LOCUS       NM_018273               2263 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 143 (TMEM143), transcript
            variant 1, mRNA.
ACCESSION   NM_018273
VERSION     NM_018273.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2263)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2263)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2263)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 2263)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2263)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2263)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 2263)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC357566.1, BC016919.1, AC008392.6 and AW136519.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018273.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129801.1, SRR1803616.113790.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293261.8/ ENSP00000293261.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DC357566.1         299-309
            12-1202             BC016919.1         1-1191
            1203-1857           AC008392.6         89199-89853         c
            1858-2263           AW136519.1         18-423              c
FEATURES             Location/Qualifiers
     source          1..2263
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2263
                     /gene="TMEM143"
                     /note="transmembrane protein 143"
                     /db_xref="GeneID:55260"
                     /db_xref="HGNC:HGNC:25603"
     exon            1..43
                     /gene="TMEM143"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1400
                     /gene="TMEM143"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 143 isoform a"
                     /protein_id="NP_060743.2"
                     /db_xref="CCDS:CCDS12716.1"
                     /db_xref="GeneID:55260"
                     /db_xref="HGNC:HGNC:25603"
                     /translation="MTVELWLRLRGKGLAMLHVTRGVWGSRVRVWPLLPALLGPPRAL
                     SSLAAKMGEYRKMWNPREPRDWAQQYRERFIPFSKEQLLRLLIQEFHSSPAEKAALEA
                     FSAHVDFCTLFHYHQILARLQALYDPINPDRETLDQPSLTDPQRLSNEQEVLRALEPL
                     LAQANFSPLSEDTLAYALVVHHPQDEVQVTVNLDQYVYIHFWALGQRVGQMPLKSSVG
                     SRRGFFTKLPPAERRYFKRVVLAARTKRGHLVLKSFKDTPLEGLEQLLPELKVRTPTL
                     QRALLNLMLVVSGVAIFVNVGMVVLTDLKVATSLLLLLFAIFMGLRASKMFGQRRSAQ
                     ALELAHMLYYRSTSNNSELLSALALRAQDEHTKEALLAHSFLARRPGGTQGSPEETSR
                     WLRSEVENWLLAKSGCEVTFNGTRALAHLQALTPSMGLYPPPGFPKLDPVAPITSEPP
                     QATPSSNIS"
     exon            44..284
                     /gene="TMEM143"
                     /inference="alignment:Splign:2.1.0"
     exon            285..389
                     /gene="TMEM143"
                     /inference="alignment:Splign:2.1.0"
     exon            390..584
                     /gene="TMEM143"
                     /inference="alignment:Splign:2.1.0"
     exon            585..715
                     /gene="TMEM143"
                     /inference="alignment:Splign:2.1.0"
     exon            716..995
                     /gene="TMEM143"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1185
                     /gene="TMEM143"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..2263
                     /gene="TMEM143"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2240..2245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM143"
                     /note="hexamer: AATAAA"
     polyA_site      2263
                     /gene="TMEM143"
                     /note="major polyA site"
ORIGIN      
        1 gcacatgcgc aggaggctca atgacagtcg agctttggct aaggctccgg ggaaagggtc
       61 tagccatgct gcatgtgacc cggggggtct gggggtccag ggtccgagta tggccactgt
      121 tgcccgcgct cctcgggccc ccccgggccc tctcatcgct ggcagccaaa atgggggagt
      181 atcgcaagat gtggaacccc agggagcccc gcgactgggc ccagcagtac cgcgagcgct
      241 tcattccctt ctccaaggag cagctgctcc gcctcctaat acaggaattc cactcgagtc
      301 cggcagagaa ggcggctttg gaggcgttct cggcccacgt ggacttctgc accctgttcc
      361 actaccacca aatcctggcc cggctgcagg ccttatatga ccccatcaac cctgacaggg
      421 agaccctcga tcagccatca ctaacggatc cccagcgtct gtctaatgag caggaggtgc
      481 ttcgggctct ggagcccctg ctggcccagg ccaacttctc cccgctgtct gaggacaccc
      541 tggcctacgc gctggtggtc caccaccctc aggatgaggt ccaggtgaca gtaaatttgg
      601 atcagtatgt ctacattcac ttctgggccc tgggccagcg agtcgggcag atgcccctga
      661 agtccagcgt gggctccagg cgtggcttct tcaccaagct gccccctgcg gagaggagat
      721 actttaagcg ggtggtcctg gcagcccgga ccaaacgggg acacctggta ctgaagagtt
      781 tcaaggacac gccgctggaa ggcctggagc agctgctgcc ggagctgaag gtgcgcacgc
      841 ccaccctgca gcgcgccctg ctcaacctca tgctggtagt ctccggcgtg gcgatcttcg
      901 tcaacgtggg catggtggtg ctaaccgacc tcaaggtggc cacctccctg ctgctgctgc
      961 tcttcgccat cttcatgggc ctgcgggcct ccaagatgtt cgggcagcgg cgcagcgcgc
     1021 aggcgttgga gctggcgcac atgctgtact atcgcagtac gtccaacaac tcggagctgc
     1081 tcagcgccct ggccctgcgc gcgcaggacg agcacaccaa ggaggcgctg ctggctcaca
     1141 gcttcctggc ccggcggcca gggggcactc aaggctcgcc cgaagagacc tccaggtggc
     1201 tccggtcgga ggtggagaac tggctcctag ccaagtcagg ctgtgaggtg accttcaacg
     1261 gaactcgggc cctggcgcat ctgcaggccc tgacccccag catgggattg tacccacccc
     1321 cgggtttccc caaactagac ccagtggctc cgatcacttc cgagcccccg caagccacgc
     1381 ccagcagtaa catctcctga gtagaaccta cctccctgcc cagtcagcag gctaggaact
     1441 aagccccgcc tccttcacga caggctgtca attacggtta ttatactttt cactccaact
     1501 tccaataact gacaggtgat tatttttgct gcactgtgtg cttaagcaaa gcagccaatc
     1561 aaagcagcta gcagttgtta agtcttcccc gccccttcga tgaacagcca atcaaagcga
     1621 tttagctctg cttctgttcc atttcttagt cccaccctca ccataaacat ccaagtgtgg
     1681 tttggctgag gagctgaggg tgtctgccaa tcacagctgc tcagctctgg cttctgtaaa
     1741 ccgccaggta gaagagttaa agctgcgccc tcccgagact atatatcatt gtctttttca
     1801 gcccgctccg ggcaaactgc ccatcatgtg caccaaggcc gttagccctg cctcctggca
     1861 aacgtccagt gacagctgct gggttccatc aactttgggc agccggttgt cgctgcaggg
     1921 aaggaaccaa taagaatttc taaaggaaac ctgatcttgc tatcaattgc tgctgcttaa
     1981 atggcaggcc aactggtcag ctgctgatca gggtgtctag gctgaaggag ttggagacct
     2041 tgtgctaggt aggtgaacca gaaaccaccc tcgccaccaa gactcgctcc caacctggct
     2101 cccggcaacc tcaggtgcct tcctcgccca ggtctttcac cctttctaca gaaactacct
     2161 cggtctggat ctccccacca ccagcagcct gtgcaatatt tattggtcta tcaatttctc
     2221 ccgtctcctg tcccaaagta ataaatcatg tttaataagt ctg
//
