LOCUS       NM_007024               2107 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 115 (TMEM115), mRNA.
ACCESSION   NM_007024
VERSION     NM_007024.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2107)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2107)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2107)
  AUTHORS   Ong,Y.S., Tran,T.H., Gounko,N.V. and Hong,W.
  TITLE     TMEM115 is an integral membrane protein of the Golgi complex
            involved in retrograde transport
  JOURNAL   J Cell Sci 127 (Pt 13), 2825-2839 (2014)
   PUBMED   24806965
  REMARK    GeneRIF: Results establish that TMEM115 is an integral membrane
            protein of the Golgi stack regulating Golgi-to-ER retrograde
            transport and is likely to be part of the machinery of the COG
            complex.
REFERENCE   4  (bases 1 to 2107)
  AUTHORS   Ivanova,A.V., Vortmeyer,A., Ivanov,S.V., Nickerson,M.L., Maher,E.R.
            and Lerman,M.I.
  TITLE     Loss of PL6 protein expression in renal clear cell carcinomas and
            other VHL-deficient tumours
  JOURNAL   J Pathol 214 (1), 46-57 (2008)
   PUBMED   17973242
REFERENCE   5  (bases 1 to 2107)
  AUTHORS   Muzny,D.M., Scherer,S.E., Kaul,R., Wang,J., Yu,J., Sudbrak,R.,
            Buhay,C.J., Chen,R., Cree,A., Ding,Y., Dugan-Rocha,S., Gill,R.,
            Gunaratne,P., Harris,R.A., Hawes,A.C., Hernandez,J., Hodgson,A.V.,
            Hume,J., Jackson,A., Khan,Z.M., Kovar-Smith,C., Lewis,L.R.,
            Lozado,R.J., Metzker,M.L., Milosavljevic,A., Miner,G.R.,
            Morgan,M.B., Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z.,
            Steffen,D., Wei,S., Wheeler,D.A., Wright,M.W., Worley,K.C.,
            Yuan,Y., Zhang,Z., Adams,C.Q., Ansari-Lari,M.A., Ayele,M.,
            Brown,M.J., Chen,G., Chen,Z., Clendenning,J.,
            Clerc-Blankenburg,K.P., Chen,R., Chen,Z., Davis,C., Delgado,O.,
            Dinh,H.H., Dong,W., Draper,H., Ernst,S., Fu,G.,
            Gonzalez-Garay,M.L., Garcia,D.K., Gillett,W., Gu,J., Hao,B.,
            Haugen,E., Havlak,P., He,X., Hennig,S., Hu,S., Huang,W.,
            Jackson,L.R., Jacob,L.S., Kelly,S.H., Kube,M., Levy,R., Li,Z.,
            Liu,B., Liu,J., Liu,W., Lu,J., Maheshwari,M., Nguyen,B.V.,
            Okwuonu,G.O., Palmeiri,A., Pasternak,S., Perez,L.M., Phelps,K.A.,
            Plopper,F.J., Qiang,B., Raymond,C., Rodriguez,R.,
            Saenphimmachak,C., Santibanez,J., Shen,H., Shen,Y., Subramanian,S.,
            Tabor,P.E., Verduzco,D., Waldron,L., Wang,J., Wang,J., Wang,Q.,
            Williams,G.A., Wong,G.K., Yao,Z., Zhang,J., Zhang,X., Zhao,G.,
            Zhou,J., Zhou,Y., Nelson,D., Lehrach,H., Reinhardt,R., Naylor,S.L.,
            Yang,H., Olson,M., Weinstock,G. and Gibbs,R.A.
  TITLE     The DNA sequence, annotation and analysis of human chromosome 3
  JOURNAL   Nature 440 (7088), 1194-1198 (2006)
   PUBMED   16641997
REFERENCE   6  (bases 1 to 2107)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
REFERENCE   7  (bases 1 to 2107)
  AUTHORS   Kawasaki,H., Springett,G.M., Mochizuki,N., Toki,S., Nakaya,M.,
            Matsuda,M., Housman,D.E. and Graybiel,A.M.
  TITLE     A family of cAMP-binding proteins that directly activate Rap1
  JOURNAL   Science 282 (5397), 2275-2279 (1998)
   PUBMED   9856955
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z84492.2, BF305563.1 and BC011948.1.
            
            On Nov 24, 2018 this sequence version replaced NM_007024.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.547632.1,
                                           SRR1660807.13279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266025.4/ ENSP00000266025.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                Z84492.2           27110-27122
            14-49               BF305563.1         1-36
            50-2107             BC011948.1         1-2058
FEATURES             Location/Qualifiers
     source          1..2107
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2107
                     /gene="TMEM115"
                     /gene_synonym="PL6"
                     /note="transmembrane protein 115"
                     /db_xref="GeneID:11070"
                     /db_xref="HGNC:HGNC:30055"
                     /db_xref="MIM:607069"
     exon            1..1309
                     /gene="TMEM115"
                     /gene_synonym="PL6"
                     /inference="alignment:Splign:2.1.0"
     CDS             459..1514
                     /gene="TMEM115"
                     /gene_synonym="PL6"
                     /note="placental protein 6; PP6; testicular tissue protein
                     Li 201"
                     /codon_start=1
                     /product="transmembrane protein 115"
                     /protein_id="NP_008955.1"
                     /db_xref="CCDS:CCDS2828.1"
                     /db_xref="GeneID:11070"
                     /db_xref="HGNC:HGNC:30055"
                     /db_xref="MIM:607069"
                     /translation="MQRALPGARQHLGAILASASVVVKALCAAVLFLYLLSFAVDTGC
                     LAVTPGYLFPPNFWIWTLATHGLMEQHVWDVAISLTTVVVAGRLLEPLWGALELLIFF
                     SVVNVSVGLLGAFAYLLTYMASFNLVYLFTVRIHGALGFLGGVLVALKQTMGDCVVLR
                     VPQVRVSVMPMLLLALLLLLRLATLLQSPALASYGFGLLSSWVYLRFYQRHSRGRGDM
                     ADHFAFATFFPEILQPVVGLLANLVHSLLVKVKICQKTVKRYDVGAPSSITISLPGTD
                     PQDAERRRQLALKALNERLKRVEDQSIWPSMDDDEEESGAKVDSPLPSDKAPTPPGKG
                     AAPESSLITFEAAPPTL"
     exon            1310..2107
                     /gene="TMEM115"
                     /gene_synonym="PL6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2083..2088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM115"
                     /gene_synonym="PL6"
                     /note="hexamer: AATAAA"
     polyA_site      2107
                     /gene="TMEM115"
                     /gene_synonym="PL6"
                     /note="major polyA site"
ORIGIN      
        1 acccctgttt gtcggccccc cgagagaaga ggtacggtcg aagccaggag ccaggccgag
       61 cgggagctga ccaggcttga ctcgggtaca gaacgaggca ccagtcccct tgcgaaccga
      121 agggcctcgc agtggatgga ggaggcccag ccctgaggtc aacgccaacc aggctagcct
      181 ggcacggggc ctacagggtg ggtaggcggg cgtgccgcag ccgtccaggg ccttccctca
      241 ggtcccgggc gaggggccta cgctgcggcc cggcaacaag gcccgactcg gcccctcggg
      301 accagagccc cacccgatcg gaagcggatc ctttaccagg gccataggcc agtgactagg
      361 ccgggcctgg gcctcccatc ggggccggac taggacgagg ccccggggag gcccctggcc
      421 taccagaccc ttttctcagg ccgacagccg ccaggaagat gcaacgtgcc ctgccaggcg
      481 cccgccagca cttgggggcc attctggcca gcgccagcgt ggtggtgaag gctctgtgtg
      541 cggcggtact attcctctac ctgctctcct tcgccgtgga cacaggctgc ctggcggtca
      601 ccccgggcta cctctttcct cccaacttct ggatctggac cctggccacc catgggctga
      661 tggagcagca tgtgtgggac gtggccatca gcctgacaac ggtggtggtg gccgggcgtt
      721 tgctggagcc cctctggggg gccttggagc tgctcatctt cttctcagtg gtgaatgtgt
      781 ctgtagggct gctgggggcc ttcgcctacc tcctcaccta catggcttcc ttcaacctgg
      841 tctacctgtt cactgtccgt atccacggcg ccttgggctt cctaggtggc gtcctggtgg
      901 cactcaagca aaccatgggg gactgtgtgg tcctgcgagt gccccaggtg cgcgtcagtg
      961 tgatgcccat gctgctgctg gcgctgctgc tcctgctgcg gctcgccacg ctgctccaga
     1021 gcccggcgct ggcttcctat ggcttcgggc tgctctccag ttgggtatat cttcgcttct
     1081 accagcgcca tagccggggc cgaggggaca tggctgacca ctttgctttc gccactttct
     1141 tccctgagat cctgcagcct gtggtgggtt tgctggcgaa cttggtgcac agcctcctgg
     1201 tgaaggtaaa gatatgccag aagacggtga agcgctacga tgtgggtgcc ccatcctcca
     1261 tcaccatcag cctgccaggc acagaccctc aagacgccga gcggagaagg caactggccc
     1321 tgaaggcact caatgagcgg ctgaagagag tggaagacca gtccatctgg cccagcatgg
     1381 atgatgatga agaggagtct ggggccaagg tggacagccc cctgccctca gacaaagctc
     1441 ccacaccccc agggaagggg gctgccccag aatccagtct aatcaccttc gaggcagctc
     1501 ccccgacgct gtaactccag accaccttga gtgtggcacc tcccctccca agcccccctt
     1561 gacatcctct cagctactcc agggcacctg actgctctga ggagagggaa gaaggcctgc
     1621 tggggctttc catggccttc tgctgtttct cgccaacact acccaggact cttgctacct
     1681 ggttccaact ccagacaacc actatgccag gcccggagcc tctgaggcat cggccagtcc
     1741 aggccctcat ctgaggtaag aatgtacatc agctggcagc cccaagcaag tggctgcagg
     1801 gacactgatg ccacagctcc tgggccggcc ctcacatctg aaactggttg ccgagagccc
     1861 tgagccaagg caaggatttg ccaaaaatgt tctgggggcc cagcaaatgc aggagccgac
     1921 ctggggctgc acatccctgc ccatccccag aaagactgtt cctgtcagga tttgtttccc
     1981 tctgctgtgg cggtgactgc ttctggacca gaacagctcc agctcccagg tattttctac
     2041 aggaccactt gagtgggcag ccaagcccag gctcgcagta tcaataaagc agttctctga
     2101 ggaatga
//
