LOCUS       NM_144626               1797 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 125 (TMEM125), transcript
            variant 2, mRNA.
ACCESSION   NM_144626
VERSION     NM_144626.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1797)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   2  (bases 1 to 1797)
  AUTHORS   Bonaldo,M.F., Lennon,G. and Soares,M.B.
  TITLE     Normalization and subtraction: two approaches to facilitate gene
            discovery
  JOURNAL   Genome Res 6 (9), 791-806 (1996)
   PUBMED   8889548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093420.2, BI768096.1, BI821566.1 and BM677938.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144626.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279861.4631.1, BI821566.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439858.6/ ENSP00000429775.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC093420.2         84893-84903
            12-71               BI768096.1         1-60
            72-463              BI821566.1         36-427
            464-1770            AC093420.2         87579-88885
            1771-1797           BM677938.1         18-44               c
FEATURES             Location/Qualifiers
     source          1..1797
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..1797
                     /gene="TMEM125"
                     /note="transmembrane protein 125"
                     /db_xref="GeneID:128218"
                     /db_xref="HGNC:HGNC:28275"
     exon            1..103
                     /gene="TMEM125"
                     /inference="alignment:Splign:2.1.0"
     exon            104..216
                     /gene="TMEM125"
                     /inference="alignment:Splign:2.1.0"
     exon            217..372
                     /gene="TMEM125"
                     /inference="alignment:Splign:2.1.0"
     exon            373..1797
                     /gene="TMEM125"
                     /inference="alignment:Splign:2.1.0"
     CDS             518..1177
                     /gene="TMEM125"
                     /codon_start=1
                     /product="transmembrane protein 125"
                     /protein_id="NP_653227.1"
                     /db_xref="CCDS:CCDS480.1"
                     /db_xref="GeneID:128218"
                     /db_xref="HGNC:HGNC:28275"
                     /translation="MSEQEAQAPGGRGLPPDMLAEQVELWWSQQPRRSALCFVVAVGL
                     VAGCGAGGVALLSTTSSRSGEWRLATGTVLCLLALLVLVKQLMSSAVQDMNCIRQAHH
                     VALLRSGGGADALVVLLSGLVLLVTGLTLAGLAAAPAPARPLAAMLSVGIALAALGSL
                     LLLGLLLYQVGVSGHCPSICMATPSTHSGHGGHGSIFSISGQLSAGRRHETTSSIASL
                     I"
     regulatory      1764..1769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM125"
                     /note="hexamer: AATAAA"
     polyA_site      1797
                     /gene="TMEM125"
                     /note="major polyA site"
ORIGIN      
        1 actcaaatcc tgcttcccca gtaggatcca gtctgtgggg ctcatttgag ggagaatgag
       61 cacggggctt ttggaggctg cagcctaggg ccaagggatg gaggctcacc tgagtgcagg
      121 ttaggcaggt gaagtgtctc cccggaaacc aagctagagt gccccacctg ctcggccctg
      181 ccttctcgga tcggatccag cacatccagg cttctcctcc tcccgaggaa ccagtggtga
      241 cagctgaggc catgtgagta ggatcctgaa tgaggcttta tctctggctg ttcgtcccat
      301 cgtccaccgt ggcaccagct ccctcagcca gccgggatgg gaccagcgac tgagagagcc
      361 agaggcagag aggtgagggt gaccatatcc tggactgtga gaggaatggg actctgggcc
      421 tgtagctgcc aagcaggtgg caggtgctcc aggctgtgat ctgaaccctc tgacccctga
      481 cattgacctc ctaccctgac ccctgcctga ccaagccatg tctgaacagg aggctcaagc
      541 cccagggggc cgggggctgc ccccggacat gctggcagag caggtggagc tgtggtggtc
      601 ccagcagccg cggcgctcgg cgctctgctt cgtcgtggcc gtgggcctcg tggcaggctg
      661 tggcgcgggc ggcgtggcac tgctgtcaac caccagcagc cgctcaggtg aatggcggct
      721 agcaacgggc actgtgctct gtttgctggc tctgctggtt ctggtgaaac agctgatgag
      781 ctcggctgtg caggacatga actgcatccg ccaggcccac catgtggccc tgctgcgcag
      841 tggtggaggg gccgacgccc tcgtggtgct gctcagtggc ctcgtgctgc tggtcaccgg
      901 cctgaccctg gccgggctgg ccgccgcccc tgcccctgct cggccgctgg ccgccatgct
      961 gtctgtgggc attgctctgg ctgccttggg ctcgcttttg ctgctgggcc tgctgctgta
     1021 tcaagtgggt gtgagcggac actgcccctc catctgtatg gccactccct ccacccacag
     1081 tggccatggc ggccatggca gcatcttcag catctcagga cagttgtctg ctggccggcg
     1141 tcacgagacc acatccagca ttgccagcct catctgacgg agccagagcc gtccttcttc
     1201 tcacagcggc ctcagcgtcc ccagagccga gccagggtgt gagtgcatgt gaacgttgag
     1261 tacacatgag tgcgtgtatg cccccaggct gggtcagctc ttctgtggat tgcatggcgt
     1321 gtgattaaaa gcccatgtgt tcccacacat ccacatcatg ggaaggttaa tgtgtgcctc
     1381 cttggaactg ggtgttggtg tccatggaac ttcctctctg tatctcaggt cagtaggcgc
     1441 agaaacgcct catgatgaag attcttgagc cccatttcca agacccctca catccaatcc
     1501 tgtcctgtaa catccatcaa ggatttccat aggggtgact ggtgcccacc caagactgca
     1561 ccagtgcctg ctcattgagg agagtaactg ctggccaggc agaaagaata tgggctctgc
     1621 aatgagacag acctggaggg gactctcccg ttgagcacta gcagctggag gagttgggag
     1681 ttcatggcta tcatggttgt gttaatcgat tgtggggatg aaatgtcatt gtgtatggaa
     1741 ggcggggctc atggctgatt ggcaataaaa tggcggctgc cgttgtcatt gtctcca
//
