LOCUS       NM_181724               2662 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens transmembrane protein 119 (TMEM119), mRNA.
ACCESSION   NM_181724
VERSION     NM_181724.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2662)
  AUTHORS   Xu,M., Wang,D., Li,K., Ma,T., Wang,Y. and Xia,B.
  TITLE     TMEM119 (c.G143A, p.S48L) Mutation Is Involved in Primary Failure
            of Eruption by Attenuating Glycolysis-Mediated Osteogenesis
  JOURNAL   Int J Mol Sci 25 (5), 2821 (2024)
   PUBMED   38474068
  REMARK    GeneRIF: TMEM119 (c.G143A, p.S48L) Mutation Is Involved in Primary
            Failure of Eruption by Attenuating Glycolysis-Mediated
            Osteogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2662)
  AUTHORS   Yang,B., Wang,F. and Zheng,G.
  TITLE     Transmembrane protein TMEM119 facilitates the stemness of breast
            cancer cells by activating Wnt/beta-catenin pathway
  JOURNAL   Bioengineered 12 (1), 4856-4867 (2021)
   PUBMED   34334123
  REMARK    GeneRIF: Transmembrane protein TMEM119 facilitates the stemness of
            breast cancer cells by activating Wnt/beta-catenin pathway.
REFERENCE   3  (bases 1 to 2662)
  AUTHORS   Sun,T., Bi,F., Liu,Z. and Yang,Q.
  TITLE     TMEM119 facilitates ovarian cancer cell proliferation, invasion,
            and migration via the PDGFRB/PI3K/AKT signaling pathway
  JOURNAL   J Transl Med 19 (1), 111 (2021)
   PUBMED   33731124
  REMARK    GeneRIF: TMEM119 facilitates ovarian cancer cell proliferation,
            invasion, and migration via the PDGFRB/PI3K/AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2662)
  AUTHORS   Bohnert,S., Seiffert,A., Trella,S., Bohnert,M., Distel,L.,
            Ondruschka,B. and Monoranu,C.M.
  TITLE     TMEM119 as a specific marker of microglia reaction in traumatic
            brain injury in postmortem examination
  JOURNAL   Int J Legal Med 134 (6), 2167-2176 (2020)
   PUBMED   32719959
  REMARK    GeneRIF: TMEM119 as a specific marker of microglia reaction in
            traumatic brain injury in postmortem examination.
REFERENCE   5  (bases 1 to 2662)
  AUTHORS   van Wageningen,T.A., Vlaar,E., Kooij,G., Jongenelen,C.A.M.,
            Geurts,J.J.G. and van Dam,A.M.
  TITLE     Regulation of microglial TMEM119 and P2RY12 immunoreactivity in
            multiple sclerosis white and grey matter lesions is dependent on
            their inflammatory environment
  JOURNAL   Acta Neuropathol Commun 7 (1), 206 (2019)
   PUBMED   31829283
  REMARK    GeneRIF: Regulation of microglial TMEM119 and P2RY12
            immunoreactivity in multiple sclerosis white and grey matter
            lesions is dependent on their inflammatory environment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2662)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2662)
  AUTHORS   Mizuhashi,K., Kanamoto,T., Ito,M., Moriishi,T., Muranishi,Y.,
            Omori,Y., Terada,K., Komori,T. and Furukawa,T.
  TITLE     OBIF, an osteoblast induction factor, plays an essential role in
            bone formation in association with osteoblastogenesis
  JOURNAL   Dev Growth Differ 54 (4), 474-480 (2012)
   PUBMED   22416756
REFERENCE   8  (bases 1 to 2662)
  AUTHORS   Hisa,I., Inoue,Y., Hendy,G.N., Canaff,L., Kitazawa,R., Kitazawa,S.,
            Komori,T., Sugimoto,T., Seino,S. and Kaji,H.
  TITLE     Parathyroid hormone-responsive Smad3-related factor, Tmem119,
            promotes osteoblast differentiation and interacts with the bone
            morphogenetic protein-Runx2 pathway
  JOURNAL   J Biol Chem 286 (11), 9787-9796 (2011)
   PUBMED   21239498
REFERENCE   9  (bases 1 to 2662)
  AUTHORS   Kanamoto,T., Mizuhashi,K., Terada,K., Minami,T., Yoshikawa,H. and
            Furukawa,T.
  TITLE     Isolation and characterization of a novel plasma membrane protein,
            osteoblast induction factor (obif), associated with osteoblast
            differentiation
  JOURNAL   BMC Dev Biol 9, 70 (2009)
   PUBMED   20025746
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2662)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL521683.3, DC349145.1, BC096825.1 and ES311302.1.
            
            On Nov 23, 2018 this sequence version replaced NM_181724.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096825.1, SRR3476690.412095.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392806.4/ ENSP00000376553.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL521683.3         41-51
            12-261              DC349145.1         12-261
            262-1309            BC096825.1         207-1254
            1310-1310           ES311302.1         55-55
            1311-2662           BC096825.1         1256-2607
FEATURES             Location/Qualifiers
     source          1..2662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..2662
                     /gene="TMEM119"
                     /gene_synonym="OBIF"
                     /note="transmembrane protein 119"
                     /db_xref="GeneID:338773"
                     /db_xref="HGNC:HGNC:27884"
                     /db_xref="MIM:618989"
     exon            1..115
                     /gene="TMEM119"
                     /gene_synonym="OBIF"
                     /inference="alignment:Splign:2.1.0"
     exon            116..2662
                     /gene="TMEM119"
                     /gene_synonym="OBIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..981
                     /gene="TMEM119"
                     /gene_synonym="OBIF"
                     /note="osteoblast induction factor"
                     /codon_start=1
                     /product="transmembrane protein 119 precursor"
                     /protein_id="NP_859075.2"
                     /db_xref="CCDS:CCDS9119.1"
                     /db_xref="GeneID:338773"
                     /db_xref="HGNC:HGNC:27884"
                     /db_xref="MIM:618989"
                     /translation="MVSAAAPSLLILLLLLLGSVPATDARSVPLKATFLEDVAGSGEA
                     EGSSASSPSLPPPWTPALSPTSMGPQPITLGGPSPPTNFLDGIVDFFRQYVMLIAVVG
                     SLAFLLMFIVCAAVITRQKQKASAYYPSSFPKKKYVDQSDRAGGPRAFSEVPDRAPDS
                     RPEEALDSSRQLQADILAATQNLKSPTRAALGGGDGARMVEGRGAEEEEKGSQEGDQE
                     VQGHGVPVETPEAQEEPCSGVLEGAVVAGEGQGELEGSLLLAQEAQGPVGPPESPCAC
                     SSVHPSV"
     regulatory      2644..2649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM119"
                     /gene_synonym="OBIF"
                     /note="hexamer: AATAAA"
     polyA_site      2662
                     /gene="TMEM119"
                     /gene_synonym="OBIF"
                     /note="major polyA site"
ORIGIN      
        1 aggcgccagc ccagagcagc cccgggcacc agcacggact ctctcttcca gcccaggtgc
       61 cccccactct cgctccattc ggcgggagca cccagtcctg tacgccaagg aactggtcct
      121 gggggcacca tggtttcggc ggcagccccc agcctcctca tccttctgtt gctgctcctg
      181 gggtctgtgc ctgctaccga cgcccgctct gtgcccctga aggccacgtt cctggaggat
      241 gtggcgggta gtggggaggc cgagggctcg tcggcctcct ccccgagcct cccgccaccc
      301 tggaccccgg ccctcagccc cacatcgatg gggccccagc ccataaccct ggggggccca
      361 tcacccccca ccaacttcct ggatgggata gtggacttct tccgccagta cgtgatgctg
      421 attgctgtgg tgggctccct ggcctttctg ctgatgttca tcgtctgtgc cgcggtcatc
      481 acccggcaga agcagaaggc ctcggcctat tacccatcgt ccttccccaa gaagaagtac
      541 gtggaccaga gtgaccgggc cgggggcccc cgggccttca gtgaggtccc cgacagagcc
      601 cccgacagca ggcccgagga agccctggat tcctcccggc agctccaggc cgacatcttg
      661 gccgccaccc agaacctcaa gtcccccacc agggctgcac tgggcggtgg ggacggagcc
      721 aggatggtgg agggcagggg cgcagaggaa gaggagaagg gcagccagga gggggaccag
      781 gaagtccagg gacatggggt cccagtggag acaccagagg cgcaggagga gccgtgctca
      841 ggggtccttg agggggctgt ggtggccggt gagggccaag gggagctgga agggtctctc
      901 ttgttagccc aggaagccca gggaccagtg ggtccccccg aaagcccctg tgcttgcagc
      961 agtgtccacc ccagtgtcta acagtcctcc cgggctgcca gccctgactg tcgggccccc
     1021 aagtggtcac ctccccgtgt atgaaaaggc cttcagccct gactgcttcc tgacactccc
     1081 tccttggcct ccctgtggtg ccaatcccag catgtgctga ttctacagca ggcagaaatg
     1141 ctggtccccg gtgccccgga ggaatcttac caagtgccat catccttcac ctcagcagcc
     1201 ccaaagggct acatcctaca gcacagctcc cctgacaaag tgagggaggg cacgtgtccc
     1261 tgtgacagcc aggataaaac atccctcaag gctgggtgtg gaggctcaca cctgtaatct
     1321 cagcattttg ggaggccaag tgcggacatc acttgagacc aggagttcca aaccagccct
     1381 ggcaacattg tgagacccat ctctataaaa acaaaaaaca gtccactaaa tcagccacat
     1441 taattgggaa tcatatgtca caggtcattt gtggggcaaa catcactgct tttccatcaa
     1501 gggagcaaag aataagtggg agttttggaa gagtttggat gagagacgcc aaggtgccca
     1561 gcgttcgtaa ggcaacatgc agcctggcgt gaagcagtat tttgaaactg caaatggttc
     1621 ccttcttgtg tcctttcaat gctgaatatt ttagtgtcat tctgcctgtg ctcagagctc
     1681 cagcagcaga agtgtgtgtg gttaattagg acacttctgt gagaggaccc ctgcacacat
     1741 tacgacaggt ccctaaatga gcatttccca aactaggttc cccgaggcac tctacggaaa
     1801 caagattttt ttttttgaga cggagtctcg gtctgtcacc caggctggag tgcagtggtg
     1861 caatcttggt gcaatcttgg ctcagtgcaa tccgcctccc aggttcaagc gattctcccg
     1921 cctcagtagc tgggattaca ggtgcccacc actgcgccca gctaaatttt gtatttttag
     1981 tagagatggg gcttcaccat gttggccagg ctggtctgga actcctgacc ttcaggtgat
     2041 ccacctgcct ctgcctccca aagtgctggg attacaggcg tgagccaccg tgcccggccc
     2101 aaactacttt ttaaaacagc tacagggtaa aatcctgcag cacccactct ggaaaatact
     2161 gctcttaatt ttcctgaagg tggccccctg tttctagttg gtccaggatt agggatgtgg
     2221 ggtatagggc atttaaatcc tctcaagcgc tctccaagca cccccggcct gggggtgagt
     2281 ttctcatccc gctactgctg ctgggatcag gttgaatgaa tggaactctt cctgtctggc
     2341 ctccaaagca gcctagaagc tgaggggctg tgtttgaggg gacctccacc ctggggaagt
     2401 ccgaggggct ggggaagggt ttctgacgcc cagcctggag caggggggcc ctggccaccc
     2461 cctgttgctc acacattgtc tggcagcctg tgtccacaat attcgtcagt cctcgacagg
     2521 gagcctgggc tccgtcctgc tttagggagg ctctggcagg aggtcctctc ccccatccct
     2581 ccatctgggg ctcccccaac ctctgcacag ctctccaggt gctgagatat aatgcaccag
     2641 cacaataaac ctttattccg gc
//
