LOCUS       NM_153354               2750 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 161B (TMEM161B), transcript
            variant 2, mRNA.
ACCESSION   NM_153354
VERSION     NM_153354.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2750)
  AUTHORS   Luo,L., Xu,R., Mu,F., Li,H., Liu,Y., Gao,J., Wu,Y., Wang,K.,
            Liu,Y., Zhang,Y., Wang,J. and Liu,Y.
  TITLE     The interaction between TMEM161B (rs768705) and paranoid
            personality traits in relation to the risk of major depressive
            disorder: Results form a longitudinal study of 7642 Chinese
            freshmen
  JOURNAL   J Affect Disord 365, 171-177 (2024)
   PUBMED   39147160
  REMARK    GeneRIF: The interaction between TMEM161B (rs768705) and paranoid
            personality traits in relation to the risk of major depressive
            disorder: Results form a longitudinal study of 7642 Chinese
            freshmen.
REFERENCE   2  (bases 1 to 2750)
  AUTHORS   Wang,L., Heffner,C., Vong,K.I., Barrows,C., Ha,Y.J., Lee,S.,
            Lara-Gonzalez,P., Jhamb,I., Van Der Meer,D., Loughnan,R.,
            Parker,N., Sievert,D., Mittal,S., Issa,M.Y., Andreassen,O.A.,
            Dale,A., Dobyns,W.B., Zaki,M.S., Murray,S.A. and Gleeson,J.G.
  TITLE     TMEM161B modulates radial glial scaffolding in neocortical
            development
  JOURNAL   Proc Natl Acad Sci U S A 120 (4), e2209983120 (2023)
   PUBMED   36669109
  REMARK    GeneRIF: TMEM161B modulates radial glial scaffolding in neocortical
            development.
REFERENCE   3  (bases 1 to 2750)
  AUTHORS   Koopman,C.D., De Angelis,J., Iyer,S.P., Verkerk,A.O., Da Silva,J.,
            Berecki,G., Jeanes,A., Baillie,G.J., Paterson,S., Uribe,V.,
            Ehrlich,O.V., Robinson,S.D., Garric,L., Petrou,S., Simons,C.,
            Vetter,I., Hogan,B.M., de Boer,T.P., Bakkers,J. and Smith,K.A.
  TITLE     The zebrafish grime mutant uncovers an evolutionarily conserved
            role for Tmem161b in the control of cardiac rhythm
  JOURNAL   Proc Natl Acad Sci U S A 118 (9) (2021)
   PUBMED   33597309
REFERENCE   4  (bases 1 to 2750)
  AUTHORS   Hou,B., Ji,L., Chen,Z., An,L., Zhang,N., Ren,D., Yuan,F., Liu,L.,
            Bi,Y., Guo,Z., Ma,G., Xu,F., Yang,F., Yu,S., Yi,Z., Xu,Y., He,L.,
            Liu,C., Bai,B., Wu,S., Zhao,L., Cai,C., Yu,T., He,G., Shi,Y. and
            Li,X.
  TITLE     Role of rs454214 in Personality mediated Depression and Subjective
            Well-being
  JOURNAL   Sci Rep 10 (1), 5702 (2020)
   PUBMED   32231262
  REMARK    GeneRIF: Role of rs454214 in Personality mediated Depression and
            Subjective Well-being.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2750)
  AUTHORS   Muench,C., Schwandt,M., Jung,J., Cortes,C.R., Momenan,R. and
            Lohoff,F.W.
  TITLE     The major depressive disorder GWAS-supported variant rs10514299 in
            TMEM161B-MEF2C predicts putamen activation during reward processing
            in alcohol dependence
  JOURNAL   Transl Psychiatry 8 (1), 131 (2018)
   PUBMED   30006604
  REMARK    GeneRIF: The previously identified major depressive disorder risk
            variant rs10514299 in TMEM161B-MEF2C predicts neuronal correlates
            of reward processing in an alcohol dependence phenotype, possibly
            explaining part of the shared pathophysiology and comorbidity
            between the disorders.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2750)
  AUTHORS   Hyde,C.L., Nagle,M.W., Tian,C., Chen,X., Paciga,S.A.,
            Wendland,J.R., Tung,J.Y., Hinds,D.A., Perlis,R.H. and Winslow,A.R.
  TITLE     Identification of 15 genetic loci associated with risk of major
            depression in individuals of European descent
  JOURNAL   Nat Genet 48 (9), 1031-1036 (2016)
   PUBMED   27479909
  REMARK    GeneRIF: Single nucleotide polymorphism in TMEM161B gene is
            associated with major depressive disorder.
REFERENCE   7  (bases 1 to 2750)
  AUTHORS   Sim,X., Jensen,R.A., Ikram,M.K., Cotch,M.F., Li,X., MacGregor,S.,
            Xie,J., Smith,A.V., Boerwinkle,E., Mitchell,P., Klein,R.,
            Klein,B.E., Glazer,N.L., Lumley,T., McKnight,B., Psaty,B.M., de
            Jong,P.T., Hofman,A., Rivadeneira,F., Uitterlinden,A.G., van
            Duijn,C.M., Aspelund,T., Eiriksdottir,G., Harris,T.B., Jonasson,F.,
            Launer,L.J., Attia,J., Baird,P.N., Harrap,S., Holliday,E.G.,
            Inouye,M., Rochtchina,E., Scott,R.J., Viswanathan,A., Li,G.,
            Smith,N.L., Wiggins,K.L., Kuo,J.Z., Taylor,K.D., Hewitt,A.W.,
            Martin,N.G., Montgomery,G.W., Sun,C., Young,T.L., Mackey,D.A., van
            Zuydam,N.R., Doney,A.S., Palmer,C.N., Morris,A.D., Rotter,J.I.,
            Tai,E.S., Gudnason,V., Vingerling,J.R., Siscovick,D.S., Wang,J.J.
            and Wong,T.Y.
  CONSRTM   Wellcome Trust Case Control Consortium 2; Global BPGen Consortium
  TITLE     Genetic loci for retinal arteriolar microcirculation
  JOURNAL   PLoS One 8 (6), e65804 (2013)
   PUBMED   23776548
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2750)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   9  (bases 1 to 2750)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2750)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DW423642.1, BC037287.2, AK300893.1, BX647345.1, BX390411.2,
            AI570193.1 and AC010243.7.
            
            On Feb 27, 2020 this sequence version replaced NM_153354.4.
            
            Transcript Variant: This variant (2) contains a 3' terminal exon
            that extends past a splice site that is used in variant 1. This
            results in a novel 3' coding region and 3' UTR, compared to variant
            1. It encodes isoform 2, which is shorter and has a distinct
            C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037287.2, SRR1660809.67381.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296595.11/ ENSP00000296595.6
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DW423642.1         56-56
            2-965               BC037287.2         5-968
            966-1677            AK300893.1         1082-1793
            1678-2068           BX647345.1         1732-2122
            2069-2333           BX390411.2         362-626
            2334-2591           AI570193.1         10-267              c
            2592-2750           AC010243.7         103985-104143       c
FEATURES             Location/Qualifiers
     source          1..2750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.3"
     gene            1..2750
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /note="transmembrane protein 161B"
                     /db_xref="GeneID:153396"
                     /db_xref="HGNC:HGNC:28483"
     exon            1..125
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1586
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transmembrane protein 161B isoform 2"
                     /protein_id="NP_699185.1"
                     /db_xref="CCDS:CCDS4065.1"
                     /db_xref="GeneID:153396"
                     /db_xref="HGNC:HGNC:28483"
                     /translation="MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPT
                     EEELRILAGKQQKGKTKKDRKYNGHIESKPLTIPKDIDLHLETKSVTEVDTLALHYFP
                     EYQWLVDFTVAATVVYLVTEVYYNFMKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYF
                     KVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLE
                     SQSPVSKLTFKFFLAIFCSFIGAFLTFPGLRLAQMHLDALNLATEKITQTLLHINFLA
                     PLFMVLLWVKPITKDYIMNPPLGKESIPLMTEATFDTLRLWLIILLCALRLAMMRSHL
                     QAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHTTLLL
                     KTLGNHSWGIYPESISTLPVDNSLLSNSVYSELPSAEGKMKVTVTQITVALSSLKNIF
                     TPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA"
     exon            126..229
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /inference="alignment:Splign:2.1.0"
     exon            230..313
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /inference="alignment:Splign:2.1.0"
     exon            314..411
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /inference="alignment:Splign:2.1.0"
     exon            412..568
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /inference="alignment:Splign:2.1.0"
     exon            569..720
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /inference="alignment:Splign:2.1.0"
     exon            721..781
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /inference="alignment:Splign:2.1.0"
     exon            782..922
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1036
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1211
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1308
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..2750
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2568..2573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /note="hexamer: ATTAAA"
     regulatory      2573..2578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /note="hexamer: AATACA"
     polyA_site      2591
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
                     /note="major polyA site"
     polyA_site      2604
                     /gene="TMEM161B"
                     /gene_synonym="FLB3342; PRO1313"
ORIGIN      
        1 agagccggaa gaccctctct ttcgctgttt gagagtctct cggctcaagg accgggaggt
       61 aagaggtttg ggactgcccc ggcaactcca gggtgtctgg tccacgacct atcctaggcg
      121 ccatgggtgt gataggtata cagctggttg ttaccatggt gatggccagt gtcatgcaga
      181 agattatacc tcactattct cttgctcgat ggctactctg taatggcagt ttgaggtggt
      241 atcaacatcc tacagaagaa gaattaagaa ttcttgcagg gaaacaacaa aaagggaaaa
      301 ccaaaaaaga taggaaatat aatggtcaca ttgaaagtaa gccattaacc attccaaagg
      361 atattgacct tcatctagaa acaaagtcag ttacagaagt ggatacttta gcattgcatt
      421 actttccaga ataccagtgg ctggtggatt tcacagtggc tgctacagtt gtgtatctag
      481 taactgaagt ctactacaat tttatgaagc ctacacagga aatgaatatc agcttagtct
      541 ggtgcctact tgttttgtct tttgcaatca aagttctatt ttcattaact acacactatt
      601 ttaaagtaga agatggtggt gaaagatctg tttgtgtcac ctttggattt tttttctttg
      661 tcaaagcaat ggcagtgttg attgtaacag aaaattatct ggaatttgga cttgaaacag
      721 ggtttacaaa tttttcagac agtgcgatgc agtttcttga aaagcaaggt ttagaatctc
      781 agagtcctgt ttcaaaactt actttcaaat ttttcctggc tattttctgt tcattcattg
      841 gggctttttt gacatttcct ggattacgac tggctcaaat gcatctggat gccctgaatt
      901 tggcaacaga aaaaattaca caaactttac ttcatatcaa cttcttggca cctttattta
      961 tggttctgct ctgggtaaaa ccaatcacca aagactacat tatgaaccca ccactgggca
     1021 aagaaagtat ccctttaatg acagaagcca cattcgatac tctgcgactc tggttaataa
     1081 tcctgctgtg tgctttgcgg ttggccatga tgcgtagtca cctgcaagct tatttaaatt
     1141 tagcccaaaa atgtgtggat cagatgaaga aagaagcggg gcgaataagc acggttgagc
     1201 tacagaaaat ggtggctcga gtcttttatt atctttgtgt cattgcactg cagtatgtgg
     1261 cgcctctggt aatgctgctt cacacaactc tgcttttgaa aacactaggt aatcattcct
     1321 ggggtattta tccagaatct atctctacct taccagtgga taatagtcta ctgtccaatt
     1381 ctgtttactc tgaattacca tcagctgaag ggaaaatgaa ggtaactgtt acacaaataa
     1441 cagtggcact gagcagctta aaaaatattt ttactcctct tctttttcga ggacttctgt
     1501 cttttctgac ctggtggatt gctgcttgcc tcttttctac aagccttttt gggcttttct
     1561 atcaccagta tctgactgtg gcatgaatct cagttaacaa aaaagcatat ccaaatcacc
     1621 ctttaaatta aaatatctgt gcccttaaag ggctgatgaa aaccagaaga aagcaaatac
     1681 aatgggaaaa aaaaaacata tcagaatgtc ttgtattaaa tgtttcctct gtattctcag
     1741 ggtgaattaa tgtagtaata tttaaaatta caaaatagat tgttaactgt tacactgtgg
     1801 cattggaatt ttaactcttt gtatttactg gtatgagagg gctatctaca agggtaatat
     1861 ttctgattac cctggtttac agaaacctcc agcagtcttt gaaacatctc acatgactct
     1921 agttattgat tgcttttaat ggttttatgg tactgttgat agtcatagtg gctgcctata
     1981 gaacaatctt caaactgagc catgctttag gggagggaaa ggggctaaag tctcttctgt
     2041 tggtaattta ttagttactc ttgaaacaat aaaatccaac agaaaggaag agatagctac
     2101 tgtatattac agtaaagaaa gctgcatagt tattttaaat ttaatggaga tgaatatggt
     2161 taaaatatat aactactgct gcttgagaat agcaagagta ttgttttaaa acatattcca
     2221 cccaacttga gagttctttt aaaatgattg gccatatgaa catttgtaat cttgccatta
     2281 ggtttggacc tgccatattt tgttttattc tgtgatccta actagttcct tttaataggc
     2341 taaaatattt atcaatactg atcagacttt aaagaaatta ctttgtaaac ctgctgacta
     2401 cctgtatgta ttgtatatat attatatatt aaatatataa tatattgaga ttataaaaga
     2461 tgaaaatatt gaatccttat aatattttaa gttgcagaat gtatgttaaa aagtgacttg
     2521 aatgagatgt atttgtatct agaaatttta tttctttttg gaatgagatt aaaatacatt
     2581 ttgaaagttc agcagagtaa gcaatttatt tgtgttgcct atgtgtgagt gtatttaaag
     2641 ttttatggac gcttaatggt ttctcccaaa ttaaaattct ttttctgtca tttccaaaaa
     2701 tcagaatctt tccctctcaa atcaggtcta caggtatcat gtatgccttt
//
