LOCUS       NM_030969                929 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens transmembrane protein 14B (TMEM14B), transcript
            variant 1, mRNA.
ACCESSION   NM_030969
VERSION     NM_030969.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 929)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 929)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 929)
  AUTHORS   Liu,J., Liu,W., Yang,L., Wu,Q., Zhang,H., Fang,A., Li,L., Xu,X.,
            Sun,L., Zhang,J., Tang,F. and Wang,X.
  TITLE     The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and
            Promotes Cortical Expansion and Folding
  JOURNAL   Cell Stem Cell 21 (5), 635-649 (2017)
   PUBMED   29033352
  REMARK    GeneRIF: TMEM14B drives NP proliferation by increasing the
            phosphorylation and nuclear translocation of IQGAP1, which in turn
            promotes G1/S cell cycle transitions.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK311340.1 and BC071660.1.
            
            On May 17, 2019 this sequence version replaced NM_030969.4.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.296523.1,
                                           SRR5189667.352769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379542.10/ ENSP00000368858.5
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AK311340.1         47-68
            23-929              BC071660.1         13-919
FEATURES             Location/Qualifiers
     source          1..929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.2"
     gene            1..929
                     /gene="TMEM14B"
                     /note="transmembrane protein 14B"
                     /db_xref="GeneID:81853"
                     /db_xref="HGNC:HGNC:21384"
                     /db_xref="MIM:619865"
     exon            1..77
                     /gene="TMEM14B"
                     /inference="alignment:Splign:2.1.0"
     exon            78..144
                     /gene="TMEM14B"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..466
                     /gene="TMEM14B"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 14B isoform a"
                     /protein_id="NP_112231.3"
                     /db_xref="CCDS:CCDS4515.1"
                     /db_xref="GeneID:81853"
                     /db_xref="HGNC:HGNC:21384"
                     /db_xref="MIM:619865"
                     /translation="MEKPLFPLVPLHWFGFGYTALVVSGGIVGYVKTGSVPSLAAGLL
                     FGSLAGLGAYQLYQDPRNVWGFLAATSVTFVGVMGMRSYYYGKFMPVGLIAGASLLMA
                     AKVGVRMLMTSD"
     exon            145..221
                     /gene="TMEM14B"
                     /inference="alignment:Splign:2.1.0"
     exon            222..323
                     /gene="TMEM14B"
                     /inference="alignment:Splign:2.1.0"
     exon            324..414
                     /gene="TMEM14B"
                     /inference="alignment:Splign:2.1.0"
     exon            415..929
                     /gene="TMEM14B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      500..505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM14B"
                     /note="hexamer: ATTAAA"
     polyA_site      523
                     /gene="TMEM14B"
                     /note="major polyA site"
ORIGIN      
        1 aatcgcgttt ccggagagac ctggctgctg tgtcccgcgg cttgcgctcc gtagtggact
       61 ccgcgggcct tcggcagatg caggcctggg gtagtctcct ttctggactg agaagagaag
      121 aatggagaag cccctcttcc cattagtgcc tttgcattgg tttggctttg gctacacagc
      181 actggttgtt tctggtggga tcgttggcta tgtaaaaaca ggcagcgtgc cgtccctggc
      241 tgcagggctg ctcttcggca gtctagccgg cctgggtgct taccagctgt atcaggatcc
      301 aaggaacgtt tggggtttcc tagccgctac atctgttact tttgttggtg ttatgggaat
      361 gagatcctac tactatggaa aattcatgcc tgtaggttta attgcaggtg ccagtttgct
      421 gatggccgcc aaagttggag ttcgtatgtt gatgacatct gattagcaga agtcatgttc
      481 cagcttggac tcatgaagga ttaaaaatct gcatcttcca ctattttcaa tgtattaaga
      541 gaaataagtg cagcattttt gcatctgaca ttttacctaa aaaaaaaaag acaccaaatt
      601 tggcggaggg gtggaaaatc agttgttacc attataaccc tacagaggtg gtgagcatgt
      661 aacatgagct tattgagacc atcatagaga tcgattcttg tatattgatt ttatctcttt
      721 ctgtatctat aggtaaatct caagggtaaa atgttaggtg ttgacattga gaaccctgaa
      781 accccattcc ctgctcagag gaacagtgtg aaaaaaaatc tcttgagaga tttagaatat
      841 cttttctttt gctcatctta gaccacagac tgactttgaa attatgttaa gtgaaatatc
      901 aatgaaaata aagtttacta taaataata
//
