LOCUS       NM_001282011             983 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens transmembrane protein 150B (TMEM150B), transcript
            variant 1, mRNA.
ACCESSION   NM_001282011 XM_005258813
VERSION     NM_001282011.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 983)
  AUTHORS   Shao T, Ke H, Liu R, Zhao S and Qin Y.
  TITLE     Variation analysis of theTMEM150B gene in Chinese women with
            premature ovarian insufficiency
  JOURNAL   Reprod. Biomed. Online 38 (3), 407-412 (2019)
   PUBMED   30704953
  REMARK    GeneRIF: The results suggest that the perturbations in the TMEM150B
            gene are not a common explanation for premature ovarian
            insufficiency in Chinese women.
REFERENCE   2  (bases 1 to 983)
  AUTHORS   Wang Y and Tatakis DN.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J. Clin. Periodontol. 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: TMEM150B expression is significantly upregulated in human
            masticatory mucosa during wound healing
REFERENCE   3  (bases 1 to 983)
  AUTHORS   Hong GS, Lee B, Wee J, Chun H, Kim H, Jung J, Cha JY, Riew TR, Kim
            GH, Kim IB and Oh U.
  TITLE     Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in
            Dorsal-Root Ganglion Neurons with Proprioceptive Function
  JOURNAL   Neuron 91 (1), 107-118 (2016)
   PUBMED   27321926
REFERENCE   4  (bases 1 to 983)
  AUTHORS   Mrschtik M and Ryan KM.
  TITLE     Another DRAM involved in autophagy and cell death
  JOURNAL   Autophagy 12 (3), 603-605 (2016)
   PUBMED   27046253
REFERENCE   5  (bases 1 to 983)
  AUTHORS   Mrschtik M, O'Prey J, Lao LY, Long JS, Beaumatin F, Strachan D,
            O'Prey M, Skommer J and Ryan KM.
  TITLE     DRAM-3 modulates autophagy and promotes cell survival in the
            absence of glucose
  JOURNAL   Cell Death Differ. 22 (10), 1714-1726 (2015)
   PUBMED   25929859
  REMARK    GeneRIF: TMEM150B, renamed as DRAM-3, is a modulator of both
            macroautophagy and cell survival under starvation conditions.
            Erratum:[Cell Death Differ. 2017 Jun 30;(8):1470. PMID: 28665403]
REFERENCE   6  (bases 1 to 983)
  AUTHORS   Chung J, Nakatsu F, Baskin JM and De Camilli P.
  TITLE     Plasticity of PI4KIIIalpha interactions at the plasma membrane
  JOURNAL   EMBO Rep. 16 (3), 312-320 (2015)
   PUBMED   25608530
REFERENCE   7  (bases 1 to 983)
  AUTHORS   Perry JR, Corre T, Esko T, Chasman DI, Fischer K, Franceschini N,
            He C, Kutalik Z, Mangino M, Rose LM, Vernon Smith A, Stolk L, Sulem
            P, Weedon MN, Zhuang WV, Arnold A, Ashworth A, Bergmann S, Buring
            JE, Burri A, Chen C, Cornelis MC, Couper DJ, Goodarzi MO, Gudnason
            V, Harris T, Hofman A, Jones M, Kraft P, Launer L, Laven JS, Li G,
            McKnight B, Masciullo C, Milani L, Orr N, Psaty BM, Ridker PM,
            Rivadeneira F, Sala C, Salumets A, Schoemaker M, Traglia M, Waeber
            G, Chanock SJ, Demerath EW, Garcia M, Hankinson SE, Hu FB, Hunter
            DJ, Lunetta KL, Metspalu A, Montgomery GW, Murabito JM, Newman AB,
            Ong KK, Spector TD, Stefansson K, Swerdlow AJ, Thorsteinsdottir U,
            Van Dam RM, Uitterlinden AG, Visser JA, Vollenweider P, Toniolo D
            and Murray A.
  CONSRTM   ReproGen Consortium
  TITLE     A genome-wide association study of early menopause and the combined
            impact of identified variants
  JOURNAL   Hum. Mol. Genet. 22 (7), 1465-1472 (2013)
   PUBMED   23307926
REFERENCE   8  (bases 1 to 983)
  AUTHORS   Stolk L, Perry JR, Chasman DI, He C, Mangino M, Sulem P, Barbalic
            M, Broer L, Byrne EM, Ernst F, Esko T, Franceschini N, Gudbjartsson
            DF, Hottenga JJ, Kraft P, McArdle PF, Porcu E, Shin SY, Smith AV,
            van Wingerden S, Zhai G, Zhuang WV, Albrecht E, Alizadeh BZ,
            Aspelund T, Bandinelli S, Lauc LB, Beckmann JS, Boban M, Boerwinkle
            E, Broekmans FJ, Burri A, Campbell H, Chanock SJ, Chen C, Cornelis
            MC, Corre T, Coviello AD, d'Adamo P, Davies G, de Faire U, de Geus
            EJ, Deary IJ, Dedoussis GV, Deloukas P, Ebrahim S, Eiriksdottir G,
            Emilsson V, Eriksson JG, Fauser BC, Ferreli L, Ferrucci L, Fischer
            K, Folsom AR, Garcia ME, Gasparini P, Gieger C, Glazer N, Grobbee
            DE, Hall P, Haller T, Hankinson SE, Hass M, Hayward C, Heath AC,
            Hofman A, Ingelsson E, Janssens AC, Johnson AD, Karasik D, Kardia
            SL, Keyzer J, Kiel DP, Kolcic I, Kutalik Z, Lahti J, Lai S, Laisk
            T, Laven JS, Lawlor DA, Liu J, Lopez LM, Louwers YV, Magnusson PK,
            Marongiu M, Martin NG, Klaric IM, Masciullo C, McKnight B, Medland
            SE, Melzer D, Mooser V, Navarro P, Newman AB, Nyholt DR,
            Onland-Moret NC, Palotie A, Pare G, Parker AN, Pedersen NL, Peeters
            PH, Pistis G, Plump AS, Polasek O, Pop VJ, Psaty BM, Raikkonen K,
            Rehnberg E, Rotter JI, Rudan I, Sala C, Salumets A, Scuteri A,
            Singleton A, Smith JA, Snieder H, Soranzo N, Stacey SN, Starr JM,
            Stathopoulou MG, Stirrups K, Stolk RP, Styrkarsdottir U, Sun YV,
            Tenesa A, Thorand B, Toniolo D, Tryggvadottir L, Tsui K, Ulivi S,
            van Dam RM, van der Schouw YT, van Gils CH, van Nierop P, Vink JM,
            Visscher PM, Voorhuis M, Waeber G, Wallaschofski H, Wichmann HE,
            Widen E, Wijnands-van Gent CJ, Willemsen G, Wilson JF,
            Wolffenbuttel BH, Wright AF, Yerges-Armstrong LM, Zemunik T, Zgaga
            L, Zillikens MC, Zygmunt M, Arnold AM, Boomsma DI, Buring JE,
            Crisponi L, Demerath EW, Gudnason V, Harris TB, Hu FB, Hunter DJ,
            Launer LJ, Metspalu A, Montgomery GW, Oostra BA, Ridker PM, Sanna
            S, Schlessinger D, Spector TD, Stefansson K, Streeten EA,
            Thorsteinsdottir U, Uda M, Uitterlinden AG, van Duijn CM, Volzke H,
            Murray A, Murabito JM, Visser JA and Lunetta KL.
  CONSRTM   LifeLines Cohort Study
  TITLE     Meta-analyses identify 13 loci associated with age at menopause and
            highlight DNA repair and immune pathways
  JOURNAL   Nat. Genet. 44 (3), 260-268 (2012)
   PUBMED   22267201
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 983)
  AUTHORS   Stolk L, Zhai G, van Meurs JB, Verbiest MM, Visser JA, Estrada K,
            Rivadeneira F, Williams FM, Cherkas L, Deloukas P, Soranzo N, de
            Keyzer JJ, Pop VJ, Lips P, Lebrun CE, van der Schouw YT, Grobbee
            DE, Witteman J, Hofman A, Pols HA, Laven JS, Spector TD and
            Uitterlinden AG.
  TITLE     Loci at chromosomes 13, 19 and 20 influence age at natural
            menopause
  JOURNAL   Nat. Genet. 41 (6), 645-647 (2009)
   PUBMED   19448619
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020922.9, AU311823.1 and
            BC171904.1.
            
            On May 17, 2019 this sequence version replaced NM_001282011.1.
            
            Summary: This gene encodes a protein that belongs to the DRAM
            (damage-regulated autophagy modulator) family of membrane-spanning
            proteins. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same protein (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC171904.1, BM922629.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326652.9/ ENSP00000320757.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC020922.9         33624-33624         c
            2-40                AU311823.1         1-39
            41-200              BC171904.1         1-160
            201-201             AC020922.9         29342-29342         c
            202-819             BC171904.1         162-779
            820-820             AC020922.9         21247-21247         c
            821-983             BC171904.1         781-943
FEATURES             Location/Qualifiers
     source          1..983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..983
                     /gene="TMEM150B"
                     /gene_synonym="DRAM3; TMEM224; TTN2"
                     /note="transmembrane protein 150B"
                     /db_xref="GeneID:284417"
                     /db_xref="HGNC:HGNC:34415"
                     /db_xref="MIM:617291"
     exon            1..70
                     /gene="TMEM150B"
                     /gene_synonym="DRAM3; TMEM224; TTN2"
                     /inference="alignment:Splign:2.1.0"
     exon            71..166
                     /gene="TMEM150B"
                     /gene_synonym="DRAM3; TMEM224; TTN2"
                     /inference="alignment:Splign:2.1.0"
     exon            167..291
                     /gene="TMEM150B"
                     /gene_synonym="DRAM3; TMEM224; TTN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..925
                     /gene="TMEM150B"
                     /gene_synonym="DRAM3; TMEM224; TTN2"
                     /note="isoform a is encoded by transcript variant 1;
                     hCG1651476; transmembrane protein LOC284417; transmembrane
                     protein 224; tentonin 2; protein DRAM-3; modulator of
                     macroautophagy TMEM150B; DRAM-Related/Associated Member 3"
                     /codon_start=1
                     /product="modulator of macroautophagy TMEM150B isoform a"
                     /protein_id="NP_001268940.1"
                     /db_xref="CCDS:CCDS42629.1"
                     /db_xref="GeneID:284417"
                     /db_xref="HGNC:HGNC:34415"
                     /db_xref="MIM:617291"
                     /translation="MWGYLSLMPVFLAVWAISGVWIVFAIAVTNRTVDLSKGFPYISI
                     CGSFPPQSCIFSQVLNMGAALAAWICIVRYHQLRDWGVRRWPNQLILWTGLLCALGTS
                     VVGNFQEKNQRPTHLAGAFLAFILGNVYFWLQLLLWRLKRLPQPGAAWIGPLRLGLCS
                     VCTILIVAMIVLHACSLRSVSAACEWVVAMLLFALFGLLAVDFSALESCTLCVQPWPS
                     LSPPPASPISLPVQL"
     exon            292..351
                     /gene="TMEM150B"
                     /gene_synonym="DRAM3; TMEM224; TTN2"
                     /inference="alignment:Splign:2.1.0"
     exon            352..419
                     /gene="TMEM150B"
                     /gene_synonym="DRAM3; TMEM224; TTN2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..547
                     /gene="TMEM150B"
                     /gene_synonym="DRAM3; TMEM224; TTN2"
                     /inference="alignment:Splign:2.1.0"
     exon            548..728
                     /gene="TMEM150B"
                     /gene_synonym="DRAM3; TMEM224; TTN2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..983
                     /gene="TMEM150B"
                     /gene_synonym="DRAM3; TMEM224; TTN2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccaggcc agcagcccta gcttctggaa ggatccttca ggctccagac acccaaccta
       61 cccgtggccg gatgtctgcc tgagccccac cccgaatgcc agcccttctt ccctgagctc
      121 acccagcccc agctccagga ctgagagccc caggaagctt ggagaggtgt gagagagaca
      181 ggtgtccagc ctcagccccg atccttcacc tgcagagccc ggcatgtggg gctacctgtc
      241 gctgatgcct gtcttcctag ctgtctgggc tatctctggc gtctggatcg tttttgccat
      301 tgcagtgacc aacaggactg tggacctcag taaaggcttt ccctacatca gcatctgcgg
      361 atccttcccc cctcagagct gcatcttcag ccaggtgctc aatatgggag ctgctctggc
      421 cgcgtggatc tgcattgtcc gttaccacca gctccgggac tggggcgtca gaaggtggcc
      481 taaccagctg atcctatgga cgggtcttct gtgtgccctg ggcacctccg tggtaggcaa
      541 tttccaggaa aagaaccagc ggcctacgca cttggcaggg gccttccttg ccttcatctt
      601 gggtaacgtc tacttctggc tgcagctcct cctgtggagg ctgaagaggc tgccccagcc
      661 cggggctgcc tggattgggc ccctccgcct gggcctctgc agcgtctgca ccatcctcat
      721 tgtggccatg atcgtcctcc acgcctgctc gctgcgtagc gtctctgcgg cctgcgagtg
      781 ggtcgtggcc atgctgctgt tcgcgctctt cggtctctta gccgttgact tctccgccct
      841 ggagagctgc accctgtgtg ttcagccgtg gcccagcctc agccccccgc cggcctcccc
      901 catctccctg ccggtccagc tgtagcaggc accctgaccc gggccttgcc ctcaccagtg
      961 aagcaggaaa gatggggcca atc
//
