LOCUS       NM_178031               3498 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens transmembrane protein 132A (TMEM132A), transcript
            variant 2, mRNA.
ACCESSION   NM_178031
VERSION     NM_178031.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3498)
  AUTHORS   Sanchez-Pulido,L. and Ponting,C.P.
  TITLE     TMEM132: an ancient architecture of cohesin and immunoglobulin
            domains define a new family of neural adhesion molecules
  JOURNAL   Bioinformatics 34 (5), 721-724 (2018)
   PUBMED   29088312
REFERENCE   2  (bases 1 to 3498)
  AUTHORS   Oh-hashi,K., Hirata,Y., Koga,H. and Kiuchi,K.
  TITLE     GRP78-binding protein regulates cAMP-induced glial fibrillary
            acidic protein expression in rat C6 glioblastoma cells
  JOURNAL   FEBS Lett 580 (16), 3943-3947 (2006)
   PUBMED   16806201
REFERENCE   3  (bases 1 to 3498)
  AUTHORS   Oh-hashi,K., Naruse,Y., Amaya,F., Shimosato,G. and Tanaka,M.
  TITLE     Cloning and characterization of a novel GRP78-binding protein in
            the rat brain
  JOURNAL   J Biol Chem 278 (12), 10531-10537 (2003)
   PUBMED   12514190
  REMARK    GeneRIF: describes characterization of the rat protein
REFERENCE   4  (bases 1 to 3498)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   5  (bases 1 to 3498)
  AUTHORS   Lee,E., Salic,A. and Kirschner,M.W.
  TITLE     Physiological regulation of [beta]-catenin stability by Tcf3 and
            CK1epsilon
  JOURNAL   J Cell Biol 154 (5), 983-993 (2001)
   PUBMED   11524435
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC028106.1, AP003721.3,
            AL359557.2 and AK000546.1.
            
            On Jun 2, 2019 this sequence version replaced NM_178031.2.
            
            Summary: This gene encodes a protein that is highly similar to the
            rat Grp78-binding protein (GBP). Alternatively spliced transcript
            variants encoding different isoforms have been described. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses a different in-frame
            splice site in the coding region, compared to variant 1. The
            resulting isoform (b) is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1788575.1,
                                           SRR7346977.1848363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453848.7/ ENSP00000405823.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-677               BC028106.1         219-895
            678-708             AP003721.3         34083-34113
            709-1112            BC028106.1         927-1330
            1113-1855           AL359557.2         380-1122
            1856-3079           AK000546.1         1095-2318
            3080-3498           AP003721.3         42995-43413
FEATURES             Location/Qualifiers
     source          1..3498
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..3498
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /note="transmembrane protein 132A"
                     /db_xref="GeneID:54972"
                     /db_xref="HGNC:HGNC:31092"
                     /db_xref="MIM:617363"
     exon            1..274
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..3246
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; GRP78-binding protein; heat shock 70kDa protein
                     5 (glucose-regulated protein, 78kDa) binding protein 1;
                     heat shock 70kDa protein 5 binding protein 1;
                     HSPA5-binding protein 1"
                     /codon_start=1
                     /product="transmembrane protein 132A isoform b precursor"
                     /protein_id="NP_821174.1"
                     /db_xref="CCDS:CCDS44618.1"
                     /db_xref="GeneID:54972"
                     /db_xref="HGNC:HGNC:31092"
                     /db_xref="MIM:617363"
                     /translation="MCARMAGRTTAAPRGPYGPWLCLLVALALDVVRVDCGQAPLDPV
                     YLPAALELLDAPEHFRVQQVGHYPPANSSLSSRSETFLLLQPWPRAQPLLRASYPPFA
                     TQQVVPPRVTEPHQRPVPWDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGSGSLPCA
                     RLHATHPAGTAHQACRFQPSLGACVVELELPSHWFSQASTTRAELAYTLEPAAEGPGG
                     CGSGEENDPGEQALPVGGVELRPADPPQYQEVPLDEAVTLRVPDMPVRPGQLFSATLL
                     LRHNFTASLLTLRIKVKKGLHVTAARPAQPTLWTAKLDRFKGSRHHTTLITCHRAGLT
                     EPDSSPLELSEFLWVDFVVENSTGGGVAVTRPVTWQLEYPGQAPEAEKDKMVWEILVS
                     ERDIRALIPLAKAEELVNTAPLTGVPQHVPVRLVTVDGGGALVEVTEHVGCESANTQV
                     LQVSEACDAVFVAGKESRGARGVRVDFWWRRLRASLRLTVWAPLLPLRIELTDTTLEQ
                     VRGWRVPGPAEGPAEPAAEASDEAERRARGCHLQYQRAGVRFLAPFAAHPLDGGRRLT
                     HLLGPDWLLDVSHLVAPHARVLDSRVASLEGGRVVVGREPGVTSIEVRSPLSDSILGE
                     QALAVTDDKVSVLELRVQPVMGISLTLSRGTAHPGEVTATCWAQSALPAPKQEVALSL
                     WLSFSDHTVAPAELYDRRDLGLSVSAEEPGAILPAEEQGAQLGVVVSGAGAEGLPLHV
                     ALHPPEPCRRGRHRVPLASGTAWLGLPPASTPAPALPSSPAWSPPATEATMGGKRQVA
                     GSVGGNTGVRGKFERAEEEARKEETEAREEEEEEEEEMVPAPQHVTELELGMYALLGV
                     FCVAIFIFLVNGVVFVLRYQRKEPPDSATDPTSPQPHNWVWLGTDQEELSRQLDRQSP
                     GPPKGEGSCPCESGGGGEAPTLAPGPPGGTTSSSSTLARKEAGGRRKRVEFVTFAPAP
                     PAQSPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEELRNYMERIRGSS"
     exon            275..489
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..708
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..1040
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1190
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1386
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1530
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1733
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..2010
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2202
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..3498
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3476..3481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /note="hexamer: AATAAA"
     polyA_site      3498
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /note="major polyA site"
ORIGIN      
        1 actgctcccg ctccattgtc tgggaattgc agccgcgggg cgggcggcgg cggcggcggc
       61 ggcggccggg acccagcggg ccaggtgggg acggcgcgga gcgggtgcgg gagatgccgt
      121 gcgggactgg ggccacctga gccgcccgcc tcgtccccgc cttctgtggg aaggatgtgc
      181 gcgcggatgg ccggtcgcac aacagcggcc cctcgggggc cctacggccc ctggctctgc
      241 ctcctggtgg ccctcgccct ggacgtcgtg agagtggact gtggccaggc tcccctggac
      301 cctgtctacc tgccggcagc cctggagctc ctagacgccc ctgaacactt ccgtgtgcag
      361 caggtgggcc actacccacc tgccaactcc tctctgagct cccgatctga gacctttctg
      421 ctcctacagc cctggcccag ggcccagcca cttctccggg cctcctaccc accttttgcc
      481 actcagcagg tggtcccccc tcgagtcact gagccccacc aacggccagt cccatgggac
      541 gtgcgggccg tttcagtgga agcggctgtg actccagcag agccctacgc ccgggttctc
      601 ttccacctca aagggcagga ttggccacca gggtctggca gcctgccctg tgcccggctc
      661 catgccacac accctgccgg cactgctcac caagcctgcc gcttccagcc atccctgggc
      721 gcctgcgtgg tggagctgga gcttccctcg cactggttct cacaggcctc caccacacgg
      781 gccgagctgg cctacacgct tgagcctgca gctgagggcc ctgggggctg tggctccggc
      841 gaggagaacg accctgggga gcaggccctc ccagtggggg gtgtggagct gcgcccagca
      901 gaccccccgc agtaccagga ggtacctctg gacgaggctg tgactctgcg ggtgcctgac
      961 atgccagtgc ggcccggcca gctctttagt gctaccctcc tgcttcggca caacttcaca
     1021 gccagcctcc tgaccctgcg gatcaaggtg aagaaggggc tgcatgtgac agccgcccgc
     1081 ccagcccagc ccacactctg gactgccaag ctggaccgct tcaagggctc caggcaccac
     1141 accaccctca tcacctgcca ccgtgctggg ctcacagagc cagattccag tccccttgaa
     1201 ctgtctgagt tcctatgggt ggactttgtg gtggagaata gcactggtgg gggcgtagcg
     1261 gtcactcgcc ccgtcacgtg gcagctggag tacccaggcc aggcccctga agcagagaag
     1321 gacaaaatgg tgtgggaaat cctggtgtct gagcgggaca tcagagccct tatcccactg
     1381 gccaaggctg aggagctggt gaatacagca ccactgactg gagtgcccca gcatgtcccc
     1441 gtgcgccttg tcactgtgga cggcgggggg gccttggtgg aggtgacaga gcatgtcggc
     1501 tgcgagtctg ccaacacaca ggtcctgcag gtgtctgagg cctgtgatgc cgtgttcgtg
     1561 gctggcaagg agagccgggg cgcccggggg gtgcgagtgg acttctggtg gcgccggctc
     1621 cgcgcctcgc tgcggctgac cgtgtgggcc cccctgctac cgctgcgtat cgagctcacc
     1681 gacaccaccc tcgagcaggt ccgcggctgg agggtacctg gccctgctga agggcctgcg
     1741 gaacccgctg cagaggcgtc ggatgaggcc gagcggcgcg cccgtggctg ccacctgcag
     1801 taccagcggg ccggtgtgcg cttcctcgcc cccttcgcgg cccacccgct ggacggcggc
     1861 cgccgcctca cgcacctgct tggccccgac tggctgctag acgtgtccca cctcgtggcg
     1921 ccacacgccc gcgtgctgga ctcgcgtgta gcctctctgg agggtggccg tgtcgtggtg
     1981 ggccgggagc ccggtgtcac ctccattgag gtgcgttccc cactgtctga ctccatcctg
     2041 ggggagcagg cgctggctgt gacggacgac aaggtctcag tgctggagct gagggtgcag
     2101 ccagtgatgg gcatctcgct gaccttgagc cggggcactg cccaccccgg ggaggtcaca
     2161 gctacgtgct gggcacagtc agcccttccc gccccaaagc aggaggtggc cctctcccta
     2221 tggctgtcct tctctgatca cactgtggcc ccagctgagc tctacgaccg ccgtgacctg
     2281 ggactgtccg tctcagccga ggagcctggt gccatcctgc cagctgagga gcagggtgcc
     2341 cagctcgggg tggtggtgag tggggcaggc gccgaggggc tgccgctgca tgtggctctg
     2401 cacccgcccg agccctgccg ccggggccgc caccgtgtgc ctctggcctc tggcaccgcc
     2461 tggctggggc tgccccctgc ctccactcca gcccctgctc tcccatccag ccctgcttgg
     2521 agcccaccag ccacagaagc caccatgggt ggtaaacggc aggtggcagg cagtgtcggg
     2581 ggcaacacag gtgtgagggg caagtttgag cgggcagagg aggaggccag gaaggaggag
     2641 accgaagcca gggaggagga ggaggaagag gaggaggaga tggtccctgc ccctcagcat
     2701 gtcactgagc tagagctggg catgtacgcc ctgctgggag tcttctgcgt ggccatcttc
     2761 atcttcttgg tcaatggtgt ggtcttcgtc ctgcgctatc agcgcaaaga acctcccgac
     2821 agtgccactg accccacctc cccccagccc cacaactggg tctggctggg cactgaccag
     2881 gaggaactga gccgccagct ggaccggcag tcccctggcc cgcccaaggg ggaggggagc
     2941 tgcccctgtg agagtggggg aggaggggag gcccctaccc tggcccctgg ccctcctggg
     3001 ggcaccacca gctcctcaag caccctggcc cgaaaggagg ctggggggcg gcggaagcga
     3061 gtagagtttg tgacatttgc gccagcccct ccagcccagt cacctgagga gcctgtaggg
     3121 gcccctgctg tgcagtccat ccttgtggca ggcgaggagg acatccgctg ggtgtgtgag
     3181 gacatggggc tgaaggaccc tgaggagctt cgcaactaca tggagaggat ccggggcagc
     3241 tcctgaccct ccacagccac ctggtcagcc accagctggg gcaacgaggg tggaggtccc
     3301 actgagcctc tcgcctgccc ccgccactcg tctggtgctt gttgatccaa gtcccctgcc
     3361 tggtccccca caaggactcc catccaggcc ccctctgccc tgccccttgt catggaccat
     3421 ggtcgtgagg aagggctcat gccccttatt tatgggaacc atttcattct aacagaataa
     3481 accgagaagg aaaccaga
//
