LOCUS       NM_173633               1797 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 145 (TMEM145), transcript
            variant 2, mRNA.
ACCESSION   NM_173633
VERSION     NM_173633.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1797)
  AUTHORS   Hoel,C.M., Zhang,L. and Brohawn,S.G.
  TITLE     Structure of the GOLD-domain seven-transmembrane helix protein
            family member TMEM87A
  JOURNAL   Elife 11, e81704 (2022)
   PUBMED   36373655
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024078.4, DA694683.1 and AK075286.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173633.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465404 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301204.8/ ENSP00000301204.2
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC024078.4         30980-30995         c
            17-27               DA694683.1         1-11
            28-908              AK075286.1         1-881
            909-968             AC024078.4         27341-27400         c
            969-1276            AK075286.1         942-1249
            1277-1469           AC024078.4         20515-20707         c
            1470-1795           AK075286.1         1443-1768
            1796-1797           AC024078.4         19240-19241         c
FEATURES             Location/Qualifiers
     source          1..1797
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1797
                     /gene="TMEM145"
                     /note="transmembrane protein 145"
                     /db_xref="GeneID:284339"
                     /db_xref="HGNC:HGNC:26912"
     exon            1..188
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1550
                     /gene="TMEM145"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="transmembrane protein 145 isoform 2 precursor"
                     /protein_id="NP_775904.2"
                     /db_xref="CCDS:CCDS12603.1"
                     /db_xref="GeneID:284339"
                     /db_xref="HGNC:HGNC:26912"
                     /translation="MEPLRAPALRRLLPPLLLLLLSLPPRARAKYVRGNLSSKEDWVF
                     LTRFCFLSDYGRLDFRFRYPEAKCCQNILLYFDDPSQWPAVYKAGDKDCLAKESVIRP
                     ENNQVINLTTQYAWSGCQVVSEEGTRYLSCSSGRSFRSGDGLQLEYEMVLTNGKSFWT
                     RHFSADEFGILETDVTFLLIFILIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLS
                     LLFFCIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRISHAG
                     SVKLSVYMTLYTLTHVVLLIYEAEFFDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAV
                     LVSLRHFPEKQPFYVPFFAAYTLWFFAVPVMALIANFGIPKWAREKIVNGIQLGIHLY
                     AHGVFLIMTRPSAANKNFPYHVRTSQIASAGVPGPGGSQSADKAFPQHVYGNVTFISD
                     SVPNFTELFSIPPPATSPLPRAAPDSGLPLFRDLRPPGPLRDL"
     exon            189..263
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            264..341
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            342..428
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            429..488
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            489..573
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            574..645
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            646..714
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            715..795
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            796..874
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            875..968
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1141
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1262
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1469
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1797
                     /gene="TMEM145"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1769..1774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM145"
                     /note="hexamer: AATAAA"
     polyA_site      1797
                     /gene="TMEM145"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgctctc gcctccattg ccgggccagt gcgggagccg gagcggagcc ggggccggag
       61 cgggcggaat ggagcccctg cgcgcgcccg cgctgcgccg cctgctgccg ccgctgctgc
      121 tcctgctgct gtcactgccc ccccgcgccc gggccaagta cgtgcggggc aacctcagtt
      181 ccaaggagga ctgggtgttc ctgacaagat tttgtttcct ctcggattac ggccgactgg
      241 acttccgttt ccgctaccct gaggccaagt gctgtcagaa catcctcctc tattttgatg
      301 acccatccca gtggccagcc gtgtacaagg caggggacaa ggactgcctg gccaaggagt
      361 cagtgatccg gccggagaac aaccaggtca tcaacctcac cacccagtat gcctggtccg
      421 gctgtcaggt ggtatcagag gagggaaccc gctacctgag ctgctccagt ggccgcagct
      481 tccgctcagg tgatggattg cagctggagt atgagatggt cctcaccaat ggcaagtcct
      541 tctggacacg acacttctcc gctgatgagt ttgggatcct ggagacagat gtgaccttcc
      601 tcctcatctt catcctcatc ttcttcctct cttgttactt tggatatttg ctgaaaggtc
      661 gtcagttgct ccacacaact tataaaatgt tcatggccgc agcaggagta gaggtcctga
      721 gcctcctatt tttctgcatc tactggggtc aatatgccac cgatggcatt ggcaacgaga
      781 gtgtgaagat cttggccaag ctgctcttct cctccagctt cctcatcttc ctgctgatgc
      841 ttatcctcct ggggaaggga ttcacggtga cacggggccg catcagccac gcgggctccg
      901 tgaagttgtc tgtctacatg accctgtaca cgctcaccca tgtggtgctg ctcatctacg
      961 aggcggaatt ctttgaccca ggccaggtac tgtacacgta tgagtcgccg gccggctacg
     1021 ggctcattgg actgcaggtg gcggcctacg tgtggttctg ctatgctgtg cttgtctcac
     1081 tgcgacactt tcctgagaag cagccttttt atgtgccctt ctttgctgcc tataccctct
     1141 ggttctttgc ggttcctgtc atggccctga ttgccaattt cggcatcccc aagtgggccc
     1201 gggagaagat tgtcaatggc atccagctgg ggatccactt gtacgcccat ggcgtgtttc
     1261 tgatcatgac ccgcccatca gcggccaaca agaacttccc gtaccacgtg cgcacgtcgc
     1321 agatcgcttc agccggagtc cctggacccg gagggagcca atccgctgac aaggccttcc
     1381 cgcagcacgt ctatgggaac gtgacgttta tcagcgactc ggtgcccaac ttcacggagc
     1441 tcttctccat ccccccgccc gccacctccc ccctgccccg agcggcgccg gattctgggc
     1501 tcccgctgtt ccgtgacctc cggccccctg gcccccttcg agacctctga ccccgctgga
     1561 ctccggaaca cccgtggtga ccgccgggac cctgcctgtg actctccagg actctgcgac
     1621 cccgggatgg atattgcgat gctggtctcg accctgaaac cctccctcgg atctgtgacc
     1681 tcggacccgt actccatctg ccgcatctcc attccggggg ccttccctcg ggtccctggc
     1741 agaaagacat tttacccctt cttgccaaaa taaaaaagga ttcgttttta tctataa
//
