LOCUS       NM_031925               1398 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 120A (TMEM120A), transcript
            variant 1, mRNA.
ACCESSION   NM_031925
VERSION     NM_031925.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1398)
  AUTHORS   Liu,X., Zhang,R., Fatehi,M., Wang,Y., Long,W., Tian,R., Deng,X.,
            Weng,Z., Xu,Q., Light,P.E., Tang,J. and Chen,X.Z.
  TITLE     Regulation of PKD2 channel function by TACAN
  JOURNAL   J Physiol 601 (1), 83-98 (2023)
   PUBMED   36420836
REFERENCE   2  (bases 1 to 1398)
  AUTHORS   Chen,X., Wang,Y., Li,Y., Lu,X., Chen,J., Li,M., Wen,T., Liu,N.,
            Chang,S., Zhang,X., Yang,X. and Shen,Y.
  TITLE     Cryo-EM structure of the human TACAN in a closed state
  JOURNAL   Cell Rep 38 (9), 110445 (2022)
   PUBMED   35235791
  REMARK    GeneRIF: Cryo-EM structure of the human TACAN in a closed state.
REFERENCE   3  (bases 1 to 1398)
  AUTHORS   Li,S., Qian,N., Jiang,C., Zu,W., Liang,A., Li,M., Elledge,S.J. and
            Tan,X.
  TITLE     Gain-of-function genetic screening identifies the antiviral
            function of TMEM120A via STING activation
  JOURNAL   Nat Commun 13 (1), 105 (2022)
   PUBMED   35013224
  REMARK    GeneRIF: Gain-of-function genetic screening identifies the
            antiviral function of TMEM120A via STING activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1398)
  AUTHORS   Ke,M., Yu,Y., Zhao,C., Lai,S., Su,Q., Yuan,W., Yang,L., Deng,D.,
            Wu,K., Zeng,W., Geng,J., Wu,J. and Yan,Z.
  TITLE     Cryo-EM structures of human TMEM120A and TMEM120B
  JOURNAL   Cell Discov 7 (1), 77 (2021)
   PUBMED   34465718
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1398)
  AUTHORS   Rong,Y., Jiang,J., Gao,Y., Guo,J., Song,D., Liu,W., Zhang,M.,
            Zhao,Y., Xiao,B. and Liu,Z.
  TITLE     TMEM120A contains a specific coenzyme A-binding site and might not
            mediate poking- or stretch-induced channel activities in cells
  JOURNAL   Elife 10, e71474 (2021)
   PUBMED   34409941
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1398)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 1398)
  AUTHORS   Beaulieu-Laroche,L., Christin,M., Donoghue,A., Agosti,F.,
            Yousefpour,N., Petitjean,H., Davidova,A., Stanton,C., Khan,U.,
            Dietz,C., Faure,E., Fatima,T., MacPherson,A.,
            Mouchbahani-Constance,S., Bisson,D.G., Haglund,L., Ouellet,J.A.,
            Stone,L.S., Samson,J., Smith,M.J., Ask,K., Ribeiro-da-Silva,A.,
            Blunck,R., Poole,K., Bourinet,E. and Sharif-Naeini,R.
  TITLE     TACAN Is an Ion Channel Involved in Sensing Mechanical Pain
  JOURNAL   Cell 180 (5), 956-967 (2020)
   PUBMED   32084332
REFERENCE   8  (bases 1 to 1398)
  AUTHORS   Batrakou,D.G., de Las Heras,J.I., Czapiewski,R., Mouras,R. and
            Schirmer,E.C.
  TITLE     TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important
            for Adipocyte Differentiation
  JOURNAL   PLoS One 10 (5), e0127712 (2015)
   PUBMED   26024229
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1398)
  AUTHORS   Cornelis,M.C., Byrne,E.M., Esko,T., Nalls,M.A., Ganna,A.,
            Paynter,N., Monda,K.L., Amin,N., Fischer,K., Renstrom,F.,
            Ngwa,J.S., Huikari,V., Cavadino,A., Nolte,I.M., Teumer,A., Yu,K.,
            Marques-Vidal,P., Rawal,R., Manichaikul,A., Wojczynski,M.K.,
            Vink,J.M., Zhao,J.H., Burlutsky,G., Lahti,J., Mikkila,V.,
            Lemaitre,R.N., Eriksson,J., Musani,S.K., Tanaka,T., Geller,F.,
            Luan,J., Hui,J., Magi,R., Dimitriou,M., Garcia,M.E., Ho,W.K.,
            Wright,M.J., Rose,L.M., Magnusson,P.K., Pedersen,N.L., Couper,D.,
            Oostra,B.A., Hofman,A., Ikram,M.A., Tiemeier,H.W.,
            Uitterlinden,A.G., van Rooij,F.J., Barroso,I., Johansson,I.,
            Xue,L., Kaakinen,M., Milani,L., Power,C., Snieder,H., Stolk,R.P.,
            Baumeister,S.E., Biffar,R., Gu,F., Bastardot,F., Kutalik,Z.,
            Jacobs,D.R. Jr., Forouhi,N.G., Mihailov,E., Lind,L., Lindgren,C.,
            Michaelsson,K., Morris,A., Jensen,M., Khaw,K.T., Luben,R.N.,
            Wang,J.J., Mannisto,S., Perala,M.M., Kahonen,M., Lehtimaki,T.,
            Viikari,J., Mozaffarian,D., Mukamal,K., Psaty,B.M., Doring,A.,
            Heath,A.C., Montgomery,G.W., Dahmen,N., Carithers,T., Tucker,K.L.,
            Ferrucci,L., Boyd,H.A., Melbye,M., Treur,J.L., Mellstrom,D.,
            Hottenga,J.J., Prokopenko,I., Tonjes,A., Deloukas,P., Kanoni,S.,
            Lorentzon,M., Houston,D.K., Liu,Y., Danesh,J., Rasheed,A.,
            Mason,M.A., Zonderman,A.B., Franke,L., Kristal,B.S.,
            Karjalainen,J., Reed,D.R., Westra,H.J., Evans,M.K., Saleheen,D.,
            Harris,T.B., Dedoussis,G., Curhan,G., Stumvoll,M., Beilby,J.,
            Pasquale,L.R., Feenstra,B., Bandinelli,S., Ordovas,J.M., Chan,A.T.,
            Peters,U., Ohlsson,C., Gieger,C., Martin,N.G., Waldenberger,M.,
            Siscovick,D.S., Raitakari,O., Eriksson,J.G., Mitchell,P.,
            Hunter,D.J., Kraft,P., Rimm,E.B., Boomsma,D.I., Borecki,I.B.,
            Loos,R.J., Wareham,N.J., Vollenweider,P., Caporaso,N., Grabe,H.J.,
            Neuhouser,M.L., Wolffenbuttel,B.H., Hu,F.B., Hypponen,E.,
            Jarvelin,M.R., Cupples,L.A., Franks,P.W., Ridker,P.M., van
            Duijn,C.M., Heiss,G., Metspalu,A., North,K.E., Ingelsson,E.,
            Nettleton,J.A., van Dam,R.M. and Chasman,D.I.
  CONSRTM   Coffee and Caffeine Genetics Consortium; International Parkinson's
            Disease Genomics Consortium (IPDGC); North American Brain
            Expression Consortium (NABEC); UK Brain Expression Consortium
            (UKBEC)
  TITLE     Genome-wide meta-analysis identifies six novel loci associated with
            habitual coffee consumption
  JOURNAL   Mol Psychiatry 20 (5), 647-656 (2015)
   PUBMED   25288136
  REMARK    Review article
REFERENCE   10 (bases 1 to 1398)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051850.1, AF327923.1, CX869634.1 and AC006330.5.
            
            On Nov 22, 2018 this sequence version replaced NM_031925.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.152716.1, BC051850.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000493111.7/ ENSP00000473983.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-625               BC051850.1         65-689
            626-1240            AF327923.1         666-1280
            1241-1392           CX869634.1         27-178              c
            1393-1398           AC006330.5         65720-65725
FEATURES             Location/Qualifiers
     source          1..1398
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..1398
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /note="transmembrane protein 120A"
                     /db_xref="GeneID:83862"
                     /db_xref="HGNC:HGNC:21697"
                     /db_xref="MIM:616550"
     exon            1..106
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1057
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein induced by tumor necrosis factor
                     alpha; ion channel TACAN"
                     /codon_start=1
                     /product="transmembrane protein 120A isoform 1"
                     /protein_id="NP_114131.1"
                     /db_xref="CCDS:CCDS64688.1"
                     /db_xref="GeneID:83862"
                     /db_xref="HGNC:HGNC:21697"
                     /db_xref="MIM:616550"
                     /translation="MQPPPPGPLGDCLRDWEDLQQDFQNIQETHRLYRLKLEELTKLQ
                     NNCTSSITRQKKRLQELALALKKCKPSLPAEAEGAAQELENQMKERQGLFFDMEAYLP
                     KKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILILISFTCRFLLNSRVT
                     DAAFNFLLVWYYCTLTIRESILINNGSRIKGWWVFHHYVSTFLSGVMLTWPDGLMYQK
                     FRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALGERHTMDLTVEGFQSWMWRGLTFLL
                     PFLFFGHFWQLFNALTLFNLAQDPQCKEWQVLMCGFPFLLLFLGNFFTTLRVVHHKFH
                     SQRHGSKKD"
     exon            107..225
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /inference="alignment:Splign:2.1.0"
     exon            226..342
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /inference="alignment:Splign:2.1.0"
     exon            343..402
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /inference="alignment:Splign:2.1.0"
     exon            403..498
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /inference="alignment:Splign:2.1.0"
     exon            499..588
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /inference="alignment:Splign:2.1.0"
     exon            589..654
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /inference="alignment:Splign:2.1.0"
     exon            655..716
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /inference="alignment:Splign:2.1.0"
     exon            717..809
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /inference="alignment:Splign:2.1.0"
     exon            810..874
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /inference="alignment:Splign:2.1.0"
     exon            875..943
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1398
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1223..1228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /note="hexamer: AATAAA"
     polyA_site      1240
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /note="major polyA site"
     regulatory      1372..1377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
                     /note="hexamer: AATACA"
     polyA_site      1398
                     /gene="TMEM120A"
                     /gene_synonym="NET29; TACAN; TMPIT"
ORIGIN      
        1 actactggct actggcgctg cagccatgca gcccccgccc ccgggcccgc tgggcgactg
       61 cctgcgggac tgggaggatc tacagcagga cttccagaac atccaggaga cccatcggct
      121 ctaccgcctg aagctggagg agctgaccaa acttcagaac aattgcacca gctccatcac
      181 gcggcagaag aagcggctcc aggagctggc cctcgccctg aagaaatgca aaccctccct
      241 cccagcagag gccgaggggg ccgcacagga gctggagaac cagatgaaag agcgccaagg
      301 cctcttcttt gacatggagg cctatttgcc taagaagaat ggattgtacc tgagcctggt
      361 tctggggaac gtcaacgtca cgctcctgag caagcaggct aagtttgcct acaaggacga
      421 gtatgagaag ttcaagctct acctcaccat catcctcatc ctcatctcct tcacttgccg
      481 cttcctgctc aactccaggg tgacagatgc tgccttcaac ttcctgctgg tctggtacta
      541 ctgcaccctg accatccggg agagcatcct catcaacaac ggctcccgga tcaaaggctg
      601 gtgggtgttc catcactacg tgtccacctt cctgtcggga gtcatgctga cgtggcccga
      661 cggtctcatg taccagaaat tccggaacca attcctctcc ttttccatgt accagagctt
      721 cgtgcagttt ctccagtact actaccagag cggctgcctc taccgcctgc gggcgctggg
      781 cgagcggcac accatggacc tcactgtgga gggcttccag tcctggatgt ggcggggcct
      841 caccttcctg ctgccttttc ttttctttgg acacttctgg cagcttttta acgcgctgac
      901 gttgttcaac ctggcccagg accctcagtg caaggagtgg caggtgctta tgtgcggctt
      961 tcccttcctc ctccttttcc tcggcaattt cttcaccacc ctgagggttg tgcaccacaa
     1021 gtttcacagt cagcggcacg ggagcaagaa ggattgaggc tgggccttcc cctgccggcc
     1081 cagaggggct tctgtcctgt gtgttgtggg aggggatggg aggcgcccct cgagtgtgcg
     1141 tgtatcaggg ggtctcttct attctccctt gggttttatg ggcgctgtgg gccctgaagg
     1201 aagacctggg cccagtgccc tcaataaaga gaggcccaga ggtggcctga gcgtgtgtgt
     1261 tctcctgggg gaggggaggg ctgggtggcc ccaccacatg ggttcctggg gtctgagtta
     1321 gttaagttga tgcaggtgga ggtcccagat ctactcacac aataccaggc aaatacagaa
     1381 aacagaactt tattccaa
//
