LOCUS       NM_014051                988 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 14A (TMEM14A), mRNA.
ACCESSION   NM_014051 XM_005249031
VERSION     NM_014051.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 988)
  AUTHORS   Jang,T.H., Lin,S.C., Yang,Y.Y., Wu,S.H., Kuo,T.H. and Chuang,S.E.
  TITLE     AXL transcriptionally up-regulates TMEM14A expression to mediate
            cell proliferation in non-small-cell lung cancer cells
  JOURNAL   Biochem Biophys Res Commun 682, 365-370 (2023)
   PUBMED   37839105
  REMARK    GeneRIF: AXL transcriptionally up-regulates TMEM14A expression to
            mediate cell proliferation in non-small-cell lung cancer cells.
REFERENCE   2  (bases 1 to 988)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 988)
  AUTHORS   An,J., Shi,H., Zhang,N. and Song,S.
  TITLE     Elevation of circular RNA circ_0003645 forecasts unfavorable
            prognosis and facilitates cell progression via miR-1179/TMEM14A
            pathway in non-small cell lung cancer
  JOURNAL   Biochem Biophys Res Commun 511 (4), 921-925 (2019)
   PUBMED   30853176
  REMARK    GeneRIF: MiR-1179 is sponged by circular RNA circ_0003645 and
            TMEM14A is a target of miR-1179.
REFERENCE   4  (bases 1 to 988)
  AUTHORS   Woo,I.S., Jin,H., Kang,E.S., Kim,H.J., Lee,J.H., Chang,K.C.,
            Park,J.Y., Choi,W.S. and Seo,H.G.
  TITLE     TMEM14A inhibits N-(4-hydroxyphenyl)retinamide-induced apoptosis
            through the stabilization of mitochondrial membrane potential
  JOURNAL   Cancer Lett 309 (2), 190-198 (2011)
   PUBMED   21723035
  REMARK    GeneRIF: findings show for the first time that TMEM14A inhibits
            apoptosis by blocking the mitochondrial permeability transition and
            stabilizing mitochondrial membrane potential
REFERENCE   5  (bases 1 to 988)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 988)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB117714.1, BC019328.1 and AF239771.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014051.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.368072.1, AF239771.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000211314.5/ ENSP00000211314.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                CB117714.1         28-45
            19-675              BC019328.1         1-657
            676-988             AF239771.1         682-994
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.2"
     gene            1..988
                     /gene="TMEM14A"
                     /gene_synonym="C6orf73; PTD011"
                     /note="transmembrane protein 14A"
                     /db_xref="GeneID:28978"
                     /db_xref="HGNC:HGNC:21076"
                     /db_xref="MIM:616870"
     exon            1..133
                     /gene="TMEM14A"
                     /gene_synonym="C6orf73; PTD011"
                     /inference="alignment:Splign:2.1.0"
     exon            134..219
                     /gene="TMEM14A"
                     /gene_synonym="C6orf73; PTD011"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..449
                     /gene="TMEM14A"
                     /gene_synonym="C6orf73; PTD011"
                     /codon_start=1
                     /product="transmembrane protein 14A"
                     /protein_id="NP_054770.1"
                     /db_xref="CCDS:CCDS4943.1"
                     /db_xref="GeneID:28978"
                     /db_xref="HGNC:HGNC:21076"
                     /db_xref="MIM:616870"
                     /translation="MDLIGFGYAALVTFGSIFGYKRRGGVPSLIAGLFVGCLAGYGAY
                     RVSNDKRDVKVSLFTAFFLATIMGVRFKRSKKIMPAGLVAGLSLMMILRLVLLLL"
     exon            220..321
                     /gene="TMEM14A"
                     /gene_synonym="C6orf73; PTD011"
                     /inference="alignment:Splign:2.1.0"
     exon            322..409
                     /gene="TMEM14A"
                     /gene_synonym="C6orf73; PTD011"
                     /inference="alignment:Splign:2.1.0"
     exon            410..988
                     /gene="TMEM14A"
                     /gene_synonym="C6orf73; PTD011"
                     /inference="alignment:Splign:2.1.0"
     regulatory      654..659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM14A"
                     /gene_synonym="C6orf73; PTD011"
                     /note="hexamer: ATTAAA"
     polyA_site      678
                     /gene="TMEM14A"
                     /gene_synonym="C6orf73; PTD011"
     regulatory      966..971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM14A"
                     /gene_synonym="C6orf73; PTD011"
                     /note="hexamer: AATAAA"
     polyA_site      988
                     /gene="TMEM14A"
                     /gene_synonym="C6orf73; PTD011"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgagac ggctgggcgc cgagtgggac agcgctggtg cggagactgc ttccggactc
       61 caggtaccgc gcttggcggc agctggcccc agacttctgt cttttcagct gcagtgaagg
      121 ctcggggctg cagaattgca accttgccaa tggacctgat cggttttggt tatgcagccc
      181 tcgtgacatt tggaagcatt tttggatata agcggagagg tggtgttccg tctttgattg
      241 ctggtctttt tgttggatgt ttggccggct atggagctta ccgtgtctcc aatgacaaac
      301 gagatgtaaa agtgtcactg tttacagctt tcttcctggc taccataatg ggtgtgagat
      361 ttaagaggtc caagaaaata atgcctgctg gtttggttgc aggtttaagc ctcatgatga
      421 tcctgagact tgtcttgttg ctgctctgag catctggagg aacagaaaac taagttcatg
      481 tcatcctgct gtaatgggca gagcatattt tttttgtatt taaaagataa acttcaatat
      541 ggaatgctag aaacacaaat agcactgtca cctctaatat gaacattagt ttgaggtagt
      601 ttttttctaa agcaaaaatt ttaactgttt tctaattgtc aagcactatt ttcattaaaa
      661 gtgtctaatg aatcatgata tactcttcca tttgttgtgt ctatttttta tatatttggt
      721 attttttgaa aattccaaat actcatgtct caagtaagct taaactacaa cttgtcacat
      781 aaaggaagtc ttaagtggag ttcacagaat gataatgtat ctatttgtca tttgtgttat
      841 atttgaaatt attagaaatt atgctttttc cattttaatt gtattgctgc cagtgctatt
      901 tttttcttta aaaaatttta ttcttagcac actgttatgt cctaactgaa tgtattcagt
      961 attcaaataa aagacatttt ggttcaaa
//
