LOCUS       NM_153266               2538 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 151A (TMEM151A), mRNA.
ACCESSION   NM_153266 XM_938846
VERSION     NM_153266.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2538)
  AUTHORS   Huang,H.L., Zhang,Q.X., Huang,F., Long,X.Y., Song,Z., Xiao,B.,
            Li,G.L., Ma,C.Y. and Liu,D.
  TITLE     TMEM151A variants associated with paroxysmal kinesigenic dyskinesia
  JOURNAL   Hum Genet 142 (8), 1017-1028 (2023)
   PUBMED   36856871
  REMARK    GeneRIF: TMEM151A variants associated with paroxysmal kinesigenic
            dyskinesia.
REFERENCE   2  (bases 1 to 2538)
  AUTHORS   Mounir Alaoui,O., Charbonneau,P.F., Prin,P., Mongin,M., Choquer,M.,
            Damier,P., Riant,F. and Degos,B.
  TITLE     TMEM151A as an alternative to PRRT2 in paroxysmal kinesigenic
            dyskinesia: About three new cases
  JOURNAL   Parkinsonism Relat Disord 108, 105295 (2023)
   PUBMED   36724570
  REMARK    GeneRIF: TMEM151A as an alternative to PRRT2 in paroxysmal
            kinesigenic dyskinesia: About three new cases.
REFERENCE   3  (bases 1 to 2538)
  AUTHORS   Chen,Y.L., Chen,D.F., Li,H.F. and Wu,Z.Y.
  TITLE     Features Differ Between Paroxysmal Kinesigenic Dyskinesia Patients
            with PRRT2 and TMEM151A Variants
  JOURNAL   Mov Disord 37 (3), 608-613 (2022)
   PUBMED   35083789
  REMARK    GeneRIF: Features Differ Between Paroxysmal Kinesigenic Dyskinesia
            Patients with PRRT2 and TMEM151A Variants.
REFERENCE   4  (bases 1 to 2538)
  AUTHORS   Tian,W.T., Zhan,F.X., Liu,Z.H., Liu,Z., Liu,Q., Guo,X.N.,
            Zhou,Z.W., Wang,S.G., Liu,X.R., Jiang,H., Li,X.H., Zhao,G.H.,
            Li,H.Y., Tang,J.G., Bi,G.H., Zhong,P., Yin,X.M., Liu,T.T., Ni,R.L.,
            Zheng,H.R., Liu,X.L., Qian,X.H., Wu,J.Y., Cao,Y.W., Zhang,C.,
            Liu,S.H., Wu,Y.Y., Wang,Q.F., Xu,T., Hou,W.Z., Li,Z.Y., Ke,H.Y.,
            Zhu,Z.Y., Zheng,L., Wang,T., Rong,T.Y., Wu,L., Zhang,Y., Fang,K.,
            Wang,Z.H., Zhang,Y.K., Zhang,M., Zhao,Y.W., Tang,B.S., Luan,X.H.,
            Huang,X.J. and Cao,L.
  TITLE     TMEM151A Variants Cause Paroxysmal Kinesigenic Dyskinesia: A
            Large-Sample Study
  JOURNAL   Mov Disord 37 (3), 545-552 (2022)
   PUBMED   34820915
  REMARK    GeneRIF: TMEM151A Variants Cause Paroxysmal Kinesigenic Dyskinesia:
            A Large-Sample Study.
REFERENCE   5  (bases 1 to 2538)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 2538)
  AUTHORS   Li,H.F., Chen,Y.L., Zhuang,L., Chen,D.F., Ke,H.Z., Luo,W.J.,
            Liu,G.L., Wu,S.N., Zhou,W.H., Xiong,Z.Q. and Wu,Z.Y.
  TITLE     TMEM151A variants cause paroxysmal kinesigenic dyskinesia
  JOURNAL   Cell Discov 7 (1), 83 (2021)
   PUBMED   34518509
  REMARK    Erratum:[Cell Discov. 2021 Oct 28;7(1):102. doi:
            10.1038/s41421-021-00345-3.. PMID: 34711800]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2538)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001107.5, DB477253.1, BC033898.2, BM727563.1 and BU732410.1.
            
            On Nov 22, 2018 this sequence version replaced NM_153266.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY155283.1, BC033898.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327259.5/ ENSP00000326244.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AP001107.5         32150-32157
            9-502               DB477253.1         1-494
            503-1534            BC033898.2         526-1557
            1535-1535           BM727563.1         94-94
            1536-2534           BC033898.2         1558-2556
            2535-2538           BU732410.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..2538
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..2538
                     /gene="TMEM151A"
                     /gene_synonym="DYT36; EKD3; TMEM151"
                     /note="transmembrane protein 151A"
                     /db_xref="GeneID:256472"
                     /db_xref="HGNC:HGNC:28497"
                     /db_xref="MIM:620108"
     exon            1..195
                     /gene="TMEM151A"
                     /gene_synonym="DYT36; EKD3; TMEM151"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1527
                     /gene="TMEM151A"
                     /gene_synonym="DYT36; EKD3; TMEM151"
                     /note="transmembrane protein 151"
                     /codon_start=1
                     /product="transmembrane protein 151A"
                     /protein_id="NP_694998.1"
                     /db_xref="CCDS:CCDS8133.1"
                     /db_xref="GeneID:256472"
                     /db_xref="HGNC:HGNC:28497"
                     /db_xref="MIM:620108"
                     /translation="MPEDGAGDGGEVPALIPDGEPLREEQRPLKQSLGSSLCRESHWK
                     CLLLTLLIHACGAVVAWCRLATVPRLVLGPEAALARGAGGPPPTYPASPCSDGYLYIP
                     LAFVSLLYLLYLAECWHCHVRSCQAPRTDAHTVLALIRRLQQAPPCVWWKATSYHYVR
                     RTRQITRYRNGDAYTTTQVYHERADSRTARGEFDYSAHGVRDVSKELVGLAEHAATRL
                     RFTKCFSFGSAEAEASYLTQRARFFSANEGLDDYLEAREGMHLKDVDFRESLMVFADP
                     RSPPWYARAWVFWLVSAATLSWPLRVVAAYGTAHVHYQVEKLFGASSPPPGAVPSGPP
                     LSRVATVDFTELEWHICSNRQLVPSYSEAVVMGAGSGAYLRGCQRCRRSVSSNSLPPA
                     RPSGPRLPFSRSRLSLGAGGRATPGVFRSLSGGPLGRRGEDTEPLESPPCYEDALYFP
                     VLIVHGDSGCQGDGQGAL"
     exon            196..2538
                     /gene="TMEM151A"
                     /gene_synonym="DYT36; EKD3; TMEM151"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2519..2524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM151A"
                     /gene_synonym="DYT36; EKD3; TMEM151"
                     /note="hexamer: AATAAA"
     polyA_site      2538
                     /gene="TMEM151A"
                     /gene_synonym="DYT36; EKD3; TMEM151"
                     /note="major polyA site"
ORIGIN      
        1 gcactccctc cgcggccgct gagccgagcg gacgcccccg ggggccgcgt cgcagccctc
       61 cgtgctcccc cctatcatgc ccggtgccca ggctggggcc gcccaagcag ccaggacacc
      121 atgcccgagg acggcgctgg cgacggcggg gaggtgcccg cgctcatccc ggacggcgag
      181 ccgctgcggg aagagcagcg gcccctgaaa cagtccctgg gaagctccct gtgccgcgag
      241 tcgcactgga agtgcctgct cctcacgctg ctcatccacg cctgcggggc cgtggtggcc
      301 tggtgtcgcc tggccacagt gccgcggctg gtcctggggc ccgaggccgc cttggcccgg
      361 ggagccgggg gcccgccacc gacctacccg gccagcccct gctccgatgg ctacctgtac
      421 atcccgctgg ccttcgtctc cctcctctac ctcctctacc tggctgagtg ctggcactgt
      481 cacgtgcggt cctgccaggc gccacgcacc gacgcccaca cggtgctggc gctgatccgc
      541 cggctgcagc aggcgccgcc gtgcgtctgg tggaaggcca ccagctatca ctacgtgcgg
      601 cgcacacgcc agatcacgcg ctaccgcaac ggcgacgcct acaccaccac gcaggtgtac
      661 catgagcgcg ctgacagccg cacggcccgc ggcgagtttg actactcggc gcacggcgtc
      721 cgcgacgtct ccaaggagct ggtggggctg gcggagcacg cggccacgcg gctgcgcttc
      781 accaagtgct tcagcttcgg cagcgcggag gccgaggcct cgtacctcac gcagcgggcg
      841 cgcttcttca gcgccaacga gggcctggac gactatctgg aggcgcgcga gggcatgcac
      901 ctgaaggacg tagacttccg cgagtcgctc atggtcttcg ccgacccccg cagcccgccc
      961 tggtacgcgc gcgcctgggt cttctggctc gtgtcggcgg ccacgctgtc gtggcccctg
     1021 cgcgtcgtgg ccgcctatgg cacggctcac gtgcactacc aggtggagaa gctctttggc
     1081 gccagctcgc ccccgccggg ggccgtgccc agcgggcccc cgctgtcccg cgtggccaca
     1141 gtggacttca ctgagctcga gtggcacatc tgctccaacc ggcagctggt gcccagctac
     1201 tcggaggccg tggtcatggg cgcgggctcg ggcgcctacc tcagaggctg ccagcgctgc
     1261 cgccgctctg tcagcagcaa ctcgctgccc cccgcccggc ccagcgggcc ccgcctgccc
     1321 ttcagccgca gccgcctctc gctgggcgct ggcggccggg ccacgccagg ggtcttccgc
     1381 agcctgagcg gggggccgct ggggcgccgt ggagaggaca cggaacccct ggagagcccg
     1441 ccctgctatg aggacgccct ctacttcccg gtgctcattg tccacggaga cagcggctgc
     1501 cagggggatg ggcagggtgc tctctgagac cccccacggc ccccagagtg gccccctccc
     1561 caccattcca ccatgggctt agatgcccga gtgattgttg tccaaaacag gcgggaaaac
     1621 agaccagcca cacacaaggg gcaggggtga gggtgggggt gggggtcctt aaacagacta
     1681 aaatgcagtt acctgtggtc attttggagg aagtggaagc ctaagaatcg cccccagcat
     1741 ggcttcatcc cccaagatgg ccgatgatct ggcctgaagg cctctcacaa agggcaggag
     1801 aagaagcttc cagaaaggct gggatggagg aggagtcctg cggccagctg ttgcctgcag
     1861 cagaggctgc ctgtggacac ttccctaccg gggctgaggc catgctggga gcccccccag
     1921 tgacgcagaa gcacaaattg gaggcttggg gccatgccca gccaggttgg cttccctggg
     1981 gctgaagagc tggctgtggt ggcaccatgg ccttggccct gctactcacc caacattccc
     2041 atcctcccct gataggcccc tcctccttgc ctgccctctc tcccgctgct cagggccagt
     2101 cactcccccc acatgcagct acccctacaa cctggggttc cttctcaggg cctcacctgg
     2161 tccccacatc ccctggcctc tgctcctgcc tcccaaagtc catgtctgcc tccatcagcc
     2221 acacacacgc agggacgccc gttccttgcc ctcccggact tatctactct tcactttcct
     2281 gatgatccat ggggcccagg cctagagggc atccgagggg ctgggccttg gccacagcct
     2341 cttggatgat gtccttgctc caccacgcag gcccttgctt ctcccatcaa cgagtcttgg
     2401 cccaggggac actgaccctc ccccagggag gagagaggag ttccttccct ttcaacgagg
     2461 gcttccacgc cctctaaggg gtggcgggga agggaggagg ctgagaagat gcagattaaa
     2521 taaaggtatg gaatggaa
//
