LOCUS       NM_031890               5064 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 121B (TMEM121B), transcript
            variant 1, mRNA.
ACCESSION   NM_031890
VERSION     NM_031890.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5064)
  AUTHORS   Cai,D.C., Fonteijn,H., Guadalupe,T., Zwiers,M., Wittfeld,K.,
            Teumer,A., Hoogman,M., Arias-Vasquez,A., Yang,Y., Buitelaar,J.,
            Fernandez,G., Brunner,H.G., van Bokhoven,H., Franke,B.,
            Hegenscheid,K., Homuth,G., Fisher,S.E., Grabe,H.J., Francks,C. and
            Hagoort,P.
  TITLE     A genome-wide search for quantitative trait loci affecting the
            cortical surface area and thickness of Heschl's gyrus
  JOURNAL   Genes Brain Behav 13 (7), 675-685 (2014)
   PUBMED   25130324
REFERENCE   2  (bases 1 to 5064)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 5064)
  AUTHORS   Footz,T.K., Brinkman-Mills,P., Banting,G.S., Maier,S.A.,
            Riazi,M.A., Bridgland,L., Hu,S., Birren,B., Minoshima,S.,
            Shimizu,N., Pan,H., Nguyen,T., Fang,F., Fu,Y., Ray,L., Wu,H.,
            Shaull,S., Phan,S., Yao,Z., Chen,F., Huan,A., Hu,P., Wang,Q.,
            Loh,P., Qi,S., Roe,B.A. and McDermid,H.E.
  TITLE     Analysis of the cat eye syndrome critical region in humans and the
            region of conserved synteny in mice: a search for candidate genes
            at or near the human chromosome 22 pericentromere
  JOURNAL   Genome Res 11 (6), 1053-1070 (2001)
   PUBMED   11381032
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006946.20, CN365831.1, AF307451.1, BG472529.1, AK055398.1 and
            BQ006940.1.
            
            On May 17, 2019 this sequence version replaced NM_031890.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF307451.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331437.4/ ENSP00000329318.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC006946.20        140837-140873       c
            38-107              CN365831.1         4-73
            108-2102            AF307451.1         1-1995
            2103-2104           BG472529.1         333-334
            2105-4006           AF307451.1         1998-3899
            4007-4295           AK055398.1         1252-1540
            4296-5061           AF307451.1         4190-4955
            5062-5062           BQ006940.1         19-19               c
            5063-5064           AC006946.20        135810-135811       c
FEATURES             Location/Qualifiers
     source          1..5064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.1"
     gene            1..5064
                     /gene="TMEM121B"
                     /gene_synonym="CECR6"
                     /note="transmembrane protein 121B"
                     /db_xref="GeneID:27439"
                     /db_xref="HGNC:HGNC:1844"
     exon            1..5064
                     /gene="TMEM121B"
                     /gene_synonym="CECR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1970
                     /gene="TMEM121B"
                     /gene_synonym="CECR6"
                     /note="isoform a is encoded by transcript variant 1; cat
                     eye syndrome critical region protein 6; cat eye syndrome
                     chromosome region, candidate 6"
                     /codon_start=1
                     /product="transmembrane protein 121B isoform a"
                     /protein_id="NP_114096.1"
                     /db_xref="CCDS:CCDS13740.1"
                     /db_xref="GeneID:27439"
                     /db_xref="HGNC:HGNC:1844"
                     /translation="MRPALGHPRSVSSASGSFPPPPAAARLQPLFLRGGSFRGRRGSG
                     DSSTSTSTSRGGGGGRRGGGGGSPSSSTGAEREDDDESLSVSKPLVPNAALLGPPAQV
                     GAPAGPAPVAFSSSAATSSSTSTPTSSCSMTAADFGGGAAAGAVGGPGSRSAGGAGGT
                     GTGSGASCCPCCCCCGCPDRPGRRGRRRGCAPSPRCRWGYQALSVVLLLAQGGLLDLY
                     LIAVTDLYWCSWIATDLVVVVGWAIFFAKNSRGRRGGAASGAHNHHLHHHHAAPPLHL
                     PAPSAATAGAKARGARGGAGGAGGGLGAAAAAGEFAFAYLAWLIYSIAFTPKVVLILG
                     TSILDLIELRAPFGTTGFRLTMALSVPLLYSLVRAISEAGAPPGSAGPLLLQPQRHRA
                     AGCFLGTCLDLLDSFTLVELMLEGRVPLPAHLRYLLIAVYFLTLASPVLWLYELNAAA
                     AAAASWGQASGPGSCSRLLRLLGGCLVDVPLLALRCLLVVSYQQPLSIFMLKNLFFLG
                     CRGLEALEGCWDRGNRASPSRARGGYGAPPSAPPPPPPPPQGGSQLGHCISENEGGAH
                     GYVNTLAVASQN"
     regulatory      5042..5047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM121B"
                     /gene_synonym="CECR6"
                     /note="hexamer: AATAAA"
     polyA_site      5064
                     /gene="TMEM121B"
                     /gene_synonym="CECR6"
                     /note="major polyA site"
ORIGIN      
        1 gtcttcaccg cggtccgctc ggttcaccgc ctgccccctc tccctgccgc ccggcccggc
       61 tcgcccagtc cagtggctcc agtccggatc tcgccgccgc ccggcccagg tgcgagtccc
      121 cactgctggg gaggcggcgg gccccggctc ccctcggccg cctagcccgc ctcgcccgcc
      181 cggggttggc ggggagggaa cagctgggcg gccccagagc ccctcggagg acaatgcgcc
      241 cggcgctcgg ccaccctcgc tcggtctcct ccgcgtccgg ttccttcccg ccgcccccgg
      301 cagccgcccg gctgcagccc ctcttcctcc gcgggggctc cttccgcggc cggagaggct
      361 ccggcgacag cagcaccagc accagcacca gccgcggggg aggcggcggc agacgcggcg
      421 ggggcggcgg ctccccgagc agcagcacgg gcgccgagcg cgaggacgac gacgagagcc
      481 tcagcgtcag caagccgctg gtgcccaacg ccgcgctcct ggggccgccg gctcaggtgg
      541 gcgcccccgc cggccccgcg cctgtcgcct tctcctcctc agcggccacc tcctcctcca
      601 cctccacgcc cacctcctcc tgcagcatga cagccgcgga cttcggcggg ggcgccgcgg
      661 ccggggccgt cgggggcccc gggagccgct cggcgggggg cgcgggcggc accgggaccg
      721 gcagcggcgc ctcctgctgc ccgtgttgct gctgctgcgg ctgcccagac cgccccggcc
      781 gcagaggtcg gcgccgcggc tgcgccccca gtcccaggtg ccgctggggc taccaggcgc
      841 tgtccgtggt gctgctgctg gcgcagggcg gcctgctgga cctgtacctc atcgccgtca
      901 ccgacctgta ctggtgctcc tggatcgcca ctgacctggt ggtggtggtg ggctgggcca
      961 tcttcttcgc caagaacagc cggggccgtc ggggcggcgc agccagcggc gcgcacaacc
     1021 accacctgca ccaccaccac gccgcgccgc ccctgcatct gcccgccccc tcggccgcta
     1081 ccgctggggc caaggcacgc ggagcccgcg ggggcgccgg cggcgcgggg ggcggcctgg
     1141 gggcggccgc ggcagcgggc gagttcgcct tcgcctacct ggcctggctt atctactcca
     1201 tcgccttcac tcccaaggtg gtgctgatcc tgggcacgtc catcctagac ctcatcgagc
     1261 tacgcgcgcc cttcggcacc acgggcttcc gtctcaccat ggcgctgtcg gtgcccctgc
     1321 tctacagctt ggtgcgggcc atcagcgagg cgggcgcgcc cccgggatcg gcaggacccc
     1381 tgctgctgca gccccagcgg caccgcgcgg ccggatgctt cctgggcacg tgcttggacc
     1441 tgctcgacag cttcacgctg gtggagctga tgctggaggg ccgcgtgccg ctgcccgcgc
     1501 acctgcgcta cctgcttatc gccgtctact tcctcaccct cgcctcgccg gtgctctggc
     1561 tctacgagct caacgccgcg gccgcagcgg ctgcatcctg gggccaggcc tccgggcctg
     1621 gcagctgcag ccgccttctg cgcctgctgg gcggctgcct ggtggacgtg cccttgctgg
     1681 cgctgcgctg cctcctggtg gtcagctacc agcagcccct ctccatcttc atgctcaaga
     1741 acctcttctt cctcggctgc cggggcctgg aggccctgga gggctgctgg gaccggggca
     1801 atcgggcctc cccgagtcgg gccagagggg gctacggtgc tccgccctcc gcccctccac
     1861 cacctccgcc accacctcag ggaggctccc agctgggcca ctgcatctcg gagaacgagg
     1921 ggggtgctca tggctatgtc aacaccctgg ctgtggcctc tcagaattga gggtgaaggg
     1981 cacgggtcct tgtttttggg ttgagagtcc ccaaccccct tgtcttctac cttctgtcac
     2041 ctagatttga tcagggtcta tttggaagag gtaacccttt tcagggctaa gggccagggt
     2101 gttcttctgc accctggggt gaggacggct tggagggaga ccagcagtta acggtgaggg
     2161 aggtaggtgc acttaccctc tcctctcttc tcctatccta ccccaatcct gacctccaag
     2221 gggctggtac ctctgcttct tgctttgccc acctccactc taattcccat ccattaggag
     2281 gagaggggtg ctgggccttg gaccttctcc cttgcttaga agtgccagcc tcttttaggc
     2341 tgtggttagt ggccattgtc ccatgccttg aaattgaccc agaacccact ttccactgat
     2401 gtgtctcttg gatttcttcc aggtgataga tacaaagtgt atgtctctgt gtgtgtagtg
     2461 ttgttttctc gtgtccaccc tgtggccctt tgcaatgggt aggagatctg gggaggccct
     2521 gccccctaca ccatacttat caccaccctc ctcttttctg cctggatttg tgaccatgaa
     2581 ttcccaggaa gagctgggcc cctgggagct gcccaggtac tccccttgaa gggagaatct
     2641 cacccaggat cttcctcaat actgctcctc tcttctcagc tcagggagag gaggggatcc
     2701 attctctaag gaccaaactg caccctttct tgggtgagtg agcatttcta cctccgtgct
     2761 ttcaactttt gttgcatcat gcactgatgc tgcttgcaaa aaatgaagac aaaatactca
     2821 gaagttgcat ttgccatggc cactggctcc agctggggtt tggtgccagt gttattacag
     2881 ggtctgcgga gtatcagcca ttggcttggc ctctctctgt tcctccctct gcacctagaa
     2941 ctcttatcct tcctgtggtt tggtgccgac tgggtcggat ctgggcttag agtaatagct
     3001 ttggtgggtt tcctggatgg atgtgaagtt gggcctccca tgggcccaag ggagtaggaa
     3061 gccccattcc ccacctgtcc ttcctctagg aagtgtagat cagaaagtga ggtggtgacc
     3121 tcccacctct ggtctggtta agagtctcac tagggccaag gcaggctgca gaactttccc
     3181 tcttcctctc attgagggtg atgacaagag acatccgggg actgtgcact tacagtcggt
     3241 gtggaatgtc actcttgcag tctttgaggc aggataagta tttttacata ttttaagggt
     3301 gcaggaggac agcagctaac aaggccagga aatactcact tccctccacc ctcaacagga
     3361 tgtggtgggg gtgaaacttg aagaattttt gtttcccctt ctcccttctt acgtttggga
     3421 agttttatgt agtgtaacaa actctagacg agttaccaga agatgtggat tctagttctg
     3481 attctgtcac tcattggctt tgagtgacat atttttattt cctgggcctg ttttctcaca
     3541 ttaaaaaagt agaagttaga tgagtgatct ctaaggttga aggtaatttc agctctcaca
     3601 ttcttttgag tttgtggctc ttgaaagccc tggtcctgat gctccctgta aaggtggctg
     3661 ggagagaagc cagccaggct gcacttgcag aacattccct gctctgtact gggtgtgtga
     3721 agccccagca gagaaggccg gagggagggc ttgggtgcct gggctgggtg tggggcaggg
     3781 cctggcacag ctgcagagtg cacagggagg gtcagaagtg ccaagtcact ggccgttaac
     3841 tcagcaccca ggccaagccc ccgcctccca cttgaagccc cctcttacaa ctgttttggg
     3901 ggcttggagc agaagacacc cttgtagaca gacataagag gggcagaagg cttgaccaga
     3961 gttctcttga gcctcctcat gctctcagag cagggaacag cgggggaaaa tgtttacact
     4021 ccatgcacaa tctgtgcttc cagtccctca ccctatgtgg cccaatagct ggctggattt
     4081 cacacttaat tggtattttt ttctgccttc ttcccctgcc cccactgact cctctcctct
     4141 ccctttgatt gtactcaagg ttctggggcc tgggccctgg gtgggtacca acagctgctc
     4201 gctgttccca tgtcctctct ccagctttgc tgtgtttctc tgctacctaa tctcagtgac
     4261 tgtgaaagga cattgtgtct gagccatggc cagccgctgg ctggccccct gatctgcccc
     4321 ccttctattg tttggatggc catctcctgc tgggcctccc tgactgtaaa atctctgtac
     4381 tgtttgttag gtttttggtg ggaggctgtg ataagttcca atgagctgcc acttccctgg
     4441 atatgtcaag aagctgatgg caacttggcc aattctggca gatatcaggc ccccagttca
     4501 gccccagtca ccctctttta cacatgtggg tcaaccactg tgtgctcaga gggtcagtcc
     4561 cttcctctgc tgtgtttttc ttgagtcctt gcactcactt cccctgcccc agtcacgatg
     4621 acccctaaag cttcctttgc ccttgctttc tagggcatcc ctagtgaagg ggcaaacctg
     4681 agatttctcc gtggacctga cagccaaggc agggcactgt ctcctgaggc cagtgccagc
     4741 acgtgcatgg ttcacagaaa aggatcctgg gctcagaatc tcgagaaccg cctgctccta
     4801 acaattcagc aagtcagggg cttcctctct gttagtcccc aaatccttac ttattttaaa
     4861 aagactagac cctctctaaa gactgttcca ttttaacatg tcctgattct gcatccgtgg
     4921 gttttgtgaa agagagctag ctggcggtta gagcctggaa gaaggaggga agtggcacct
     4981 cactagcatt tatcactttt ttccttctct ttttaaaaat aaaaccagac tctgttctga
     5041 aaataaaaaa cttgagactt gtga
//
