LOCUS       NM_017698               4951 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens transmembrane protein 164 (TMEM164), transcript
            variant 1, mRNA.
ACCESSION   NM_017698 XM_001714477 XM_002343838
VERSION     NM_017698.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4951)
  AUTHORS   Su,Y., Li,L., Chen,J. and Gao,C.
  TITLE     TMEM164 promotes ferroptosis by selectively mediating
            ATG5-dependent autophagosome formation to inhibit the progression
            of LUAD
  JOURNAL   Autoimmunity 57 (1), 2410192 (2024)
   PUBMED   39392409
  REMARK    GeneRIF: TMEM164 promotes ferroptosis by selectively mediating
            ATG5-dependent autophagosome formation to inhibit the progression
            of LUAD.
REFERENCE   2  (bases 1 to 4951)
  AUTHORS   Reed,A., Ware,T., Li,H., Fernando Bazan,J. and Cravatt,B.F.
  TITLE     TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether
            phospholipids
  JOURNAL   Nat Chem Biol 19 (3), 378-388 (2023)
   PUBMED   36782012
REFERENCE   3  (bases 1 to 4951)
  AUTHORS   Liu,J., Liu,Y., Wang,Y., Li,C., Xie,Y., Klionsky,D.J., Kang,R. and
            Tang,D.
  TITLE     TMEM164 is a new determinant of autophagy-dependent ferroptosis
  JOURNAL   Autophagy 19 (3), 945-956 (2023)
   PUBMED   35947500
REFERENCE   4  (bases 1 to 4951)
  AUTHORS   Poreau,B., Ramond,F., Harbuz,R., Satre,V., Barro,C., Vettier,C.,
            Adouard,V., Thevenon,J., Jouk,P.S., Coutton,C., Touraine,R. and
            Dieterich,K.
  TITLE     Xq22.3q23 microdeletion harboring TMEM164 and AMMECR1 genes: Two
            case reports confirming a recognizable phenotype with short
            stature, midface hypoplasia, intellectual delay, and elliptocytosis
  JOURNAL   Am J Med Genet A 179 (4), 650-654 (2019)
   PUBMED   30737907
  REMARK    GeneRIF: Xq22.3q23 microdeletion harboring TMEM164 and AMMECR1
            genes are associated with Alport syndrome, intellectual disability,
            midface hypoplasia, and elliptocytosis.
REFERENCE   5  (bases 1 to 4951)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK094127.1, CN349076.1, AL359079.15 and BU681952.1.
            
            On Aug 13, 2020 this sequence version replaced NM_017698.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4294439.1,
                                           SRR18074967.2746740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               AK094127.1         29-426
            399-636             CN349076.1         230-467
            637-1519            AK094127.1         665-1547
            1520-4417           AL359079.15        40018-42915         c
            4418-4951           BU681952.1         15-548              c
FEATURES             Location/Qualifiers
     source          1..4951
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..4951
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /note="transmembrane protein 164"
                     /db_xref="GeneID:84187"
                     /db_xref="HGNC:HGNC:26217"
     exon            1..110
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     exon            111..160
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     exon            161..227
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..614
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /note="isoform a is encoded by transcript variant 1;
                     RP13-360B22.2; arachidonoyl ether phospholipid synthase"
                     /codon_start=1
                     /product="transmembrane protein 164 isoform a"
                     /protein_id="NP_060168.2"
                     /db_xref="CCDS:CCDS55475.1"
                     /db_xref="GeneID:84187"
                     /db_xref="HGNC:HGNC:26217"
                     /translation="MHMLNGALLALLFPVVNTRLLPFELEIYYIQHVMLYVVPIYLLW
                     KGGAYTPEPLSSFRWALLSTGLMFFYHFSVLQILGLVTEVNLNNMLCPAISDPFYGPW
                     YRIWASGHQTLMTMTHGKLVILFSYMAGPLCKYLLDLLRLPAKKID"
     exon            228..306
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     exon            307..407
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     exon            408..4951
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4800..4805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /note="hexamer: AATAAA"
     polyA_site      4837
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
     regulatory      4933..4938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /note="hexamer: ATTAAA"
     polyA_site      4951
                     /gene="TMEM164"
                     /gene_synonym="bB360B22.3"
                     /note="major polyA site"
ORIGIN      
        1 gaggaggagc cgtgcgccgc ggcggcggcc gccaggggaa ccgagcgccc ggcgcggaga
       61 gcgcgggagc ggagcagtag cccgatccgg ggccgcgggc cgagctgccg atctttctcc
      121 tggcctgccc tccatgtcgg ggagctatcg tcgtcttcaa gctacagatg cacatgttga
      181 atggagctct tctggcattg ctgtttcctg tggtaaacac tcggctgctc ccctttgaat
      241 tggagattta ctacattcag catgttatgc tctacgtggt acccatctac ctgctttgga
      301 aaggaggtgc ttacactcca gagcccctca gcagtttccg gtgggctctt ctctcaactg
      361 gcctcatgtt cttttatcac ttcagcgtct tgcagatcct cggcctggtc accgaagtga
      421 atttgaacaa catgctgtgt ccggccatct cagacccatt ctacggcccc tggtatcgca
      481 tctgggcctc gggacaccag actctcatga ccatgaccca cgggaagctg gtcatcctgt
      541 tctcatacat ggctgggccc ttgtgtaaat atctgctgga tttgctccgg cttccagcca
      601 agaaaataga ctgaaggtgc ttattttttt tttttttcct ccctgaggaa gcaagtcgtg
      661 acttgacttg gagaacaccc agttcttgat aaaatcatgg gagagggcag taggatgttt
      721 ggtgtatttc tttttcctcc tttctgtccc tttcttctac cactcttcct ttcccagctc
      781 ttccccctac gatgtctcct tgagcctggg gtgtagtgct gggcgctgga ttttcctcct
      841 tccctttggc tctctctctg ctcctagtgg ccttacatgg ggagattgca gtgagcggct
      901 ctttcactct gcttgtcggt gctttaacaa cagctggttg aggagaaagg gaacaacaag
      961 tagtagttct tttggcatcg aagcaatgag attgggttgt gtttcatttc tccactgcca
     1021 gggacctcca ggcttatgct ggcgtcccat ttagtctcca gcacagccct taccacgggg
     1081 gactgaggcc ttgtttctat accagcggca agcccagagc cgagggattt cacagctcgt
     1141 ggtcaagaca gaaccagcca gattctggtc actggtgtcc catgactcaa agtaaacagc
     1201 caaccagcca ctccctccag gatgctgcct ggggtgggag gtgagagcac cacccagccc
     1261 aagggctaga ttccattgag agggttggag atctattgca atgacaaatc caaagtgaag
     1321 agggtcaaga tatatacagt actaggccag accctgtgta agttctgcct gtgagagttg
     1381 agaactgatg catatcccaa tcagaagtga gcacagaaaa ctgtgatttg aatcatacac
     1441 tctgttttag gaaaatgttg ataatagata ccattttaat cttgagtgcc ccttaaatgt
     1501 gttccctctc cctttccctc tccccccacc cctccccctc ccccctccct ccctctttcc
     1561 ctctctcagg cagcttcagg gaagaatgag ctggaattgg ctggttggtt ggtttttgag
     1621 tttggagaat cctcgcatca gggcccattt ctggaagatt ctgtagatct gtttcttggt
     1681 tttacagggc cagtgttgtt tccctagggc cagatttctt cagtgtatcc acactcagtg
     1741 ctgaattgtt taatgtgggg gacatcacgt cctcctcatc ctgtctaccc ccaaatccca
     1801 tgtctaggtt gaaagggggc tgccaaagaa ttaagtcctc atgggtggag gttcaggtgc
     1861 tccacaagga ggagcttttg ttgaaggact tcagctcagt tatgcacgga cctcaagcag
     1921 gcaggaagtg gctgggcatt gctgactcca cattgactcc cactaggaac agatttgctt
     1981 aagaacagaa aagctcattt ggtgattttg tctgatgagc ctcccttccc ctgtcccact
     2041 ctaggcaaca cagttgacct agaccagttc cagtatttcc agtttgaccg tgtttgacct
     2101 acactgagct tcggtgcctc agtggtcata attttagcaa gtggacctat aggaagcaac
     2161 cctgggaggg accgtccttc tgcagaggcc tgcgggcatt gaggctatca atccccaggg
     2221 cttggggagc aggaggggag ggcaccaagt gctcttactc tcctgagctc cttttgatgc
     2281 gtaagctttg tttttggccc tctttgaagg cagggccaaa cttttcttag tgcctctcac
     2341 cttagggtgg ccctccaggg aaggtgctcc ttgaatggct ggattggccc tgcccaccgt
     2401 caaactgcta catgtaggaa tagctgatga ggaaatacac aaggcctcag tgccccttgg
     2461 cctctttaca aaaggagaag ttggaagggg attgtgggag gagcccctgg gggcctggtc
     2521 tgtcctccac cagaacttgg agttgctgcc agcagaggat ctgtgcctca gctgaagact
     2581 agctccggaa tgtcataggg gtgtgactgt gtaggccttc tcctcctcct cgtttctgtg
     2641 gcatggcaca ggttgcctgg ttgctcgagc cttccccatg ttgacatcct ccacaagctt
     2701 gcctttgctc tgtctacagc ttagtacccc attctggagg gcactttctg gtgcttggaa
     2761 ggagagaaga aagcaaaagc cacatgcctg gcatggccaa gccagagaca gatccacctg
     2821 tcagaggaag gaagaagtaa agggggcatg cagggctttt gggggccaga ttggctcaga
     2881 aacatgtagg tcaaaagaat agagggggcc cagtctatag gcttcacaag gagccatggc
     2941 ctgtatttgg ggcattgggg agcataaggc atctgaactg gtccagatct cactcttatc
     3001 ttgggccaag ccaacgtgga gagaagcaac ccaaccagac tcttggcagc ctgccttaca
     3061 gggtagccca ccttataggg tagccctcat atctgccctg tgccggccct ctactgcccc
     3121 agctttggta caggagtgag ggagaagctg gagcttgcac acccagtggc cagtggggct
     3181 gtcttcccag ctcctcctca gggctttcct gtcagtgcca agccagttcc ccagccaggt
     3241 ttccgtgtgc catttgccag cgtgtgggag ctctgcgcgt gtgtgagggt gtttgtagaa
     3301 gagggcagtt tcctttcaaa tggccttagg aagggaaaag agtactccct ccagccccta
     3361 ggtagccttg gccagggatg tgggccaaga acagtctgtg gagctggcca acttgtggca
     3421 tccactccaa atagcagaga cccagtcacg cctgcttctg gtcctccctg ccctcagtat
     3481 ttggttttgt acaccaaaga tgatctggcc catcttcctc ccagaggcac aacagtaaca
     3541 tgttcctctg tcagcctgtg aaggcatgca gggttctgaa gccacagact cagtctcccc
     3601 aagtcagcaa tctctttctc tctctctcct caaacttcat cgcattcata gaagctgctt
     3661 gcagggtcgc cgggctaacc agggtgatcg gcgaacttta ccgtacagta cctcagtcta
     3721 gctgtcagat cacccctttt gctgtagcct ctgttgaggt ttttatattt gtgatcattg
     3781 gtaattcagt gtcctatgaa gtgggcacag ctccccacag agagcaagtt gtcagcaggt
     3841 ctctgtgcac tggtattggg gcagggcagt gccctggggg taagctaggt ggctcaggga
     3901 gtggcagaag ggccattttt ccctctgcca aaaagacttc cttggatttg tagatgttga
     3961 cccagagtcc tctgtcccct cctgaagagg attttcttac tggtttctac tgaaggggag
     4021 gtaggggagg aggaaaaaag gaccatgtgt gatgctgtta gacaagacac tgacgctgat
     4081 tatggagggt ctcctgcagg cccttgtggg ctccttggca aggccccagg ctgggaagga
     4141 gctcccccca ctgcccatcc tgcccgcttt gtggcgggta gagtcagtga cagggaggca
     4201 gccctccttt tgtgtatata gagtgagctg atttgggctc aggaaaacct agtcgcttgt
     4261 tgctctcgtc tgtgacattt ttgtacactg gtttgctact catggcaaga aacagacaaa
     4321 gccccatgaa aaataaaaca aaacaaaagt catttcaaac aaagctgttg ttttgaaaac
     4381 tcttgctttc ttttggtgtc cattttgtgt tctattttaa agaatctttc atttatattg
     4441 gtgttattgt agtgaagaga atgtgatagg ctgatctgta atggtttctg tcaggagctt
     4501 agcaaatgcc tctgcccctc ttcccctacc cctgtccttc ctcagttccc agctgggatt
     4561 gctatgcact gggcagaccc gtcactgtct cccctgaacc cccacacagt ggcttccctt
     4621 agaaccagtc tttgtactct ccctaaacag cagcaggctt aggatttttg tcaggctggt
     4681 tcttgcgtgc tctgtgcccc caccagtttg ctcacctctt ggggcatttt gtaatgtgtt
     4741 ttctctgtct tgtaaaacct tttgattgta ccgaaatggt atctgcagtc gcctttggaa
     4801 ataaatggtc attaatttgt gtacttagca ttctgaattt tagtctcagg tgtttctgtt
     4861 gttgaagatc cttgaatgaa aaggaaccct caccatgggg cttactgtta taatgtttct
     4921 tcatttactg ttattaaaag atttatgaga a
//
