LOCUS       NM_001031738            1553 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 150A (TMEM150A), transcript
            variant 1, mRNA.
ACCESSION   NM_001031738
VERSION     NM_001031738.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1553)
  AUTHORS   Fan,S.T., Xu,H.Q., He,Y., Tu,M.X., Shi,K., Zhang,Y.Q., Guo,Q.,
            Yang,W.Q. and Qin,Y.
  TITLE     Overexpression of TMEM150A in glioblastoma multiforme patients
            correlated with dismal prognoses and compromised immune statuses
  JOURNAL   PLoS One 18 (12), e0294144 (2023)
   PUBMED   38055673
  REMARK    GeneRIF: Overexpression of TMEM150A in glioblastoma multiforme
            patients correlated with dismal prognoses and compromised immune
            statuses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1553)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1553)
  AUTHORS   Hong,G.S., Lee,B., Wee,J., Chun,H., Kim,H., Jung,J., Cha,J.Y.,
            Riew,T.R., Kim,G.H., Kim,I.B. and Oh,U.
  TITLE     Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in
            Dorsal-Root Ganglion Neurons with Proprioceptive Function
  JOURNAL   Neuron 91 (1), 107-118 (2016)
   PUBMED   27321926
REFERENCE   4  (bases 1 to 1553)
  AUTHORS   Chung,J., Nakatsu,F., Baskin,J.M. and De Camilli,P.
  TITLE     Plasticity of PI4KIIIalpha interactions at the plasma membrane
  JOURNAL   EMBO Rep 16 (3), 312-320 (2015)
   PUBMED   25608530
  REMARK    GeneRIF: TMEM150A is a functional homologue of Sfk1 in mammalian
            cells and plays a role in the homeostatic regulation of PI(4,5)P2
            at the plasma membrane.
REFERENCE   5  (bases 1 to 1553)
  AUTHORS   Zhang,J., D'Ercole,A.J. and Underwood,L.E.
  TITLE     Identification of a new gene (rat TM6P1) encoding a
            fasting-inducible, integral membrane protein with six transmembrane
            domains
  JOURNAL   Biochim Biophys Acta 1492 (1), 280-284 (2000)
   PUBMED   10858565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA434376.1, BC050466.1 and AW009533.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001031738.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.723105.1,
                                           SRR3476690.955077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159368 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334462.10/ ENSP00000334708.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DA434376.1         3-41
            40-1551             BC050466.1         1-1512
            1552-1553           AW009533.1         3-4                 c
FEATURES             Location/Qualifiers
     source          1..1553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..1553
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /note="transmembrane protein 150A"
                     /db_xref="GeneID:129303"
                     /db_xref="HGNC:HGNC:24677"
                     /db_xref="MIM:616757"
     exon            1..92
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            93..273
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1024
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transmembrane protein 150; fasting-inducible
                     integral membrane protein TM6P1; tentonin 1"
                     /codon_start=1
                     /product="transmembrane protein 150A isoform 1 precursor"
                     /protein_id="NP_001026908.1"
                     /db_xref="CCDS:CCDS33233.1"
                     /db_xref="GeneID:129303"
                     /db_xref="HGNC:HGNC:24677"
                     /db_xref="MIM:616757"
                     /translation="MTAWILLPVSLSAFSITGIWTVYAMAVMNHHVCPVENWSYNESC
                     PPDPAEQGGPKTCCTLDDVPLISKCGSYPPESCLFSLIGNMGAFMVALICLLRYGQLL
                     EQSRHSWVNTTALITGCTNAAGLLVVGNFQVDHARSLHYVGAGVAFPAGLLFVCLHCA
                     LSYQGATAPLDLAVAYLRSVLAVIAFITLVLSGVFFVHESSQLQHGAALCEWVCVIDI
                     LIFYGTFSYEFGAVSSDTLVAALQPTPGRACKSSGSSSTSTHLNCAPESIAMI"
     exon            274..321
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..408
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..476
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..604
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..782
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1553
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1532..1537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /note="hexamer: ATTAAA"
     polyA_site      1553
                     /gene="TMEM150A"
                     /gene_synonym="TM6P1; TMEM150; TTN1"
                     /note="major polyA site"
ORIGIN      
        1 aaacctttca gggctgctcc gagggccgca gctagagtcg gcgccacgag ggggccgagc
       61 agggtgcggc ggcggcgggg cgctccgggg aggccaggac agctgatggt tgtggcagaa
      121 acatctcaag gtagctggtc cgcccccact tccccatcta cctcttgtcc tccccccaac
      181 accaccacca ccctggctcc cctccctcat gaccgcctgg atcctcctgc ctgtcagcct
      241 gtcagcgttc tccatcactg gcatatggac tgtgtatgcc atggctgtga tgaaccacca
      301 tgtatgccct gtggagaact ggtcctacaa cgagtcctgc cctcctgacc ctgctgagca
      361 agggggtccc aagacctgct gcaccctgga cgatgtcccc ctcatcagca agtgtggctc
      421 ctatccccca gaaagctgcc tcttcagcct cattggcaac atgggtgctt tcatggtggc
      481 cctgatctgc ctcctgcgct acgggcagct cctggagcag agtcggcact cttgggttaa
      541 caccacggca ctcatcacag gctgcaccaa cgctgcgggc ctcttggtgg ttggcaactt
      601 tcaggtggat catgccaggt ctctgcacta cgttggagct ggcgtggcct tccctgcggg
      661 gctgctcttt gtttgcctgc actgtgctct ctcctaccaa ggggccaccg ccccgctgga
      721 cctggctgtg gcctatctgc gaagtgtgct ggctgtcatc gcctttatca ccctggtcct
      781 cagtggagtc ttctttgtcc atgagagttc tcagctgcaa catggggcag ccctgtgtga
      841 gtgggtgtgt gtcatcgata tcctcatttt ctatggcacc ttcagctacg agtttggggc
      901 agtctcctca gacacactgg tggctgcact gcagcctacc cctggccggg cctgcaagtc
      961 ctccgggagc agcagcacct ccacccacct caactgtgcc cccgagagca tcgctatgat
     1021 ctaaggtctg gggagggtgg ctggcccggc ctccacagca ccccacccca tatcttcttt
     1081 ccatttattt cgtaccaaaa acaattttga gaaagtattc tgttgggatc tgggcttcct
     1141 cacttctgga gaagtggcca tcccatgccc acctgtgcca tggaggagtg ggccctgcca
     1201 gctgccacag ctgcatgacc tgcttcccca ccccacggtg tcgttttgtt tttaaaggtc
     1261 acctgtcctc actcacccag ccagcccttc aggtgccttc tactcccagt gccaaagcca
     1321 gaccactggg gtttcctgct gcaggaattg ggggctggga acagcagagg ggatagaagt
     1381 ctggtggagg tggagtgggc acgccttagc ctacggaaag gcccatttct gggcccactg
     1441 agctgcactg ggattcttca ctctgcccct cacttccttt agggcaaata acacagcaga
     1501 accacgtggg tattttagta ctttttttta tattaaaaga attctaattt gca
//
