LOCUS       NM_015444               1822 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 158 (TMEM158), mRNA.
ACCESSION   NM_015444
VERSION     NM_015444.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1822)
  AUTHORS   Xu,T., Yin,F. and Shi,K.
  TITLE     TMEM158 functions as an oncogene and promotes lung adenocarcinoma
            progression through the PI3K/AKT pathway via interaction with
            TWIST1
  JOURNAL   Exp Cell Res 437 (1), 114010 (2024)
   PUBMED   38508329
  REMARK    GeneRIF: TMEM158 functions as an oncogene and promotes lung
            adenocarcinoma progression through the PI3K/AKT pathway via
            interaction with TWIST1.
REFERENCE   2  (bases 1 to 1822)
  AUTHORS   Li,J., Wang,X., Chen,L., Zhang,J., Zhang,Y., Ren,X., Sun,J.,
            Fan,X., Fan,J., Li,T., Tong,L., Yi,L., Chen,L., Liu,J., Shang,G.,
            Ren,X., Zhang,H., Yu,S., Ming,H., Huang,Q., Dong,J., Zhang,C. and
            Yang,X.
  TITLE     TMEM158 promotes the proliferation and migration of glioma cells
            via STAT3 signaling in glioblastomas
  JOURNAL   Cancer Gene Ther 29 (8-9), 1117-1129 (2022)
   PUBMED   34992215
  REMARK    GeneRIF: TMEM158 promotes the proliferation and migration of glioma
            cells via STAT3 signaling in glioblastomas.
            Erratum:[Cancer Gene Ther. 2024 Mar;31(3):495-496. doi:
            10.1038/s41417-024-00733-3.. PMID: 38272983]
REFERENCE   3  (bases 1 to 1822)
  AUTHORS   Li,H.N., Du,Y.Y., Xu,T., Zhang,R., Wang,G., Lv,Z.T. and Li,X.R.
  TITLE     TMEM158 May Serve as a Diagnostic Biomarker for Anaplastic Thyroid
            Carcinoma: An Integrated Bioinformatic Analysis
  JOURNAL   Curr Med Sci 40 (6), 1137-1147 (2020)
   PUBMED   33428142
  REMARK    GeneRIF: TMEM158 May Serve as a Diagnostic Biomarker for Anaplastic
            Thyroid Carcinoma: An Integrated Bioinformatic Analysis.
REFERENCE   4  (bases 1 to 1822)
  AUTHORS   Fu,Y., Yao,N., Ding,D., Zhang,X., Liu,H., Ma,L., Shi,W., Zhu,C. and
            Tang,L.
  TITLE     TMEM158 promotes pancreatic cancer aggressiveness by activation of
            TGFbeta1 and PI3K/AKT signaling pathway
  JOURNAL   J Cell Physiol 235 (3), 2761-2775 (2020)
   PUBMED   31531884
  REMARK    GeneRIF: TMEM158 promotes pancreatic cancer aggressiveness by
            activation of TGFbeta1 and PI3K/AKT signaling pathway.
REFERENCE   5  (bases 1 to 1822)
  AUTHORS   Liu,L., Zhang,J., Li,S., Yin,L. and Tai,J.
  TITLE     Silencing of TMEM158 Inhibits Tumorigenesis and Multidrug
            Resistance in Colorectal Cancer
  JOURNAL   Nutr Cancer 72 (4), 662-671 (2020)
   PUBMED   31389251
  REMARK    GeneRIF: Silencing of TMEM158 Inhibits Tumorigenesis and Multidrug
            Resistance in Colorectal Cancer.
REFERENCE   6  (bases 1 to 1822)
  AUTHORS   Zhang,Z.D., Frankish,A., Hunt,T., Harrow,J. and Gerstein,M.
  TITLE     Identification and analysis of unitary pseudogenes: historic and
            contemporary gene losses in humans and other primates
  JOURNAL   Genome Biol 11 (3), R26 (2010)
   PUBMED   20210993
REFERENCE   7  (bases 1 to 1822)
  AUTHORS   Sussan,T.E., Pletcher,M.T., Murakami,Y. and Reeves,R.H.
  TITLE     Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth
            properties and gene expression
  JOURNAL   Mol Cancer 4, 28 (2005)
   PUBMED   16083501
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1822)
  AUTHORS   Verlinden,I., Janssens,J., Raus,J. and Michiels,L.
  TITLE     Microdissection and SAGE as a combined tool to reveal gene
            expression in ductal carcinoma in situ of the breast
  JOURNAL   Mol Carcinog 41 (4), 197-206 (2004)
   PUBMED   15486950
REFERENCE   9  (bases 1 to 1822)
  AUTHORS   Barradas,M., Gonos,E.S., Zebedee,Z., Kolettas,E., Petropoulou,C.,
            Delgado,M.D., Leon,J., Hara,E. and Serrano,M.
  TITLE     Identification of a candidate tumor-suppressor gene specifically
            activated during Ras-induced senescence
  JOURNAL   Exp Cell Res 273 (2), 127-137 (2002)
   PUBMED   11822868
REFERENCE   10 (bases 1 to 1822)
  AUTHORS   Hama,T., Maruyama,M., Katoh-Semba,R., Takizawa,M., Iwashima,M. and
            Nara,K.
  TITLE     Identification and molecular cloning of a novel brain-specific
            receptor protein that binds to brain injury-derived neurotrophic
            peptide. Possible role for neuronal survival
  JOURNAL   J Biol Chem 276 (34), 31929-31935 (2001)
   PUBMED   11399754
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX459891.2, AF438313.1,
            BX401325.2, BQ000094.1 and BU627971.1.
            
            On May 17, 2019 this sequence version replaced NM_015444.2.
            
            Summary: Constitutive activation of the Ras pathway triggers an
            irreversible proliferation arrest reminiscent of replicative
            senescence. Transcription of this gene is upregulated in response
            to activation of the Ras pathway, but not under other conditions
            that induce senescence. The encoded protein is similar to a rat
            cell surface receptor proposed to function in a neuronal survival
            pathway. An allelic polymorphism in this gene results in both
            functional and non-functional (frameshifted) alleles; the reference
            genome represents the functional allele. [provided by RefSeq, Jul
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF438313.1, DRR138528.771567.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000503771.2/ ENSP00000422431.1
            polymorphic pseudogene :: PMID: 20210993
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BX459891.2         43-67
            26-458              AF438313.1         1-433
            459-670             BX401325.2         427-638
            671-721             AF438313.1         646-696
            722-869             BX401325.2         690-837
            870-1224            AF438313.1         845-1199
            1225-1730           BQ000094.1         19-524              c
            1731-1822           BU627971.1         20-111              c
FEATURES             Location/Qualifiers
     source          1..1822
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1822
                     /gene="TMEM158"
                     /gene_synonym="BBP; p40BBP; RIS1"
                     /note="transmembrane protein 158"
                     /db_xref="GeneID:25907"
                     /db_xref="HGNC:HGNC:30293"
                     /db_xref="MIM:620257"
     exon            1..1822
                     /gene="TMEM158"
                     /gene_synonym="BBP; p40BBP; RIS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1163
                     /gene="TMEM158"
                     /gene_synonym="BBP; p40BBP; RIS1"
                     /note="brain injury-derived neurotrophic peptide (BINP)
                     binding protein; Ras induced senescence 1; brain specific
                     binding protein; BINP receptor; 40 kDa BINP-binding
                     protein"
                     /codon_start=1
                     /product="transmembrane protein 158 precursor"
                     /protein_id="NP_056259.2"
                     /db_xref="CCDS:CCDS54573.1"
                     /db_xref="GeneID:25907"
                     /db_xref="HGNC:HGNC:30293"
                     /db_xref="MIM:620257"
                     /translation="MLPLLAALLAAACPLPPVRGGAADAPGLLGVPSNASVNASSADE
                     PIAPRLLASAAPGPPERPGPEEAAAAAAPCNISVQRQMLSSLLVRWGRPRGFQCDLLL
                     FSTNAHGRAFFAAAFHRVGPPLLIEHLGLAAGGAQQDLRLCVGCGWVRGRRTGRLRPA
                     AAPSAAAATAGAPTALPAYPAAEPPGPLWLQGEPLHFCCLDFSLEELQGEPGWRLNRK
                     PIESTLVACFMTLVIVVWSVAALIWPVPIIAGFLPNGMEQRRTTASTTAATPAAVPAG
                     TTAAAAAAAAAAAAAAVTSGVATK"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM158"
                     /gene_synonym="BBP; p40BBP; RIS1"
                     /note="hexamer: AATACA"
     polyA_site      1822
                     /gene="TMEM158"
                     /gene_synonym="BBP; p40BBP; RIS1"
                     /note="major polyA site"
ORIGIN      
        1 agagcagcgc ggcagcccaa gggccccggc gccgggggcg gcggggaacc ccaaacgcaa
       61 ccgggtctgg agggatcccc gcgccgagcc agccgccgtc accgcctccg cgccgcccct
      121 gcgggcttgg caggcgcccg gcgcgcccgc actgcgcccg gccgccggct cccgcggtcc
      181 caccgtgagc tcgccggccc gtcgcccgct cgccatgcaa ccgccgccgg cctcgcgcgc
      241 gtaggcgccc gccgcaggcc atgctgcccc tgctcgccgc gctcctggcc gccgcctgcc
      301 cgctgccgcc cgtccgcggc ggggccgcgg acgcgcccgg cctcctcggg gtgccctcca
      361 atgcttcagt caacgcgtcc tccgcggacg agcccatcgc cccgcggctg ctggcctcgg
      421 cggcccccgg gccccccgag cgcccgggcc cggaggaggc ggcggcggcg gcggcgccgt
      481 gcaacatcag cgtgcagcgg cagatgctga gctcgctgct cgtgcgctgg ggccgcccgc
      541 ggggcttcca gtgcgaccta ctgctcttct ccaccaacgc gcacggccgc gctttcttcg
      601 ccgccgcctt ccaccgcgtc gggccgccgc tgctcatcga gcacctgggg ctggcggcgg
      661 gcggcgcgca gcaggacctg cgcctctgcg tgggctgcgg ctgggtgcgc ggtcgccgca
      721 ccggccgcct ccggcccgcc gccgccccca gcgccgccgc cgccaccgcc ggggcgccca
      781 ccgcgctgcc agcctacccc gcggccgagc cgcccgggcc gctgtggctg cagggcgagc
      841 cgctgcattt ctgctgccta gacttcagcc tggaggagct gcagggcgag ccgggctggc
      901 ggctgaaccg taagcccatt gagtccacgc tggtggcctg cttcatgacc ctggtcatcg
      961 tggtgtggag cgtggccgcc ctcatctggc cggtgcccat catcgccggc ttcctgccca
     1021 acggcatgga acagcgccgg accaccgcca gcaccaccgc agccaccccc gccgcagtgc
     1081 ccgcagggac caccgcagcc gccgccgccg ccgccgctgc cgccgccgcc gcggccgtca
     1141 cttcgggggt ggcgaccaag tgacccgctc cgctcctccc tgtgtccgtc ctgtgtccgc
     1201 gcgcgcgggt gcctttcccg ccggagactc ggccggtgtg cttcgtgctg tagttatcgt
     1261 tagttcctct tcccgagatg gggccgccga gagaccccag cgcctttgaa aagcaaggtt
     1321 tgtgctgcgc ttccagttcc gaaaagcaga tgtttaagcc cttggactga gggtgggatc
     1381 gcagctccga agacggagag gagggaaatg gggccctttc ccctctattg catccccctg
     1441 cccgactcct tccccgcacc cacgtgccct agattcatgg cagaaaatga ccaaatcctg
     1501 tgtatttgtt ttatatattt aataactgtt ttaaatgaaa gttttagtaa aaaaaataca
     1561 aaacaaaaag attaaattgc tattgctgta gtaagagaag ctctttgtat ctgaacatag
     1621 ttgtatttga aatttgtggt tttttaattt atttaaaatt ggggggaggg catgggaagg
     1681 atttaacacc gatatattgt taccgctgaa aatgaacttt atgaaccttt tccaagttga
     1741 tctatccagt gacgtggcct ggtgggcgtt tcttcttgta cttatgtggt tttttggctt
     1801 ttaatacaga cattttcctc ca
//
