LOCUS       NM_052932               3304 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 123 (TMEM123), mRNA.
ACCESSION   NM_052932
VERSION     NM_052932.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3304)
  AUTHORS   Pesce,E., Cordiglieri,C., Bombaci,M., Eppenberger-Castori,S.,
            Oliveto,S., Manara,C., Crosti,M., Ercan,C., Coto,M., Gobbini,A.,
            Campagnoli,S., Donnarumma,T., Martinelli,M., Bevilacqua,V., De
            Camilli,E., Gruarin,P., Sarnicola,M.L., Cassinotti,E., Baldari,L.,
            Viale,G., Biffo,S., Abrignani,S., Terracciano,L.M. and
            Grifantini,R.
  TITLE     TMEM123 a key player in immune surveillance of colorectal cancer
  JOURNAL   Front Immunol 14, 1194087 (2023)
   PUBMED   37426665
  REMARK    GeneRIF: TMEM123 a key player in immune surveillance of colorectal
            cancer.
            Erratum:[Front Immunol. 2023 Jul 28;14:1256713. doi:
            10.3389/fimmu.2023.1256713.. PMID: 37575239]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3304)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3304)
  AUTHORS   Dabbagh,D., He,S., Hetrick,B., Chilin,L., Andalibi,A. and Wu,Y.
  TITLE     Identification of the SHREK Family of Proteins as Broad-Spectrum
            Host Antiviral Factors
  JOURNAL   Viruses 13 (5), 832 (2021)
   PUBMED   34064525
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3304)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3304)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3304)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 3304)
  AUTHORS   Bonkobara,M., Das,A., Takao,J., Cruz,P.D. and Ariizumi,K.
  TITLE     Identification of novel genes for secreted and membrane-anchored
            proteins in human keratinocytes
  JOURNAL   Br J Dermatol 148 (4), 654-664 (2003)
   PUBMED   12752121
REFERENCE   8  (bases 1 to 3304)
  AUTHORS   Dekker,J., Rossen,J.W., Buller,H.A. and Einerhand,A.W.
  TITLE     The MUC family: an obituary
  JOURNAL   Trends Biochem Sci 27 (3), 126-131 (2002)
   PUBMED   11893509
  REMARK    Review article
REFERENCE   9  (bases 1 to 3304)
  AUTHORS   Ma,F., Zhang,C., Prasad,K.V., Freeman,G.J. and Schlossman,S.F.
  TITLE     Molecular cloning of Porimin, a novel cell surface receptor
            mediating oncotic cell death
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9778-9783 (2001)
   PUBMED   11481458
REFERENCE   10 (bases 1 to 3304)
  AUTHORS   Zhang,C., Xu,Y., Gu,J. and Schlossman,S.F.
  TITLE     A cell surface receptor defined by a mAb mediates a unique type of
            cell death similar to oncosis
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6290-6295 (1998)
   PUBMED   9600958
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB146474.1, BC032296.1,
            AP000942.6 and AL137643.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052932.2.
            
            Summary: This gene encodes a highly glycosylated transmembrane
            protein with a high content of threonine and serine residues in its
            extracellular domain, similar to a broadly defined category of
            proteins termed mucins. Exposure of some cell types to anti-PORIMIN
            (pro-oncosis receptor inducing membrane injury) antibody,
            crosslinks this protein on the cell surface and induces a type of
            cell death termed oncosis. Oncosis is distinct from apoptosis and
            is characterized by a loss of cell membrane integrity without DNA
            fragmentation. This gene product is proposed to function as a cell
            surface receptor that mediates cell death. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.221948.1, AK075420.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1970526 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398136.7/ ENSP00000381204.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                DB146474.1         280-323
            45-968              BC032296.1         11-934
            969-969             AP000942.6         174011-174011       c
            970-3299            BC032296.1         935-3264
            3300-3304           AL137643.1         1536-1540
FEATURES             Location/Qualifiers
     source          1..3304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.2"
     gene            1..3304
                     /gene="TMEM123"
                     /gene_synonym="KCT3; PORIMIN; PORMIN"
                     /note="transmembrane protein 123"
                     /db_xref="GeneID:114908"
                     /db_xref="HGNC:HGNC:30138"
                     /db_xref="MIM:606356"
     exon            1..242
                     /gene="TMEM123"
                     /gene_synonym="KCT3; PORIMIN; PORMIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..769
                     /gene="TMEM123"
                     /gene_synonym="KCT3; PORIMIN; PORMIN"
                     /note="pro-oncosis receptor inducing membrane injury;
                     serine/threonine-rich receptor; keratinocytes associated
                     transmembrane protein 3; KCT-3"
                     /codon_start=1
                     /product="porimin precursor"
                     /protein_id="NP_443164.2"
                     /db_xref="CCDS:CCDS41702.1"
                     /db_xref="GeneID:114908"
                     /db_xref="HGNC:HGNC:30138"
                     /db_xref="MIM:606356"
                     /translation="MGLGARGAWAALLLGTLQVLALLGAAHESAAMAASANIENSGLP
                     HNSSANSTETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTAASNTTTPGM
                     VSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEAKK
                     GSKFDTGSFVGGIVLTLGVLSILYIGCKMYYSRRGIRYRTIDEHDAII"
     exon            243..299
                     /gene="TMEM123"
                     /gene_synonym="KCT3; PORIMIN; PORMIN"
                     /inference="alignment:Splign:2.1.0"
     exon            300..590
                     /gene="TMEM123"
                     /gene_synonym="KCT3; PORIMIN; PORMIN"
                     /inference="alignment:Splign:2.1.0"
     exon            591..744
                     /gene="TMEM123"
                     /gene_synonym="KCT3; PORIMIN; PORMIN"
                     /inference="alignment:Splign:2.1.0"
     exon            745..3304
                     /gene="TMEM123"
                     /gene_synonym="KCT3; PORIMIN; PORMIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3281..3286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM123"
                     /gene_synonym="KCT3; PORIMIN; PORMIN"
                     /note="hexamer: AATAAA"
     polyA_site      3304
                     /gene="TMEM123"
                     /gene_synonym="KCT3; PORIMIN; PORMIN"
                     /note="major polyA site"
ORIGIN      
        1 attcgggggg caagcggcgg gaggggaaac gtgcgcggcc gaaggggaag cggagccggc
       61 gccggctgcg cagaggagcc gctctcgccg ccgccacctc ggctgggagc ccacgaggct
      121 gccgcatcct gccctcggaa caatgggact cggcgcgcga ggtgcttggg ccgcgctgct
      181 cctggggacg ctgcaggtgc tagcgctgct gggggccgcc catgaaagcg cagccatggc
      241 ggcatctgca aacatagaga attctgggct tccacacaac tccagtgcta actcaacaga
      301 gactctccaa catgtgcctt ctgaccatac aaatgaaact tccaacagta ctgtgaaacc
      361 accaacttca gttgcctcag actccagtaa tacaacggtc accaccatga aacctacagc
      421 ggcatctaat acaacaacac cagggatggt ctcaacaaat atgacttcta ccaccttaaa
      481 gtctacaccc aaaacaacaa gtgtttcaca gaacacatct cagatatcaa catccacaat
      541 gaccgtaacc cacaatagtt cagtgacatc tgctgcttca tcagtaacaa tcacaacaac
      601 tatgcattct gaagcaaaga aaggatcaaa atttgatact gggagctttg ttggtggtat
      661 tgtattaacg ctgggagttt tatctattct ttacattgga tgcaaaatgt attactcaag
      721 aagaggcatt cggtatcgaa ccatagatga acatgatgcc atcatttaag gaaatccatg
      781 gaccaaggat ggaatacaga ttgatgctgc cctatcaatt aattttggtt tattaatagt
      841 ttaaaacaat attctctttt tgaaaatagt ataaacaggc catgcatata atgtacagtg
      901 tattacgtaa atatgtaaag attcttcaag gtaacaaggg tttgggtttt gaaataaaca
      961 tctggatcct tatagaccgt tcatacaatg gttttagcaa gttcatagta agacaaacaa
     1021 gtcctatctt tttttttttg gctggggtgg gggcattggt cacatatgac cagtaattga
     1081 aagacgtcat cactgaaaga cagaatgcca tctgggcata caaataagaa gtttgtcaca
     1141 gcactcagga ttttgggtat cttttgtagc tcacataaag aacttcagtg cttttcagag
     1201 ctggatatat cttaattact aatgccacac agaaattata caatcaaact agatctgaag
     1261 cataatttaa gaaaaacatc aacatttttt gtgctttaaa ctgtagtagt tggtctagaa
     1321 acaaaatact ccaagaaaaa gaaaattttc aaataaaacc caaaataata gctttgctta
     1381 gccctgttag ggatccattg gagcattaag gagcacatat ttttattaac ttcttttgag
     1441 ctttcaatgt tgatgtaatt tttgttctct gtgtaattta ggtaaactgc agtgtttaac
     1501 ataataatgt tttaaagact tagttgtcag tattaaataa tcctggcatt atagggaaaa
     1561 aacctcctag aagttagatt atttgctact gtgagaatat tgtcaccact ggaagttact
     1621 ttagttcatt taattttaat tttatatttt gtgaatattt taagaactgt agagctgctt
     1681 tcaatatcta gaaattttta attgagtgta aacacaccta actttaagaa aaagaaccgc
     1741 ttgtatgatt ttcaaaagaa catttagaat tctatagagt caaaactata gcgtaatgct
     1801 gtgtttatta agccagggat tgtgggactt cccccaggca actaaacctg caggatgaaa
     1861 atgctatatt ttctttcatg cactgtcgat attactcaga tttggggaaa tgacattttt
     1921 atactaaaac aaacaccaaa atattttaga ataaattctt agaaagtttt gagaggaatt
     1981 tttagagagg acatttcctc cttcctgatt tggatattcc ctcaaatccc tcctcttact
     2041 ccatgctgaa ggagaagtac tctcagatgc attatgttaa tggagagaaa aagcacagta
     2101 ttgtagagac accaatatta gctaatgtat tttggagtgt tttccatttt acagtttata
     2161 ttccagcact caaaactcag ggtcaagttt taacaaaaga ggtatgtagt cacagtaaat
     2221 actaagatgg catttctatc tcagagggcc aaagtgaatc acaccagttt ctgaaggtcc
     2281 taaaaatagc tcagatgtcc taatgaacat gcacctacat ttaataggag tacaataaaa
     2341 ctgttgtcag cttttgtttt acagagaacg ctagatatta agaattttga aatggatcat
     2401 ttctacttgc tgtgcatttt aaccaataat ctgatgaata tagaaaaaaa tgatccaaaa
     2461 tatggatatg attggatgta tgtaacacat acatggagta tggaggaaat tttctgaaaa
     2521 atacatttag attagtttag tttgaaggag aggtgggctg atggctgagt tgtatgttac
     2581 taacttggcc ctgactggtt gtgcaaccat tgcttcattt ctttgcaaaa tgtagttaag
     2641 atatacttta ttctaatgaa ggccttttaa atttgtccac tgcattcttg gtatttcact
     2701 acttcaagtc agtcagaact tcgtagaccg acctgaagtt tctttttgaa tacttgtttc
     2761 tttagcactt tgaagataga aaaaccactt tttaagtact aagtcatcat ttgccttgaa
     2821 agtttcctct gcattgggtt tgaagtagtt tagttatgtc tttttctctg tatgtaagta
     2881 gtataatttg ttactttcaa atacccgtac tttgaatgta ggtttttttg ttgttgttat
     2941 ctataaaaat tgagggaaat ggttatgcaa aaaaatattt tgctttggac catatttctt
     3001 aagcataaaa aaaatgctca gttttgcttg cattccttga gaatgtattt atctgaagat
     3061 caaaacaaac aatccagatg tataagtact aggcagaagc caattttaaa atttccttga
     3121 ataatccatg aaaggaataa ttcaaataca gataaacaga gttggcagta tattatagtg
     3181 ataattttgt attttcacaa aaaaaaagtt aaactcttct tttcttttta ttataatgac
     3241 cagcttttgg tatttcattg ttaccaagtt ctatttttag aataaaattg ttctccttct
     3301 aaaa
//
