LOCUS       NM_001369917            1791 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 150A (TMEM150A), transcript
            variant 3, mRNA.
ACCESSION   NM_001369917
VERSION     NM_001369917.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1791)
  AUTHORS   Fan,S.T., Xu,H.Q., He,Y., Tu,M.X., Shi,K., Zhang,Y.Q., Guo,Q.,
            Yang,W.Q. and Qin,Y.
  TITLE     Overexpression of TMEM150A in glioblastoma multiforme patients
            correlated with dismal prognoses and compromised immune statuses
  JOURNAL   PLoS One 18 (12), e0294144 (2023)
   PUBMED   38055673
  REMARK    GeneRIF: Overexpression of TMEM150A in glioblastoma multiforme
            patients correlated with dismal prognoses and compromised immune
            statuses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1791)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1791)
  AUTHORS   Hong,G.S., Lee,B., Wee,J., Chun,H., Kim,H., Jung,J., Cha,J.Y.,
            Riew,T.R., Kim,G.H., Kim,I.B. and Oh,U.
  TITLE     Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in
            Dorsal-Root Ganglion Neurons with Proprioceptive Function
  JOURNAL   Neuron 91 (1), 107-118 (2016)
   PUBMED   27321926
REFERENCE   4  (bases 1 to 1791)
  AUTHORS   Chung,J., Nakatsu,F., Baskin,J.M. and De Camilli,P.
  TITLE     Plasticity of PI4KIIIalpha interactions at the plasma membrane
  JOURNAL   EMBO Rep 16 (3), 312-320 (2015)
   PUBMED   25608530
  REMARK    GeneRIF: TMEM150A is a functional homologue of Sfk1 in mammalian
            cells and plays a role in the homeostatic regulation of PI(4,5)P2
            at the plasma membrane.
REFERENCE   5  (bases 1 to 1791)
  AUTHORS   Zhang,J., D'Ercole,A.J. and Underwood,L.E.
  TITLE     Identification of a new gene (rat TM6P1) encoding a
            fasting-inducible, integral membrane protein with six transmembrane
            domains
  JOURNAL   Biochim Biophys Acta 1492 (1), 280-284 (2000)
   PUBMED   10858565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016753.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.288280.1,
                                           SRR1660807.408641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159368 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               AC016753.9         168843-169353       c
            512-559             AC016753.9         168394-168441       c
            560-646             AC016753.9         167980-168066       c
            647-714             AC016753.9         167304-167371       c
            715-842             AC016753.9         166850-166977       c
            843-1020            AC016753.9         166484-166661       c
            1021-1791           AC016753.9         165506-166276       c
FEATURES             Location/Qualifiers
     source          1..1791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..1791
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /note="transmembrane protein 150A"
                     /db_xref="GeneID:129303"
                     /db_xref="HGNC:HGNC:24677"
                     /db_xref="MIM:616757"
     exon            1..511
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             447..1262
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; transmembrane protein 150; fasting-inducible
                     integral membrane protein TM6P1; tentonin 1"
                     /codon_start=1
                     /product="transmembrane protein 150A isoform 1 precursor"
                     /protein_id="NP_001356846.1"
                     /db_xref="CCDS:CCDS33233.1"
                     /db_xref="GeneID:129303"
                     /db_xref="HGNC:HGNC:24677"
                     /db_xref="MIM:616757"
                     /translation="MTAWILLPVSLSAFSITGIWTVYAMAVMNHHVCPVENWSYNESC
                     PPDPAEQGGPKTCCTLDDVPLISKCGSYPPESCLFSLIGNMGAFMVALICLLRYGQLL
                     EQSRHSWVNTTALITGCTNAAGLLVVGNFQVDHARSLHYVGAGVAFPAGLLFVCLHCA
                     LSYQGATAPLDLAVAYLRSVLAVIAFITLVLSGVFFVHESSQLQHGAALCEWVCVIDI
                     LIFYGTFSYEFGAVSSDTLVAALQPTPGRACKSSGSSSTSTHLNCAPESIAMI"
     exon            512..559
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..646
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..714
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..842
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1020
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1791
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1770..1775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /note="hexamer: ATTAAA"
     polyA_site      1791
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /note="major polyA site"
ORIGIN      
        1 gactcgccac cgctccactg ggccggcacc cagcctctcc ttggcgtggc ctcttcggtt
       61 gtccagccct tctcccagcc ctggtccctc agaaggaggg taactccctt ccagatgtta
      121 cggtccgcct gcgtctctca gcacgccggt ggcatttggg ttgaccgcgg aggcccccag
      181 tgccagaggg tgttcacgtt ctgccgtggg ctcagcccaa actttggacg ctcagagacc
      241 caacgggagc gctggataag gtgttgaccc ccttcccctc ccccttcccg gccagttacc
      301 cactcctgga ctttgatctc tctccaccag gccaggacag ctgatggttg tggcagaaac
      361 atctcaaggt agctggtccg cccccacttc cccatctacc tcttgtcctc cccccaacac
      421 caccaccacc ctggctcccc tccctcatga ccgcctggat cctcctgcct gtcagcctgt
      481 cagcgttctc catcactggc atatggactg tgtatgccat ggctgtgatg aaccaccatg
      541 tatgccctgt ggagaactgg tcctacaacg agtcctgccc tcctgaccct gctgagcaag
      601 ggggtcccaa gacctgctgc accctggacg atgtccccct catcagcaag tgtggctcct
      661 atcccccaga aagctgcctc ttcagcctca ttggcaacat gggtgctttc atggtggccc
      721 tgatctgcct cctgcgctac gggcagctcc tggagcagag tcggcactct tgggttaaca
      781 ccacggcact catcacaggc tgcaccaacg ctgcgggcct cttggtggtt ggcaactttc
      841 aggtggatca tgccaggtct ctgcactacg ttggagctgg cgtggccttc cctgcggggc
      901 tgctctttgt ttgcctgcac tgtgctctct cctaccaagg ggccaccgcc ccgctggacc
      961 tggctgtggc ctatctgcga agtgtgctgg ctgtcatcgc ctttatcacc ctggtcctca
     1021 gtggagtctt ctttgtccat gagagttctc agctgcaaca tggggcagcc ctgtgtgagt
     1081 gggtgtgtgt catcgatatc ctcattttct atggcacctt cagctacgag tttggggcag
     1141 tctcctcaga cacactggtg gctgcactgc agcctacccc tggccgggcc tgcaagtcct
     1201 ccgggagcag cagcacctcc acccacctca actgtgcccc cgagagcatc gctatgatct
     1261 aaggtctggg gagggtggct ggcccggcct ccacagcacc ccaccccata tcttctttcc
     1321 atttatttcg taccaaaaac aattttgaga aagtattctg ttgggatctg ggcttcctca
     1381 cttctggaga agtggccatc ccatgcccac ctgtgccatg gaggagtggg ccctgccagc
     1441 tgccacagct gcatgacctg cttccccacc ccacggtgtc gttttgtttt taaaggtcac
     1501 ctgtcctcac tcacccagcc agcccttcag gtgccttcta ctcccagtgc caaagccaga
     1561 ccactggggt ttcctgctgc aggaattggg ggctgggaac agcagagggg atagaagtct
     1621 ggtggaggtg gagtgggcac gccttagcct acggaaaggc ccatttctgg gcccactgag
     1681 ctgcactggg attcttcact ctgcccctca cttcctttag ggcaaataac acagcagaac
     1741 cacgtgggta ttttagtact tttttttata ttaaaagaat tctaatttgc a
//
