LOCUS       NM_017854                655 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 160 (TMEM160), mRNA.
ACCESSION   NM_017854
VERSION     NM_017854.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 655)
  AUTHORS   Dai,X., Wu,Z., Ruan,R., Chen,J., Huang,C., Lei,W., Yao,Y., Li,L.,
            Tang,X., Xiong,J., Feng,M. and Deng,J.
  TITLE     TMEM160 promotes tumor immune evasion and radiotherapy resistance
            via PD-L1 binding in colorectal cancer
  JOURNAL   Cell Commun Signal 22 (1), 168 (2024)
   PUBMED   38454413
  REMARK    GeneRIF: TMEM160 promotes tumor immune evasion and radiotherapy
            resistance via PD-L1 binding in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 655)
  AUTHORS   Yamashita,K., Haraguchi,M. and Yano,M.
  TITLE     Knockdown of TMEM160 leads to an increase in reactive oxygen
            species generation and the induction of the mitochondrial unfolded
            protein response
  JOURNAL   FEBS Open Bio 12 (12), 2179-2190 (2022)
   PUBMED   36217717
  REMARK    GeneRIF: Knockdown of TMEM160 leads to an increase in reactive
            oxygen species generation and the induction of the mitochondrial
            unfolded protein response.
REFERENCE   3  (bases 1 to 655)
  AUTHORS   Segelcke,D., Fischer,H.K., Hutte,M., Dennerlein,S., Benseler,F.,
            Brose,N., Pogatzki-Zahn,E.M. and Schmidt,M.
  TITLE     Tmem160 contributes to the establishment of discrete nerve
            injury-induced pain behaviors in male mice
  JOURNAL   Cell Rep 37 (12), 110152 (2021)
   PUBMED   34936870
REFERENCE   4  (bases 1 to 655)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 655)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 655)
  AUTHORS   Wen,W., Zheng,W., Okada,Y., Takeuchi,F., Tabara,Y., Hwang,J.Y.,
            Dorajoo,R., Li,H., Tsai,F.J., Yang,X., He,J., Wu,Y., He,M.,
            Zhang,Y., Liang,J., Guo,X., Sheu,W.H., Delahanty,R., Guo,X.,
            Kubo,M., Yamamoto,K., Ohkubo,T., Go,M.J., Liu,J.J., Gan,W.,
            Chen,C.C., Gao,Y., Li,S., Lee,N.R., Wu,C., Zhou,X., Song,H.,
            Yao,J., Lee,I.T., Long,J., Tsunoda,T., Akiyama,K., Takashima,N.,
            Cho,Y.S., Ong,R.T., Lu,L., Chen,C.H., Tan,A., Rice,T.K.,
            Adair,L.S., Gui,L., Allison,M., Lee,W.J., Cai,Q., Isomura,M.,
            Umemura,S., Kim,Y.J., Seielstad,M., Hixson,J., Xiang,Y.B.,
            Isono,M., Kim,B.J., Sim,X., Lu,W., Nabika,T., Lee,J., Lim,W.Y.,
            Gao,Y.T., Takayanagi,R., Kang,D.H., Wong,T.Y., Hsiung,C.A.,
            Wu,I.C., Juang,J.M., Shi,J., Choi,B.Y., Aung,T., Hu,F., Kim,M.K.,
            Lim,W.Y., Wang,T.D., Shin,M.H., Lee,J., Ji,B.T., Lee,Y.H.,
            Young,T.L., Shin,D.H., Chun,B.Y., Cho,M.C., Han,B.G., Hwu,C.M.,
            Assimes,T.L., Absher,D., Yan,X., Kim,E., Kuo,J.Z., Kwon,S.,
            Taylor,K.D., Chen,Y.D., Rotter,J.I., Qi,L., Zhu,D., Wu,T.,
            Mohlke,K.L., Gu,D., Mo,Z., Wu,J.Y., Lin,X., Miki,T., Tai,E.S.,
            Lee,J.Y., Kato,N., Shu,X.O. and Tanaka,T.
  TITLE     Meta-analysis of genome-wide association studies in East
            Asian-ancestry populations identifies four new loci for body mass
            index
  JOURNAL   Hum Mol Genet 23 (20), 5492-5504 (2014)
   PUBMED   24861553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK000519.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017854.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000519.1, BC002907.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2163105 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253047.7/ ENSP00000253047.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-655               AK000519.1         1-655
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..655
                     /gene="TMEM160"
                     /note="transmembrane protein 160"
                     /db_xref="GeneID:54958"
                     /db_xref="HGNC:HGNC:26042"
                     /db_xref="MIM:620258"
     exon            1..218
                     /gene="TMEM160"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..577
                     /gene="TMEM160"
                     /codon_start=1
                     /product="transmembrane protein 160 precursor"
                     /protein_id="NP_060324.1"
                     /db_xref="CCDS:CCDS12695.1"
                     /db_xref="GeneID:54958"
                     /db_xref="HGNC:HGNC:26042"
                     /db_xref="MIM:620258"
                     /translation="MGGGWWWARAARLARLRFRRSLLPPQRPRSGGARGSFAPGHGPR
                     AGASPPPVSELDRADAWLLRKAHETAFLSWFRNGLLASGIGVISFMQSDMGREAAYGF
                     FLLGGLCVVWGSASYAVGLAALRGPMQLTLGGAAVGAGAVLAASLLWACAVGLYMGQL
                     ELDVELVPEDDGTASAEGPDEAGRPPPE"
     exon            219..311
                     /gene="TMEM160"
                     /inference="alignment:Splign:2.1.0"
     exon            312..655
                     /gene="TMEM160"
                     /inference="alignment:Splign:2.1.0"
     regulatory      631..636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM160"
                     /note="hexamer: ATTAAA"
     polyA_site      655
                     /gene="TMEM160"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgaatc atgggaggcg gctggtggtg ggctcgggcc gctcgccttg cccgtcttcg
       61 cttccggagg tcgctactgc cgcctcagcg gccccggagc gggggcgccc gggggtcctt
      121 cgcccccggc cacggtcccc gcgccggggc ttcgccgccc ccagtgtccg agctggatcg
      181 tgcggacgcc tggctcctcc gaaaagcgca cgagacagcc ttcctctcct ggttccgcaa
      241 tggcctcctg gcatcgggca tcggggtcat ctccttcatg cagagtgaca tgggtcggga
      301 agcagcatat ggcttcttcc tgctgggcgg cctgtgcgtg gtgtggggca gcgcctcgta
      361 cgccgtgggc ctggcggcgc tgcgaggacc catgcagctg acgctggggg gcgcggccgt
      421 gggcgcgggc gccgtgctgg ccgccagcct gctctgggcg tgcgccgtgg gcctctacat
      481 ggggcagctg gagctggacg tggagctggt gcccgaggac gacgggacgg cctccgcgga
      541 aggccctgat gaggcgggtc ggccgccacc cgagtgagcg acacggccgt ggggcctggc
      601 aggcgctgga cagcgcccga ggactgggac attaaacctg acctcccctc ctcca
//
