LOCUS       NM_152680              10534 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 154 (TMEM154), mRNA.
ACCESSION   NM_152680
VERSION     NM_152680.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10534)
  AUTHORS   Walia,G.K., Sharma,P., Agarwal,T., Lal,M., Negandhi,H.,
            Prabhakaran,D., Khadgawat,R., Sachdeva,M.P. and Gupta,V.
  TITLE     Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2
            diabetes in an endogamous business community of North India
  JOURNAL   PLoS One 18 (9), e0291339 (2023)
   PUBMED   37738238
  REMARK    GeneRIF: Genetic associations of TMEM154, PRC1 and ZFAND6 loci with
            type 2 diabetes in an endogamous business community of North India.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10534)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 10534)
  AUTHORS   Harder,M.N., Appel,E.V., Grarup,N., Gjesing,A.P., Ahluwalia,T.S.,
            Jorgensen,T., Christensen,C., Brandslund,I., Linneberg,A.,
            Sorensen,T.I., Pedersen,O. and Hansen,T.
  TITLE     The type 2 diabetes risk allele of TMEM154-rs6813195 associates
            with decreased beta cell function in a study of 6,486 Danes
  JOURNAL   PLoS One 10 (3), e0120890 (2015)
   PUBMED   25799151
  REMARK    GeneRIF: the diabetogenic impact of the C-allele of
            TMEM154-rs6813195 is mediated through reduced beta cell function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10534)
  AUTHORS   Mahajan,A., Go,M.J., Zhang,W., Below,J.E., Gaulton,K.J.,
            Ferreira,T., Horikoshi,M., Johnson,A.D., Ng,M.C., Prokopenko,I.,
            Saleheen,D., Wang,X., Zeggini,E., Abecasis,G.R., Adair,L.S.,
            Almgren,P., Atalay,M., Aung,T., Baldassarre,D., Balkau,B., Bao,Y.,
            Barnett,A.H., Barroso,I., Basit,A., Been,L.F., Beilby,J.,
            Bell,G.I., Benediktsson,R., Bergman,R.N., Boehm,B.O.,
            Boerwinkle,E., Bonnycastle,L.L., Burtt,N., Cai,Q., Campbell,H.,
            Carey,J., Cauchi,S., Caulfield,M., Chan,J.C., Chang,L.C.,
            Chang,T.J., Chang,Y.C., Charpentier,G., Chen,C.H., Chen,H.,
            Chen,Y.T., Chia,K.S., Chidambaram,M., Chines,P.S., Cho,N.H.,
            Cho,Y.M., Chuang,L.M., Collins,F.S., Cornelis,M.C., Couper,D.J.,
            Crenshaw,A.T., van Dam,R.M., Danesh,J., Das,D., de Faire,U.,
            Dedoussis,G., Deloukas,P., Dimas,A.S., Dina,C., Doney,A.S.,
            Donnelly,P.J., Dorkhan,M., van Duijn,C., Dupuis,J., Edkins,S.,
            Elliott,P., Emilsson,V., Erbel,R., Eriksson,J.G., Escobedo,J.,
            Esko,T., Eury,E., Florez,J.C., Fontanillas,P., Forouhi,N.G.,
            Forsen,T., Fox,C., Fraser,R.M., Frayling,T.M., Froguel,P.,
            Frossard,P., Gao,Y., Gertow,K., Gieger,C., Gigante,B., Grallert,H.,
            Grant,G.B., Grrop,L.C., Groves,C.J., Grundberg,E., Guiducci,C.,
            Hamsten,A., Han,B.G., Hara,K., Hassanali,N., Hattersley,A.T.,
            Hayward,C., Hedman,A.K., Herder,C., Hofman,A., Holmen,O.L.,
            Hovingh,K., Hreidarsson,A.B., Hu,C., Hu,F.B., Hui,J.,
            Humphries,S.E., Hunt,S.E., Hunter,D.J., Hveem,K., Hydrie,Z.I.,
            Ikegami,H., Illig,T., Ingelsson,E., Islam,M., Isomaa,B.,
            Jackson,A.U., Jafar,T., James,A., Jia,W., Jockel,K.H., Jonsson,A.,
            Jowett,J.B., Kadowaki,T., Kang,H.M., Kanoni,S., Kao,W.H.,
            Kathiresan,S., Kato,N., Katulanda,P., Keinanen-Kiukaanniemi,K.M.,
            Kelly,A.M., Khan,H., Khaw,K.T., Khor,C.C., Kim,H.L., Kim,S.,
            Kim,Y.J., Kinnunen,L., Klopp,N., Kong,A., Korpi-Hyovalti,E.,
            Kowlessur,S., Kraft,P., Kravic,J., Kristensen,M.M., Krithika,S.,
            Kumar,A., Kumate,J., Kuusisto,J., Kwak,S.H., Laakso,M., Lagou,V.,
            Lakka,T.A., Langenberg,C., Langford,C., Lawrence,R., Leander,K.,
            Lee,J.M., Lee,N.R., Li,M., Li,X., Li,Y., Liang,J., Liju,S.,
            Lim,W.Y., Lind,L., Lindgren,C.M., Lindholm,E., Liu,C.T., Liu,J.J.,
            Lobbens,S., Long,J., Loos,R.J., Lu,W., Luan,J., Lyssenko,V.,
            Ma,R.C., Maeda,S., Magi,R., Mannisto,S., Matthews,D.R., Meigs,J.B.,
            Melander,O., Metspalu,A., Meyer,J., Mirza,G., Mihailov,E.,
            Moebus,S., Mohan,V., Mohlke,K.L., Morris,A.D., Muhleisen,T.W.,
            Muller-Nurasyid,M., Musk,B., Nakamura,J., Nakashima,E., Navarro,P.,
            Ng,P.K., Nica,A.C., Nilsson,P.M., Njolstad,I., Nothen,M.M.,
            Ohnaka,K., Ong,T.H., Owen,K.R., Palmer,C.N., Pankow,J.S.,
            Park,K.S., Parkin,M., Pechlivanis,S., Pedersen,N.L., Peltonen,L.,
            Perry,J.R., Peters,A., Pinidiyapathirage,J.M., Platou,C.G.,
            Potter,S., Price,J.F., Qi,L., Radha,V., Rallidis,L., Rasheed,A.,
            Rathman,W., Rauramaa,R., Raychaudhuri,S., Rayner,N.W., Rees,S.D.,
            Rehnberg,E., Ripatti,S., Robertson,N., Roden,M., Rossin,E.J.,
            Rudan,I., Rybin,D., Saaristo,T.E., Salomaa,V., Saltevo,J.,
            Samuel,M., Sanghera,D.K., Saramies,J., Scott,J., Scott,L.J.,
            Scott,R.A., Segre,A.V., Sehmi,J., Sennblad,B., Shah,N., Shah,S.,
            Shera,A.S., Shu,X.O., Shuldiner,A.R., Sigurdsson,G., Sijbrands,E.,
            Silveira,A., Sim,X., Sivapalaratnam,S., Small,K.S., So,W.Y.,
            Stancakova,A., Stefansson,K., Steinbach,G., Steinthorsdottir,V.,
            Stirrups,K., Strawbridge,R.J., Stringham,H.M., Sun,Q., Suo,C.,
            Syvanen,A.C., Takayanagi,R., Takeuchi,F., Tay,W.T., Teslovich,T.M.,
            Thorand,B., Thorleifsson,G., Thorsteinsdottir,U., Tikkanen,E.,
            Trakalo,J., Tremoli,E., Trip,M.D., Tsai,F.J., Tuomi,T.,
            Tuomilehto,J., Uitterlinden,A.G., Valladares-Salgado,A.,
            Vedantam,S., Veglia,F., Voight,B.F., Wang,C., Wareham,N.J.,
            Wennauer,R., Wickremasinghe,A.R., Wilsgaard,T., Wilson,J.F.,
            Wiltshire,S., Winckler,W., Wong,T.Y., Wood,A.R., Wu,J.Y., Wu,Y.,
            Yamamoto,K., Yamauchi,T., Yang,M., Yengo,L., Yokota,M., Young,R.,
            Zabaneh,D., Zhang,F., Zhang,R., Zheng,W., Zimmet,P.Z.,
            Altshuler,D., Bowden,D.W., Cho,Y.S., Cox,N.J., Cruz,M., Hanis,C.L.,
            Kooner,J., Lee,J.Y., Seielstad,M., Teo,Y.Y., Boehnke,M.,
            Parra,E.J., Chambers,J.C., Tai,E.S., McCarthy,M.I. and Morris,A.P.
  CONSRTM   DIAbetes Genetics Replication And Meta-analysis (DIAGRAM)
            Consortium; Asian Genetic Epidemiology Network Type 2 Diabetes
            (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D)
            Consortium; Mexican American Type 2 Diabetes (MAT2D) Consortium;
            Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in
            muylti-Ethnic Samples (T2D-GENES) Consortium
  TITLE     Genome-wide trans-ancestry meta-analysis provides insight into the
            genetic architecture of type 2 diabetes susceptibility
  JOURNAL   Nat Genet 46 (3), 234-244 (2014)
   PUBMED   24509480
REFERENCE   5  (bases 1 to 10534)
  AUTHORS   Heaton,M.P., Clawson,M.L., Chitko-Mckown,C.G., Leymaster,K.A.,
            Smith,T.P., Harhay,G.P., White,S.N., Herrmann-Hoesing,L.M.,
            Mousel,M.R., Lewis,G.S., Kalbfleisch,T.S., Keen,J.E. and
            Laegreid,W.W.
  TITLE     Reduced lentivirus susceptibility in sheep with TMEM154 mutations
  JOURNAL   PLoS Genet 8 (1), e1002467 (2012)
   PUBMED   22291605
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106882.5 and AC023424.7.
            
            On Nov 23, 2018 this sequence version replaced NM_152680.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.55393.1, AK056590.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304385.8/ ENSP00000302144.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC106882.5         59499-59626         c
            129-389             AC106882.5         32296-32556         c
            390-428             AC106882.5         32167-32205         c
            429-456             AC106882.5         24044-24071         c
            457-542             AC106882.5         22717-22802         c
            543-600             AC106882.5         20557-20614         c
            601-8790            AC106882.5         1-8190              c
            8791-10534          AC023424.7         196404-198147       c
FEATURES             Location/Qualifiers
     source          1..10534
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..10534
                     /gene="TMEM154"
                     /note="transmembrane protein 154"
                     /db_xref="GeneID:201799"
                     /db_xref="HGNC:HGNC:26489"
     exon            1..128
                     /gene="TMEM154"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..616
                     /gene="TMEM154"
                     /codon_start=1
                     /product="transmembrane protein 154 precursor"
                     /protein_id="NP_689893.1"
                     /db_xref="CCDS:CCDS3779.1"
                     /db_xref="GeneID:201799"
                     /db_xref="HGNC:HGNC:26489"
                     /translation="MQAPRAALVFALVIALVPVGRGNYEELENSGDTTVESERPNKVT
                     IPSTFAAVTIKETLNANINSTNFAPDENQLEFILMVLIPLILLVLLLLSVVFLATYYK
                     RKRTKQEPSSQGSQSALQTYELGSENVKVPIFEEDTPSVMEIEMEELDKWMNSMNRNA
                     DFECLPTLKEEKESNHNPSDSES"
     exon            129..389
                     /gene="TMEM154"
                     /inference="alignment:Splign:2.1.0"
     exon            390..428
                     /gene="TMEM154"
                     /inference="alignment:Splign:2.1.0"
     exon            429..456
                     /gene="TMEM154"
                     /inference="alignment:Splign:2.1.0"
     exon            457..542
                     /gene="TMEM154"
                     /inference="alignment:Splign:2.1.0"
     exon            543..600
                     /gene="TMEM154"
                     /inference="alignment:Splign:2.1.0"
     exon            601..10534
                     /gene="TMEM154"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3027..3032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM154"
                     /note="hexamer: AATAAA"
     polyA_site      3048
                     /gene="TMEM154"
                     /note="major polyA site"
     regulatory      6845..6850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM154"
                     /note="hexamer: AATAAA"
     polyA_site      6872
                     /gene="TMEM154"
     regulatory      10378..10383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM154"
                     /note="hexamer: ATTAAA"
     polyA_site      10399
                     /gene="TMEM154"
     regulatory      10502..10507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM154"
                     /note="hexamer: ATTAAA"
     polyA_site      10534
                     /gene="TMEM154"
ORIGIN      
        1 acgtttcaga gaggctgcag cccggcgcag catcctgagc gcgcctctgc cgaggcgagc
       61 ggacatgcag gctccccgcg cagccctagt cttcgccctg gtgatcgcgc tcgttcccgt
      121 cggccggggt aattatgagg aattagaaaa ctcaggagat acaactgtgg aatctgaaag
      181 accaaataaa gtgactattc caagcacatt tgctgcagtg accatcaaag aaacattaaa
      241 tgcaaatata aattctacca actttgctcc ggatgaaaat cagttagagt ttatactgat
      301 ggtgttaatc ccattgattt tattggtcct cttactttta tccgtggtat tccttgcaac
      361 atactataaa agaaaaagaa ctaaacaaga accttctagc caaggatctc agagtgcttt
      421 acagacatat gaactgggaa gtgaaaacgt gaaagtccct atttttgagg aagatacacc
      481 ctctgttatg gaaattgaaa tggaagagct tgataaatgg atgaacagca tgaatagaaa
      541 tgccgacttt gaatgtttac ctaccttgaa ggaagagaag gaatcaaatc acaacccaag
      601 tgacagtgaa tcctaaacct gaatggcgct catgttttcc aagagaagca gcccctgagg
      661 gagtctgctg aggctgccaa cagaggatga agaggataca aatttaatta atttcaaatc
      721 aacatagaca caagaacctt ttgctgtttc ttccaacgcc cactcttcct aatgatggca
      781 tcacttgcac ttggaagaat gtgcaattga gaagtactag gaaaaggcct ggctgccatc
      841 catcgctgcc tctgagggtg gagaaggagg cgggtgatgt gctcacttct gatcaacatg
      901 tgttgcctcc tctcagccaa cttctagctc actgaactca ctctggtcat gataaatgtt
      961 cgtcaccttt ctgcttcatt ccttagggcc taaatcagga agctgtttta tcgatggttt
     1021 ccttttgggt cagtaaccag ctttggataa tttcctctga ttattcaagt cgtgggacag
     1081 gtaaactaca ttcagcagga acttttctcg aggagtgtta tgtcatggaa aagacaccaa
     1141 acacagcaag tattttaatg aatacaccat cccagggggt cagtaagctc tgcctgccaa
     1201 gaagacacag tgagaggggt ccacagtcct gatgaggtgg cgtttggtaa cttgtagacc
     1261 ctagcatggc caggtctggt cacccttaag aacttctcag agaaactagg aatcttcagt
     1321 gaaagaacta atgttctcct cagctgaaat tcccttgctt gtcagcattt ctgcaaagct
     1381 cacacttgtt tcaccatacc tcccttggat gtgacatgta ggtaggaagt atgtgcaggt
     1441 gggagtcatc tgtcagcctt ctatgtttca gagatcctga aggtggtttg aaacaaacag
     1501 aagaggagca ggaaatatcc gtgcctgtgg cagatctcac tcatcatgct tagcattctc
     1561 tcccgccaag ctgggataag cctcatgtcc taacacagca caacaggagg tctctgtcag
     1621 tccatcagag atgacattct atgtgatatt tttgacatcc ttgtgctaaa agcaatggca
     1681 caaaatggaa aagggcctat tgaccacacc tactccagta aaattgttct tcatttattc
     1741 cttaattttc taaatctgac ccctttaaag caatctagca aattgagaat cctcagctct
     1801 ccttggatac ctgatatttt atttcaagaa agagacaaag aaggaaaatt ttatttattt
     1861 tactacccac atataaaccg aagggagatg ggactaccca aacatttgct gctcaatttt
     1921 gtgtcttgtg cttgaaagtc tgccctaatg cataacaaaa actacttgtc tcctaccttt
     1981 tgggatccct ttaacaagta tttgccttct gaactacgtg gataatttca aaggcagagt
     2041 tccagaccag agaggtcttt ccatacaatg aaagctataa ctagctggtt gtgtttaacc
     2101 actgctatca cgctatcctg ggactgcata gaactttgac aaaagacaga cttcatggta
     2161 cacaacttca acagattttc tgtcatattc tcaccagcac atctgaatga ggctttgtgt
     2221 tttccttgct ctcttgcatg ttccttttca actcatggcc cacagtgact ctcagatatt
     2281 tatgccaaaa ttgcatacaa ttgttttctg aatcataact tgtctatttt tctgcctatg
     2341 tgtgctactt tcagtttgtt tctcatcaac attttgactc tcagaagagc ctccatttgc
     2401 ccctttctct ctttaggtat ctaagatctt tgaacacctg ggcctttaca tttgatccaa
     2461 ccctatcaaa taatgaactt ctcagagagg catctggggt cctggaactt catgttgatg
     2521 aagtcatatt atataatatg ataaaaatat tctcatgcag tattttaaat aatttcaaat
     2581 tctagaagaa gcaaatttca gcgacatgtc attgagtttt tatttggtaa agctataatt
     2641 gtgcagtgta caaagcactt tttaaaaaga tagtttattc tgtcagggta tatgaagtta
     2701 gtatacagcc agaacagcca agcctcaatt cttgtacctt gtgtcttttt attactgttt
     2761 aatcaataga tatcatatgt ttatgacagt ttcaagaatt gtttttaaac ccaaacttaa
     2821 ttttatgttt cagactattg ttaaaaaaac aaaacaaaaa ccaaaaaaac cctcactaat
     2881 ttgccctaat tggatagggc aatcagaaca aaatctgact ttcgaatatt taaaagatat
     2941 gtaagtttga ttgcattttc gtacatttta agcaaactag gttaacaaca acatagccta
     3001 gtcaaacttc tcaggaaact tgttttaata aatatgtaaa aatacccatt catgactctt
     3061 gacccaatgg tgtgactcct ccctctggga agggctttgt tacccaatgc aagaccacag
     3121 cctggatcca ccttgatgta ggtggctcct ggataaccca catcaaacaa atgtgataaa
     3181 gatgagtaaa actggtcttg ggaaaataat ttcatagttt ttttttctcc tagttatgct
     3241 gtataataca ggagaaccaa aagctgtaaa attattttat tttatttttt aaagacaggg
     3301 tctcactatg ttgcccaggc tggtttcaaa ctcctgggct caagcagtcc tcctgtctca
     3361 gcctcccaaa gtgctgggat tacaggcatg agccactgag cccgaccagc tgtaaaatta
     3421 ttatattcat tttcactatg tgctacttct tctcacctga cttttttttt ttttttttga
     3481 gatggagtct cactctgtca cccaggttag agtgcagtgt cacgatctcg gctcactgca
     3541 acctccgcct cccaggttca agcaattctc ttgcctcagc ctcccaagca actgagatta
     3601 caggcctgtg tcactatgcc cagctaattt ttgtattttt agtagagatg gggttttcac
     3661 catgttggtc aggctggtct caaactcctg acctcaagtg atccaccagc ctcggcctcc
     3721 caaagtgctg gattacaatt gtgagccact gtgtctggcc acacactgac tttcactgta
     3781 atatctggat gttttatgta acatatctgg gcaatagggc ttatggcaga attggccctc
     3841 gtggtgtagg ccttccaagt tccaagtctc atttttagta ttcctccgtt ccaacccctg
     3901 gatccaccag ttccaacagc ctggatccac cttgatattg acagccaggc agatgcttct
     3961 gctgatcacc gcagctctag caatggaaat ggatatgtta agaaaatact tgtctattct
     4021 tttattttgg tggtttaaac tattaattca caccatctct gaaaaaaggc cttatgttga
     4081 ctaaagaaaa cataggcttt agtttcagct tctgtcagaa ttagtaccaa ttctgaatct
     4141 ggtggagtga taagacatgg tttcatgctg ggaagacact gctgaaatcc tccttgtggg
     4201 agaacatgga aattttatac tgaattaaat taacgcatgt gacttttcac attcagagac
     4261 attcaggatg aattctgggg tttccattta atagctataa caggcagtcc agaacaactt
     4321 cacatatagc agcatttctg ctatgtgaca atgaccaaaa gagttcctgt atattagtgt
     4381 ctagtggaat atttcaaatt gcagaaccca gacaaccaat tgcctgaatt attattattt
     4441 tttgttttta gcaactcttt ggctttatct tgatactgtc ttgtctggca ccaaagtttt
     4501 atttccttct tagtcctctt ggggatagtt tttgggtgtt tttttttatt tttctttttt
     4561 tgagacgggg tctcatgctg atgcccaggc tggagtgcaa tggtgtgatt atggctcact
     4621 gcagcctcaa cttcccaggc tcaggtgatt ctattacctc agcctcccaa gtagctggga
     4681 ctactggtgt gcactactag gactggctaa ttttttgtat cttttgtaca gatagggttt
     4741 caccgtgttg ctcaggctgg ttttgaactt ctaggttcaa gcaatcctcc caccacagcc
     4801 tccaaaagtc ctgggattac aggtgtgagc caccataact ggctggaatt atttgtacct
     4861 ggaccttgtg ttttgttttt ttgccctact atcttttcta aataacatat catgttcctg
     4921 agatagcagt atatacaatt atgtaaaata gagctttata tgaactctgt acatgctcta
     4981 agctcttttt gaatgatatt ttaagaagtt tctaaaccaa agtgcttaag aaaacatgaa
     5041 gatgttaatt tcatgaagac tgtacaagtt tagaagtaca atgtagacct gtttaagaca
     5101 aaggtggatg ggctttgggg ttttttttac aattggactt caggtacaga aggcttgggt
     5161 aatggtactc ctcagttcat atcaccttat cattggcctt tagtattttg taaataagta
     5221 actggacttt tatgaaaagc atattcttaa cagtttccca tttccttttt tttttttttt
     5281 aagatagtgt tttgctctgt tgccctggct ggagtgcagt ggcatgatct tggctcactg
     5341 cagcctccac ctcccaggct caggcgatcc tcctgcccca gcctcccaag tagctgggat
     5401 tacaggcgtg cacaactgca tgcacaacta atttttgtat ttttagtaga gacagggttt
     5461 cgccatgttg gccaagctag tctcaaactc ctgggctcaa gtgatccgcc cacctcagcc
     5521 tcccaacatg ttgggattat aggcataagc caccatgccc agccagtttt catttctttg
     5581 gtctgcatgt aaaggactaa agaatgatat gtagctacta cactgcagca aacaacattt
     5641 ttccagtgta caaatcagtg gagagtaagc aatgtattac tctgatgtcg gtgaaacacc
     5701 tcaaattata aataatgcca ggaacatgtg aaaactccac atgtttaata aatgccagct
     5761 ttcagaaaaa gcagagatta taggtattca acaagttaaa caataatctg gtagattagt
     5821 aataatttaa cacatgtgta tcttgtattt aaagttaact gaaaattatg taaaaaaaaa
     5881 aaacactgtg tttgactttc ttttgtttta caagtgatgc agagtatctg ctgagaaggt
     5941 cagttagatc atctgatgtc atatttgcca cttagctttt gtcccagcag catataaatt
     6001 ctaccttgta agcctcatat tagaagtggt cccagccagg cacagtggct tacttcccaa
     6061 cactttggga gtccacggct ggtggattgc ctgagctcgg gagtttgaga ccagcctggc
     6121 caacatggtg aaaccccatt tttacaaaaa tgcaaaaatt agccaggtgt ggtagtacac
     6181 acctgtaatc ccacctactc ggggggctga ggcccaagaa tcacttgaac ccaggaggcg
     6241 gcagttgcag tgagccaaga ttgtgccact gcactgcatc ctgggtgaca gagcaagatt
     6301 ctgtctcaaa gaaaagaaaa agaaatggtc ccattgctac ggattagaac taatttgtaa
     6361 aactatcaga attttaagac tgattaaagg ttttaggtgt ttttctccta ctttgcatac
     6421 tgagaataat atgtatagta tttttccagt atgatttaca attttataaa tgtcagtata
     6481 catatgtata tataaattat tctcaactcc attttttttt aaataaaata agtacatgtt
     6541 tgtgtgctaa attgctcatt tggcagtgat agattgaaaa acatttataa atttaaaaat
     6601 aaagcactat aagatatgag gaatgaatag cttctatgtg aatttctatg taattaatat
     6661 caatatttag aataaaagtg tatttgagga taagatattt gtttactaaa atgttttatt
     6721 tactaagagt agaggtgaat tatgcatctt tctaaggaaa agttctttta atttctgtgt
     6781 ctatgaaaaa gaattcataa ttcataattc ttaattgccc tcttttgatc catataattc
     6841 tttaaataaa cgaaacaata ccaattcaaa aaggggcctg ctttgtataa aattgtctaa
     6901 cctaaaaatt aagtagactt tctgcatatc taaaatatat tattacacat tcttgtcttt
     6961 attcttcctt acaaaacatt tttaaatgaa ggaatgaaat tttaattgtt tatgagaata
     7021 taacttttaa aaatatttct agtaggccag gcatggtggc tcatgcctgt aatcccagca
     7081 ctttgggagg ctgaggcacg tggatcacct gaggtcagga gttcgagacc agtctgacca
     7141 atatggtgaa accctgtctc tactaaaaat acaaaaatta gccaggcatg gtggctgtcg
     7201 cctgtaatcc cagctattcg ggaggctgag gcaggagaat tgcttgaacc tgggaggcgg
     7261 ggtttgcagt gagtgccaag actgagccac tgcactgcag gctgggtgac agagtgaaac
     7321 tccatctcaa aaaaaaaaaa aattctagta aaaatggaaa aatccacaag aaaacctctt
     7381 tttttcctga ttactcactt ttcttcatgc ctttaatttt aacctcatct cacaccttga
     7441 tattagaaga aagtaaggct gaaaggcaga ttcataagtt gtagataaca tgaagacttc
     7501 cttgaataag gatttattct ttcggctcac aaagaccagt cagtattatt gacaaacaac
     7561 aggcaggaag atttctccta aaagtctcaa ctaaagttaa acctggtcca ttatggcatc
     7621 aatctacccc tagaaactga tgcagagtct atttcctccc tgttttaact agaacttagc
     7681 cagactggag acagcatgga cccaaagagc atgcagtccc acagagttag ggaaaggatg
     7741 catcttgacc agcattcatc atgtggatca gttaggaatt aagttcctga ttcaaggtga
     7801 gctcatatgg ccgctccctg gtcatctagg acacaagttc cttctaactc ttccccacct
     7861 tcattagtac agggcttctt tcctgtgttg ccacatgatc caaaatggtg gttgtaactc
     7921 cagcatgata ttcacaagaa ggaaagagag ggaaccagca caagggtgag cctcccaagt
     7981 aggtcagcca cttttaaata gctttcctgc cagcccagtg aagcaactct gcttacatct
     8041 cattggccaa tctctgcaag gcagcaggga acagtcatct ctatggttgg tacattatca
     8101 ctttcaacaa taagggattc tgtctcacaa agtggtggaa gaatattggg tatctgaaga
     8161 ggtagccacc ctggccagaa ggtgctaaac actaaacata catcatctca ttttaatcct
     8221 agtaattact tatgaggtag gtttagagaa cttatacctt gttccatgtc tttccaactc
     8281 caaagcacaa gtttttaatc actgcactgc actgcatccc caataactag ccgtaggaaa
     8341 gtgttttaaa aggcatcact tggcggggtg cagtggctca cacctgtaat cccaccactt
     8401 tgggaggccg aggcaggcgg atcacctgag gtcaggagtt tgagaccagc ctggccaaca
     8461 tggtgaaacc cccgtctcaa ctaaaaatac aaaaattagc caggcatagt ggcatgtacc
     8521 tgtaatccca gctactcagg aggctgaggc aggagaatca cttgaacctg ggaggcggag
     8581 gttacagtga gatgagatca caccattgta ctccagcctt gtctaaaaaa aaacaacaaa
     8641 aaaacaaaca aaaaaaagtt tcagtcattg tcaaggatgc cttaaggtga gcatagcctg
     8701 agataagaag taacagaggc tgcaggctga gataagaagg aacagaggca gtgaaggcag
     8761 gaccctaggc ccagaagtaa tggtctatca tgctgagaaa aaagccaggg cttagaatag
     8821 gggtgataag taaaaagcct agttttaaaa tctaagtgct ggtaaaggtt tggtcactag
     8881 gtgaaaaaat aaagttccca cttactagag ctgacataaa cagcatatga tcctctttaa
     8941 ggttgcagtg gagaggcatg tccagggact ctcaagttag agacaggtgt gtttagtgct
     9001 agaattggaa agacattcaa gcagactggc atgttgcctc ttcacagcca tagtcgtgct
     9061 ggcttgcagg atactccagc ctagaatgta tataggagtg tggagaacag caaaatcagc
     9121 attgcttggg attcagcctg agctcaagtg gcccacccct ggaggcatcc agtgttcaca
     9181 cttcccaaga gagaaaacct gattggatgg gtgtttcagc agtctattgc tgcttaaaca
     9241 cctcaaaact tagcagctta aaacaacaac actcaattta tttttcacac aaatctgcaa
     9301 tttgcatgag gctcagtgca aatggttcaa ctctctccca cacggcattg gctgggcagt
     9361 tcaactggat ctgggggtcc cactttcaga tgactcacat ggctggcaag tttgttctgg
     9421 ctgtcggata ggagcccagc caagcctgtg gtccagcggc cttggctttt atgatgtggg
     9481 cctctccata gactccttgg gcttcttcac agcatggcag ctgagttcca agagcaagtg
     9541 tcccaagaga gcaaagtaga aatgcatagt atttttataa tttagactca gaaatcacat
     9601 cacatcactt ctgccatact ttattgtttg agacagttac aaagtctacc taggttcaag
     9661 gtggaaagga cataaacccc acttgtcctt ggaggcgtgt caaagccaca ttatgagaag
     9721 agcaagtggg ataagggatt tgttgcaggc accgttggaa aatgtgatct gcccaaattg
     9781 gtgtgtcttc atgcaatatc gaggaaatat attaggtagt ttcgtgtcaa ggaacattgt
     9841 ggatatttga cctccctgaa tcccagtgcc tatgtgctct ttggcttgga catagacccc
     9901 tggtccagta gtctgtagta ggtggtagaa ctagttttac caactacatg agtcatgagc
     9961 catgggactg aatgggttgt aggtggatca gacacataga aatgtatgac tactctcaaa
    10021 gcatgaggtt aaaatgggag cagattagac tgagcacctt gaggataggg atcagtctta
    10081 ctcatctctg tatcctgaaa agtgcttggc gctactgcac gctccataat aacagaaaaa
    10141 ccaattattt aatgagctag gagttacata tcatctttcc ttaagtacct aatcagtctt
    10201 tatcatcagt gagtgcagaa ctcaaatatg gtattgttca tcttccatca ccattttctc
    10261 ccaagtttcc tggtttaatt gcattttcct cactttccat ctaatggatc ctgatgtcat
    10321 tctttatctt tatttcatat tgtcctattg tgtgtattgt attgtatttt tagctacatt
    10381 aaatccaata tggaaggaag cagagaacga tcataattga actaacaagc aagtggaggt
    10441 ggagagaaag tggccccaat ttggaaggtg aaggaaaact ggggatggag cctaactgat
    10501 cattaaaatg ctcgaagcag ctctttccaa ccca
//
