LOCUS       NM_003876                958 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 11 (TMEM11), transcript variant
            1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_003876
VERSION     NM_003876.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 958)
  AUTHORS   Gok,M.O., Connor,O.M., Wang,X., Menezes,C.J., Llamas,C.B.,
            Mishra,P. and Friedman,J.R.
  TITLE     The outer mitochondrial membrane protein TMEM11 demarcates
            spatially restricted BNIP3/BNIP3L-mediated mitophagy
  JOURNAL   J Cell Biol 222 (4) (2023)
   PUBMED   36795401
  REMARK    GeneRIF: The outer mitochondrial membrane protein TMEM11 demarcates
            spatially restricted BNIP3/BNIP3L-mediated mitophagy.
REFERENCE   2  (bases 1 to 958)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 958)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 958)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 958)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 958)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 958)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 958)
  AUTHORS   Rival,T., Macchi,M., Arnaune-Pelloquin,L., Poidevin,M., Maillet,F.,
            Richard,F., Fatmi,A., Belenguer,P. and Royet,J.
  TITLE     Inner-membrane proteins PMI/TMEM11 regulate mitochondrial
            morphogenesis independently of the DRP1/MFN fission/fusion pathways
  JOURNAL   EMBO Rep 12 (3), 223-230 (2011)
   PUBMED   21274005
  REMARK    GeneRIF: study demonstrates that the Drosophila PMI gene and its
            human orthologue TMEM11 encode mitochondrial inner-membrane
            proteins that regulate mitochondrial morphogenesis
REFERENCE   9  (bases 1 to 958)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 958)
  AUTHORS   Murphy,P.M. and Malech,H.L.
  TITLE     Nucleotide sequence of a cDNA encoding a protein with primary
            structural similarity to G-protein coupled receptors
  JOURNAL   Nucleic Acids Res 18 (7), 1896 (1990)
   PUBMED   2110658
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087294.18 and AC087393.7.
            
            On Nov 27, 2019 this sequence version replaced NM_003876.2.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020815.1, BX386109.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317635.6/ ENSP00000319992.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC087294.18        133475-133545
            72-958              AC087393.7         12338-13224
FEATURES             Location/Qualifiers
     source          1..958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..958
                     /gene="TMEM11"
                     /gene_synonym="C17orf35; PM1; PMI"
                     /note="transmembrane protein 11"
                     /db_xref="GeneID:8834"
                     /db_xref="HGNC:HGNC:16823"
                     /db_xref="MIM:618817"
     exon            1..71
                     /gene="TMEM11"
                     /gene_synonym="C17orf35; PM1; PMI"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..588
                     /gene="TMEM11"
                     /gene_synonym="C17orf35; PM1; PMI"
                     /note="putative receptor protein"
                     /codon_start=1
                     /product="transmembrane protein 11, mitochondrial"
                     /protein_id="NP_003867.1"
                     /db_xref="CCDS:CCDS11216.1"
                     /db_xref="GeneID:8834"
                     /db_xref="HGNC:HGNC:16823"
                     /db_xref="MIM:618817"
                     /translation="MAAWGRRRLGPGSSGGSARERVSLSATDCYIVHEIYNGENAQDQ
                     FEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGTACLFTPLALPLD
                     YSHYISLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLV
                     RKDDLHRKRLHNTIALAALVYCVKKIYELYAV"
     exon            72..958
                     /gene="TMEM11"
                     /gene_synonym="C17orf35; PM1; PMI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      937..942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM11"
                     /gene_synonym="C17orf35; PM1; PMI"
                     /note="hexamer: ATTAAA"
     polyA_site      958
                     /gene="TMEM11"
                     /gene_synonym="C17orf35; PM1; PMI"
                     /note="major polyA site"
ORIGIN      
        1 gtctccaaga tggccgcttg gggaaggagg cgtcttggcc cgggcagcag tggcggcagc
       61 gcccgagaga gggtgagctt gtcggccaca gactgctaca ttgtgcatga gatctacaat
      121 ggggagaatg cccaagacca gtttgagtac gagctggagc aggccctgga agcccagtac
      181 aagtacattg tgattgagcc cactcgcatt ggcgacgaga cagcccgctg gatcaccgtg
      241 ggcaactgcc tgcacaagac ggccgtgctg gcgggcaccg cctgcctctt caccccgttg
      301 gcgctgccct tagattattc ccactacatt tccctgcccg ctggtgtgct gagcctggcc
      361 tgctgcaccc tctatgggat ctcctggcag tttgaccctt gctgcaagta ccaagtggag
      421 tacgacgcct ataaactgtc gcgcctgcct ctgcacacac tcacctcctc caccccggtg
      481 gtgctggtcc ggaaggacga cctgcacaga aagagactgc acaacacgat agcactggcc
      541 gccctggtgt actgtgtaaa gaagatttac gaactctatg ccgtatgatt tcagtagaac
      601 agggagcgaa gcaaaaccac ccggcccaca agagacaaca gagtattcag atcgccacac
      661 tctgtgaggc agcagagcct gggcaggtgt ttggcttagt atttgttatt tttaaaaaat
      721 aacagatcac gggtgtaccc agggtttttc agctcattac actaagatgt ggatttccat
      781 aacccaagag gggggtctga ggctgtggaa gtccgactgg gcagtggaat gctgatggag
      841 gcagacgctg ccgagggggt gtggacgtgc tttgggggag gtctttaagt ctattgttta
      901 actgtaccat ccagagccca ccagaagcta ttgatcatta aaattatgag aatttcaa
//
