LOCUS       NM_032928                839 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 141 (TMEM141), mRNA.
ACCESSION   NM_032928
VERSION     NM_032928.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 839)
  AUTHORS   Sun,L., Yang,X., Khan,A., Yu,X., Zhang,H., Han,S., Habulieti,X.,
            Sun,Y., Wang,R. and Zhang,X.
  TITLE     Panoramic variation analysis of a family with neurodevelopmental
            disorders caused by biallelic loss-of-function variants in TMEM141,
            DDHD2, and LHFPL5
  JOURNAL   Front Med 18 (1), 81-97 (2024)
   PUBMED   37837560
  REMARK    GeneRIF: Panoramic variation analysis of a family with
            neurodevelopmental disorders caused by biallelic loss-of-function
            variants in TMEM141, DDHD2, and LHFPL5.
REFERENCE   2  (bases 1 to 839)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 839)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 839)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 839)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 839)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB107060.1, BC007834.2 and BU740670.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032928.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ082677.1, SRR5189667.46676.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290079.9/ ENSP00000290079.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CB107060.1         20-30
            12-430              BC007834.2         1-419
            431-839             BU740670.1         18-426              c
FEATURES             Location/Qualifiers
     source          1..839
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..839
                     /gene="TMEM141"
                     /note="transmembrane protein 141"
                     /db_xref="GeneID:85014"
                     /db_xref="HGNC:HGNC:28211"
     exon            1..81
                     /gene="TMEM141"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..354
                     /gene="TMEM141"
                     /codon_start=1
                     /product="transmembrane protein 141"
                     /protein_id="NP_116317.1"
                     /db_xref="CCDS:CCDS7007.1"
                     /db_xref="GeneID:85014"
                     /db_xref="HGNC:HGNC:28211"
                     /translation="MVNLGLSRVDDAVAAKHPGLGEYAACQSHAFMKGVFTFVTGTGM
                     AFGLQMFIQRKFPYPLQWSLLVAVVAGSVVSYGVTRVESEKCNNLWLFLETGQLPKDR
                     STDQRS"
     exon            82..148
                     /gene="TMEM141"
                     /inference="alignment:Splign:2.1.0"
     exon            149..232
                     /gene="TMEM141"
                     /inference="alignment:Splign:2.1.0"
     exon            233..340
                     /gene="TMEM141"
                     /inference="alignment:Splign:2.1.0"
     exon            341..839
                     /gene="TMEM141"
                     /inference="alignment:Splign:2.1.0"
     regulatory      755..760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM141"
                     /note="hexamer: AATAAA"
     polyA_site      779
                     /gene="TMEM141"
                     /note="major polyA site"
     regulatory      807..812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM141"
                     /note="hexamer: AACAAA"
     polyA_site      839
                     /gene="TMEM141"
ORIGIN      
        1 aggcccgctc cccgagccct gccaaccatg gtgaacttgg gtctgtcccg ggtggacgac
       61 gccgtggctg ccaagcaccc gggactcggg gagtatgccg catgccagtc acacgccttc
      121 atgaagggcg ttttcacctt cgtcacaggc accggcatgg cctttggctt gcagatgttc
      181 attcagagga agtttccata ccctttgcag tggagcctcc tagtggccgt ggttgcaggc
      241 tctgtggtca gctacggggt gacgagagtg gagtcggaga aatgcaacaa cctctggctc
      301 ttcctggaga ccgggcagct ccccaaagac aggagcacag atcagagaag ctaggagagc
      361 tccagcaggg gcacagagga ttgggggcag gaggagtctg gaacacagcc ttcatgcccc
      421 ctgaccccag gccgaccctc cccacaccct agggtacccc agtcgtatcc tctgtccgca
      481 tgtgtggcca ggcctgacaa acacctgcag atggctgctg ccccaacctg ggacctgccc
      541 aggaggttgg agcagaaagg gctctccctg gggtggtgtt tctcctctag ggtattggga
      601 tgcatgttct gcactgccag cagagagggt gtgtctgggg gccaccacct atgggacacg
      661 gggtcgaagg ggcctgtaca ctctgtcatt tcctttctag cccctgcatc tccaacaagt
      721 ccaaggtgac agctggtgct aggggcgtgg ggttaataaa tggcttatcc ttctctccac
      781 ccaagtttcc acctgaccag gtgaaaaaca aatcagaagg gtaagatgat gacaggtca
//
