LOCUS       NM_001131007            5006 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane 131 like (TMEM131L), transcript variant
            1, mRNA.
ACCESSION   NM_001131007
VERSION     NM_001131007.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5006)
  AUTHORS   Szuplewski,S., Maharzi,N., Nelson,E., Alhaj Hussen,K., Mignotte,B.,
            Guenal,I. and Canque,B.
  TITLE     Evolutionary conservation of Notch signaling inhibition by TMEM131L
            overexpression
  JOURNAL   Biochem Biophys Res Commun 486 (4), 909-915 (2017)
   PUBMED   28347816
  REMARK    GeneRIF: These results show that TMEM131L corresponds to an
            evolutionary conserved regulator of the Notch signaling pathway.
REFERENCE   2  (bases 1 to 5006)
  AUTHORS   Low,S.K., Chung,S., Takahashi,A., Zembutsu,H., Mushiroda,T.,
            Kubo,M. and Nakamura,Y.
  TITLE     Genome-wide association study of chemotherapeutic agent-induced
            severe neutropenia/leucopenia for patients in Biobank Japan
  JOURNAL   Cancer Sci 104 (8), 1074-1082 (2013)
   PUBMED   23648065
REFERENCE   3  (bases 1 to 5006)
  AUTHORS   Maharzi,N., Parietti,V., Nelson,E., Denti,S., Robledo-Sarmiento,M.,
            Setterblad,N., Parcelier,A., Pla,M., Sigaux,F., Gluckman,J.C. and
            Canque,B.
  TITLE     Identification of TMEM131L as a novel regulator of thymocyte
            proliferation in humans
  JOURNAL   J Immunol 190 (12), 6187-6197 (2013)
   PUBMED   23690469
  REMARK    GeneRIF: these data indicate that, during thymopoiesis,
            stage-specific surface translocation of TMEM131L may regulate
            immature single-positive thymocyte proliferation arrest
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK092270.1, AK308448.1, AK096538.1 and BC044932.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001131007.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.113328.1,
                                           SRR1803611.115260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409959.8/ ENSP00000386787.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-549               AK092270.1         12-560
            550-626             AK308448.1         550-626
            627-3200            AK092270.1         638-3211
            3201-5003           AK096538.1         1032-2834
            5004-5006           BC044932.1         4297-4299
FEATURES             Location/Qualifiers
     source          1..5006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..5006
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /note="transmembrane 131 like"
                     /db_xref="GeneID:23240"
                     /db_xref="HGNC:HGNC:29146"
                     /db_xref="MIM:616243"
     exon            1..162
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..4871
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="transmembrane protein 131-like isoform 1
                     precursor"
                     /protein_id="NP_001124479.1"
                     /db_xref="CCDS:CCDS47148.1"
                     /db_xref="GeneID:23240"
                     /db_xref="HGNC:HGNC:29146"
                     /db_xref="MIM:616243"
                     /translation="MAGLRRPQPGCYCRTAAAVNLLLGVFQVLLPCCRPGGAQGQAIE
                     PLPNVVELWQAEEGELLLPTQGDSEEGLEEPSQEQSFSDKLFSGKGLHFQPSVLDFGI
                     QFLGHPVAKILHAYNPSRDSEVVVNSVFAAAGHFHVPPVPCRVIPAMGKTSFRIIFLP
                     TEEGSIESSLFINTSSYGVLSYHVSGIGTRRISTEGSAKQLPNAYFLLPKVQSIQLSQ
                     MQAETTNTSLLQVQLECSLHNKVCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEEN
                     TQHLLDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEP
                     VLLPTSTTNFTKIASFTCKAATSCDSGIIEDVKKTTHTPTLKACLFSSVAQGYFRMDS
                     SATQFHIETHENTSGLWSIWYRNHFDRSVVLNDVFLSKETKHMLKILNFTGPLFLPPG
                     CWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSAPTKEGSLGFEVIAHCGM
                     HYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVLGTTRF
                     AHLKKSKESESFVFFLPRLIAEPGLMLNFSATALRSRMIKYFVVQNPSSWPVSLQLLP
                     LSLYPKPEALVHLLHRWFGTDMQMINFTTGEFQLTEACPYLGTHSEESRFGILHLHLQ
                     PLEMKRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGS
                     LRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSLKINGYNCQGYGFE
                     VLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLP
                     LCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNASSSS
                     QQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRIQNAAKRSPATY
                     GHSQKKHKCSVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDICTDAMRENW
                     ISLRYASGINVNLQKNLTLPKNLLNKEENTLKNTIVFSNPSSECSMKEGIQTCMFPKE
                     TDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYHQPDLPEISRKNNGNNQQVP
                     VKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKRE
                     GNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCIQ
                     ESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCGSSSGSVRASR
                     GSWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVN
                     SLPQYAEPSCPSLPAGPTGVEEDKGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQE
                     SAPVHNSFIDWSATCEGQFSSAYCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDH
                     NSQSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAPQSDVYENCCPI
                     NPTTEHSTHMENQAVVCKEYYPGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV
                     "
     exon            163..233
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            234..277
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            278..346
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            347..470
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            471..587
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            588..698
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            699..776
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            777..930
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            931..989
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1098
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1195
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1349
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1520
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1590
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1708
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1850
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1960
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2033
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2161
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2304
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2491
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2677
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2827
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..3456
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3605
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3730
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            3731..3897
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..4083
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4162
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4245
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            4246..4366
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..4455
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            4456..4595
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     exon            4596..5006
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4898..4903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /note="hexamer: AATAAA"
     polyA_site      4919
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
     regulatory      4988..4993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /note="hexamer: AATAAA"
     polyA_site      5006
                     /gene="TMEM131L"
                     /gene_synonym="KIAA0922"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcggcg agcaacggag aggagcgcga gcagcagcat ggcggggctc cgacgcccgc
       61 agcccggctg ctactgccgc accgcggcgg ccgtgaacct cctgctgggc gtcttccagg
      121 tcctgctgcc ctgctgtcgc ccgggagggg ctcagggaca agcgattgag ccgttgccga
      181 acgtggtgga gctgtggcag gcagaagaag gggaactcct gctgcccact cagggtgatt
      241 ctgaagaggg tctggaggag ccttctcaag aacagagctt ctcggacaaa ctatttagtg
      301 gaaaaggctt acattttcag ccatcagttt tagattttgg aatacagttc ctgggacatc
      361 ctgtagcaaa gattctccat gcttacaacc ctagtaggga cagcgaggtt gtggtgaatt
      421 cagtgtttgc agctgctgga catttccatg taccgccagt tccctgcagg gtaattccag
      481 caatggggaa aacttccttc agaattattt tcttacctac tgaagaagga agcattgaaa
      541 gttccttatt tattaatacc tcttcgtatg gagtcctttc ctatcatgta tctggaattg
      601 gcactcgtag aatctctaca gaagggtctg caaagcagct accaaatgct tattttctgc
      661 ttccaaaggt ccagagcatt cagctgtctc aaatgcaggc agaaaccact aatactagcc
      721 tcttgcaggt gcaactggaa tgcagtttac ataataaagt gtgtcagcaa ttaaagggtt
      781 gttatctgga atctgatgat gttttgcgtc tacaaatgag cataatggta acaatggaaa
      841 acttttcaaa agaatttgaa gaaaacacac aacatttgtt agatcatctc tctattgttt
      901 acgtagctac agatgaatct gagacctcag atgattcagc agtaaatatg tatatattac
      961 attcaggaaa cagccttata tggatacagg atatacgcca tttctcacag agagatgctc
     1021 tgtctctgca gtttgaacca gtactactac ctacttctac aacaaacttt acaaaaattg
     1081 cttcttttac ctgcaaagca gctacatcat gtgacagtgg aattatagaa gatgtgaaga
     1141 aaacaacaca cactccaaca ctaaaagcat gcctcttctc ttctgtggct caggggtatt
     1201 ttagaatgga ctcttctgca acccagtttc acatagagac tcatgagaac acatcaggac
     1261 tttggtcaat atggtaccgc aaccattttg accgtagtgt tgtattaaat gatgtgtttc
     1321 tttccaagga gaccaagcac atgttaaaga ttctgaattt cactggccct ttatttctac
     1381 ctccaggctg ttggaatata ttttctttga aacttgctgt taaagacatt gccataaatc
     1441 tattcaccaa tgtatttttg actacaaaca taggtgccat ttttgcaata cctctacaga
     1501 tttattcagc accaaccaag gaagggagtc tgggttttga agtgatagca cattgtggca
     1561 tgcattattt catgggaaaa tcaaaagcag gaaatcctaa ttggaatggg agcctttctc
     1621 tggatcaatc tacctggaat gtggattctg aacttgcaaa taaattgtat gaaagatgga
     1681 agaaatataa aaatggtgac gtctgcaaga ggaatgtttt gggaacaact cgatttgctc
     1741 acttgaagaa atccaaggag tcagagtcct ttgttttctt tttgcctcgt ttgatcgcag
     1801 agcctggcct catgttaaac ttcagcgcaa ctgcccttag gagcaggatg atcaagtact
     1861 ttgtggtgca gaacccgtcc tcttggccgg tctccttgca gctcctgcct ctctccttgt
     1921 accctaaacc cgaagcccta gtgcacctgc tccacagatg gtttggcact gatatgcaga
     1981 tgattaattt cacaactggt gaattccagc tcaccgaagc ttgcccttac ctgggtacgc
     2041 attctgagga atccaggttt ggcatcctcc acttacatct gcagcctttg gaaatgaaaa
     2101 gggttggcgt agttttcaca cctgctgact atggaaaagt tacctcactc atactaatcc
     2161 ggaataactt gactgttatt gacatgattg gcgtggaagg atttggagca agagagttat
     2221 taaaagtggg tggaagactt cctggtgcag gaggctcact ccgatttaag gtgcccgagt
     2281 ccacgctgat ggactgccgt agacaactga aagacagtaa gcaaatttta tctattacaa
     2341 agaactttaa agttgagaat attggacctc ttcctataac tgtttcgtct ctgaaaatta
     2401 atgggtataa ctgccaaggt tatggattcg aggtgctgga ttgtcatcag ttttccctgg
     2461 acccaaacac atcccgcgat atcagcattg tgttcactcc agactttacc tcctcctggg
     2521 taattcggga cctaagtctt gtaaccgcag cggacctaga atttcgcttc actctcaatg
     2581 tgactctccc tcatcacctg ttgcccttgt gtgcagacgt ggttccagga cccagctggg
     2641 aggagtcatt ttggaggctc acggtcttct ttgtcagttt gtccctgttg ggtgtgattt
     2701 taatagcctt ccaacaagca cagtacattc tcatggaatt catgaaaaca agacagaggc
     2761 aaaatgctag ctcctcttca cagcaaaaca atggtcctat ggatgtaatc agcccccatt
     2821 cttacaaaag caattgcaag aactttctcg atacatatgg cccctctgat aaaggcaggg
     2881 ggaagaactg ccttccagtg aacactcccc aaagcaggat ccagaatgct gcaaagagga
     2941 gcccagccac ctatggtcat tctcagaaga agcacaaatg ctcagtgtat tacagtaaac
     3001 acaaaaccag cacagctgcg gccagcagca ccagcacgac tactgaggaa aaacagactt
     3061 cacccctggg cagctcactg cctgctgcta aagaggacat ttgcactgat gccatgcgtg
     3121 agaactggat cagcctcaga tatgcaagtg gcataaatgt caacctgcag aagaatttaa
     3181 cccttcccaa aaacttactg aataaagaag aaaacacact gaaaaacaca attgttttca
     3241 gtaatccttc ttcagaatgt agtatgaagg agggaataca gacatgtatg tttcctaagg
     3301 aaactgacat taaaacttca gagaacacag ccgagttcaa ggaacgggag ctctgtccac
     3361 tgaagacctc caagaaacta cctgaaaacc atttaccaag aaactcacct cagtaccacc
     3421 agccagactt gccagaaatt tccaggaaaa ataatgggaa taaccagcaa gtacctgtca
     3481 agaatgaagt agatcattgt gaaaatttga agaaggtgga cacaaagcct tcttcagaaa
     3541 agaagattca caaaacatct agagaagaca tgttttctga gaaacaggac atacctttcg
     3601 tagagcaaga agatccttat aggaagaaaa agcttcagga gaaaagagaa ggaaatttac
     3661 aaaatttaaa ttggagtaaa agtcgaacat gtagaaagaa caagaaaagg ggtgttgctc
     3721 cagtctcaag gcctcctgaa cagagtgatc taaagcttgt gtgcagtgac tttgagaggt
     3781 ctgagctgag cagtgacatc aatgtaagaa gctggtgtat acaggaaagc actagggagg
     3841 tttgtaaagc agatgccgaa attgcaagca gtttacctgc tgcccagaga gaggcagaag
     3901 gttactacca gaagcctgag aagaaatgtg tggacaagtt ctgctccgat tccagctctg
     3961 actgtgggag ctcctctggc agcgtgcgtg ccagccgggg cagctggggg agctggagca
     4021 gcaccagcag ctccgacggg gataagaagc ccatggtgga cgcccagcac ttcctgccgg
     4081 ccggagacag tgtttcacaa aatgattttc cttctgaagc tcccatctcc ttgaatcttt
     4141 ctcataacat ctgcaatccc atgaccgtga atagtctccc acaatacgca gagccttcct
     4201 gtcccagcct tcctgccggg cccacaggtg ttgaagaaga taaaggtctt tactcacctg
     4261 gagacctgtg gcccactccg ccagtgtgtg tgacaagcag cttaaactgc accctggaga
     4321 acggcgtgcc ttgtgtgatt caggagtcgg ccccggttca taatagtttc attgattgga
     4381 gtgcaacatg cgaaggccag ttttccagcg catactgtcc attggaattg aacgattaca
     4441 atgcctttcc agaagaaaac atgaactatg ccaatggctt cccctgtcct gcagatgttc
     4501 agacagactt tattgatcac aactctcagt ctacctggaa caccccaccc aacatgcctg
     4561 ctgcctgggg acatgccagt ttcatcagct ctccgcccta cctcacaagc acccgaagct
     4621 tgtctccaat gtctggactt tttggttcca tctgggcccc gcaaagcgat gtgtatgaaa
     4681 attgctgccc catcaacccc accacggaac attcgaccca catggaaaac caagcggtcg
     4741 tgtgcaagga atactacccg gggttcaacc cgtttcgcgc ctatatgaac ctggacatat
     4801 ggactaccac agcgaatagg aatgcaaatt tcccactgtc tagagactcg agttactgtg
     4861 ggaatgtgtg aaaataattg gatttttaaa caatgtgaat aaagaggctt gtgttttgat
     4921 tactagtgta aactggttat tgagatagat tatgacattg gtggatattt tggcactttt
     4981 atatgaaaat aaatttttta atgaaa
//
