LOCUS       NM_001168724            8914 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 135 (TMEM135), transcript
            variant 2, mRNA.
ACCESSION   NM_001168724
VERSION     NM_001168724.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8914)
  AUTHORS   Hu,D., Tan,M., Lu,D., Kleiboeker,B., Liu,X., Park,H., Kravitz,A.V.,
            Shoghi,K.I., Tseng,Y.H., Razani,B., Ikeda,A. and Lodhi,I.J.
  TITLE     TMEM135 links peroxisomes to the regulation of brown fat
            mitochondrial fission and energy homeostasis
  JOURNAL   Nat Commun 14 (1), 6099 (2023)
   PUBMED   37773161
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8914)
  AUTHORS   Wang,R., Zhang,M., Hu,Y., He,J., Lin,Q. and Peng,N.
  TITLE     MiR-100-5p inhibits osteogenic differentiation of human bone
            mesenchymal stromal cells by targeting TMEM135
  JOURNAL   Hum Cell 35 (6), 1671-1683 (2022)
   PUBMED   35947339
  REMARK    GeneRIF: MiR-100-5p inhibits osteogenic differentiation of human
            bone mesenchymal stromal cells by targeting TMEM135.
REFERENCE   3  (bases 1 to 8914)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 8914)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   5  (bases 1 to 8914)
  AUTHORS   Maharjan,Y., Lee,J.N., Kwak,S.A., Dutta,R.K., Park,C., Choe,S.K.
            and Park,R.
  TITLE     TMEM135 regulates primary ciliogenesis through modulation of
            intracellular cholesterol distribution
  JOURNAL   EMBO Rep 21 (5), e48901 (2020)
   PUBMED   32157776
  REMARK    GeneRIF: TMEM135 regulates primary ciliogenesis through modulation
            of intracellular cholesterol distribution.
REFERENCE   6  (bases 1 to 8914)
  AUTHORS   Zarsky,V. and Dolezal,P.
  TITLE     Evolution of the Tim17 protein family
  JOURNAL   Biol Direct 11 (1), 54 (2016)
   PUBMED   27760563
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8914)
  AUTHORS   Moayyeri,A., Hsu,Y.H., Karasik,D., Estrada,K., Xiao,S.M.,
            Nielson,C., Srikanth,P., Giroux,S., Wilson,S.G., Zheng,H.F.,
            Smith,A.V., Pye,S.R., Leo,P.J., Teumer,A., Hwang,J.Y., Ohlsson,C.,
            McGuigan,F., Minster,R.L., Hayward,C., Olmos,J.M.,
            Lyytikainen,L.P., Lewis,J.R., Swart,K.M., Masi,L., Oldmeadow,C.,
            Holliday,E.G., Cheng,S., van Schoor,N.M., Harvey,N.C., Kruk,M., del
            Greco,M. F, Igl,W., Trummer,O., Grigoriou,E., Luben,R., Liu,C.T.,
            Zhou,Y., Oei,L., Medina-Gomez,C., Zmuda,J., Tranah,G., Brown,S.J.,
            Williams,F.M., Soranzo,N., Jakobsdottir,J., Siggeirsdottir,K.,
            Holliday,K.L., Hannemann,A., Go,M.J., Garcia,M., Polasek,O.,
            Laaksonen,M., Zhu,K., Enneman,A.W., McEvoy,M., Peel,R., Sham,P.C.,
            Jaworski,M., Johansson,A., Hicks,A.A., Pludowski,P., Scott,R.,
            Dhonukshe-Rutten,R.A., van der Velde,N., Kahonen,M., Viikari,J.S.,
            Sievanen,H., Raitakari,O.T., Gonzalez-Macias,J., Hernandez,J.L.,
            Mellstrom,D., Ljunggren,O., Cho,Y.S., Volker,U., Nauck,M.,
            Homuth,G., Volzke,H., Haring,R., Brown,M.A., McCloskey,E.,
            Nicholson,G.C., Eastell,R., Eisman,J.A., Jones,G., Reid,I.R.,
            Dennison,E.M., Wark,J., Boonen,S., Vanderschueren,D., Wu,F.C.,
            Aspelund,T., Richards,J.B., Bauer,D., Hofman,A., Khaw,K.T.,
            Dedoussis,G., Obermayer-Pietsch,B., Gyllensten,U.,
            Pramstaller,P.P., Lorenc,R.S., Cooper,C., Kung,A.W., Lips,P.,
            Alen,M., Attia,J., Brandi,M.L., de Groot,L.C., Lehtimaki,T.,
            Riancho,J.A., Campbell,H., Liu,Y., Harris,T.B., Akesson,K.,
            Karlsson,M., Lee,J.Y., Wallaschofski,H., Duncan,E.L., O'Neill,T.W.,
            Gudnason,V., Spector,T.D., Rousseau,F., Orwoll,E., Cummings,S.R.,
            Wareham,N.J., Rivadeneira,F., Uitterlinden,A.G., Prince,R.L.,
            Kiel,D.P., Reeve,J. and Kaptoge,S.K.
  TITLE     Genetic determinants of heel bone properties: genome-wide
            association meta-analysis and replication in the GEFOS/GENOMOS
            consortium
  JOURNAL   Hum Mol Genet 23 (11), 3054-3068 (2014)
   PUBMED   24430505
REFERENCE   8  (bases 1 to 8914)
  AUTHORS   Exil,V.J., Silva Avila,D., Benedetto,A., Exil,E.A., Adams,M.R.,
            Au,C. and Aschner,M.
  TITLE     Stressed-induced TMEM135 protein is part of a conserved genetic
            network involved in fat storage and longevity regulation in
            Caenorhabditis elegans
  JOURNAL   PLoS One 5 (12), e14228 (2010)
   PUBMED   21151927
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8914)
  AUTHORS   Pei,L.
  TITLE     Pituitary tumor-transforming gene protein associates with ribosomal
            protein S10 and a novel human homologue of DnaJ in testicular cells
  JOURNAL   J Biol Chem 274 (5), 3151-3158 (1999)
   PUBMED   9915854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX648678.1, AP000811.4 and DB325683.1.
            
            On May 31, 2019 this sequence version replaced NM_001168724.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region, compared to variant 1. The
            encoded isoform (2) is shorter, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648678.1, SRR1803613.172771.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-697               BX648678.1         77-773
            698-698             AP000811.4         25046-25046
            699-3615            BX648678.1         775-3691
            3616-8345           AP000811.4         46176-50905
            8346-8695           DB325683.1         220-569             c
            8696-8696           AP000811.4         51256-51256
            8697-8914           DB325683.1         1-218               c
FEATURES             Location/Qualifiers
     source          1..8914
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.2"
     gene            1..8914
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="transmembrane protein 135"
                     /db_xref="GeneID:65084"
                     /db_xref="HGNC:HGNC:26167"
                     /db_xref="MIM:616360"
     exon            1..253
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1423
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="isoform 2 is encoded by transcript variant 2;
                     peroxisomal membrane protein 52; peroxisomal protein 52"
                     /codon_start=1
                     /product="transmembrane protein 135 isoform 2"
                     /protein_id="NP_001162195.1"
                     /db_xref="CCDS:CCDS53692.1"
                     /db_xref="GeneID:65084"
                     /db_xref="HGNC:HGNC:26167"
                     /db_xref="MIM:616360"
                     /translation="MAALSKSIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAP
                     LYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPG
                     FGAALPASYVAILIERKSRRGLLTIYMANLVLLFCITAAMYMFFFRCKDGLKGFTFSA
                     LRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRH
                     RCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENF
                     QLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASK
                     LVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKG
                     KFAVMNRKVLDVFGTGASKHFQDFIPRLDPRYTTVTPELPTEFS"
     exon            254..381
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            382..474
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            475..508
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            509..555
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            556..597
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            598..744
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            745..814
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            815..982
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1046
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1123
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1222
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1290
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..8914
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3599..3604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="hexamer: AATAGA"
     polyA_site      3620
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="major polyA site"
     regulatory      3796..3801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="hexamer: AATAAA"
     polyA_site      3816
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
     regulatory      3824..3829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="hexamer: AGTAAA"
     polyA_site      3848
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
     regulatory      8891..8896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /note="hexamer: AATAAA"
     polyA_site      8914
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
ORIGIN      
        1 attccgcacc tccgagtgct ggccgggcga gaggctggcg gctgggctct cgcgcccctc
       61 cctgcagggc tcaggctctc cccctcctgt cttctccgcg ctgttcctcg tcatggcggc
      121 cctcagcaag tccatccctc ataactgcta tgagatcggc cacacttggc acccttcctg
      181 ccgggtctcc ttcctgcaga tcaccggggg cgccctggag gagtccctga agatctatgc
      241 tcctctgtac ttgattgcag caattctccg gaaacggaaa ttagactatt atttacacaa
      301 actactccct gagatcctac aatccgcttc atttctaact gctaatgggg ccttgtatat
      361 ggctttcttt tgcattttaa ggaagatact tggaaaattc tactcatgga ctcctggctt
      421 tggtgccgct ctgccagcat cttatgtggc cattctcatt gaaagaaaaa gcaggagagg
      481 gctgctcaca atttatatgg ccaacttggt ccttttgttt tgcatcacag ctgccatgta
      541 catgttcttt ttcaggtgca aggatggctt gaaaggattt acattttctg cacttaggtt
      601 cattgtaggg aaggaagaaa ttcccacaca ttctttttca ccagaggcag catatgcaaa
      661 agtggaacaa aagagagagc aacatgagga aaaacccgga agaatgaata tgattggtct
      721 agtcaggaaa tttgtggatt caatatgcaa acatggacca aggcatagat gttgcaaaca
      781 ttatgaagat aattgcatct cttattgcat taaaggtttc atcagaatgt ttagcgtggg
      841 gtacttgatc cagtgctgcc tccgaatccc ttctgcattt aggcatctgt ttacacagcc
      901 atctcggcta ctttctctct tctacaataa agaaaacttc cagcttggag cttttcttgg
      961 ctcttttgtt agtatataca agggtactag ttgcttcctg cgctggatca gaaacttaga
     1021 tgatgaacta catgctatta tagctggatt tttggcaggt atatcaatga tgttttataa
     1081 aagcacaaca atttccatgt atttagcgtc caaattggta gagacaatgt atttcaaagg
     1141 cattgaagca gggaaggttc cctattttcc tcatgcagat actatcatct attccatctc
     1201 tacagcaatt tgcttccagg cagctgtcat ggaagttcag actttgagac catcttactg
     1261 gaagttcctt ttaagactca ccaagggcaa atttgctgtc atgaaccgaa aagtccttga
     1321 tgtttttggt actggtgcat ctaaacactt tcaggatttc atccccaggt tggatccaag
     1381 atacacaact gtaacaccag agttgcccac agagttttcc tgaagatgac tgtaacttat
     1441 taatgtgact aaatgtttca tcttgaagag ttaattatgt tgaacacaaa ggagggggcc
     1501 caagctcgaa cttcagtgtt atttcagtta gagatactct tttcatttgt tttgtttttc
     1561 ttatgaatca gaaattcaga agctttttag gaagatgttg cttaataatt aagcttcctc
     1621 catagccaga ataagattct ggatcactgt agtgactgac attatatatt attgatcaaa
     1681 ttatgtccac aagcaatatt atataatcta cgtagaagtg taataacaaa caagagtaca
     1741 cttaaaatta ctttaaaaga tgtctttagt tcattccaat ataattcttg attaaaatta
     1801 ggattatttc tacattttag gatttacaaa ggatcacggg tacatggatt tggtctatat
     1861 atttttttaa agttttgaat tggtatctgt agtagtggaa tgttatagat ttgaagtaac
     1921 tctccacgga cagtgctgct ttcgtgtaga gcaatttaat tggagaagtg gccattctta
     1981 cttcagggat gcaaagatgg gtctcatacc atttggataa atgtcgtggt atccatgctt
     2041 tttttcaact aataacatca tctctcttca tgaccagtta attgggctat ttggcagccc
     2101 agtgaaccta tgtactaatg gcaagttagg ggcaaatgga aatggacaca tccgataaag
     2161 ttgaaatgta tgttttaatc tttcacagaa gtattacact tgaatattta aaaacaaaac
     2221 ttttaaactt cctataggtt tatgatgttt gttttcattt atatggacat aatccttcat
     2281 agctcagttt atatgccatt gttgtattag aagggatcaa aatcctatgg aacaaagtag
     2341 tcttggcaag ttggcagttt gtgtcctctc agctgtttaa cttatgtaat ggatgttttg
     2401 cacctgaaaa cactataaaa atccagtggt tgtttaaaaa gtccatttgt cactaattcc
     2461 attcaggttc tccaaccttc ttcttgaata tcattgtcac catttttact gttagaataa
     2521 agaggtgaca ccataaagtc ctgctgataa tgagagtagt tcaggacagc tgtgattgaa
     2581 atatggtcgc tatttacagt ttttcaggga aaagttatac ttttctatgt taataaagag
     2641 ctgaagtggt ctacagttaa tgtgacatgt agggatgatg atatttttaa aatacatttt
     2701 gttgctaaaa agtttttagg ccagtgcaaa ttatgcagta gaacttgtgt tgcaaaagga
     2761 attataaccc atactttaaa aatgcttaat ccctcatatt caatttcatc aagccttgta
     2821 tacttctgct taaatgtaat tcaatccttg gttgttatgg caaacagaaa cccaacaaaa
     2881 agacagactc tggtactatg gtaacagagc cactttatca tttggtcaaa atttggcatt
     2941 atgattagct ttgtagaact gacctgttta tttggcaatg ctgttaaagg atcatttcgg
     3001 tttcagactt caaagttgat taataaattt aatcttaact ttttattcac tggaatcaaa
     3061 acgatggttg gtactgtgtt tactgtttaa aatgaagtac taaagccctg agaactgcac
     3121 ctcattttct ttatccagaa attgtgctta tatattttcc tgtcaggttt aaaaagatgt
     3181 tttaattcat aaattattgt tttcattgac attaaaagac tgtgatattg aaagatgaat
     3241 tacgaaattt gctgagattg tttagtaaaa ttttgctggt caaaaaggtg tatttctaca
     3301 atttaccttt tcatttttat aaattgcagt cattttttta aattttatgt aaaatgtaaa
     3361 atgaaatagc tatcatgaag cagaatacaa tgatgaatgt ataggttgag tgaataacca
     3421 atttgcagtg gtggattgag aagtccagtt tgatttcatt gggacagact gcaaagtgta
     3481 gttgtttgag caaacacaaa gaaactttgt gtttttgaag acaatcagaa tgattacctt
     3541 tctacctcta actaatcagg tattgattga caactttttg gcattataaa taaagtaaaa
     3601 tagatctctg cattccaaaa tatgtttttt agtttattta tatcctgaag aaatggtaag
     3661 ttttcactgg aactgattac agtaaacaat aatatgtccc cttagtcttt ctgacatttt
     3721 tatatagatt gagattgaaa aaccgtgcat ttggggcagt ggtattatgg tcatttcgtt
     3781 gctattttct gttttaataa aatcctagaa ctagtagcaa ccgagtaaag attgagtttg
     3841 caagataaca gattgtctca aatctattca attctcagca gtttttcatc aaataatttc
     3901 aggatccatt ttattactca tttttgaagt aacacctttg gtttagtttt attttcccat
     3961 aaattctgct tttgcttctg taactttttt cttgaactat aagcatagtc atcactcagt
     4021 tgatatctag tttatttttt gccttcattc gttgtttagt cagttgttat ttaatttaga
     4081 attttatatt tttttggctc tcagatttta taatgaactt ttattagact gaacatgtat
     4141 gtttttgatg gaatccaaac tgagcaaatg tcacacagta ttttcttgtt gtgctcgagt
     4201 gttcgtctcc ttgtagattg tatctaggct aacatttcat ttagttgtta atgctgacgt
     4261 aattgtttcc tgcttatatt ttatcatatc cctgagcttc tgtgtgctct acatttcata
     4321 ggtaatgaaa agcaatgtcc tttactctca gggagcttcg tccacttgcc tgtgtcacaa
     4381 cctctccctt ggtgctaatt aggaagcttc ttgtgggact gaagggaact gaccactgga
     4441 gcaatggccc aaatgttgtt tttggagcag agaaattatt agcccagaga ttccttaaat
     4501 tctccgtgtg atttattttt ttattttttg agttgaggtc tagctctgtt gcccgggttg
     4561 gagtacagtg gtgcaatcat agctcattga aacctcaaat tccttggttc aagcaattat
     4621 ttcccctcag tctctaatag ctgggacaac aggcatgtgc caccatgcct ggctaatatt
     4681 tattttattt attttttttt tgtagaaaca aggtgttgct atgttgtcca ggctggtctt
     4741 aaactcctgg cctcaagtga tcctcttggg ttggcctccc gggactctgg gattccaggt
     4801 gtgagccacg gtacctagcc atatttttat ttgtatgagt attaagtagt ttgacacagc
     4861 aacaaagttg tcctttgttt cccaaaggca aaagtataca tttcttacta agatatctta
     4921 taaacattct ctctcctaac acctccttct agtaatcatt ttcacatagt agaatacttc
     4981 actcagctga aaatgagtgg ccaagaaaaa aatacaagaa aaggaataag aagtgattat
     5041 tttctttagg gctgcacttt gaatgtgatg agtaataagg ttaccttcat tgtggaggtg
     5101 atgtttacaa ttgcctccag ccctttacta ttggtgctga agccaccatt ggtgccagct
     5161 ctataatttc ttcttcttgt ggaattaaca aagaaaggag tgtcaaggac tgagatgacc
     5221 ctcagattgg ggggctgtct tagattctag ggctttgtag tactatgttt ctgtttaaag
     5281 tagtggcctc aggtgacttt gtaatagccc tgtagttgca aaaagggtaa ctacaaagaa
     5341 atgaaactga ctctagtgtg tgtgacttct ggaaacagaa gtggggcagt aagttggcca
     5401 tgatatagct agtgtcatag gactacagca gagtagtgag tgaatggcct taagcttaca
     5461 gctgtggtga ataagaatgt gtgctatttt acacacagaa gaaaatgatt gacttttggt
     5521 tggaggaaag aatttatatc tggtcttttg gaaattattc tgttgctgtt ttatgtgggc
     5581 tctctctctc tccctctctc tctctctctg tctgtctctc ttgctgctcc ctctccctgc
     5641 caccttgtcc attctctgct tgctggtgtt actttatgtt aactagtctc cttggacttc
     5701 attgcaacct tttaagccag ccgttcaagt gagaggctct ggagtgatca taacggtgat
     5761 aacaatggag taaacatttc cagagacact gatttttttt ttatatgctc tgtttttctt
     5821 aggcaggatg atgtagaaga taattgcaca gatatggaag gagatgtttc tctgtatgtg
     5881 aagcctttaa atccagaaca attaatttct tctcttctta aaaccccgta acatcacttg
     5941 actctggaat ttcctatttt cttttacttt ctccattttt tttccatctg tccctcctac
     6001 gaatatgttt tacatgaaat aatgtattgg gttttatctt ttgtcccagc agacctgaaa
     6061 atcccagtat attaccacag acacacatac catctggtca ccaacaggga catcagggcc
     6121 aagagcagtt tatacttctt tctttagctc acaaactact atagcttgcc tgttcagttt
     6181 tttttttttt taatattcag ttttgtgcca tactctcccc cacccccagc ctgctgcctc
     6241 tgcagagcat aacattctaa tcttgtcaga ccgtggataa taggatgttc cctggtcttg
     6301 gcatagaggc cataggcata caacatgctt tatctgcctt gcttagactc agcatccctt
     6361 tctgtcttga gagattcagg cttccataaa gtagacctgt agacctatgt tggctgaggt
     6421 caccctgcat tactactttc ctccatccct gaactaggac cagttaattt tcgaagtcta
     6481 gttcttcagt gtctattaaa ctttttccag tagttaatcg atctcttaaa ttaattttct
     6541 tttcagatta tttttggtca cctaagagga ccctgaagct atagtgccaa aggtttaaag
     6601 catgaagtac attctgtggt tggtcattat gggattggat gccaaaagga atgggagaga
     6661 agagactata aacatatttt aagccttatc tcttttctcc tattcttttc tttacctttc
     6721 ctggcccatg ctttcctgcc atatctttgc tatgtatttc ttcatcttga gctctcaagg
     6781 gaaaaaacag gagtccttat ttttctattt atttcaggga aaattgaagg taaataatat
     6841 ctgcaaagct tcaggaagaa attcagttgc atctgaatct gagtcggcag tttttgatag
     6901 cctgtcactg ctcagggata gcactaaggc tctcttcaga accaaagggc aggataaata
     6961 aatctatgaa actagaggca tcattgaatc atctgaggac cttttttttt tttttttttt
     7021 cactaaaacg cttcctataa cttggattaa aattcaaaaa tgggattgca gtcattgtta
     7081 attgctcaac tagtggcagt ttttccttgc tgagggaaca ctgatgttgt ttaagacagt
     7141 tacatgccta gccccaggga tgaatcataa ttgttctagg cctttcatgt ctttcctttc
     7201 ttcttgtcca gatacttttc caaccagcct ttactcggag gtgttcatgt gaccctgttt
     7261 tggccaataa aatgtaatgg aaaatctggg aaacacttgg gaaaaatctt ccctctctgc
     7321 ttaaaggaaa gttcttttta cctctttttc tcttgttcaa ggtattagta ttagtcagta
     7381 gggtctgaat ctgtggcagc aatcttgcag acatgaaatg aaaagtacaa acatgaaaaa
     7441 ccagcatatt aaagatgcca ggtcagaaaa atagaaagaa cctgcttctg tgagccactg
     7501 aatggtgcca ttaaccatct gcatttgagc attttgagaa aataaacctc tatttcttaa
     7561 agttctgtat cagtcagggt ttcccagaga ggcagaacaa tagggataga gagatacata
     7621 gagagagata tgagagggat agagagagac acagagagag atatgagagg ggattaaggg
     7681 agttggctca tgtgattgtg gaggctgaga aaccccacca caggccattc ataacctgga
     7741 gaccttggga tgctggtggt ctggctcagt acaagtccaa aagccttgga accagggaaa
     7801 ctgatggtgt aattctcagt ccaaggctga attttcaagt ctgagaacct gggggtggga
     7861 tgggggagtg atagttttaa gtcctggagt cccaaggtta gaggatctgg ggtcctaatg
     7921 tccatgggca gttggagaag agtgtatccc tgctgcaggg gagagagaga agccaattct
     7981 cctttcttct gtttttattc tacccaggcc tccagtggat tggaggtgcc tgcccatatt
     8041 gagggcagat cttctctgcc tagtccacgc taactcacat gccaatctcc tctggaaaca
     8101 ccctcacaga cacaccccaa aataatgcct taccagttct ctagatattc cttaatccag
     8161 tcaagttgat gcctaaaatt aaccatcaca ggctttatgg ctctattacc caagaattct
     8221 gttactttca gctgaaaaca tttctaatgg acatattcca attctgtata gatcagatct
     8281 cagtttcatt tcccattata tccttctctc tcttgattta gaattctctt tttctccact
     8341 cttctgtgta tgctaaaata ctgtcaatct cgtctttgaa ggttttgctc atctttaaaa
     8401 aatcttagtt gattatgttt tatgtgtcat ttaattaagg aatgaatttg cttattttta
     8461 tttcagtagc ttttggggta caagtggttt ttggttgcat ggatgaattg tatattggtg
     8521 aagtctgaaa ttttagtgca cctgtcacca gaatagtgtg cattgtaccc aatatatagc
     8581 tttttattcc ttccccttct gagtctccat agtccattat atcactctgt atacccttgt
     8641 gtatccatag cttagctccc acttacagtt gagaacatac agaatttgat tttctattcc
     8701 ggagttactt tacttagaat aatggcctcc agctccatcc aagatgctgc aaaagacatt
     8761 atttcatctt ttatttttta tggctgagta gtattccatg gtgcatatat accacatttt
     8821 ctttatccac tcattggtct atgggcactt tggttgattc tgtatctttg caattgtgaa
     8881 ctgtgttaac aataaaaata tatatacgag tgtc
//
