LOCUS       NM_001136103            5176 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 132C (TMEM132C), transcript
            variant 1, mRNA.
ACCESSION   NM_001136103 XM_001715575 XM_044062 XM_941994
VERSION     NM_001136103.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5176)
  AUTHORS   Sanchez-Pulido,L. and Ponting,C.P.
  TITLE     TMEM132: an ancient architecture of cohesin and immunoglobulin
            domains define a new family of neural adhesion molecules
  JOURNAL   Bioinformatics 34 (5), 721-724 (2018)
   PUBMED   29088312
REFERENCE   2  (bases 1 to 5176)
  AUTHORS   Hao,Y., Liu,X., Lu,X., Yang,X., Wang,L., Chen,S., Li,H., Li,J.,
            Cao,J., Chen,J., Li,Y., Zhao,L., Shi,Y., Shen,C., Yan,W., He,J.,
            Huang,J. and Gu,D.
  TITLE     Genome-wide association study in Han Chinese identifies three novel
            loci for human height
  JOURNAL   Hum Genet 132 (6), 681-689 (2013)
   PUBMED   23456168
REFERENCE   3  (bases 1 to 5176)
  AUTHORS   Chung,S., Low,S.K., Zembutsu,H., Takahashi,A., Kubo,M., Sasa,M. and
            Nakamura,Y.
  TITLE     A genome-wide association study of chemotherapy-induced alopecia in
            breast cancer patients
  JOURNAL   Breast Cancer Res 15 (5), R81 (2013)
   PUBMED   24025145
REFERENCE   4  (bases 1 to 5176)
  AUTHORS   Willour,V.L., Seifuddin,F., Mahon,P.B., Jancic,D., Pirooznia,M.,
            Steele,J., Schweizer,B., Goes,F.S., Mondimore,F.M., Mackinnon,D.F.,
            Perlis,R.H., Lee,P.H., Huang,J., Kelsoe,J.R., Shilling,P.D.,
            Rietschel,M., Nothen,M., Cichon,S., Gurling,H., Purcell,S.,
            Smoller,J.W., Craddock,N., DePaulo,J.R. Jr., Schulze,T.G.,
            McMahon,F.J., Zandi,P.P. and Potash,J.B.
  CONSRTM   Bipolar Genome Study Consortium
  TITLE     A genome-wide association study of attempted suicide
  JOURNAL   Mol Psychiatry 17 (4), 433-444 (2012)
   PUBMED   21423239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC061709.25, AC023595.19, AC090424.18 and AC107020.4.
            
            On Sep 23, 2020 this sequence version replaced NM_001136103.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.145432.1,
                                           SRR1803613.116553.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435159.3/ ENSP00000410852.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AC061709.25        134356-134673
            319-1207            AC023595.19        6037-6925           c
            1208-1354           AC090424.18        45656-45802         c
            1355-1538           AC107020.4         98550-98733         c
            1539-1682           AC107020.4         45325-45468         c
            1683-1888           AC107020.4         20851-21056         c
            1889-2162           AC107020.4         18782-19055         c
            2163-2354           AC107020.4         17470-17661         c
            2355-5176           AC107020.4         6974-9795           c
FEATURES             Location/Qualifiers
     source          1..5176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.32-q24.33"
     gene            1..5176
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /note="transmembrane protein 132C"
                     /db_xref="GeneID:92293"
                     /db_xref="HGNC:HGNC:25436"
     exon            1..318
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..3560
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein phosphatase 1, regulatory subunit 152"
                     /codon_start=1
                     /product="transmembrane protein 132C isoform 1 precursor"
                     /protein_id="NP_001129575.2"
                     /db_xref="CCDS:CCDS45009.2"
                     /db_xref="GeneID:92293"
                     /db_xref="HGNC:HGNC:25436"
                     /translation="MRSEGAAPGPAAPLCGALSLLLGALLGKVIEGHGVTDNIQRFSS
                     LPPYLPVSYHILRAETSFFLKEANQDLLRNSSLQARVESFFTYKTRQPPVLNASYGPF
                     SVEKVVPLDLMLTSNFLGPTNKFSFDWKLKAHILRDKVYLSRPKVQVLFHIMGRDWDD
                     HGAGEKLPCLRVFAFRETREVRGSCRLKGDLGLCVAELELLSSWFSAPTVGAGRKKSM
                     DQPEGTPVELYYTVHPGNERGDCAGGDFRKGNAIRPGKDGLEETTSHLQRIGTVGLYR
                     AQDSAQLSELRLDGNVVIWLPSRPVKQGEVVTAYVTISSNSSVDLFILRAKVKKGVNI
                     LSAQTREPRQWGVKQEVGSGGKHVTATVACQRLGPSPRNRSSSLFNEVVQMNFEIASF
                     SSLSGTQPITWQVEYPRKGTTDIAVSEIFVSQKDLVGIVPLAMDTEILNTAVLTGKTV
                     AMPIKVVSVEENSAVMDISESVECKSTDEDVIKVSERCDYIFVNGKEIKGKMDAVVNF
                     TYQYLSAPLCVTVWVPRLPLQIEVSDTELSQIKGWRVPIVTNKRPTRESEDEDEEERR
                     GRGCALQYQHATVRVLTQFVSEGAGPWGQPNYLLSPNWQFDITHLVADFMKLEEPHVA
                     TLQDSRVLVGREVGMTTIQVLSPLSDSILAEKTITVLDDKVSVTDLAIQLVAGLSVAL
                     YPNAENSKAVTAVVTAEEVLRTPKQEAVFSTWLQFSDGSVTPLDIYDTKDFSLAATSQ
                     DEAVVSVPQPRSPRWPVVVAEGEGQGPLIRVDMTIAEACQKSKRKSILAVGVGNVRVK
                     FGQNDADSSPGGDYEEDEIKNHASDRRQKGQHHERTGQDGHLYGSSPVEREEGALRRA
                     TTTARSLLDNKVVKNSRADGGRLAGEGQLQNIPIDFTNFPAHVDLPKAGSGLEENDLV
                     QTPRGLSDLEIGMYALLGVFCLAILVFLINCATFALKYRHKQVPLEGQASMTHSHDWV
                     WLGNEAELLESMGDAPPPQDEHTTIIDRGPGACEESNHLLLNGGSHKHVQSQIHRSAD
                     SGGRQGREQKQDPLHSPTSKRKKVKFTTFTTIPPDDSCPTVNSIVSSNDEDIKWVCQD
                     VAVGAPKELRNYLEKLKDKA"
     exon            319..1207
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1354
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1538
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1682
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1888
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2162
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2354
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..5176
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3939..3944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /note="hexamer: AATAAA"
     polyA_site      3963
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /note="major polyA site"
     regulatory      5150..5155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /note="hexamer: ATTAAA"
     polyA_site      5176
                     /gene="TMEM132C"
                     /gene_synonym="PPP1R152"
                     /note="major polyA site"
ORIGIN      
        1 gaaaagttgt cccggccgga gcgcgagcag cggcggagcc ggagccgcca gagccagagc
       61 cggagctgcg gcggcgtgga cccggcaggg gcgggcctcg gacagcagag acgcagcggg
      121 cccggccgac cgggctgcgg gagtggcccc gggcatgggg cggccggcgg gggccgcggg
      181 cgggcgctgc gcttcgggct ggcggcgggc tgcgtgagcg gccgggacgc aggatgcgct
      241 ccgagggtgc ggcccccggg ccggcggcgc cgctgtgcgg ggcgctgagc ctgctgctgg
      301 gcgcgctgct gggcaaagtg atagagggtc acggggtcac agacaacata cagagattct
      361 cctcactgcc accttaccta cctgtgagct accacatcct cagagcagag acctccttct
      421 tcctcaagga agccaaccag gacctgctgc ggaactccag cctgcaggcg agggtggagt
      481 ccttctttac ctacaaaacc aggcagcccc cagtgctcaa tgccagctat ggaccctttt
      541 ctgtggagaa ggttgtgcct ctggacttga tgttgacttc aaacttttta ggtccaacca
      601 ataagtttag ttttgattgg aaactaaaag cccacatcct gcgggacaaa gtctacctga
      661 gccggcccaa agtgcaggtt cttttccaca tcatgggcag agactgggat gaccacggcg
      721 ccggggagaa gctgccatgc ctgagggtct ttgctttccg agaaaccaga gaggtgcggg
      781 gcagctgccg gctgaagggg gacctggggc tgtgtgtggc tgagctggag ctcctgtcca
      841 gctggttcag tgccccgacg gtgggtgccg ggaggaagaa gtccatggac cagccggagg
      901 ggacccctgt ggagctctac tacaccgtgc acccaggaaa cgagcgaggg gactgtgccg
      961 ggggtgactt caggaagggc aacgccatcc gtccaggaaa ggatgggctg gaggaaacca
     1021 cgtcccacct gcagaggatc ggcaccgtcg gcctttaccg ggcccaggac agcgcccagc
     1081 tcagcgagct gcgtttggat ggtaacgtgg tcatctggct gccttccagg ccagtcaagc
     1141 agggagaggt ggtcacggcc tatgtcacca tctcgagcaa ttcctctgtg gacctcttca
     1201 tcttgagagc caaggtgaag aagggggtga acatcctgag tgctcagacc cgtgagcccc
     1261 ggcagtgggg cgtcaagcag gaggtgggca gcggcggaaa gcacgtgacg gccaccgtgg
     1321 cctgccagcg cctggggccc agcccacgca acaggagcag cagtttattc aatgaggttg
     1381 tgcagatgaa ctttgaaata gccagtttca gcagcctttc agggactcag cccatcacgt
     1441 ggcaggtgga gtacccacgg aaggggacca cagacatcgc cgtgtccgag atctttgtca
     1501 gccagaagga cctggtgggc atcgttccct tggctatgga cactgaaatt ctgaacaccg
     1561 ccgtactcac aggaaagaca gttgccatgc ctatcaaggt ggtctctgtg gaggagaaca
     1621 gtgccgtgat ggacatctca gagtcggtgg agtgcaagtc cacagacgag gacgttatca
     1681 aagtgtctga gcgctgtgac tacatctttg tcaatggcaa agagatcaaa ggaaagatgg
     1741 atgcggtggt gaacttcaca taccagtacc tgagcgcccc cctgtgtgtc accgtgtggg
     1801 tgccccggct gcccctgcag atcgaggtct ctgacacgga gctcagccag ataaagggct
     1861 ggagggtccc cattgtgacc aataagaggc ccactcgtga gagcgaggat gaggacgagg
     1921 aggagcggcg gggccggggc tgcgcactgc aataccagca cgccaccgtg cgggtcctca
     1981 cccagtttgt gtctgagggc gccggtccat ggggccagcc gaactacctg cttagtccta
     2041 actggcagtt cgacatcact cacctggtgg cagacttcat gaagctggag gaacctcacg
     2101 tggccaccct ccaggacagc cgggtcctgg ttgggcgaga ggttgggatg acgaccatcc
     2161 aggtgttgtc tccactgtct gactccatcc tggcagagaa gacaataacc gtgctagatg
     2221 acaaagtatc ggtgacagac ttggccatcc agctcgtggc tgggctgtct gtcgcccttt
     2281 accccaacgc agaaaacagc aaggccgtaa cagctgtggt cacagctgag gaggtgctgc
     2341 ggacccccaa acaggaggct gtattcagca cgtggctgca gttcagtgat ggctctgtga
     2401 cgcccctgga catctacgac accaaggact tctccctggc agccacctcc caggacgagg
     2461 ctgtcgtgtc agtcccccag ccccgctctc ccaggtggcc cgttgtggtg gccgaagggg
     2521 aaggccaggg cccactgatc cgagtggaca tgacgatcgc cgaggcctgc cagaaatcta
     2581 aacgcaagag catcctggct gtgggcgtcg gcaacgtcag ggtcaagttc ggacagaacg
     2641 atgctgactc cagccccggc ggggactatg aggaagatga gatcaagaac cacgccagcg
     2701 accgccggca gaagggccag caccatgagc gcacaggcca agatgggcac ctctatggca
     2761 gctctcccgt ggagcgtgag gaaggggctc tccgaagagc cactaccacg gccaggtccc
     2821 tgctggacaa caaagtggtg aagaacagtc gggcagacgg gggcaggctg gcaggagagg
     2881 ggcagctgca gaacatcccc attgacttca ccaacttccc tgcccacgtg gacctcccca
     2941 aggccgggag tgggctggag gaaaacgacc tggtgcagac tccgcggggc ctgagtgatc
     3001 tggagatagg gatgtacgcc ctcctggggg tgttctgcct ggccatcctc gtcttcctga
     3061 tcaactgcgc cacctttgcc ctgaagtaca ggcacaagca agtgcccctg gaaggtcagg
     3121 cctccatgac ccactctcac gactgggtgt ggcttggcaa tgaggccgaa ctcctggaga
     3181 gcatggggga tgcgccgccg ccccaggacg agcacaccac catcatagac cgcggaccgg
     3241 gggcctgcga ggagagcaac catctcctgc tcaatggtgg ctcccacaag cacgtgcaga
     3301 gccagattca caggtcagcc gactccgggg ggcggcaggg cagagaacag aagcaggacc
     3361 ccctgcactc gcccacctcc aagaggaaga aggtgaaatt taccaccttt accaccatcc
     3421 ccccggacga cagctgcccc acggtgaact ccatcgtcag cagcaatgat gaggacatca
     3481 aatgggtgtg tcaagacgtg gctgtgggtg cccccaagga acttagaaac tatctggaga
     3541 aactcaaaga taaggcttag gcccctctag ccaaagggcc ctgcccagat gccttccttg
     3601 tactggaaac tggcccaagt ggggcagaag gcgttgtcag tggggttaag aagggacggt
     3661 cccagggtcc atgctagacc agttggaaag ttttgaagtc aggaaaagac gtttttgtat
     3721 caagggattt ttagcagtta atggtggtgg atttttaaag gtcaggggaa taaagtctgg
     3781 ggcatgggga gtgcagacca agttactgaa ctgcacaggc aaaattagga aggttatttt
     3841 atgagtcaaa acatactaca gacaagctac caaaaattat ttgttaaaaa atgcaacaag
     3901 acaaataaaa agagaaataa tcatctgttt atatttctaa taaaggagca aaatataaaa
     3961 ataggacctg ctaagagaca ttttccattc taattcacga ttcacttttc caaggacagc
     4021 cttcaactgt caccacacag ctggggggga gtcatttctt aacaagggat gcctcttggg
     4081 atagaactag ggagttttaa atctttactt gatcatcttt tattttcttt tccacttttt
     4141 ccttttttct ctctctctgt gtcctagact tccattgcat ttatatttaa tgtttatttc
     4201 tgagaatcaa gcagtatatt tttcctaaat gaaacataaa ttatattcct attcattaga
     4261 taggttccta ggaacaatgc caattaatcc attgtttaag tagtaacttg aatgtttttc
     4321 tatatccctc cagctttgtt gatagtggcg ggttttgtac aattggaggg agccctcaga
     4381 gccttctggg ggaggagagg aactgtcctt aatccatcac cactaccata gggcaaagcc
     4441 agcaggtgtg gccctgtgag gggctgtaca gacgggatgt ggccaggaga acagagcccc
     4501 acctggacca cctgacccct cgggattcca cccctgtcat cgtggggatg ttcctatatg
     4561 ggagaaagtt gggttaaatc aaaaaagagg ccacgcccag gtgtaatcag agccaacctg
     4621 gtgggcttgg tctatcacaa gacataactg atgctgaaca tgaacaaaga taaaaactgt
     4681 ttggagggtt tttgagttgt ttttcttatg ttgttgggtg gggtatacca gcataaactc
     4741 taaagataaa atctatgtta gattgtcaat caactgtgtt tttgaacagc ataattgtgt
     4801 agcagcacat tgcaaaaatg cattcatcca aagcgacaca tgtggcaacg tagaccacgc
     4861 cagtgaaata agccccttcg tgatcacctg actccagttc tccgtgtgct ccattggctg
     4921 cggctgcagg aggaagatgc ctgacagccc tcatgctctc cgcagggggg cgctcacaaa
     4981 gatgccaggg gtgtttattg tgtttatttt tttaattact aaaatcagta gctaagaaag
     5041 ggtccttgaa gcctcctaac ctgggttgga cctttgaaaa atatatttgt agcacatatt
     5101 atagatggaa agaagaagat atttatttat acctgtgatg ccaattgtca ttaaaaggct
     5161 tttcatggct tgacaa
//
