LOCUS       NM_015348               6701 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens transmembrane protein 131 (TMEM131), mRNA.
ACCESSION   NM_015348 XM_371542 XM_939932 XM_944389
VERSION     NM_015348.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6701)
  AUTHORS   Zhang,Z., Bai,M., Barbosa,G.O., Chen,A., Wei,Y., Luo,S., Wang,X.,
            Wang,B., Tsukui,T., Li,H., Sheppard,D., Kornberg,T.B. and Ma,D.K.
  TITLE     Broadly conserved roles of TMEM131 family proteins in intracellular
            collagen assembly and secretory cargo trafficking
  JOURNAL   Sci Adv 6 (7), eaay7667 (2020)
   PUBMED   32095531
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6701)
  AUTHORS   Alves da Silva,A.F., Machado,F.B., Pavarino,E.C.,
            Biselli-Perico,J.M., Zampieri,B.L., da Silva Francisco Junior,R.,
            Mozer Rodrigues,P.T., Terra Machado,D., Santos-Reboucas,C.B., Gomes
            Fernandes,M., Chuva de Sousa Lopes,S.M., Lopes Rios,A.F. and
            Medina-Acosta,E.
  TITLE     Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and
            -Independent Manners
  JOURNAL   PLoS One 11 (4), e0154108 (2016)
   PUBMED   27100087
  REMARK    GeneRIF: A statistically significant loss of methylation at CpG
            dinucleotide sites within the non-syntenic TMEM131 gene is observed
            in individuals with free trisomy 21 (Down syndrome) compared with
            control disomic samples. The loss is independent of the maternal or
            the paternal origin of the chromosome 21 nondisjunction event.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6701)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   4  (bases 1 to 6701)
  AUTHORS   Tscharke,D.C., Wilkinson,R. and Simmons,A.
  TITLE     Use of mRNA differential display to study the action of lymphocyte
            subsets in vivo and application to a murine model of herpes simplex
            virus infection
  JOURNAL   Immunol Lett 74 (2), 127-132 (2000)
   PUBMED   10996388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092591.2, BE327511.1, AK098792.1, D87446.1, AU132630.1 and
            AK025852.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015348.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000186436.10/ ENSP00000186436.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC092591.2         65564-65620         c
            58-110              BE327511.1         266-318             c
            111-519             AK098792.1         95-503
            520-4359            D87446.1           1-3840
            4360-4430           AU132630.1         570-640
            4431-6701           AK025852.1         22-2292
FEATURES             Location/Qualifiers
     source          1..6701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..6701
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /note="transmembrane protein 131"
                     /db_xref="GeneID:23505"
                     /db_xref="HGNC:HGNC:30366"
                     /db_xref="MIM:615659"
     exon            1..473
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..5938
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /note="2610524E03Rik"
                     /codon_start=1
                     /product="transmembrane protein 131 precursor"
                     /protein_id="NP_056163.1"
                     /db_xref="CCDS:CCDS46368.1"
                     /db_xref="GeneID:23505"
                     /db_xref="HGNC:HGNC:30366"
                     /db_xref="MIM:615659"
                     /translation="MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLG
                     ALHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYR
                     GNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQN
                     RKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGA
                     RVPVNSSFSPIINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETK
                     GVMRASFSSREADNHTAFIRIKTNASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTL
                     RTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAITVHFKPITLKASESKYTKVASIS
                     FDASKAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFDHAATLFHIRDSPAD
                     PVERPIYLTNTFSFAILIHDVLLPEEAKTMFKVHNFSKPVLILPNESGYIFTLLFMPS
                     TSSMHIDNNILLITNASKFHLPVRVYTGFLDYFVLPPKIEERFIDFGVLSATEASNIL
                     FAIINSNPIELAIKSWHIIGDGLSIELVAVERGNRTTIISSLPEFEKSSLSDQSSVTL
                     ASGYFAVFRVKLTAKKLEGIHDGAIQITTDYEILTIPVKAVIAVGSLTCFPKHVVLPP
                     SFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYKRLRGNKEDLEPGKKSKIANI
                     YFDPGLQCGDHCYVGLPFLSKSEPKVQPGVAMQEDMWDADWDLHQSLFKGWTGIKENS
                     GHRLSAIFEVNTDLQKNIISKITAELSWPSILSSPRHLKFPLTNTNCSSEEEITLENP
                     ADVPVYVQFIPLALYSNPSVFVDKLVSRFNLSKVAKIDLRTLEFQVFRNSAHPLQSST
                     GFMEGLSRHLILNLILKPGEKKSVKVKFTPVHNRTVSSLIIVRNNLTVMDAVMVQGQG
                     TTENLRVAGKLPGPGSSLRFKITEALLKDCTDSLKLREPNFTLKRTFKVENTGQLQIH
                     IETIEISGYSCEGYGFKVVNCQEFTLSANASRDIIILFTPDFTASRVIRELKFITTSG
                     SEFVFILNASLPYHMLATCAEALPRPNWELALYIIISGIMSALFLLVIGTAYLEAQGI
                     WEPFRRRLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLSCDPGHSRGFCGAGGSSS
                     RPSAGSHKQCGPSVHPHSSHSNRNSADVENVRAKNSSSTSSRTSAQAASSQSANKTSP
                     LVLDSNTVTQGHTAGRKSKGAKQSQHGSQHHAHSPLEQHPQPPLPPPVPQPQEPQPER
                     LSPAPLAHPSHPERASSARHSSEDSDITSLIEAMDKDFDHHDSPALEVFTEQPPSPLP
                     KSKGKGKPLQRKVKPPKKQEEKEKKGKGKPQEDELKDSLADDDSSSTTTETSNPDTEP
                     LLKEDTEKQKGKQAMPEKHESEMSQVKQKSKKLLNIKKEIPTDVKPSSLELPYTPPLE
                     SKQRRNLPSKIPLPTAMTSGSKSRNAQKTKGTSKLVDNRPPALAKFLPNSQELGNTSS
                     SEGEKDSPPPEWDSVPVHKPGSSTDSLYKLSLQTLNADIFLKQRQTSPTPASPSPPAA
                     PCPFVARGSYSSIVNSSSSSDPKIKQPNGSKHKLTKAASLPGKNGNPTFAAVTAGYDK
                     SPGGNGFAKVSSNKTGFSSSLGISHAPVDSDGSDSSGLWSPVSNPSSPDFTPLNSFSA
                     FGNSFNLTGEVFSKLGLSRSCNQASQRSWNEFNSGPSYLWESPATDPSPSWPASSGSP
                     THTATSVLGNTSGLWSTTPFSSSIWSSNLSSALPFTTPANTLASIGLMGTENSPAPHA
                     PSTSSPADDLGQTYNPWRIWSPTIGRRSSDPWSNSHFPHEN"
     exon            474..535
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            536..576
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            577..645
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            646..769
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            770..886
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1009
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1090
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1241
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1298
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1360
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1469
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1578
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1732
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1903
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2014
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2149
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2254
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2341
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2494
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2570
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2688
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2827
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2937
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3004
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3156
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3299
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3486
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3672
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..3831
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..4430
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            4431..4606
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            4607..4734
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            4735..4859
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            4860..5009
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            5010..5175
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            5176..5297
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            5298..5394
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            5395..5492
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            5493..5653
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     exon            5654..6701
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6679..6684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /note="hexamer: AATAAA"
     polyA_site      6701
                     /gene="TMEM131"
                     /gene_synonym="CC28; PRO1048; RW1; YR-23"
                     /note="major polyA site"
ORIGIN      
        1 gctcgcgggc cgtgcccgtt tccagtatgg ccgcccgccg cgcctgaccc gcggcctctc
       61 cgctccgact gcttgtaggc gatgcccagg caaagaccgt gactgacact ctcgctcaca
      121 cgcacgcacg gacccaggcc cacgctcgga gatcgagccc cgggctcgca accgttgtcg
      181 ctcccggcgc cgcggccaga gcccggacca cggcttccgc gccgccgccg cctcgccgag
      241 aagggccgcg ccggacctcg agcgcggcgg cccccggccg gcagggatgg ggaagcgggc
      301 gggaggagga gcaaccggag ccaccaccgc cgccgtctcc acgtccgccg gggccgggct
      361 ggaacctgcg gccgcccgta gcgggggccc gcggagcgcg gccgccggcc tcctaggcgc
      421 gctgcacctg gtgatgaccc tcgtagtggc tgcggcgcgg gccgagaagg aagcattcgt
      481 tcagtcagag agcataatag aagtactgcg ttttgatgat ggagggctac tacagaccga
      541 gacaacactt ggactcagtt catatcagca gaaaagtata tctctctacc gggggaattg
      601 caggcccata cgatttgagc caccaatgct ggatttccat gaacaaccag ttggaatgcc
      661 aaaaatggaa aaagtctact tacataatcc tagttctgaa gaaacgatta ctttagtatc
      721 aatatctgct acaacatcac attttcatgc atcatttttt caaaatagga aaattcttcc
      781 aggaggaaat acatcatttg atgtagtttt tcttgcaaga gtagtaggaa atgtagaaaa
      841 tactttattt attaatacat ctaatcatgg ggtatttact taccaggtat ttggtgttgg
      901 agttccaaat ccatatcgat tgaggccgtt ccttggggcc agagtccctg tgaatagcag
      961 tttctcacct ataataaaca tccacaatcc tcacagtgag cctttacagg ttgtagaaat
     1021 gtactctagt ggaggagacc ttcacctaga actcccaacg ggtcaacaag gaggtaccag
     1081 aaaactgtgg gaaattcctc cttatgaaac caagggagtg atgagagcca gtttttcatc
     1141 tagagaagca gataatcaca cagccttcat aagaataaag actaatgctt cagacagcac
     1201 agagtttatc attcttcctg ttgaggttga agttacaaca gctcctggaa tttattcctc
     1261 aactgaaatg ttagattttg gtacactaag aacacaagat ctaccaaaag ttttaaacct
     1321 tcatttatta aattcaggaa caaaagatgt accaataaca agtgttcgac ctacaccaca
     1381 aaatgatgct ataacggtac actttaaacc aattacatta aaagcatcag aaagtaaata
     1441 caccaaggtt gcaagcatta gttttgatgc atcgaaggca aaaaagccat ctcagttttc
     1501 tgggaaaata acagttaaag caaaggaaaa gagttattct aaacttgaaa taccatatca
     1561 agcagaagtt ttagatggtt atttgggatt tgatcatgct gcaacattat ttcacatccg
     1621 agacagccct gctgatcctg tggaaaggcc aatttacctt actaacactt tcagttttgc
     1681 gatcctcatt cacgatgtgt tgctaccaga agaagccaaa acaatgttta aagttcacaa
     1741 cttcagcaaa ccagtcttaa ttcttcctaa tgaatcagga tacattttta ccctgctttt
     1801 tatgccttcc acatcatcca tgcacattga taacaacatt ttacttatta ccaatgcttc
     1861 taaatttcat ttacccgtgc gggtatacac aggcttttta gattactttg tattgccccc
     1921 caaaatagag gaacgtttca tagattttgg agtactgagt gctacagaag caagtaatat
     1981 tttatttgca attataaaca gcaatccaat tgagttggct ataaaaagtt ggcatatcat
     2041 aggagacggt ttatcaatag aacttgtagc tgtggaaaga ggcaatagaa ctacaataat
     2101 ttcaagcctg ccagagtttg aaaaatcctc tttatcagat caatcatcgg taacattagc
     2161 ttcaggctat tttgcagtct tcagagtcaa acttactgca aaaaaattag aggggattca
     2221 tgatggagcc atccagatca caacagacta tgagatcctg acaatccctg tgaaggctgt
     2281 gattgcagta ggctcactga cctgcttccc taagcacgtg gttcttccac cttcctttcc
     2341 agggaaaata gttcatcaaa gtttaaatat tatgaattcc ttctcacaga aggtaaaaat
     2401 acagcaaata cgatctttgt cagaagatgt gcgattttac tataaacgat tacggggcaa
     2461 taaggaagac ttggagccag gaaaaaaatc aaagattgca aacatttatt ttgatcctgg
     2521 actacagtgt ggggatcatt gctatgttgg cttgcctttt ctatccaaat ctgaacccaa
     2581 agtgcagcct ggtgtagcca tgcaggaaga tatgtgggat gctgactggg atttgcatca
     2641 aagcctgttc aagggatgga caggaataaa ggaaaattca ggtcatagat tgagtgctat
     2701 atttgaagta aatacagacc ttcaaaaaaa tataatatca aaaatcactg ctgagctctc
     2761 ctggccttcc atacttagct caccccggca cttgaaattt ccacttacta atacaaactg
     2821 ctcctcagaa gaagagatta ctttagaaaa tcctgcagat gttcctgtct atgttcagtt
     2881 tattcctctg gctttatatt ccaacccttc agtgtttgta gataagttag tatcaaggtt
     2941 taacttgagt aaggtggcaa agatagattt gagaacacta gaatttcaag tcttcagaaa
     3001 cagtgctcat ccactgcaga gttcaacagg atttatggag ggcctctctc gacatttaat
     3061 tttaaaccta attttaaaac ctggagaaaa gaaatctgtc aaagtaaagt ttactccagt
     3121 tcacaacaga actgtttctt cacttatcat agtcagaaat aacctgactg tgatggatgc
     3181 tgtgatggtc caaggacaag gaacaactga gaacttgagg gtggcaggca agcttccagg
     3241 tccaggaagc tccttacgct ttaaaatcac ggaagcattg ttaaaagatt gtacagatag
     3301 tttaaaacta agagaaccaa atttcacatt gaaaagaaca tttaaggtag agaatacagg
     3361 acaacttcaa attcacatag aaaccattga aatcagtgga tactcatgtg aaggatatgg
     3421 ctttaaagtt gttaattgtc aagagtttac tctaagtgcc aatgcttcta gagatataat
     3481 catattgttt actcctgatt ttacagcttc tagagttatt cgggaactga agtttataac
     3541 aaccagtggc tctgagtttg tatttatatt gaatgcatcc cttccttacc atatgttagc
     3601 aacctgtgca gaagccctac ccagacctaa ctgggaactg gctctgtata tcatcatctc
     3661 aggaataatg agtgcactgt ttcttttggt cattggaaca gcctatttgg aagctcaagg
     3721 aatatgggag ccatttcgaa ggcggctatc ctttgaggcc tcgaacccgc ccttcgatgt
     3781 gggaaggcca tttgatctca ggagaatcgt tggtatttca tctgaaggaa acttgaacac
     3841 actcagctgt gaccccggtc acagtagggg gttctgtgga gcaggcggtt catcatcccg
     3901 acccagtgcc gggagtcata agcagtgtgg cccatcggtc cacccacaca gcagtcacag
     3961 caatagaaac tcagctgacg tggaaaacgt cagagccaaa aacagttcaa gtacctctag
     4021 taggacttct gctcaagcag cttcttcaca gtctgctaac aaaacaagcc cccttgtctt
     4081 agattcgaac acagtgactc aaggtcatac agcgggcaga aagtccaaag gggcaaagca
     4141 gagccagcac ggcagccagc accatgccca cagcccgctg gagcagcacc ctcagcctcc
     4201 tctgccaccg ccagtgcctc agccccagga gccgcagcct gaaaggctgt ctcccgcccc
     4261 cctcgcacac ccttcccacc cagaacgtgc cagcagcgcg aggcacagtt ccgaggactc
     4321 ggacatcacc agtctcatag aagccatgga caaagacttc gaccaccatg actccccagc
     4381 cctagaagtg tttacagagc agcctccatc gccattgcca aaaagcaaag ggaaaggaaa
     4441 acctcttcag cgcaaggtga aaccacctaa gaagcaagag gaaaaggaga agaagggaaa
     4501 gggaaagcca caggaagatg agctgaagga ctctttggct gatgatgata gctcctccac
     4561 caccacagag acctccaacc ctgacacaga accgctcctc aaggaggata cagaaaagca
     4621 aaagggaaaa caagccatgc ctgaaaaaca tgaaagtgaa atgtctcaag tgaagcaaaa
     4681 aagcaaaaaa ctcttaaata ttaagaaaga aatcccaaca gatgtgaaac ccagttcatt
     4741 agaactacca tatactcccc ctttggaaag taagcaacgt agaaatctcc caagcaagat
     4801 tcctcttcca actgcaatga caagtggatc caaatcacga aatgcccaga aaacaaaagg
     4861 tacaagtaag ttagtggata acagaccacc tgccctagca aaattcctcc cgaatagtca
     4921 agaattaggc aacaccagta gctcagaggg tgaaaaagac tctcctccac cggagtggga
     4981 ttccgttcca gttcacaaac ctggcagctc tactgatagt ctttataaac tttctctgca
     5041 aaccctcaac gcagacattt tcttaaaaca acgccagacc tcaccgacac ctgcttcccc
     5101 gtctccccca gctgccccct gcccctttgt ggcccggggc agctacagca gcatcgtcaa
     5161 cagcagctcc agcagtgacc ctaaaataaa acagccaaat ggaagcaaac acaagttgac
     5221 aaaggcagcc tcgctcccgg gcaagaacgg caaccccact tttgctgcag tcacggctgg
     5281 ctacgacaag agcccaggtg ggaatggctt tgctaaagtt tcttcaaaca aaacaggttt
     5341 ctccagcagc cttggcattt cacacgctcc tgttgacagc gatggctcag acagctcggg
     5401 tttgtggagt cccgtcagca acccaagcag ccctgacttc actcccctca attcgttctc
     5461 cgcctttgga aactctttta atctaactgg tgaagttttc agcaaactcg gattatctcg
     5521 atcgtgcaat caggcctcac agaggagctg gaacgagttt aatagtggcc cttcatacct
     5581 ttgggagtcg ccagcgacag atcccagtcc ttcctggcca gccagttccg gctccccgac
     5641 ccacacagcc acatcggtcc tcggtaacac cagcggcctg tggtccacca ctccattcag
     5701 cagctccatt tggtccagca accttagcag cgcccttccc ttcaccactc cagcaaacac
     5761 gctggcaagc atcggcctca tgggcacaga aaactcccct gctcctcacg ctccctccac
     5821 ctccagtcca gctgacgact tgggacagac ctacaacccg tggcggatat ggagccccac
     5881 gattggaaga agaagctcgg acccttggtc taattcgcac tttcctcacg agaattaaat
     5941 taagcaaaaa acaaacaaac atagtgggcc ctcgtctaga tcatgatgtg ccagtttctg
     6001 agacatcttt ttaaggctct tactgcagct cccctcccca ccctcctctt ctttgcaaaa
     6061 cagacccaag cagggcaggc tcagaccact cgcttctttc agatctttct tgcaattatg
     6121 ataacatgag atttgctgtt gtgcttttag agaaaagtct ggactcagcc acaaactcta
     6181 ataagacctg tacatctgag aacctttccc gttactgcgt tttcaccacc tgtcttcccc
     6241 atgctttatt tatctgtatg aacacagatt tgacattaca gctaaggaaa taatttgagt
     6301 tgattcagaa atcctggcat gtgacaattt tgttaaatta ccaagtttgg tttttaataa
     6361 tttctcaata ttatgcgcca agatctaatt ttaaaactgt atgaggactt tgtgctgaaa
     6421 atagagtatt tttttaaagt aaggctgtct tggtttaaaa gcagattaca gaaatgtaag
     6481 tcaacttaag aacggtgaat gaatgtaaaa acattcagtt gagaccatat gcattttctg
     6541 tgctgtttgt acttgaggta tgtaacattt gtatacctga acttatttta aagatgaact
     6601 gaaatgcaca tagccaagtc ttgagataca agattgaatg tgtatttctt aaaaatacaa
     6661 ctttgtgttg tactttgaaa taaatgatgc ttttttcaaa a
//
