LOCUS       NM_001320244            1892 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 125 (TMEM125), transcript
            variant 1, mRNA.
ACCESSION   NM_001320244 XM_005270466
VERSION     NM_001320244.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1892)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   2  (bases 1 to 1892)
  AUTHORS   Bonaldo,M.F., Lennon,G. and Soares,M.B.
  TITLE     Normalization and subtraction: two approaches to facilitate gene
            discovery
  JOURNAL   Genome Res 6 (9), 791-806 (1996)
   PUBMED   8889548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093420.2, BI768096.1 and BC072393.1.
            
            On May 31, 2019 this sequence version replaced NM_001320244.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072393.1, DRR138524.618460.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC093420.2         84893-84903
            12-43               BI768096.1         1-32
            44-428              BC072393.1         21-405
            429-828             BI768096.1         323-722
            829-1892            BC072393.1         806-1869
FEATURES             Location/Qualifiers
     source          1..1892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..1892
                     /gene="TMEM125"
                     /note="transmembrane protein 125"
                     /db_xref="GeneID:128218"
                     /db_xref="HGNC:HGNC:28275"
     exon            1..103
                     /gene="TMEM125"
                     /inference="alignment:Splign:2.1.0"
     exon            104..311
                     /gene="TMEM125"
                     /inference="alignment:Splign:2.1.0"
     exon            312..467
                     /gene="TMEM125"
                     /inference="alignment:Splign:2.1.0"
     exon            468..1892
                     /gene="TMEM125"
                     /inference="alignment:Splign:2.1.0"
     CDS             613..1272
                     /gene="TMEM125"
                     /codon_start=1
                     /product="transmembrane protein 125"
                     /protein_id="NP_001307173.1"
                     /db_xref="CCDS:CCDS480.1"
                     /db_xref="GeneID:128218"
                     /db_xref="HGNC:HGNC:28275"
                     /translation="MSEQEAQAPGGRGLPPDMLAEQVELWWSQQPRRSALCFVVAVGL
                     VAGCGAGGVALLSTTSSRSGEWRLATGTVLCLLALLVLVKQLMSSAVQDMNCIRQAHH
                     VALLRSGGGADALVVLLSGLVLLVTGLTLAGLAAAPAPARPLAAMLSVGIALAALGSL
                     LLLGLLLYQVGVSGHCPSICMATPSTHSGHGGHGSIFSISGQLSAGRRHETTSSIASL
                     I"
     regulatory      1859..1864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM125"
                     /note="hexamer: AATAAA"
     polyA_site      1892
                     /gene="TMEM125"
                     /note="major polyA site"
ORIGIN      
        1 actcaaatcc tgcttcccca gtaggatcca gtctgtgggg ctcatttgag ggagaatgag
       61 cacggggctt ttggaggctg cagcctaggg ccaagggatg gaggaatgcc tcagcccagc
      121 agaaggagca gtgccacgtc agccaatcgg ctcaggccct gccctggaaa cgacacctgt
      181 tcatcctcct cccggcaggc tcacctgagt gcaggttagg caggtgaagt gtctccccgg
      241 aaaccaagct agagtgcccc acctgctcgg ccctgccttc tcggatcgga tccagcacat
      301 ccaggcttct cctcctcccg aggaaccagt ggtgacagct gaggccatgt gagtaggatc
      361 ctgaatgagg ctttatctct ggctgttcgt cccatcgtcc accgtggcac cagctccctc
      421 agccagccgg gatgggacca gcgactgaga gagccagagg cagagaggtg agggtgacca
      481 tatcctggac tgtgagagga atgggactct gggcctgtag ctgccaagca ggtggcaggt
      541 gctccaggct gtgatctgaa ccctctgacc cctgacattg acctcctacc ctgacccctg
      601 cctgaccaag ccatgtctga acaggaggct caagccccag ggggccgggg gctgcccccg
      661 gacatgctgg cagagcaggt ggagctgtgg tggtcccagc agccgcggcg ctcggcgctc
      721 tgcttcgtcg tggccgtggg cctcgtggca ggctgtggcg cgggcggcgt ggcactgctg
      781 tcaaccacca gcagccgctc aggtgaatgg cggctagcaa cgggcactgt gctctgtttg
      841 ctggctctgc tggttctggt gaaacagctg atgagctcgg ctgtgcagga catgaactgc
      901 atccgccagg cccaccatgt ggccctgctg cgcagtggtg gaggggccga cgccctcgtg
      961 gtgctgctca gtggcctcgt gctgctggtc accggcctga ccctggccgg gctggccgcc
     1021 gcccctgccc ctgctcggcc gctggccgcc atgctgtctg tgggcattgc tctggctgcc
     1081 ttgggctcgc ttttgctgct gggcctgctg ctgtatcaag tgggtgtgag cggacactgc
     1141 ccctccatct gtatggccac tccctccacc cacagtggcc atggcggcca tggcagcatc
     1201 ttcagcatct caggacagtt gtctgctggc cggcgtcacg agaccacatc cagcattgcc
     1261 agcctcatct gacggagcca gagccgtcct tcttctcaca gcggcctcag cgtccccaga
     1321 gccgagccag ggtgtgagtg catgtgaacg ttgagtacac atgagtgcgt gtatgccccc
     1381 aggctgggtc agctcttctg tggattgcat ggcgtgtgat taaaagccca tgtgttccca
     1441 cacatccaca tcatgggaag gttaatgtgt gcctccttgg aactgggtgt tggtgtccat
     1501 ggaacttcct ctctgtatct caggtcagta ggcgcagaaa cgcctcatga tgaagattct
     1561 tgagccccat ttccaagacc cctcacatcc aatcctgtcc tgtaacatcc atcaaggatt
     1621 tccatagggg tgactggtgc ccacccaaga ctgcaccagt gcctgctcat tgaggagagt
     1681 aactgctggc caggcagaaa gaatatgggc tctgcaatga gacagacctg gaggggactc
     1741 tcccgttgag cactagcagc tggaggagtt gggagttcat ggctatcatg gttgtgttaa
     1801 tcgattgtgg ggatgaaatg tcattgtgta tggaaggcgg ggctcatggc tgattggcaa
     1861 taaaatggcg gctgccgttg tcattgtctc ca
//
