttgg ccagggatgt gggccaagaa cagtctgtgg
     4021 agctggccaa cttgtggcat ccactccaaa tagcagagac ccagtcacgc ctgcttctgg
     4081 tcctccctgc cctcagtatt tggttttgta caccaaagat gatctggccc atcttcctcc
     4141 cagaggcaca acagtaacat gttcctctgt cagcctgtga aggcatgcag ggttctgaag
     4201 ccacagactc agtctcccca agtcagcaat ctctttctct ctctctcctc aaacttcatc
     4261 gcattcatag aagctgcttg cagggtcgcc gggctaacca gggtgatcgg cgaactttac
     4321 cgtacagtac ctcagtctag ctgtcagatc accccttttg ctgtagcctc tgttgaggtt
     4381 tttatatttg tgatcattgg taattcagtg tcctatgaag tgggcacagc tccccacaga
     4441 gagcaagttg tcagcaggtc tctgtgcact ggtattgggg cagggcagtg ccctgggggt
     4501 aagctaggtg gctcagggag tggcagaagg gccatttttc cctctgccaa aaagacttcc
     4561 ttggatttgt agatgttgac ccagagtcct ctgtcccctc ctgaagagga ttttcttact
     4621 ggtttctact gaaggggagg taggggagga ggaaaaaagg accatgtgtg atgctgttag
     4681 acaagacact gacgctgatt atggagggtc tcctgcaggc ccttgtgggc tccttggcaa
     4741 ggccccaggc tgggaaggag ctccccccac tgcccatcct gcccgctttg tggcgggtag
     4801 agtcagtgac agggaggcag ccctcctttt gtgtatatag agtgagctga tttgggctca
     4861 ggaaaaccta gtcgcttgtt gctctcgtct gtgacatttt tgtacactgg tttgctactc
     4921 atggcaagaa acagacaaag ccccatgaaa aataaaacaa aacaaaagtc atttcaaaca
     4981 aagctgttgt tttgaaaact cttgctttct tttggtgtcc attttgtgtt ctattttaaa
     5041 gaatctttca tttatattgg tgttattgta gtgaagagaa tgtgataggc tgatctgtaa
     5101 tggtttctgt caggagctta gcaaatgcct ctgcccctct tcccctaccc ctgtccttcc
     5161 tcagttccca gctgggattg ctatgcactg ggcagacccg tcactgtctc ccctgaaccc
     5221 ccacacagtg gcttccctta gaaccagtct ttgtactctc cctaaacagc agcaggctta
     5281 ggatttttgt caggctggtt cttgcgtgct ctgtgccccc accagtttgc tcacctcttg
     5341 gggcattttg taatgtgttt tctctgtctt gtaaaacctt ttgattgtac cgaaatggta
     5401 tctgcagtcg cctttggaaa taaatggtca ttaatttgtg tacttagcat tctgaatttt
     5461 agtctcaggt gtttctgttg ttgaagatcc ttgaatgaaa aggaaccctc accatggggc
     5521 ttactgttat aatgtttctt catttactgt tattaaaaga tttatgagaa
//
