LOCUS       NM_018295               1997 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 140 (TMEM140), mRNA.
ACCESSION   NM_018295
VERSION     NM_018295.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1997)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1997)
  AUTHORS   Guan,Y., Guo,L., Yang,E., Liao,Y., Liu,L., Che,Y., Zhang,Y.,
            Wang,L., Wang,J. and Li,Q.
  TITLE     HSV-1 nucleocapsid egress mediated by UL31 in association with UL34
            is impeded by cellular transmembrane protein 140
  JOURNAL   Virology 464-465, 1-10 (2014)
   PUBMED   25036476
  REMARK    GeneRIF: Binding of viral UL31 to host TMEM140 impedes formation of
            HSV-1 UL31-UL34 complex.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC323016.1, AC083862.2 and BU683951.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018295.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001862.1, SRR1803613.127701.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275767.3/ ENSP00000275767.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               DC323016.1         59-367
            310-1499            AC083862.2         139201-140390
            1500-1997           BU683951.1         18-515              c
FEATURES             Location/Qualifiers
     source          1..1997
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1997
                     /gene="TMEM140"
                     /note="transmembrane protein 140"
                     /db_xref="GeneID:55281"
                     /db_xref="HGNC:HGNC:21870"
     exon            1..199
                     /gene="TMEM140"
                     /inference="alignment:Splign:2.1.0"
     exon            200..1997
                     /gene="TMEM140"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..781
                     /gene="TMEM140"
                     /codon_start=1
                     /product="transmembrane protein 140"
                     /protein_id="NP_060765.4"
                     /db_xref="CCDS:CCDS5837.1"
                     /db_xref="GeneID:55281"
                     /db_xref="HGNC:HGNC:21870"
                     /translation="MAGPRPRWRDQLLFMSIIVLVIVVICLMFYALLWEAGNLTDLPN
                     LRIGFYNFCLWNEDTSTLQCHQFPELEALGVPRVGLGLARLGVYGSLVLTLFAPQPLL
                     LAQCNSDERAWRLAVGFLAVSSVLLAGGLGLFLSYVWKWVRLSLPGPGFLALGSAQAL
                     LILLLIAMAVFPLRAERAESKLESC"
     polyA_site      1681
                     /gene="TMEM140"
                     /note="major polyA site"
     regulatory      1973..1978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM140"
                     /note="hexamer: ACTAAA"
     polyA_site      1997
                     /gene="TMEM140"
ORIGIN      
        1 agagagctgt ttactaggca cgactgcgaa ggcaaggggg caccagctca ggactgcatc
       61 tgcctgccat ttcccttcca ctcctccttt ctggagtctg acattagaaa gccagcgaga
      121 aggaagattc aaacaaccaa ccctgatttc ctgcttctcc ttttcatgag tgttcctgtg
      181 gtctctgcac ctcctttctg tcccccggca gagggcagta gagatggccg gcccaaggcc
      241 tcggtggcgc gaccagctgc tgttcatgag catcatagtc ctcgtgattg tggtcatctg
      301 cctgatgttt tacgctcttc tctgggaggc tggcaacctc actgacctgc ccaacctgag
      361 aatcggcttc tataacttct gcctgtggaa tgaggacacc agcaccctac agtgtcacca
      421 gttccctgag ctggaagccc tgggggtgcc tcgggttggc ctgggcctgg ccaggcttgg
      481 cgtgtacggg tccctggtcc tcaccctctt tgccccccag cctctcctcc tagcccagtg
      541 caacagtgat gagagagcgt ggcggctggc agtgggcttc ctggctgtgt cctctgtgct
      601 gctggcaggc ggcctgggcc tcttcctctc ctatgtgtgg aagtgggtca ggctctccct
      661 cccggggcct gggtttctag ctctgggcag cgcccaggcc ttactcatcc tcttgcttat
      721 agccatggct gtgttccctc tgagggctga gagggctgag agcaagcttg agagctgcta
      781 aaggcttacg tgattgcaag ggttcagttc caaccatggt cagaggtggc acatctgctc
      841 agccatctca ttttacagct aacgctgatc tccagctcca gcgatggaac ccactacaga
      901 ggaggtgggg cccctgtgtc aaagaggccg aggggcagca agggcagcca gggcacctgt
      961 gacttcttag tacaagattg tctgtccttc aggacttcca aggctcccaa agactcccta
     1021 aaccatgcag ctcattgtca caccaattcc tgctttaatt aatggatctg agcaaatctt
     1081 cctctagctt caggagggtg gggagggagt gattgctgtc atggggccag acttccaggc
     1141 tgatttgcca aatgccaaaa tgaaacctag caaagaactt acggcaacaa acgaggacat
     1201 taaaagagcg agcacctcag tgtctctggg gacatggtta aggagcttcc actcagccca
     1261 ccatagtgag tgggccgcca taagccatca ctggaactcc aaccccagag gtccaggagt
     1321 gatctctgag tgactcaaca aagacaggac acatggggta caaagacaag gcttgactgc
     1381 ttcaaagctt ccctggacct gaagccagac agggcagagg cgtccgctga caaatcactc
     1441 ccatgatgag accctggagg actccaaatc ctcgctgtga acaggactgg acggctgcac
     1501 acaaacaaac gctgccaccc tccacttccc aacccagaac ttggaaagac attagcacaa
     1561 cttacgcatt ggggaattgt gtgtattttc tagcacttgt gtattggaaa acctgtatgg
     1621 cagtgattta ttcatatatt cctgtccaaa gccacactga aaacagaggc agagacatgt
     1681 actctggtgt gatctcttgt cctcagtgtc tcttctgggc tcctgtccct cttgctttat
     1741 agctagctgc ccggggacca aggtacaggt gaaagcaagg tagcagcttg cgggaggagg
     1801 cctgtctggc ttaccagtct atacactgtg gcctcaacct cccagacagg gcagagaact
     1861 gtgggcagct cgtttgcttt ctaggctggc tggagaggtg ggagctcatt gatagactca
     1921 tgatggaaac tatttttgaa acaggcttcc tccttcagga gagatcatgc ggactaaact
     1981 gtagcaattc cagtgca
//
