LOCUS       NM_001282876            2375 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 139 (TMEM139), transcript
            variant 8, mRNA.
ACCESSION   NM_001282876
VERSION     NM_001282876.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2375)
  AUTHORS   Zhang,S., He,Y., Xuan,Q., Ling,X., Men,K., Zhao,X., Xue,D., Li,L.
            and Zhang,Y.
  TITLE     TMEM139 prevents NSCLC metastasis by inhibiting lysosomal
            degradation of E-cadherin
  JOURNAL   Cancer Sci 113 (6), 1999-2007 (2022)
   PUBMED   35302694
  REMARK    GeneRIF: TMEM139 prevents NSCLC metastasis by inhibiting lysosomal
            degradation of E-cadherin.
REFERENCE   2  (bases 1 to 2375)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 2375)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2375)
  AUTHORS   Nuiplot,N.O., Junking,M., Duangtum,N., Khunchai,S., Sawasdee,N.,
            Yenchitsomanus,P.T. and Akkarapatumwong,V.
  TITLE     Transmembrane protein 139 (TMEM139) interacts with human kidney
            isoform of anion exchanger 1 (kAE1)
  JOURNAL   Biochem Biophys Res Commun 463 (4), 706-711 (2015)
   PUBMED   26049106
  REMARK    GeneRIF: presented data demonstrate that TMEM139 interacts with
            kAE1 and promotes its intracellular trafficking
REFERENCE   5  (bases 1 to 2375)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2375)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   7  (bases 1 to 2375)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 2375)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 2375)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA628164.1 and BC035517.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001282876.1.
            
            Transcript Variant: This variant (8) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4, 8, and 9 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035517.1, SRR1803611.258833.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359333.8/ ENSP00000352284.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA628164.1         9-20
            13-2375             BC035517.1         1-2363
FEATURES             Location/Qualifiers
     source          1..2375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2375
                     /gene="TMEM139"
                     /note="transmembrane protein 139"
                     /db_xref="GeneID:135932"
                     /db_xref="HGNC:HGNC:22058"
                     /db_xref="MIM:616524"
     exon            1..488
                     /gene="TMEM139"
                     /inference="alignment:Splign:2.1.0"
     exon            489..750
                     /gene="TMEM139"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..1156
                     /gene="TMEM139"
                     /codon_start=1
                     /product="transmembrane protein 139 precursor"
                     /protein_id="NP_001269805.1"
                     /db_xref="CCDS:CCDS5878.1"
                     /db_xref="GeneID:135932"
                     /db_xref="HGNC:HGNC:22058"
                     /db_xref="MIM:616524"
                     /translation="MVPMHLLGRLEKPLLLLCCASFLLGLALLGIKTDITPVAYFFLT
                     LGGFFLFAYLLVRFLEWGLRSQLQSMQTESPGPSGNARDNEAFEVPVYEEAVVGLESQ
                     CRPQELDQPPPYSTVVIPPAPEEEQPSHPEGSRRAKLEQRRMASEGSMAQEGSPGRAP
                     INLRLRGPRAVSTAPDLQSLAAVPTLEPLTPPPAYDVCFGHPDDDSVFYEDNWAPP"
     exon            751..2375
                     /gene="TMEM139"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1604..1609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM139"
                     /note="hexamer: ATTAAA"
     polyA_site      1623
                     /gene="TMEM139"
                     /note="major polyA site"
     regulatory      2355..2360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM139"
                     /note="hexamer: AATAAA"
     polyA_site      2375
                     /gene="TMEM139"
                     /note="major polyA site"
ORIGIN      
        1 acagtctgtg gagacaggtg agcgacgaac ttctgagaca ggtgtgggtg cgagggtcgg
       61 gagggtcatg ggattgggac cgaggtgtga ggagggaatc tgcaattcct tgctacacag
      121 agcgctggca acttctgaca ggctgtttct ggggtatggg ctgcctcggg ttgttgctgt
      181 tacaaggaaa gaaaagagtt cccctgccca ccgcctccca gccactgggc tacctcctgg
      241 caggaaattt gcaaactgag tttaacaagt taggatcagc agagggtaga ggagggccct
      301 ggcagatgtg gggtctagaa gaggacagga gttatcaggg cctccggcca ttgtgctggg
      361 cctttgcctg tacaattgtt tctcaagcag ttgtgtccct gtggctttgg tgcgcctgtg
      421 tgcactttct ccctccacct ggagcatggg ctaacaccgg aggaaaggaa aagacagagt
      481 cagacaggga gcctggggag gggccatggt gccaatgcac ttactgggga gactggagaa
      541 gccgcttctc ctcctgtgct gcgcctcctt cctactgggg ctggctttgc tgggcataaa
      601 gacggacatc acccccgttg cttatttctt tctcacattg ggtggcttct tcttgtttgc
      661 ctatctcctg gtccggtttc tggaatgggg gcttcggtcc cagctccaat caatgcagac
      721 tgagagccca gggccctcag gcaatgcacg ggacaatgaa gcctttgaag tgccagtcta
      781 tgaagaggcc gtggtgggac tagaatccca gtgccgcccc caagagttgg accaaccacc
      841 cccctacagc actgttgtga tacccccagc acctgaggag gaacaaccta gccatccaga
      901 ggggtccagg agagccaaac tggaacagag gcgaatggcc tcagaggggt ccatggccca
      961 ggaaggaagc cctggaagag ctccaatcaa ccttcggctt cggggaccac gggctgtgtc
     1021 cactgctcct gatctgcaga gcttggcggc agtccccaca ttagagcctc tgactccacc
     1081 ccctgcctat gatgtctgct ttggtcaccc tgatgatgat agtgtttttt atgaggacaa
     1141 ctgggcaccc ccttaaatga ctctcccaag atttctcttc tctccacacc agacctcgtt
     1201 catttgacta acattttcca gcgcctacta tgtgtcagaa acaagtgttt ctgcctggac
     1261 atcataaatg gggacttgga ccctgaggag agtcaggcca cggtaagccc ttcccagctg
     1321 agatatgggt ggcataattt gagtcttctg gcaacatttg gtgacctacc ccatatccaa
     1381 tatttccagc gttagattga ggatgaggta gggaggtgat ccagagaagg cggagaagga
     1441 agaagtaacc tctgagtggc ggctattgct tctgttccag gtgctgttcg agctgttaga
     1501 acccttaggc ttgacagctt tgtgagttat tattgaaaaa tgaggattcc aagagtcaga
     1561 ggagtttgat aatgtgcacg agggcacact gctagtaaat aacattaaaa taactggaat
     1621 gaactcctga tcccaaagcc tattgtgttt tcaacacaag gtaataggaa gccaagcaac
     1681 ttgcatgtct cccaatccct gtctagggac agctgctggt gcaggatgga agacttccta
     1741 taaacagaat gggcgaccaa ttgtgtctac agagggggtg ggctgagcat gggcacgcat
     1801 gtccccagcc tcctggacga gcaaagtcag tcaaagcgct ggtgatccct gctccgcgtg
     1861 cgtagcagtg tctgtgcctc tcctgcccag gggctagaga gcagtctcca gtgcagggtc
     1921 cccatcctat ctgaaaacag tggagtcagt gaccccaggt ggagggactt ccagttttaa
     1981 caatgggttg gtatgaaggc cagaaggagt gaaacatgtg aactttctgg cgaggagact
     2041 ccctcttgaa tcatccatat gtagccccgg ggtcacttgc gaagagtctc taacagcttc
     2101 tgcctcactc ctaagctctg accgctaggc tttcacccca gccgccggtc ctgattcctg
     2161 agatcccaat attgagcacc aggtttcctg gaattgtgtg ctgcggctgt gatgtaggtt
     2221 tcggtcgctg gaagctgcta aaccatagct gacgccccct cctaagccag ccttccttcc
     2281 ccgcgcgggc atctgtccag ggccttgtcg cgctctcagt ctccttcgca gcctggcccc
     2341 aaccgttcaa cttcaataaa gcaaaactcc agcca
//
