LOCUS       NM_001193531            1534 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens transmembrane protein 116 (TMEM116), transcript
            variant 1, mRNA.
ACCESSION   NM_001193531
VERSION     NM_001193531.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1534)
  AUTHORS   Zhang,S., Dai,H., Li,W., Wang,R., Wu,H., Shen,M., Hu,Y., Xie,L. and
            Xing,Y.
  TITLE     TMEM116 is required for lung cancer cell motility and metastasis
            through PDK1 signaling pathway
  JOURNAL   Cell Death Dis 12 (12), 1086 (2021)
   PUBMED   34789718
  REMARK    GeneRIF: TMEM116 is required for lung cancer cell motility and
            metastasis through PDK1 signaling pathway.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI828772.1, AC073575.30, BC048796.1, AC004024.4 and BF435254.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001193531.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048796.1, SRR11853564.7413.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000552374.7/ ENSP00000447731.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BI828772.1         55-56
            3-5                 AC073575.30        167920-167922
            6-54                BI828772.1         60-108
            55-901              BC048796.1         1-847
            902-902             AC004024.4         4974-4974           c
            903-1530            BC048796.1         849-1476
            1531-1534           BF435254.1         20-23               c
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..1534
                     /gene="TMEM116"
                     /note="transmembrane protein 116"
                     /db_xref="GeneID:89894"
                     /db_xref="HGNC:HGNC:25084"
     exon            1..164
                     /gene="TMEM116"
                     /inference="alignment:Splign:2.1.0"
     exon            165..211
                     /gene="TMEM116"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1211
                     /gene="TMEM116"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 116 isoform 1"
                     /protein_id="NP_001180460.1"
                     /db_xref="CCDS:CCDS55887.1"
                     /db_xref="GeneID:89894"
                     /db_xref="HGNC:HGNC:25084"
                     /translation="MATLSVIGSSSLIAYAVFHNIQKSPEIRPLFYLSFCDLLLGLCW
                     LTETLLYGASVANKDIICYNLQAVGQIFYISSFLYTVNYIWYLYTELRMKHTQSGQST
                     SPLVIDYTCRVCQMAFVFSSLIPLLLMTPVFCLGNTSECFQNFSQSHKCILMHSPPSA
                     MAELPPSANTSVCSTLYFYGIAIFLGSFVLSLLTIMVLLIRAQTLYKKFVKSTGFLGS
                     EQWAVIHIVDQRVRFYPVAFFCCWGPAVILMIIKLTKPQDTKLHMALYVLQALTATSQ
                     GLLNCGVYGWTQHKFHQLKQEARRDADTQTPLLCSQKRFYSRGLNSLESTLTFPASTS
                     TIF"
     exon            212..275
                     /gene="TMEM116"
                     /inference="alignment:Splign:2.1.0"
     exon            276..407
                     /gene="TMEM116"
                     /inference="alignment:Splign:2.1.0"
     exon            408..512
                     /gene="TMEM116"
                     /inference="alignment:Splign:2.1.0"
     exon            513..562
                     /gene="TMEM116"
                     /inference="alignment:Splign:2.1.0"
     exon            563..646
                     /gene="TMEM116"
                     /inference="alignment:Splign:2.1.0"
     exon            647..785
                     /gene="TMEM116"
                     /inference="alignment:Splign:2.1.0"
     exon            786..930
                     /gene="TMEM116"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1004
                     /gene="TMEM116"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1534
                     /gene="TMEM116"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1512..1517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM116"
                     /note="hexamer: AATAAA"
     polyA_site      1534
                     /gene="TMEM116"
                     /note="major polyA site"
ORIGIN      
        1 agttccgttc ctgctccgct tgaggagaag cgccaagtgc gcatggggac gctatagcaa
       61 ttcgtttgct gtccttcctc tccttcgaag atgacaaggc ctaccatcgt ttcttcctgc
      121 ctttgggccg tcaggcagtt ggttgggacc cgctccaacc ctcggttctt cctgcaatac
      181 agtggataca atttgtcatg gctactctga gtgttatagg ttcaagttca cttattgcct
      241 atgctgtatt ccataatata cagaaatctc cagagataag accacttttt tatctgagct
      301 tctgtgacct gctcctggga ctttgctggc tcacggagac acttctctat ggagcttcag
      361 tagcaaataa ggacatcatc tgctataacc tacaagcagt tggacagata ttctacattt
      421 cctcatttct ctacaccgtc aattacatct ggtatttgta cacagagctg aggatgaaac
      481 acacccagag tggacagagc acatctccac tggtgataga ttatacttgt cgagtttgtc
      541 aaatggcctt tgttttctca agcctgatac ctctgctatt gatgacacct gtattctgtc
      601 tgggaaatac tagtgaatgt ttccaaaact tcagtcagag ccacaagtgt atcttgatgc
      661 actcaccacc atcagccatg gctgaacttc caccttctgc caacacatct gtctgtagca
      721 cactttattt ttatggtatc gccattttcc tgggcagctt tgtactcagc ctccttacca
      781 ttatggtctt acttatccga gcccagacat tgtataagaa gtttgtgaag tcaactggct
      841 ttctggggag tgaacagtgg gcagtgattc acattgtgga ccaacgggtg cgcttctacc
      901 cagtggcctt cttttgctgc tggggcccag ctgtcattct aatgatcata aagctgacta
      961 agccacagga caccaagctt cacatggccc tttatgttct ccaggctcta acggcaacat
     1021 ctcagggtct actcaactgt ggagtatatg gctggacgca gcacaaattc caccaactaa
     1081 agcaggaggc tcggcgtgat gcagataccc agacaccatt attatgctca cagaagagat
     1141 tctatagcag gggcttaaat tcactggaat ccaccctgac ttttcctgcc agtacttcta
     1201 ccattttttg aaactacaat actggaacat ccaggaactg gagttattct acgctaatgg
     1261 attggaaaga atgttgggaa aggacatctt aaatcttttc taactatgcc ctaaactgca
     1321 gaactcaaag gaaatatagt gccattgtta gtagtcattc tagatgaatt gggagtatct
     1381 ctccagttat tcccagattc actagtgatc cttaaagtct ctattcaggg agaggaagac
     1441 actttccatc tcagagatag actcgtgtta ccttgatgga tattggattt gtctaagtct
     1501 cttctagaaa aaataaattc tagattatta ttta
//
