LOCUS       NM_152913               2991 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 130 (TMEM130), transcript
            variant 2, mRNA.
ACCESSION   NM_152913
VERSION     NM_152913.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2991)
  AUTHORS   Zhang,Y., Hu,S., Li,J., Shi,D. and Luo,B.
  TITLE     The promoter aberrant methylation status of TMEM130 is associated
            with gastric cancer
  JOURNAL   Dig Liver Dis 54 (6), 819-825 (2022)
   PUBMED   34162508
  REMARK    GeneRIF: The promoter aberrant methylation status of TMEM130 is
            associated with gastric cancer.
REFERENCE   2  (bases 1 to 2991)
  AUTHORS   Liu,H., Xie,H.Q., Zhao,Y., Zhang,W. and Zhang,Y.
  TITLE     DNA methylation-mediated down-regulation of TMEM130 promotes cell
            migration in breast cancer
  JOURNAL   Acta Histochem 123 (8), 151814 (2021)
   PUBMED   34763116
  REMARK    GeneRIF: DNA methylation-mediated down-regulation of TMEM130
            promotes cell migration in breast cancer.
REFERENCE   3  (bases 1 to 2991)
  AUTHORS   Chrystal,P.W., Footz,T., Hodges,E.D., Jensen,J.A., Walter,M.A. and
            Allison,W.T.
  TITLE     Functional Domains and Evolutionary History of the PMEL and GPNMB
            Family Proteins
  JOURNAL   Molecules 26 (12), 3529 (2021)
   PUBMED   34207849
  REMARK    GeneRIF: Functional Domains and Evolutionary History of the PMEL
            and GPNMB Family Proteins.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2991)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2991)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   6  (bases 1 to 2991)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA144530.1, BC030793.1, AL834348.1 and AC095044.3.
            
            On Jun 2, 2019 this sequence version replaced NM_152913.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site at the end of an exon compared to variant 1. The
            resulting isoform (b) has the same N- and C-termini but is shorter
            compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.164679.1,
                                           SRR1803614.181448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339375.9/ ENSP00000341256.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-437               DA144530.1         37-473
            438-879             BC030793.1         443-884
            880-1690            AL834348.1         762-1572
            1691-2991           AC095044.3         132734-134034       c
FEATURES             Location/Qualifiers
     source          1..2991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2991
                     /gene="TMEM130"
                     /note="transmembrane protein 130"
                     /db_xref="GeneID:222865"
                     /db_xref="HGNC:HGNC:25429"
     exon            1..238
                     /gene="TMEM130"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1425
                     /gene="TMEM130"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="transmembrane protein 130 isoform b precursor"
                     /protein_id="NP_690877.1"
                     /db_xref="CCDS:CCDS5658.1"
                     /db_xref="GeneID:222865"
                     /db_xref="HGNC:HGNC:25429"
                     /translation="MAQAVWSRLGRILWLACLLPWAPAGVAAGLYELNLTTDSPATTG
                     AVVTISASLVAKDNGSLALPADAHLYRFHWIHTPLVLTGKMEKGLSSTIRVVGHVPGE
                     FPVSVWVTAADCWMCQPVARGFVVLPITEFLVGDLVVTQNTSLPWPSSYLTKTVLKVS
                     FLLHDPSNFLKTALFLYSWDFGDGTQMVTEDSVVYYNYSIIGTFTVKLKVVAEWEEVE
                     PDATRAVKQKTGDFSASLKLQETLRGIQVLGPTLIQTFQKMTVTLNFLGSPPLTVCWR
                     LKPECLPLEEGECHPVSVASTAYNLTHTFRDPGDYCFSIRAENIISKTHQYHKIQVWP
                     SRIQPAVFAFPCATLITVMLAFIMYMTLRNATQQKDMVENPEPPSGVRCCCQMCCGPF
                     LLETPSEYLEIVRENHGLLPPLYKSVKTYTV"
     exon            239..544
                     /gene="TMEM130"
                     /inference="alignment:Splign:2.1.0"
     exon            545..704
                     /gene="TMEM130"
                     /inference="alignment:Splign:2.1.0"
     exon            705..871
                     /gene="TMEM130"
                     /inference="alignment:Splign:2.1.0"
     exon            872..956
                     /gene="TMEM130"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1159
                     /gene="TMEM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1272
                     /gene="TMEM130"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..2991
                     /gene="TMEM130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2956..2961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM130"
                     /note="hexamer: AATAAA"
     polyA_site      2991
                     /gene="TMEM130"
                     /note="major polyA site"
ORIGIN      
        1 agagcgtccc ccggcgagga cgagcgagca cggcgcccgc acctccccgc accgcccgcg
       61 ctgcgcgccc ggaggagcga ccgccgcagt tctcgagctc cagctgcatt ccctccgcgt
      121 ccgccccacg cttctcccgc tccgggcccc gcaatggccc aggcagtgtg gtcgcgcctc
      181 ggccgcatcc tctggcttgc ctgcctcctg ccctgggccc cggcaggggt ggccgcaggc
      241 ctgtatgaac tcaatctcac caccgatagc cctgccacca cgggagcggt ggtgaccatc
      301 tcggccagcc tggtggccaa ggacaacggc agcctggccc tgcccgctga cgcccacctc
      361 taccgcttcc actggatcca caccccgctg gtgcttactg gcaagatgga gaagggtctc
      421 agctccacca tccgtgtggt cggccacgtg cccggggaat tcccggtctc tgtctgggtc
      481 actgccgctg actgctggat gtgccagcct gtggccaggg gctttgtggt cctccccatc
      541 acagagttcc tcgtggggga ccttgttgtc acccagaaca cttccctacc ctggcccagc
      601 tcctatctca ctaagaccgt cctgaaagtc tccttcctcc tccacgaccc gagcaacttc
      661 ctcaagaccg ccttgtttct ctacagctgg gacttcgggg acgggaccca gatggtgact
      721 gaagactccg tggtctatta taactattcc atcatcggga ccttcaccgt gaagctcaaa
      781 gtggtggcgg agtgggaaga ggtggagccg gatgccacga gggctgtgaa gcagaagacc
      841 ggggacttct ccgcctcgct gaagctgcag gaaacccttc gaggcatcca agtgttgggg
      901 cccaccctaa ttcagacctt ccaaaagatg accgtgacct tgaacttcct ggggagccct
      961 cctctgactg tgtgctggcg tctcaagcct gagtgcctcc cgctggagga aggggagtgc
     1021 caccctgtgt ccgtggccag cacagcgtac aacctgaccc acaccttcag ggaccctggg
     1081 gactactgct tcagcatccg ggccgagaat atcatcagca agacacatca gtaccacaag
     1141 atccaggtgt ggccctccag aatccagccg gctgtctttg ctttcccatg tgctacactt
     1201 atcactgtga tgttggcctt catcatgtac atgaccctgc ggaatgccac tcagcaaaag
     1261 gacatggtgg agaacccgga gccaccctct ggggtcaggt gctgctgcca gatgtgctgt
     1321 gggcctttct tgctggagac tccatctgag tacctggaaa ttgttcgtga gaaccacggg
     1381 ctgctcccgc ccctctataa gtctgtcaaa acttacaccg tgtgagcact ccccctcccc
     1441 accccatctc agtgttaact gactgctgac ttggagtttc cagcagggtg gtgtgcacca
     1501 ctgaccagga ggggttcatt tgcgtggggc tgttggcctg gatcatccat ccatctgtac
     1561 agttcagcca ctgccacaag cccctccctc tctgtcaccc ctgaccccag ccattcaccc
     1621 atctgtacag tccagccact gacataagcc ccactcggtt accaccccct tgacccccta
     1681 cctttgaaga ggcttcgtgc aggactttga tgcttggggt gttccgtgtt gactcccagg
     1741 tgggcctggc tgcccactgc ccattcctct catattggca catctgctgt ccattggggg
     1801 ttctcagttt cctcccccag acagccctac ctgtgccaga gagctagaaa gaaggtcata
     1861 aagggttaaa aatccataac taaaggttgt acacatagat gggcacactc acagagagaa
     1921 gtgtgcatgt acacacacca cacacacaca cacacacaca cacacacaca cacacagaaa
     1981 tataaacaca tgcgtcacat gggcatttca gatgatcagc tctgtatctg gttaagtcgg
     2041 ttgctgggat gcaccctgca ctagagctga aaggaaattt gacctccaag cagccctgac
     2101 aggttctggg cccgggccct ccctttgtgc tttgtctctg cagttcttgc gccctttata
     2161 aggccatcct agtccctgct ggctggcagg gggctggatg gggggcagga ctaatactga
     2221 gtgattgcag agtgctttat aaatatcacc ttattttatc gaaacccatc tgtgaaactt
     2281 tcactgagga aaaggccttg cagcggtaga agaggttgag tcaaggccgg gcgcggtggc
     2341 tcacgcctgt aatcccagca ctttgggagg ccgaggcggg tggatcacga gatcaggaga
     2401 tcgagaccac cctggctaac acggtgaaac cccgtctcta ctaaaaaaat acaaaaagtt
     2461 agccgggcgt ggtggtgggt gcctgtagtc ccagctactc gggaggctga ggcaggagaa
     2521 tggtgcgaac ccgggaggcg gagcttgcag tgagcccaga tggcgccact gcactccagc
     2581 ctgagtgaca gagcgagact ctgtctccaa aaaaaaaaaa agaagaggtt gagtcagcag
     2641 ggacttgggt tccctgtgtg tgaggggggc attcttgcct gccagctgct cccgaggtgg
     2701 ccttgagaag gaagaagcag gatgacagag cctgagcagc ggaaccagcc tgcaccctcc
     2761 cttctggccc agcgacctgg gctgtggctg agacaataat gaggccagaa gtagccggag
     2821 cctgtcagga agggcagggg aggactgtgg ggtctgggct ctgtcgctgt aaccatctgc
     2881 tcccaggctg tgtgcagaaa atggcattta cactattgtg cagctcattc tcatgaaata
     2941 ctgccattgt tgctaaataa agcttgtgtg ctctgaatat agccaagcat a
//
