LOCUS       NM_017814               2251 bp    mRNA    linear   PRI 11-SEP-2020
DEFINITION  Homo sapiens transmembrane protein 161A (TMEM161A), transcript
            variant 1, mRNA.
ACCESSION   NM_017814
VERSION     NM_017814.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2251)
  AUTHORS   Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandia J,
            Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH,
            Deineko V, Aoki H, Amin S, Yao Z, Morato X, Otasek D, Kobayashi H,
            Menendez J, Auerbach D, Angers S, Przulj N, Bouvier M, Babu M,
            Ciruela F, Jockers R, Jurisica I and Stagljar I.
  TITLE     Systematic protein-protein interaction mapping for clinically
            relevant human GPCRs
  JOURNAL   Mol. Syst. Biol. 13 (3), 918 (2017)
   PUBMED   28298427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2251)
  AUTHORS   Montesano Gesualdi N, Chirico G, Catanese MT, Pirozzi G and
            Esposito F.
  TITLE     AROS-29 is involved in adaptive response to oxidative stress
  JOURNAL   Free Radic. Res. 40 (5), 467-476 (2006)
   PUBMED   16551573
  REMARK    GeneRIF: adaptive response to oxidative stress (AROS)-29 gene has a
            functional role in the protection against oxidative stress.
REFERENCE   3  (bases 1 to 2251)
  AUTHORS   Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J,
            Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D,
            Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS,
            Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M,
            Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J,
            Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods
            K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard
            A, Wood WI, Godowski P and Gray A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA268563.1, BC005210.1, AK096964.1, DB353676.1, DB311771.1 and
            AC002126.1.
            
            On May 17, 2019 this sequence version replaced NM_017814.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.889776.1,
                                           SRR7410570.652692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000162044.14/ ENSP00000162044.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DA268563.1         24-40
            18-1360             BC005210.1         1-1343
            1361-1361           AK096964.1         1040-1040
            1362-1746           BC005210.1         1345-1729
            1747-1798           DB353676.1         1-52                c
            1799-1804           DB311771.1         1-6                 c
            1805-2251           AC002126.1         9904-10350          c
FEATURES             Location/Qualifiers
     source          1..2251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2251
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /note="transmembrane protein 161A"
                     /db_xref="GeneID:54929"
                     /db_xref="HGNC:HGNC:26020"
                     /db_xref="MIM:618966"
     exon            1..53
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1490
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; adaptive response to oxidative stress protein
                     29"
                     /codon_start=1
                     /product="transmembrane protein 161A isoform 1 precursor"
                     /protein_id="NP_060284.1"
                     /db_xref="CCDS:CCDS12393.1"
                     /db_xref="GeneID:54929"
                     /db_xref="HGNC:HGNC:26020"
                     /db_xref="MIM:618966"
                     /translation="MAVLGVQLVVTLLTATLMHRLAPHCSFARWLLCNGSLFRYKHPS
                     EEELRALAGKPRPRGRKERWANGLSEEKPLSVPRDAPFQLETCPLTTVDALVLRFFLE
                     YQWFVDFAVYSGGVYLFTEAYYYMLGPAKETNIAVFWCLLTVTFSIKMFLTVTRLYFS
                     AEEGGERSVCLTFAFLFLLLAMLVQVVREETLELGLEPGLASMTQNLEPLLKKQGWDW
                     ALPVAKLAIRVGLAVVGSVLGAFLTFPGLRLAQTHRDALTMSEDRPMLQFLLHTSFLS
                     PLFILWLWTKPIARDFLHQPPFGETRFSLLSDSAFDSGRLWLLVVLCLLRLAVTRPHL
                     QAYLCLAKARVEQLRREAGRIEAREIQQRVVRVYCYVTVVSLQYLTPLILTLNCTLLL
                     KTLGGYSWGLGPAPLLSPDPSSASAAPIGSGEDEVQQTAARIAGALGGLLTPLFLRGV
                     LAYLIWWTAACQLLASLFGLYFHQHLAGS"
     exon            54..157
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /inference="alignment:Splign:2.1.0"
     exon            158..238
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /inference="alignment:Splign:2.1.0"
     exon            239..336
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /inference="alignment:Splign:2.1.0"
     exon            337..493
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /inference="alignment:Splign:2.1.0"
     exon            494..645
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /inference="alignment:Splign:2.1.0"
     exon            646..706
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /inference="alignment:Splign:2.1.0"
     exon            707..850
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /inference="alignment:Splign:2.1.0"
     exon            851..964
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1139
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1236
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..2251
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1776..1781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /note="hexamer: AATAAA"
     polyA_site      1803
                     /gene="TMEM161A"
                     /gene_synonym="AROS-29; AROS29"
                     /note="major polyA site"
ORIGIN      
        1 gcccggagcc ctaggccggt gggtgagtgc accgcgttct cgcacgcgtc atggcggtcc
       61 tcggagtaca gctggtggtg accctgctca ctgccaccct catgcacagg ctggcgccac
      121 actgctcctt cgcgcgctgg ctgctctgta acggcagttt gttccgatac aagcacccgt
      181 ctgaggagga gcttcgggcc ctggcgggga agccgaggcc cagaggcagg aaagagcggt
      241 gggccaatgg ccttagtgag gagaagccac tgtctgtgcc ccgagatgcc ccgttccagc
      301 tggagacctg ccccctcacg accgtggatg ccctggtcct gcgcttcttc ctggagtacc
      361 agtggtttgt ggactttgct gtgtactcgg gcggcgtgta cctcttcaca gaggcctact
      421 actacatgct gggaccagcc aaggagacta acattgctgt gttctggtgc ctgctcacgg
      481 tgaccttctc catcaagatg ttcctgacag tgacacggct gtacttcagc gccgaggagg
      541 ggggtgagcg ctctgtctgc ctcacctttg ccttcctctt cctgctgctg gccatgctgg
      601 tgcaagtggt gcgggaggag accctcgagc tgggcctgga gcctggtctg gccagcatga
      661 cccagaactt agagccactt ctgaagaagc agggctggga ctgggcgctt cctgtggcca
      721 agctggctat ccgcgtggga ctggcagtgg tgggctctgt gctgggtgcc ttcctcacct
      781 tcccaggcct gcggctggcc cagacccacc gggacgcact gaccatgtcg gaggacagac
      841 ccatgctgca gttcctcctg cacaccagct tcctgtctcc cctgttcatc ctgtggctct
      901 ggacaaagcc cattgcacgg gacttcctgc accagccgcc gtttggggag acgcgtttct
      961 ccctgctgtc cgattctgcc ttcgactctg ggcgcctctg gttgctggtg gtgctgtgcc
     1021 tgctgcggct ggcggtgacc cggccccacc tgcaggccta cctgtgcctg gccaaggccc
     1081 gggtggagca gctgcgaagg gaggctggcc gcatcgaagc ccgtgaaatc cagcagaggg
     1141 tggtccgagt ctactgctat gtgaccgtgg tgagcttgca gtacctgacg ccgctcatcc
     1201 tcaccctcaa ctgcacactt ctgctcaaga cgctgggagg ctattcctgg ggcctgggcc
     1261 cagctcctct actatccccc gacccatcct cagccagcgc tgcccccatc ggctctgggg
     1321 aggacgaagt ccagcagact gcagcgcgga ttgccggggc tctgggtggc ctgcttactc
     1381 ccctcttcct ccgtggcgtc ctggcctacc tcatctggtg gacggctgcc tgccagctgc
     1441 tcgccagcct tttcggcctc tacttccacc agcacttggc aggctcctag ctgcctgcag
     1501 accctcctgg ggccctgagg tctgttcctg gggcagcggg acactagcct gccccctctg
     1561 tttgcgcccc cgtgtcccca gctgcaaggt ggggccggac tccccggcgt tcccttcacc
     1621 acagtgcctg acccgcggcc ccccttggac gccgagtttc tgcctcagaa ctgtctctcc
     1681 tgggcccagc agcatgaggg tcccgaggcc attgtctccg aagcgtatgt gccaggtttg
     1741 agtggcaagg gtgatgctgg ctgctcttct gaacaaataa aggagcatgc cgatttttac
     1801 aaacagggtc tgagtggttt gggactcggg cttgtgcagg gtggtagctg tcttgcacgt
     1861 ccctgtggca cctgcccggg tgcagggtgg gggctgcgcg ggagggagag aggagcagga
     1921 ctgagagggg agcaaaggtc tgggaggaga aaggagagca agaaggaggc caggctcggc
     1981 ggctcacgcc cgtaatccca aatcccagca ctttgggaag ccaaggcggg cagatcactt
     2041 gaggccagca gtttgagacc agcctggtca acgcatggtg aaacccagtc tttactaaaa
     2101 taacaaaaat taggcatggt ggcgcatgca tgtagttcca gctactgaga aggatgagcc
     2161 agaagagtcg cttgaacctg agaggtggag gctgcagtga gccgagatcg catcacactc
     2221 cagcctgggt gacagagtga aactctgtct c
//
