LOCUS       NM_022918               8980 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 135 (TMEM135), transcript
            variant 1, mRNA.
ACCESSION   NM_022918
VERSION     NM_022918.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8980)
  AUTHORS   Hu,D., Tan,M., Lu,D., Kleiboeker,B., Liu,X., Park,H., Kravitz,A.V.,
            Shoghi,K.I., Tseng,Y.H., Razani,B., Ikeda,A. and Lodhi,I.J.
  TITLE     TMEM135 links peroxisomes to the regulation of brown fat
            mitochondrial fission and energy homeostasis
  JOURNAL   Nat Commun 14 (1), 6099 (2023)
   PUBMED   37773161
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8980)
  AUTHORS   Wang,R., Zhang,M., Hu,Y., He,J., Lin,Q. and Peng,N.
  TITLE     MiR-100-5p inhibits osteogenic differentiation of human bone
            mesenchymal stromal cells by targeting TMEM135
  JOURNAL   Hum Cell 35 (6), 1671-1683 (2022)
   PUBMED   35947339
  REMARK    GeneRIF: MiR-100-5p inhibits osteogenic differentiation of human
            bone mesenchymal stromal cells by targeting TMEM135.
REFERENCE   3  (bases 1 to 8980)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 8980)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   5  (bases 1 to 8980)
  AUTHORS   Maharjan,Y., Lee,J.N., Kwak,S.A., Dutta,R.K., Park,C., Choe,S.K.
            and Park,R.
  TITLE     TMEM135 regulates primary ciliogenesis through modulation of
            intracellular cholesterol distribution
  JOURNAL   EMBO Rep 21 (5), e48901 (2020)
   PUBMED   32157776
  REMARK    GeneRIF: TMEM135 regulates primary ciliogenesis through modulation
            of intracellular cholesterol distribution.
REFERENCE   6  (bases 1 to 8980)
  AUTHORS   Zarsky,V. and Dolezal,P.
  TITLE     Evolution of the Tim17 protein family
  JOURNAL   Biol Direct 11 (1), 54 (2016)
   PUBMED   27760563
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8980)
  AUTHORS   Moayyeri,A., Hsu,Y.H., Karasik,D., Estrada,K., Xiao,S.M.,
            Nielson,C., Srikanth,P., Giroux,S., Wilson,S.G., Zheng,H.F.,
            Smith,A.V., Pye,S.R., Leo,P.J., Teumer,A., Hwang,J.Y., Ohlsson,C.,
            McGuigan,F., Minster,R.L., Hayward,C., Olmos,J.M.,
            Lyytikainen,L.P., Lewis,J.R., Swart,K.M., Masi,L., Oldmeadow,C.,
            Holliday,E.G., Cheng,S., van Schoor,N.M., Harvey,N.C., Kruk,M., del
            Greco,M. F, Igl,W., Trummer,O., Grigoriou,E., Luben,R., Liu,C.T.,
            Zhou,Y., Oei,L., Medina-Gomez,C., Zmuda,J., Tranah,G., Brown,S.J.,
            Williams,F.M., Soranzo,N., Jakobsdottir,J., Siggeirsdottir,K.,
            Holliday,K.L., Hannemann,A., Go,M.J., Garcia,M., Polasek,O.,
            Laaksonen,M., Zhu,K., Enneman,A.W., McEvoy,M., Peel,R., Sham,P.C.,
            Jaworski,M., Johansson,A., Hicks,A.A., Pludowski,P., Scott,R.,
            Dhonukshe-Rutten,R.A., van der Velde,N., Kahonen,M., Viikari,J.S.,
            Sievanen,H., Raitakari,O.T., Gonzalez-Macias,J., Hernandez,J.L.,
            Mellstrom,D., Ljunggren,O., Cho,Y.S., Volker,U., Nauck,M.,
            Homuth,G., Volzke,H., Haring,R., Brown,M.A., McCloskey,E.,
            Nicholson,G.C., Eastell,R., Eisman,J.A., Jones,G., Reid,I.R.,
            Dennison,E.M., Wark,J., Boonen,S., Vanderschueren,D., Wu,F.C.,
            Aspelund,T., Richards,J.B., Bauer,D., Hofman,A., Khaw,K.T.,
            Dedoussis,G., Obermayer-Pietsch,B., Gyllensten,U.,
            Pramstaller,P.P., Lorenc,R.S., Cooper,C., Kung,A.W., Lips,P.,
            Alen,M., Attia,J., Brandi,M.L., de Groot,L.C., Lehtimaki,T.,
            Riancho,J.A., Campbell,H., Liu,Y., Harris,T.B., Akesson,K.,
            Karlsson,M., Lee,J.Y., Wallaschofski,H., Duncan,E.L., O'Neill,T.W.,
            Gudnason,V., Spector,T.D., Rousseau,F., Orwoll,E., Cummings,S.R.,
            Wareham,N.J., Rivadeneira,F., Uitterlinden,A.G., Prince,R.L.,
            Kiel,D.P., Reeve,J. and Kaptoge,S.K.
  TITLE     Genetic determinants of heel bone properties: genome-wide
            association meta-analysis and replication in the GEFOS/GENOMOS
            consortium
  JOURNAL   Hum Mol Genet 23 (11), 3054-3068 (2014)
   PUBMED   24430505
REFERENCE   8  (bases 1 to 8980)
  AUTHORS   Exil,V.J., Silva Avila,D., Benedetto,A., Exil,E.A., Adams,M.R.,
            Au,C. and Aschner,M.
  TITLE     Stressed-induced TMEM135 protein is part of a conserved genetic
            network involved in fat storage and longevity regulation in
            Caenorhabditis elegans
  JOURNAL   PLoS One 5 (12), e14228 (2010)
   PUBMED   21151927
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8980)
  AUTHORS   Pei,L.
  TITLE     Pituitary tumor-transforming gene protein associates with ribosomal
            protein S10 and a novel human homologue of DnaJ in testicular cells
  JOURNAL   J Biol Chem 274 (5), 3151-3158 (1999)
   PUBMED   9915854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX648678.1, BC051462.1, AP000811.4 and DB325683.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022918.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.60778.1,
                                           SRR1803611.269848.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305494.6/ ENSP00000306344.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                BX648678.1         77-165
            90-689              BC051462.1         1-600
            690-764             AP000811.4         24972-25046
            765-2390            BC051462.1         676-2301
            2391-8762           AP000811.4         44885-51256
            8763-8980           DB325683.1         1-218               c
FEATURES             Location/Qualifiers
     source          1..8980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.2"
     gene            1..8980
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="transmembrane protein 135"
                     /db_xref="GeneID:65084"
                     /db_xref="HGNC:HGNC:26167"
                     /db_xref="MIM:616360"
     exon            1..253
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1489
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal membrane protein 52; peroxisomal protein 52"
                     /codon_start=1
                     /product="transmembrane protein 135 isoform 1"
                     /protein_id="NP_075069.3"
                     /db_xref="CCDS:CCDS8280.1"
                     /db_xref="GeneID:65084"
                     /db_xref="HGNC:HGNC:26167"
                     /db_xref="MIM:616360"
                     /translation="MAALSKSIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAP
                     LYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPG
                     FGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCI
                     TAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPG
                     RMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPS
                     AFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAG
                     FLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQA
                     AVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDPRYTTVT
                     PELPTEFS"
     exon            254..381
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            382..474
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            475..508
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            509..574
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            575..621
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            622..663
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            664..810
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            811..880
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1048
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1112
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1189
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1288
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1356
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..8980
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3665..3670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="hexamer: AATAGA"
     polyA_site      3686
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="major polyA site"
     regulatory      3862..3867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="hexamer: AATAAA"
     polyA_site      3882
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
     regulatory      3890..3895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="hexamer: AGTAAA"
     polyA_site      3914
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
     regulatory      8957..8962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="hexamer: AATAAA"
     polyA_site      8980
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
ORIGIN      
        1 attccgcacc tccgagtgct ggccgggcga gaggctggcg gctgggctct cgcgcccctc
       61 cctgcagggc tcaggctctc cccctcctgt cttctccgcg ctgttcctcg tcatggcggc
      121 cctcagcaag tccatccctc ataactgcta tgagatcggc cacacttggc acccttcctg
      181 ccgggtctcc ttcctgcaga tcaccggggg cgccctggag gagtccctga agatctatgc
      241 tcctctgtac ttgattgcag caattctccg gaaacggaaa ttagactatt atttacacaa
      301 actactccct gagatcctac aatccgcttc atttctaact gctaatgggg ccttgtatat
      361 ggctttcttt tgcattttaa ggaagatact tggaaaattc tactcatgga ctcctggctt
      421 tggtgccgct ctgccagcat cttatgtggc cattctcatt gaaagaaaaa gcaggagagg
      481 gctgctcaca atttatatgg ccaacttggc cacagaaaca ctattcagaa tgggtgtagc
      541 aagaggaacc atcacaacat taagaaatgg agaagtcctt ttgttttgca tcacagctgc
      601 catgtacatg ttctttttca ggtgcaagga tggcttgaaa ggatttacat tttctgcact
      661 taggttcatt gtagggaagg aagaaattcc cacacattct ttttcaccag aggcagcata
      721 tgcaaaagtg gaacaaaaga gagagcaaca tgaggaaaaa cccggaagaa tgaatatgat
      781 tggtctagtc aggaaatttg tggattcaat atgcaaacat ggaccaaggc atagatgttg
      841 caaacattat gaagataatt gcatctctta ttgcattaaa ggtttcatca gaatgtttag
      901 cgtggggtac ttgatccagt gctgcctccg aatcccttct gcatttaggc atctgtttac
      961 acagccatct cggctacttt ctctcttcta caataaagaa aacttccagc ttggagcttt
     1021 tcttggctct tttgttagta tatacaaggg tactagttgc ttcctgcgct ggatcagaaa
     1081 cttagatgat gaactacatg ctattatagc tggatttttg gcaggtatat caatgatgtt
     1141 ttataaaagc acaacaattt ccatgtattt agcgtccaaa ttggtagaga caatgtattt
     1201 caaaggcatt gaagcaggga aggttcccta ttttcctcat gcagatacta tcatctattc
     1261 catctctaca gcaatttgct tccaggcagc tgtcatggaa gttcagactt tgagaccatc
     1321 ttactggaag ttccttttaa gactcaccaa gggcaaattt gctgtcatga accgaaaagt
     1381 ccttgatgtt tttggtactg gtgcatctaa acactttcag gatttcatcc ccaggttgga
     1441 tccaagatac acaactgtaa caccagagtt gcccacagag ttttcctgaa gatgactgta
     1501 acttattaat gtgactaaat gtttcatctt gaagagttaa ttatgttgaa cacaaaggag
     1561 ggggcccaag ctcgaacttc agtgttattt cagttagaga tactcttttc atttgttttg
     1621 tttttcttat gaatcagaaa ttcagaagct ttttaggaag atgttgctta ataattaagc
     1681 ttcctccata gccagaataa gattctggat cactgtagtg actgacatta tatattattg
     1741 atcaaattat gtccacaagc aatattatat aatctacgta gaagtgtaat aacaaacaag
     1801 agtacactta aaattacttt aaaagatgtc tttagttcat tccaatataa ttcttgatta
     1861 aaattaggat tatttctaca ttttaggatt tacaaaggat cacgggtaca tggatttggt
     1921 ctatatattt ttttaaagtt ttgaattggt atctgtagta gtggaatgtt atagatttga
     1981 agtaactctc cacggacagt gctgctttcg tgtagagcaa tttaattgga gaagtggcca
     2041 ttcttacttc agggatgcaa agatgggtct cataccattt ggataaatgt cgtggtatcc
     2101 atgctttttt tcaactaata acatcatctc tcttcatgac cagttaattg ggctatttgg
     2161 cagcccagtg aacctatgta ctaatggcaa gttaggggca aatggaaatg gacacatccg
     2221 ataaagttga aatgtatgtt ttaatctttc acagaagtat tacacttgaa tatttaaaaa
     2281 caaaactttt aaacttccta taggtttatg atgtttgttt tcatttatat ggacataatc
     2341 cttcatagct cagtttatat gccattgttg tattagaagg gatcaaaatc ctatggaaca
     2401 aagtagtctt ggcaagttgg cagtttgtgt cctctcagct gtttaactta tgtaatggat
     2461 gttttgcacc tgaaaacact ataaaaatcc agtggttgtt taaaaagtcc atttgtcact
     2521 aattccattc aggttctcca accttcttct tgaatatcat tgtcaccatt tttactgtta
     2581 gaataaagag gtgacaccat aaagtcctgc tgataatgag agtagttcag gacagctgtg
     2641 attgaaatat ggtcgctatt tacagttttt cagggaaaag ttatactttt ctatgttaat
     2701 aaagagctga agtggtctac agttaatgtg acatgtaggg atgatgatat ttttaaaata
     2761 cattttgttg ctaaaaagtt tttaggccag tgcaaattat gcagtagaac ttgtgttgca
     2821 aaaggaatta taacccatac tttaaaaatg cttaatccct catattcaat ttcatcaagc
     2881 cttgtatact tctgcttaaa tgtaattcaa tccttggttg ttatggcaaa cagaaaccca
     2941 acaaaaagac agactctggt actatggtaa cagagccact ttatcatttg gtcaaaattt
     3001 ggcattatga ttagctttgt agaactgacc tgtttatttg gcaatgctgt taaaggatca
     3061 tttcggtttc agacttcaaa gttgattaat aaatttaatc ttaacttttt attcactgga
     3121 atcaaaacga tggttggtac tgtgtttact gtttaaaatg aagtactaaa gccctgagaa
     3181 ctgcacctca ttttctttat ccagaaattg tgcttatata ttttcctgtc aggtttaaaa
     3241 agatgtttta attcataaat tattgttttc attgacatta aaagactgtg atattgaaag
     3301 atgaattacg aaatttgctg agattgttta gtaaaatttt gctggtcaaa aaggtgtatt
     3361 tctacaattt accttttcat ttttataaat tgcagtcatt tttttaaatt ttatgtaaaa
     3421 tgtaaaatga aatagctatc atgaagcaga atacaatgat gaatgtatag gttgagtgaa
     3481 taaccaattt gcagtggtgg attgagaagt ccagtttgat ttcattggga cagactgcaa
     3541 agtgtagttg tttgagcaaa cacaaagaaa ctttgtgttt ttgaagacaa tcagaatgat
     3601 tacctttcta cctctaacta atcaggtatt gattgacaac tttttggcat tataaataaa
     3661 gtaaaataga tctctgcatt ccaaaatatg ttttttagtt tatttatatc ctgaagaaat
     3721 ggtaagtttt cactggaact gattacagta aacaataata tgtcccctta gtctttctga
     3781 catttttata tagattgaga ttgaaaaacc gtgcatttgg ggcagtggta ttatggtcat
     3841 ttcgttgcta ttttctgttt taataaaatc ctagaactag tagcaaccga gtaaagattg
     3901 agtttgcaag ataacagatt gtctcaaatc tattcaattc tcagcagttt ttcatcaaat
     3961 aatttcagga tccattttat tactcatttt tgaagtaaca cctttggttt agttttattt
     4021 tcccataaat tctgcttttg cttctgtaac ttttttcttg aactataagc atagtcatca
     4081 ctcagttgat atctagttta ttttttgcct tcattcgttg tttagtcagt tgttatttaa
     4141 tttagaattt tatatttttt tggctctcag attttataat gaacttttat tagactgaac
     4201 atgtatgttt ttgatggaat ccaaactgag caaatgtcac acagtatttt cttgttgtgc
     4261 tcgagtgttc gtctccttgt agattgtatc taggctaaca tttcatttag ttgttaatgc
     4321 tgacgtaatt gtttcctgct tatattttat catatccctg agcttctgtg tgctctacat
     4381 ttcataggta atgaaaagca atgtccttta ctctcaggga gcttcgtcca cttgcctgtg
     4441 tcacaacctc tcccttggtg ctaattagga agcttcttgt gggactgaag ggaactgacc
     4501 actggagcaa tggcccaaat gttgtttttg gagcagagaa attattagcc cagagattcc
     4561 ttaaattctc cgtgtgattt atttttttat tttttgagtt gaggtctagc tctgttgccc
     4621 gggttggagt acagtggtgc aatcatagct cattgaaacc tcaaattcct tggttcaagc
     4681 aattatttcc cctcagtctc taatagctgg gacaacaggc atgtgccacc atgcctggct
     4741 aatatttatt ttatttattt tttttttgta gaaacaaggt gttgctatgt tgtccaggct
     4801 ggtcttaaac tcctggcctc aagtgatcct cttgggttgg cctcccggga ctctgggatt
     4861 ccaggtgtga gccacggtac ctagccatat ttttatttgt atgagtatta agtagtttga
     4921 cacagcaaca aagttgtcct ttgtttccca aaggcaaaag tatacatttc ttactaagat
     4981 atcttataaa cattctctct cctaacacct ccttctagta atcattttca catagtagaa
     5041 tacttcactc agctgaaaat gagtggccaa gaaaaaaata caagaaaagg aataagaagt
     5101 gattattttc tttagggctg cactttgaat gtgatgagta ataaggttac cttcattgtg
     5161 gaggtgatgt ttacaattgc ctccagccct ttactattgg tgctgaagcc accattggtg
     5221 ccagctctat aatttcttct tcttgtggaa ttaacaaaga aaggagtgtc aaggactgag
     5281 atgaccctca gattgggggg ctgtcttaga ttctagggct ttgtagtact atgtttctgt
     5341 ttaaagtagt ggcctcaggt gactttgtaa tagccctgta gttgcaaaaa gggtaactac
     5401 aaagaaatga aactgactct agtgtgtgtg acttctggaa acagaagtgg ggcagtaagt
     5461 tggccatgat atagctagtg tcataggact acagcagagt agtgagtgaa tggccttaag
     5521 cttacagctg tggtgaataa gaatgtgtgc tattttacac acagaagaaa atgattgact
     5581 tttggttgga ggaaagaatt tatatctggt cttttggaaa ttattctgtt gctgttttat
     5641 gtgggctctc tctctctccc tctctctctc tctctgtctg tctctcttgc tgctccctct
     5701 ccctgccacc ttgtccattc tctgcttgct ggtgttactt tatgttaact agtctccttg
     5761 gacttcattg caacctttta agccagccgt tcaagtgaga ggctctggag tgatcataac
     5821 ggtgataaca atggagtaaa catttccaga gacactgatt ttttttttat atgctctgtt
     5881 tttcttaggc aggatgatgt agaagataat tgcacagata tggaaggaga tgtttctctg
     5941 tatgtgaagc ctttaaatcc agaacaatta atttcttctc ttcttaaaac cccgtaacat
     6001 cacttgactc tggaatttcc tattttcttt tactttctcc attttttttc catctgtccc
     6061 tcctacgaat atgttttaca tgaaataatg tattgggttt tatcttttgt cccagcagac
     6121 ctgaaaatcc cagtatatta ccacagacac acataccatc tggtcaccaa cagggacatc
     6181 agggccaaga gcagtttata cttctttctt tagctcacaa actactatag cttgcctgtt
     6241 cagttttttt tttttttaat attcagtttt gtgccatact ctcccccacc cccagcctgc
     6301 tgcctctgca gagcataaca ttctaatctt gtcagaccgt ggataatagg atgttccctg
     6361 gtcttggcat agaggccata ggcatacaac atgctttatc tgccttgctt agactcagca
     6421 tccctttctg tcttgagaga ttcaggcttc cataaagtag acctgtagac ctatgttggc
     6481 tgaggtcacc ctgcattact actttcctcc atccctgaac taggaccagt taattttcga
     6541 agtctagttc ttcagtgtct attaaacttt ttccagtagt taatcgatct cttaaattaa
     6601 ttttcttttc agattatttt tggtcaccta agaggaccct gaagctatag tgccaaaggt
     6661 ttaaagcatg aagtacattc tgtggttggt cattatggga ttggatgcca aaaggaatgg
     6721 gagagaagag actataaaca tattttaagc cttatctctt ttctcctatt cttttcttta
     6781 cctttcctgg cccatgcttt cctgccatat ctttgctatg tatttcttca tcttgagctc
     6841 tcaagggaaa aaacaggagt ccttattttt ctatttattt cagggaaaat tgaaggtaaa
     6901 taatatctgc aaagcttcag gaagaaattc agttgcatct gaatctgagt cggcagtttt
     6961 tgatagcctg tcactgctca gggatagcac taaggctctc ttcagaacca aagggcagga
     7021 taaataaatc tatgaaacta gaggcatcat tgaatcatct gaggaccttt tttttttttt
     7081 ttttttcact aaaacgcttc ctataacttg gattaaaatt caaaaatggg attgcagtca
     7141 ttgttaattg ctcaactagt ggcagttttt ccttgctgag ggaacactga tgttgtttaa
     7201 gacagttaca tgcctagccc cagggatgaa tcataattgt tctaggcctt tcatgtcttt
     7261 cctttcttct tgtccagata cttttccaac cagcctttac tcggaggtgt tcatgtgacc
     7321 ctgttttggc caataaaatg taatggaaaa tctgggaaac acttgggaaa aatcttccct
     7381 ctctgcttaa aggaaagttc tttttacctc tttttctctt gttcaaggta ttagtattag
     7441 tcagtagggt ctgaatctgt ggcagcaatc ttgcagacat gaaatgaaaa gtacaaacat
     7501 gaaaaaccag catattaaag atgccaggtc agaaaaatag aaagaacctg cttctgtgag
     7561 ccactgaatg gtgccattaa ccatctgcat ttgagcattt tgagaaaata aacctctatt
     7621 tcttaaagtt ctgtatcagt cagggtttcc cagagaggca gaacaatagg gatagagaga
     7681 tacatagaga gagatatgag agggatagag agagacacag agagagatat gagaggggat
     7741 taagggagtt ggctcatgtg attgtggagg ctgagaaacc ccaccacagg ccattcataa
     7801 cctggagacc ttgggatgct ggtggtctgg ctcagtacaa gtccaaaagc cttggaacca
     7861 gggaaactga tggtgtaatt ctcagtccaa ggctgaattt tcaagtctga gaacctgggg
     7921 gtgggatggg ggagtgatag ttttaagtcc tggagtccca aggttagagg atctggggtc
     7981 ctaatgtcca tgggcagttg gagaagagtg tatccctgct gcaggggaga gagagaagcc
     8041 aattctcctt tcttctgttt ttattctacc caggcctcca gtggattgga ggtgcctgcc
     8101 catattgagg gcagatcttc tctgcctagt ccacgctaac tcacatgcca atctcctctg
     8161 gaaacaccct cacagacaca ccccaaaata atgccttacc agttctctag atattcctta
     8221 atccagtcaa gttgatgcct aaaattaacc atcacaggct ttatggctct attacccaag
     8281 aattctgtta ctttcagctg aaaacatttc taatggacat attccaattc tgtatagatc
     8341 agatctcagt ttcatttccc attatatcct tctctctctt gatttagaat tctctttttc
     8401 tccactcttc tgtgtatgct aaaatactgt caatctcgtc tttgaaggtt ttgctcatct
     8461 ttaaaaaatc ttagttgatt atgttttatg tgtcatttaa ttaaggaatg aatttgctta
     8521 tttttatttc agtagctttt ggggtacaag tggtttttgg ttgcatggat gaattgtata
     8581 ttggtgaagt ctgaaatttt agtgcacctg tcaccagaat agtgtgcatt gtacccaata
     8641 tatagctttt tattccttcc ccttctgagt ctccatagtc cattatatca ctctgtatac
     8701 ccttgtgtat ccatagctta gctcccactt acagttgaga acatacagaa tttgattttc
     8761 tattccggag ttactttact tagaataatg gcctccagct ccatccaaga tgctgcaaaa
     8821 gacattattt catcttttat tttttatggc tgagtagtat tccatggtgc atatatacca
     8881 cattttcttt atccactcat tggtctatgg gcactttggt tgattctgta tctttgcaat
     8941 tgtgaactgt gttaacaata aaaatatata tacgagtgtc
//
