LOCUS       NM_024092               2129 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 109 (TMEM109), mRNA.
ACCESSION   NM_024092
VERSION     NM_024092.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2129)
  AUTHORS   Tirincsi,A., O'Keefe,S., Nguyen,D., Sicking,M., Dudek,J.,
            Forster,F., Jung,M., Hadzibeganovic,D., Helms,V., High,S.,
            Zimmermann,R. and Lang,S.
  TITLE     Proteomics Identifies Substrates and a Novel Component in
            hSnd2-Dependent ER Protein Targeting
  JOURNAL   Cells 11 (18), 2925 (2022)
   PUBMED   36139500
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2129)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2129)
  AUTHORS   Yamashita,A., Taniwaki,T., Kaikoi,Y. and Yamazaki,T.
  TITLE     Protective role of the endoplasmic reticulum protein mitsugumin23
            against ultraviolet C-induced cell death
  JOURNAL   FEBS Lett 587 (9), 1299-1303 (2013)
   PUBMED   23542032
  REMARK    GeneRIF: MG23 plays a protective role against UVC by accumulating
            alphaBC in the close vicinity of the ER
REFERENCE   4  (bases 1 to 2129)
  AUTHORS   Kato,U., Inadome,H., Yamamoto,M., Emoto,K., Kobayashi,T. and
            Umeda,M.
  TITLE     Role for phospholipid flippase complex of ATP8A1 and CDC50A
            proteins in cell migration
  JOURNAL   J Biol Chem 288 (7), 4922-4934 (2013)
   PUBMED   23269685
REFERENCE   5  (bases 1 to 2129)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 2129)
  AUTHORS   Yamazaki,T., Sasaki,N., Nishi,M. and Takeshima,H.
  TITLE     Facilitation of DNA damage-induced apoptosis by endoplasmic
            reticulum protein mitsugumin23
  JOURNAL   Biochem Biophys Res Commun 392 (2), 196-200 (2010)
   PUBMED   20060811
  REMARK    GeneRIF: MG23 is an essential component of ER-generated lethal
            signals provoked upon DNA damage, specifying cell fate under
            pathophysiological conditions.
REFERENCE   7  (bases 1 to 2129)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI463800.1, BC001309.1 and AF131803.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024092.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.38900.1,
                                           SRR3476690.1155531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227525.8/ ENSP00000227525.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BI463800.1         291-337
            48-1563             BC001309.1         1-1516
            1564-2129           AF131803.1         668-1233
FEATURES             Location/Qualifiers
     source          1..2129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..2129
                     /gene="TMEM109"
                     /gene_synonym="hSND3; SND3"
                     /note="transmembrane protein 109"
                     /db_xref="GeneID:79073"
                     /db_xref="HGNC:HGNC:28771"
                     /db_xref="MIM:619168"
     exon            1..111
                     /gene="TMEM109"
                     /gene_synonym="hSND3; SND3"
                     /inference="alignment:Splign:2.1.0"
     exon            112..356
                     /gene="TMEM109"
                     /gene_synonym="hSND3; SND3"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..851
                     /gene="TMEM109"
                     /gene_synonym="hSND3; SND3"
                     /note="mg23; mitsugumin-23; SRP-independent targeting 3
                     homolog; voltage-gated monoatomic cation channel TMEM109"
                     /codon_start=1
                     /product="voltage-gated monoatomic cation channel TMEM109
                     precursor"
                     /protein_id="NP_076997.1"
                     /db_xref="CCDS:CCDS7996.1"
                     /db_xref="GeneID:79073"
                     /db_xref="HGNC:HGNC:28771"
                     /db_xref="MIM:619168"
                     /translation="MAASSISSPWGKHVFKAILMVLVALILLHSALAQSRRDFAPPGQ
                     QKREAPVDVLTQIGRSVRGTLDAWIGPETMHLVSESSSQVLWAISSAISVAFFALSGI
                     AAQLLNALGLAGDYLAQGLKLSPGQVQTFLLWGAGALVVYWLLSLLLGLVLALLGRIL
                     WGLKLVIFLAGFVALMRSVPDPSTRALLLLALLILYALLSRLTGSRASGAQLEAKVRG
                     LERQVEELRWRQRRAAKGARSVEEE"
     exon            357..459
                     /gene="TMEM109"
                     /gene_synonym="hSND3; SND3"
                     /inference="alignment:Splign:2.1.0"
     exon            460..2129
                     /gene="TMEM109"
                     /gene_synonym="hSND3; SND3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM109"
                     /gene_synonym="hSND3; SND3"
                     /note="hexamer: AATAAA"
     polyA_site      2129
                     /gene="TMEM109"
                     /gene_synonym="hSND3; SND3"
                     /note="major polyA site"
ORIGIN      
        1 atcccgcctt gcgcatgcgg agaaggtaaa ccagcgcccc gagttgaggc gcgggtttgg
       61 tggcgcgttt cagcgaagtc gcacgtgaag gatagcagtg gcctgagaaa gacccagtca
      121 tggcagcctc cagcatcagt tcaccatggg gaaagcatgt gttcaaagcc attctgatgg
      181 tcctagtggc ccttatcctc ctccactcag cattggccca gtcccgtcga gactttgcac
      241 caccaggcca acagaagaga gaagccccag ttgatgtctt gacccagata ggtcgatctg
      301 tgcgagggac actggatgcc tggattgggc cagagaccat gcacctggtg tcagagtctt
      361 cgtcccaagt gttgtgggcc atctcatcag ccatttctgt ggccttcttt gctctgtctg
      421 ggatcgccgc acagctgctg aatgccttgg gactagctgg tgattacctc gcccagggcc
      481 tgaagctcag ccctggccag gtccagacct tcctgctgtg gggagcaggg gccctggtcg
      541 tctactggct gctgtctctg ctcctcggct tggtcttggc cttgctgggg cggatcctgt
      601 ggggcctgaa gcttgtcatc ttcctggccg gcttcgtggc cctgatgagg tcggtgcctg
      661 acccttccac ccgggccctg ctactcctgg ccttgctgat cctctacgcc ctgctgagcc
      721 ggctcactgg ctcccgagcc tctggggccc aactcgaggc caaggtgcga gggctggaac
      781 gccaggtgga ggagctgcgc tggcgccaga ggcgagcggc caagggggcc cgcagtgtgg
      841 aggaggagtg agccggatgc cccacacacc gccagtgtca taccaaagag ctgagctgct
      901 tcggggccat gcagccctcc tgccagcccc ctgccctttt cttgccctgt ctctgaacct
      961 tcagaacatt gatccttgcc gcagccccac tagccaagag aaacagagaa agaccattcc
     1021 ccctgcctgt ccttgcggcc ctgtcttctg aggttctctg tctggggttg gctctcttaa
     1081 ccctttctct gctcccagcc tgcctcacca gggaaggttg gaggggcctc cctctggctt
     1141 ctgcatctgc gccagcaaac atcactgccg ttggtctctc atgacttaac tggcttccct
     1201 ctgctgctgc cttggcttcc tcctaatgct cgtgctctcc tgtccttctg aagttgctcc
     1261 ttggccaaat ctccagctcc cttcttgttt tcctcatcct cctaccctgt actcccacca
     1321 aaccatggtc ctttaaggca cgctcctgtc ctcctcattg cccagcagta gggaggggca
     1381 ggggtaaggg gacctgagga taaagggtgg ggaaacaggg tcccctgagg cctgtggggg
     1441 ctgcagggga ggaggatgta ccttgtgtct ctttcaagtg ccttaatccg agccagcagg
     1501 gccttctgct tgcctgctgc catactgtat gtaggaaagt gttctgtggc tgctttgtgt
     1561 caagaaaaga gcagtcactc tcagaatctt gattccccat cagccaaagc aaaagatggc
     1621 tgctgctttg taggcatgtg cctgcaagtg ggaccttgct gggcattata tgccctgtgg
     1681 gggtttcaga gaccctgaaa gaggagggag gacccgcctc cttgtctgca caactgcatg
     1741 cacttctctc cccatcgctc cacaacctga aaccgagaag gagttgctga ccagtgccca
     1801 ccccggcagc ccgggaggaa cacaggcagc tcctttccct tcacgtggtc tgcagagagc
     1861 agggtgagct gccagctgcc cctctccacc agggtaccct gtcttggtgg ttaggggcca
     1921 cttttccttt gaggctctag tggaggtgga tgtccttctc tgccaggctt ggcacatgat
     1981 gtgaagaata aatgcccaat tcttactgtt caggtttgat gtggaatcac agctgcagtg
     2041 atatatattt tttatcagtg cttggttggt tttaaataaa gtgcacgcta ttttattatc
     2101 ttgttctgaa taaaatgtat ttactccaa
//
