LOCUS       NM_001297551            1243 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 128 (TMEM128), transcript
            variant 1, mRNA.
ACCESSION   NM_001297551 XM_005248033
VERSION     NM_001297551.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1243)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1243)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1243)
  AUTHORS   Nanayakkara,S., Senevirathna,S.T., Abeysekera,T., Chandrajith,R.,
            Ratnatunga,N., Gunarathne,E.D., Yan,J., Hitomi,T., Muso,E.,
            Komiya,T., Harada,K.H., Liu,W., Kobayashi,H., Okuda,H.,
            Sawatari,H., Matsuda,F., Yamada,R., Watanabe,T., Miyataka,H.,
            Himeno,S. and Koizumi,A.
  TITLE     An integrative study of the genetic, social and environmental
            determinants of chronic kidney disease characterized by
            tubulointerstitial damages in the North Central Region of Sri Lanka
  JOURNAL   J Occup Health 56 (1), 28-38 (2014)
   PUBMED   24351856
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC091482.1, AK296007.1 and BC007729.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001297551.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091482.1, SRR5189652.107937.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382753.5/ ENSP00000372201.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BC091482.1         20-85
            67-67               AK296007.1         67-67
            68-1067             BC091482.1         87-1086
            1068-1243           BC007729.2         1557-1732
FEATURES             Location/Qualifiers
     source          1..1243
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..1243
                     /gene="TMEM128"
                     /note="transmembrane protein 128"
                     /db_xref="GeneID:85013"
                     /db_xref="HGNC:HGNC:28201"
     exon            1..118
                     /gene="TMEM128"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..519
                     /gene="TMEM128"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 128 isoform 1"
                     /protein_id="NP_001284480.1"
                     /db_xref="CCDS:CCDS75099.1"
                     /db_xref="GeneID:85013"
                     /db_xref="HGNC:HGNC:28201"
                     /translation="MDSSRARQQLRRRFLLLPDAEAQLDREGDAGPETSTAVEKKEKP
                     LPRLNIHSGFWILASIVVTYYVDFFKTLKENFHTSSWFLCGSALLLVSLSIAFYCIVY
                     LEWYCGIGEYDVKYPALIPITTASFIAAGICFNIALWHVWSFFTPLLLFTQFMGVVMF
                     ITLLG"
     exon            119..260
                     /gene="TMEM128"
                     /inference="alignment:Splign:2.1.0"
     exon            261..419
                     /gene="TMEM128"
                     /inference="alignment:Splign:2.1.0"
     exon            420..528
                     /gene="TMEM128"
                     /inference="alignment:Splign:2.1.0"
     exon            529..1243
                     /gene="TMEM128"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1222..1227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM128"
                     /note="hexamer: AATAAA"
     polyA_site      1243
                     /gene="TMEM128"
                     /note="major polyA site"
ORIGIN      
        1 gcatttcggg gcggtaccaa gatggactcc tcgcgggccc ggcagcagct ccggcggcga
       61 ttcctcctcc tgccggacgc cgaggcccag ctggaccgcg agggtgacgc cgggccggaa
      121 acctccacag ctgttgagaa aaaggagaaa cctcttccaa gacttaatat ccattctgga
      181 ttctggattt tggcatccat tgttgtgacc tattatgttg acttctttaa aacccttaaa
      241 gaaaacttcc acactagcag ctggtttctc tgtggcagtg ccttgttgct tgtcagttta
      301 tcaattgcat tttactgcat agtctacctg gaatggtatt gtggaattgg agaatatgat
      361 gtcaagtatc cagccttgat acccattacc actgcctcct ttattgcagc aggaatttgc
      421 ttcaacattg ctttatggca tgtgtggtcg tttttcactc cattgttgtt gtttacccag
      481 tttatggggg ttgtcatgtt tatcacactc cttggatgat ttccgaagag acagggtctt
      541 ctatgttgcc caggctgtct ttgaactcct gggatcaagt gatcctcctg cctcagcctt
      601 cgaagtagtt gggactacag gcccacgcca ccgtgcctgg ctggacatgt aaatttgaag
      661 tgaatggtta aacatccagc tagctgaaag catggcagac cctaacagaa aagctacagt
      721 gtgtttttgc agctatgaag tgaatggttt cctggggaaa attgtgactt tgtataactg
      781 ttgttgaaac cagaataaat tatatttcac ttgcatatgc ataaattatt aaaattttca
      841 gaagtcagtg atacagaagt actattttgc aatgttaatc tgtttgagtc tttggagaaa
      901 gtggtttcat tgtaggtaca tagtgcactg ttaatatttt aaacaagtag ttcactcttc
      961 catttaaggg atagcagttc cttgtataaa atgactggat gtgtataaag gaattatgtt
     1021 gtcatgtgcc tttaaccagc tttagtaatt actataatct catatttatg atagttttgt
     1081 taggtgacag gaccaaatga aaatatttta tgttttctca tcactttaga ttttatcatt
     1141 atgtacatta ctgggttttt agcatttcct aatgtgaagt tttaatcact tttaagtata
     1201 catttttttc tgtatcattt aaataaaata tttttataac ttt
//
