LOCUS       NM_025124               3551 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens transmembrane protein 134 (TMEM134), transcript
            variant 1, mRNA.
ACCESSION   NM_025124
VERSION     NM_025124.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3551)
  AUTHORS   Tian,Y., Huang,W., Yang,J., Wen,Z., Geng,Y., Zhao,C., Zhang,H. and
            Wang,Y.
  TITLE     Systematic identification of hepatitis E virus ORF2 interactome
            reveals that TMEM134 engages in ORF2-mediated NF-kappaB pathway
  JOURNAL   Virus Res 228, 102-108 (2017)
   PUBMED   27899274
REFERENCE   2  (bases 1 to 3551)
  AUTHORS   Talaty,P., Emery,A., Holthusen,K. and Everly,D.N. Jr.
  TITLE     Identification of transmembrane protein 134 as a novel LMP1-binding
            protein by using bimolecular fluorescence complementation and an
            enhanced retroviral mutagen
  JOURNAL   J Virol 86 (20), 11345-11355 (2012)
   PUBMED   22855487
  REMARK    GeneRIF: screen identified a novel LMP1-binding protein,
            transmembrane protein 134; Tmem134 affected LMP1-induced NF-kappaB
            induction
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY053672.1, AK025402.1, AA830850.1 and AP003419.3.
            
            On Nov 23, 2018 this sequence version replaced NM_025124.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3107377.1, AK025402.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308022.7/ ENSP00000312615.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                HY053672.1         27-48
            23-903              AK025402.1         65-945
            904-913             AA830850.1         44-53               c
            914-3551            AP003419.3         142175-144812       c
FEATURES             Location/Qualifiers
     source          1..3551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..3551
                     /gene="TMEM134"
                     /note="transmembrane protein 134"
                     /db_xref="GeneID:80194"
                     /db_xref="HGNC:HGNC:26142"
     exon            1..233
                     /gene="TMEM134"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..647
                     /gene="TMEM134"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 134 isoform a"
                     /protein_id="NP_079400.1"
                     /db_xref="CCDS:CCDS8167.1"
                     /db_xref="GeneID:80194"
                     /db_xref="HGNC:HGNC:26142"
                     /translation="MSAARPQFSIDDAFELSLEDGGPGPESSGVARFGPLHFERRARF
                     EVADEDKQSRLRYQNLENDEDGAQASPEPDGGVGTRDSSRTSIRSSQWSFSTISSSTQ
                     RSYNTCCSWTQHPLIQKNRRVVLASFLLLLLGLVLILVGVGLEATPSPGVSSAIFFVP
                     GFLLLVPGVYHVIFIYCAVKGHRGFQFFYLPYFEK"
     exon            234..298
                     /gene="TMEM134"
                     /inference="alignment:Splign:2.1.0"
     exon            299..388
                     /gene="TMEM134"
                     /inference="alignment:Splign:2.1.0"
     exon            389..465
                     /gene="TMEM134"
                     /inference="alignment:Splign:2.1.0"
     exon            466..510
                     /gene="TMEM134"
                     /inference="alignment:Splign:2.1.0"
     exon            511..564
                     /gene="TMEM134"
                     /inference="alignment:Splign:2.1.0"
     exon            565..3551
                     /gene="TMEM134"
                     /inference="alignment:Splign:2.1.0"
     regulatory      882..887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM134"
                     /note="hexamer: AATAAA"
     polyA_site      903
                     /gene="TMEM134"
                     /note="major polyA site"
     regulatory      3528..3533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM134"
                     /note="hexamer: ATTAAA"
     polyA_site      3551
                     /gene="TMEM134"
ORIGIN      
        1 gacgctgggt gtgtgggcgc agatggcggc ggcgcacggc gcctgagcgg gccggggcca
       61 tgagcgccgc ccggccccag ttcagcattg atgatgcctt cgagctgtcc ctggaggacg
      121 ggggccctgg gcccgagtcc agcggggtcg cgcgctttgg gccgctgcac ttcgagcgtc
      181 gggcccggtt cgaggtggct gacgaggaca agcagtcccg gctgcgctac cagaacctgg
      241 agaacgatga ggatggagcc caggcctctc cggagccgga tgggggagtc ggcaccaggg
      301 attccagccg aacttccatc cgcagctccc agtggtcctt cagcaccatc agcagcagca
      361 cccagcgctc ctacaacacc tgctgcagct ggacccaaca ccctttgatc cagaagaacc
      421 gccgagtggt gctggcctcc ttcctgctcc tgctgctggg gctggtgctg atcctggtcg
      481 gcgtgggact ggaggcgacc ccctctccag gtgtctccag cgccatcttc ttcgtgccgg
      541 gcttcctgtt gttggtgcct ggagtctatc acgtgatctt catctactgc gcggtcaagg
      601 gccaccgggg cttccagttc ttctacctgc cctacttcga gaagtgatcg cggcgcagcg
      661 tggacccctt gcgcccatgg gggcgcccct cttgccctgt tccgttcccc tcatctcaag
      721 ggaagaggcc ctccaggacc ctcgaaaccc cagcccctag ggagtttgct caggaagttc
      781 ggggcatgca ggcctggccc tgggaaagcc gcccgtcgcc tgctctgtgc cttaacttat
      841 tctcgggccg tgcggctgct aggttgctgt tattttgtgc taataaaaga gtaattaatt
      901 ccaccagagg caattgctct cctcctgtcc tgccactgct agcccagccc accagcctga
      961 ccacagcccc cctcccaagg actgaccctg acgctgaagg gcttcgagca ccaccgaacg
     1021 cgtggcagcc ctgatgctga ggcttgccca agggcacggg gcatgttagg ggcagagctg
     1081 ggcgtaggac tcctgccttg ccagccagga gccggccgga acagcctgcc ccacccccag
     1141 cccttggatg actcaaccag cccgtctctg tctggtggcc ctggccgagg gcacgcagag
     1201 atgacgcagg cctgggacct ggaggctggt atcctagttc cagcctggct ctggggccct
     1261 gggctgccac agccagccct gaatgtgggc catgtcaagg caatggccca gccccctcca
     1321 cccactgccc tccttcccag tcccagaggt tgggagaacc tgggggcaga gggcatagga
     1381 agccgcgcct gacagacacc ctcagtggtc aaagacttag aaatgcagaa cgttagaaac
     1441 aaaccatctc agaattttgg aacatcagca tttcagaatc ttacgaaaca agaaacagaa
     1501 tctttgagaa acctgaaatc tgagatcata gtagctacca gttatcaatt tgttgaaaga
     1561 ccccaggatg gccgggcacg gtggctcaag cctgtaatcc tagcactttg agaggccaag
     1621 gtgggaggat cgcttgagcc caggagttcg cgaccaacct ggacaacatg gcgagaaccc
     1681 atctctattt aaaaaaaaaa aaagaaaaga aaatatacta ggccctgcgc taagcactga
     1741 acacgggtta tatcttgtaa tcttcactac ctccgtccca ttttacagat aaggactgac
     1801 tcacccaagg acagccagca ggtggtaggt agaattagga acgtagccca gggctcttcc
     1861 catgacactg tcggggaggg agaaggaaac cggcactgag ctggtctccc ctaccggcca
     1921 accaagaggc tggctgagtg agcaagggtt gggaggccct gttggtgcac ctgcccgtac
     1981 tgtctatctc ccccaccaaa acacgggtcc cacaaaccac tgtctgcagc acccaacaca
     2041 gcggggcctt caggattctg agttagagga atggacaccc agactcttgc tctcgctccc
     2101 acctttccag gccccgcaga cttcccaccc tcatccccca ttcaaggcac ttagggggca
     2161 cccattggat gcaggaactc ctaaaccagt ggtcccccaa ctagctatgg taaaggacca
     2221 gttttcattt ctaatccatc acggtccagt actttcataa gaagaactag ccgggtgccg
     2281 tgcctcatgc ctgtaatccc agcactttga gaggccacgg tgggaggatc acttgagccc
     2341 aggagttcga gaccaacctg ggaaacatgg gaaaacccca tctctacaaa aaatacaaaa
     2401 acttagccag gcatggtggg gcgcctgtag tcccacccac ttgcgaggct ggagtgggag
     2461 gatcacggag cctgggaggc tgcagtggag tcatgattgc accactgcac tccagcctgg
     2521 aagacagact gagacctatt taaaaaataa ataaataaat aacataaaaa ttttaaaaac
     2581 tagaaaaatg aaataaaaaa catacagagg ctgggcgtgg tggctcatgc ctgcaatccc
     2641 agcactttgg gaggccgagg caggtgaatc atgaggtcag gagttcgaga ccagcctggc
     2701 caacagggtg aaatcccatt tctattaaaa atacaaaaaa attaccgggc atggtggtgc
     2761 gcacctgtaa tcccagctac tcaggaggct gaggcaggag aatcgcttga acccgggagg
     2821 cagaggttgc agtgagccga gatcacgcca ctacactcca gcctgagcga cagagcgaga
     2881 ctctgtctcc aaaaaaaaaa aaaatacaga atacaagtcc acagtttatc agattaatta
     2941 gacataaaat tacatttcaa taaatataat cagaacaaac ataggaaaaa ggaaaaatga
     3001 caaaaaccat tgaatatgaa caaacaggca attaacacag aatcgcagct aacaactttt
     3061 tactccttgt tttttttttt tttgtttttt ttttgagacg agtctcactg tctcccaggc
     3121 tggagtgcag tggcccgatc tcggctcact gcatcctctg cctcccggtt taagcgattc
     3181 tcatgcctca gccttctcag tagctgcgac tacaggcaca tgccaccatg cccagctaat
     3241 ctttgtattt ttagtagaga cagggtttca ctatgttggc caggctggtc tccaacccct
     3301 gagccacctc gcccgacttc attctacagt cttaacagaa agcaatttca gaagtggtga
     3361 ttcccatcat tagaagtctg cgttaggaat cagcaaggta tagtccacag agtggttttt
     3421 atattttgta atggttggag aaaagtcaaa gaataataag attttatgac ataaaattat
     3481 ataaaattca aatttccatg tcaataaatg aagttttact gttatttatt aaaatttctg
     3541 atatagccac a
//
