LOCUS       NM_001080506            3178 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens transmembrane protein 150C (TMEM150C), transcript
            variant 1, mRNA.
ACCESSION   NM_001080506 XM_496707
VERSION     NM_001080506.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3178)
  AUTHORS   Pak,S., Ryu,H., Lim,S., Nguyen,T.L., Yang,S., Kang,S., Yu,Y.G.,
            Woo,J., Kim,C., Fenollar-Ferrer,C., Wood,J.N., Lee,M.O., Hong,G.S.,
            Han,K., Kim,T.S. and Oh,U.
  TITLE     Tentonin 3 is a pore-forming subunit of a slow inactivation
            mechanosensitive channel
  JOURNAL   Cell Rep 43 (6), 114334 (2024)
   PUBMED   38850532
  REMARK    GeneRIF: Tentonin 3 is a pore-forming subunit of a slow
            inactivation mechanosensitive channel.
REFERENCE   2  (bases 1 to 3178)
  AUTHORS   Raha,A., Wu,Y., Zhong,L., Raveenthiran,J., Hong,M., Taiyab,A.,
            Wang,L., Wang,B. and Geng,F.
  TITLE     Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and
            their correlation with brain biomechanical characteristics
  JOURNAL   Mol Brain 16 (1), 83 (2023)
   PUBMED   38124148
  REMARK    GeneRIF: Exploring Piezo1, Piezo2, and TMEM150C in human brain
            tissues and their correlation with brain biomechanical
            characteristics.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3178)
  AUTHORS   Hong,G.S., Lee,B. and Oh,U.
  TITLE     Evidence for Mechanosensitive Channel Activity of Tentonin
            3/TMEM150C
  JOURNAL   Neuron 94 (2), 271-273 (2017)
   PUBMED   28426962
REFERENCE   4  (bases 1 to 3178)
  AUTHORS   Dubin,A.E., Murthy,S., Lewis,A.H., Brosse,L., Cahalan,S.M.,
            Grandl,J., Coste,B. and Patapoutian,A.
  TITLE     Endogenous Piezo1 Can Confound Mechanically Activated Channel
            Identification and Characterization
  JOURNAL   Neuron 94 (2), 266-270 (2017)
   PUBMED   28426961
REFERENCE   5  (bases 1 to 3178)
  AUTHORS   Lebedev,I.N., Nazarenko,L.P., Skryabin,N.A., Babushkina,N.P. and
            Kashevarova,A.A.
  TITLE     A de novo microtriplication at 4q21.21-q21.22 in a patient with a
            vascular malignant hemangioma, elongated sigmoid colon,
            developmental delay, and absence of speech
  JOURNAL   Am J Med Genet A 170 (8), 2089-2096 (2016)
   PUBMED   27288323
REFERENCE   6  (bases 1 to 3178)
  AUTHORS   Hong,G.S., Lee,B., Wee,J., Chun,H., Kim,H., Jung,J., Cha,J.Y.,
            Riew,T.R., Kim,G.H., Kim,I.B. and Oh,U.
  TITLE     Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in
            Dorsal-Root Ganglion Neurons with Proprioceptive Function
  JOURNAL   Neuron 91 (1), 107-118 (2016)
   PUBMED   27321926
REFERENCE   7  (bases 1 to 3178)
  AUTHORS   Chung,J., Nakatsu,F., Baskin,J.M. and De Camilli,P.
  TITLE     Plasticity of PI4KIIIalpha interactions at the plasma membrane
  JOURNAL   EMBO Rep 16 (3), 312-320 (2015)
   PUBMED   25608530
REFERENCE   8  (bases 1 to 3178)
  AUTHORS   Sokabe,M., Sawada,Y. and Kobayashi,T.
  TITLE     Ion Channels Activated by Mechanical Forces in Bacterial and
            Eukaryotic Cells
  JOURNAL   Subcell Biochem 72, 613-626 (2015)
   PUBMED   26174401
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC067942.6, BC147019.1 and
            BF508344.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001080506.2.
            
            Summary: This gene encodes a transmembrane protein component of a
            mechanosensitve ion channel that is activated by mechanical stimuli
            in various cell types and confers slowly adapting, mechanically
            activated currents in dorsal root ganglion neurons. Mechanically
            activated ion channels are sensors that are critical for hearing,
            touch, pain, and blood pressure regulation. [provided by RefSeq,
            Jul 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.131174.1,
                                           SRR1660805.202665.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449862.7/ ENSP00000403438.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC067942.6         126481-126512       c
            33-855              BC147019.1         1-823
            856-2711            AC067942.6         48167-50022         c
            2712-3178           BF508344.1         23-489              c
FEATURES             Location/Qualifiers
     source          1..3178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     gene            1..3178
                     /gene="TMEM150C"
                     /gene_synonym="TTN3"
                     /note="transmembrane protein 150C"
                     /db_xref="GeneID:441027"
                     /db_xref="HGNC:HGNC:37263"
                     /db_xref="MIM:617292"
     exon            1..83
                     /gene="TMEM150C"
                     /gene_synonym="TTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            84..173
                     /gene="TMEM150C"
                     /gene_synonym="TTN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..843
                     /gene="TMEM150C"
                     /gene_synonym="TTN3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tentonin 3"
                     /codon_start=1
                     /product="transmembrane protein 150C isoform 1"
                     /protein_id="NP_001073975.1"
                     /db_xref="CCDS:CCDS47087.1"
                     /db_xref="GeneID:441027"
                     /db_xref="HGNC:HGNC:37263"
                     /db_xref="MIM:617292"
                     /translation="MDGKKCSVWMFLPLVFTLFTSAGLWIVYFIAVEDDKILPLNSAE
                     RKPGVKHAPYISIAGDDPPASCVFSQVMNMAAFLALVVAVLRFIQLKPKVLNPWLNIS
                     GLVALCLASFGMTLLGNFQLTNDEEIHNVGTSLTFGFGTLTCWIQAALTLKVNIKNEG
                     RRVGIPRVILSASITLCVVLYFILMAQSIHMYAARVQWGLVMCFLSYFGTFAVEFRHY
                     RYEIVCSEYQENFLSFSESLSEASEYQTDQV"
     exon            174..227
                     /gene="TMEM150C"
                     /gene_synonym="TTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            228..260
                     /gene="TMEM150C"
                     /gene_synonym="TTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            261..328
                     /gene="TMEM150C"
                     /gene_synonym="TTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            329..456
                     /gene="TMEM150C"
                     /gene_synonym="TTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            457..634
                     /gene="TMEM150C"
                     /gene_synonym="TTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            635..3178
                     /gene="TMEM150C"
                     /gene_synonym="TTN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3157..3162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM150C"
                     /gene_synonym="TTN3"
                     /note="hexamer: AATAAA"
     polyA_site      3178
                     /gene="TMEM150C"
                     /gene_synonym="TTN3"
                     /note="major polyA site"
ORIGIN      
        1 acccgccgct actgctgccg ccgccgccac cgcagcaggt cacagcccct cgaggcgaca
       61 gcggccccgc cgcaccagag cagtggtaca ggcatggatg ggaagaaatg cagcgtatgg
      121 atgttcctac ctcttgtatt tactttgttt acttcagctg gattgtggat agtatacttc
      181 atagctgtgg aagatgacaa aattttacca ttaaattcag ctgaaaggaa acctggtgtg
      241 aagcatgcac catatataag cattgcaggt gatgatcctc ctgcaagctg tgtgtttagt
      301 caagttatga acatggcagc cttcctagcc cttgtggtag ctgttctgcg cttcatacaa
      361 ctgaaaccga aggttttaaa cccgtggctg aatattagtg gattggtggc tctgtgtctg
      421 gcttccttcg gaatgacctt acttggtaat tttcagctca caaatgatga agaaatccat
      481 aacgtcggaa cttccttgac ctttggattt ggcacattga cctgctggat ccaggctgcg
      541 ctgacactca aggtcaacat caagaatgaa ggacggagag ttggaattcc acgggttatt
      601 ctgtcggcat ctatcactct ctgtgtggtc ctctacttca tcctcatggc ccaaagcatc
      661 cacatgtatg cagccagggt ccagtggggc ctggtcatgt gcttcctgtc ttattttggc
      721 acctttgccg tggagttccg gcattaccgc tatgagattg tttgctctga gtaccaggag
      781 aatttcctaa gcttctcaga aagcctgtca gaagcttctg aatatcagac tgaccaggtg
      841 taaaccatca gtttttcctt gctggtgagg tgggtgtgac agtgggggag gggccagtag
      901 gacacactca caggacttga catagaacct catttcacac acacacacac acacacattc
      961 atggccacat ttgccaaatg agcttttcag ggcgagttat ttctttaatg aaaaagcaca
     1021 agcccttatg tgtcgaaata cacgctgtta cactgaaaat atatgcacga cagagcaaga
     1081 agcttgtgca tgatcacttc ttatccgtcc ccttcccagc actccctcct cttcccattc
     1141 tctccacatg tctcaagcac cctaccgagt agggcaggcc aaatgttcct tgggagtaat
     1201 gccaactccc gacgttgcct tcaggtccaa agggcttgga accagctcgt gaggaagttc
     1261 tgaatctggc actaatattc ttgagtggat aatagtgtat catagaatag gacggaaatt
     1321 gtattgagat gtgaccctgt gtcgcctgtg gaaaggcata gtgagaagaa ctttcccacg
     1381 aaagccccct tcatcgttgt tcagtggtcg gctgtgtgga tcccaggaga gacatatgcc
     1441 acagactgtg agagcaaagc ccgccgctgt gatctggact tgatgcactg tgactgagaa
     1501 tgatttccaa atgtgaatat gtgtagggac gtggtctatc aggcctggaa caagatgggg
     1561 gcagtgaagg tatggtttag tgtttgcttt catagtatgc catgtacaat gttttatatt
     1621 tcatagtttc ttttaagtaa ctaccatgag tctctctaag cctcatggac aaagatgtag
     1681 accaaatgca agagctgagc ttgctttggg ttcaaccatg atcaaagaaa aactgaggtc
     1741 acctgcaggc ttacgtggga agctaagaaa atatcacaga aaaatggaaa gaaatatgga
     1801 tgtgcagagg taataaaaag agctgctgct ggacatttat caaagatagg caccttacag
     1861 tatcttgttg caagtccaaa tcaggggaga ctttgttaat atgtatcttt tgctcaaatt
     1921 tagtagggtt tttttttttt ttggattaag ggcttttcaa atttggaatt tgtagaagcc
     1981 aattaaaaga atacccttcc taaaaaccaa attgacacag ctggcccccc tgctagccaa
     2041 cccgcagttc ccagttccca cctgctgaga gttcagaact cagaccgtag gtgtgggctt
     2101 atgagactgt gcttcatgaa gaaaagcaga attccaaatt caaactgttg gagtgagcca
     2161 agtggacaga ccctccatga gtgcactttc ttccaagaaa tccccagatt taccccatag
     2221 aggtctggga ttacctggaa tataatatga aaaacatttt ttaggctggg tgtggggctc
     2281 acacctgtaa tcccagcact ttgggaggct gaggcgggcg gatcacctga ggttgggagc
     2341 tcgagaccag cctgaccaat gtgaagaaac cccgtctcta ctaaaaaaaa tacaaaatta
     2401 gcctggtgtg gtggcgcatg cctgtaatcc cggctactca ggaggcggag gcaggagaat
     2461 cacttgaacc cgggaggcag gttgcggtga gacgagatca cgccattgca ctccagcctg
     2521 ggcaaaaaga gctaaaaact ccatctcaaa aaaaaaagaa aaaaagaaaa acgtttttta
     2581 attcaaccca aagtctgaat ttcttgagga aaaggtcaat gtcttttcat ctctgtattg
     2641 ttccccacct cttaacacag tgcctggcac atactaggtg ctcaataaat gtctgttgaa
     2701 tagaattatt aataatttaa gagtaggaaa aaggagtgtc agagagagac tcaaagatga
     2761 gtgagagagc atggaagatg gctgtttcat gtgagacagg aatggaagaa gttatgaata
     2821 gggatcagat gggggagtga gaatccctgt aagtaaaatg tgaggaaaag aacaagctga
     2881 gaacaagatt ctcctgtcaa aaaggcgtct tactgtaaat agtccaaggt gacatttgtt
     2941 agttttgaat actgcttttg ggtttctttt tttcattttt atattttaaa atttttatca
     3001 aagaacaaag acttatgtag ttttctttta ttctacacaa tccaaattaa acagcttttg
     3061 gtgatgcaat tgtacacttt cttaagaata tatctaatac cacattttag cagaaccaag
     3121 caatgactga cattattcat tgggatctgg ccactaaata aaattctttt atgcataa
//
