LOCUS       NM_023943               3727 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 108 (TMEM108), transcript
            variant 1, mRNA.
ACCESSION   NM_023943 XM_039805
VERSION     NM_023943.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3727)
  AUTHORS   Yu,J., Liao,X., Zhong,Y., Wu,Y., Lai,X., Jiao,H., Yan,M., Zhang,Y.,
            Ma,C. and Wang,S.
  TITLE     The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose
            Metabolism Homeostasis
  JOURNAL   Front Endocrinol (Lausanne) 12, 770145 (2021)
   PUBMED   34690937
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3727)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3727)
  AUTHORS   Heath,A.C., Whitfield,J.B., Martin,N.G., Pergadia,M.L., Goate,A.M.,
            Lind,P.A., McEvoy,B.P., Schrage,A.J., Grant,J.D., Chou,Y.L.,
            Zhu,R., Henders,A.K., Medland,S.E., Gordon,S.D., Nelson,E.C.,
            Agrawal,A., Nyholt,D.R., Bucholz,K.K., Madden,P.A. and
            Montgomery,G.W.
  TITLE     A quantitative-trait genome-wide association study of alcoholism
            risk in the community: findings and implications
  JOURNAL   Biol Psychiatry 70 (6), 513-518 (2011)
   PUBMED   21529783
REFERENCE   4  (bases 1 to 3727)
  AUTHORS   Elks,C.E., Perry,J.R., Sulem,P., Chasman,D.I., Franceschini,N.,
            He,C., Lunetta,K.L., Visser,J.A., Byrne,E.M., Cousminer,D.L.,
            Gudbjartsson,D.F., Esko,T., Feenstra,B., Hottenga,J.J.,
            Koller,D.L., Kutalik,Z., Lin,P., Mangino,M., Marongiu,M.,
            McArdle,P.F., Smith,A.V., Stolk,L., van Wingerden,S.H., Zhao,J.H.,
            Albrecht,E., Corre,T., Ingelsson,E., Hayward,C., Magnusson,P.K.,
            Smith,E.N., Ulivi,S., Warrington,N.M., Zgaga,L., Alavere,H.,
            Amin,N., Aspelund,T., Bandinelli,S., Barroso,I., Berenson,G.S.,
            Bergmann,S., Blackburn,H., Boerwinkle,E., Buring,J.E., Busonero,F.,
            Campbell,H., Chanock,S.J., Chen,W., Cornelis,M.C., Couper,D.,
            Coviello,A.D., d'Adamo,P., de Faire,U., de Geus,E.J., Deloukas,P.,
            Doring,A., Smith,G.D., Easton,D.F., Eiriksdottir,G., Emilsson,V.,
            Eriksson,J., Ferrucci,L., Folsom,A.R., Foroud,T., Garcia,M.,
            Gasparini,P., Geller,F., Gieger,C., Gudnason,V., Hall,P.,
            Hankinson,S.E., Ferreli,L., Heath,A.C., Hernandez,D.G., Hofman,A.,
            Hu,F.B., Illig,T., Jarvelin,M.R., Johnson,A.D., Karasik,D.,
            Khaw,K.T., Kiel,D.P., Kilpelainen,T.O., Kolcic,I., Kraft,P.,
            Launer,L.J., Laven,J.S., Li,S., Liu,J., Levy,D., Martin,N.G.,
            McArdle,W.L., Melbye,M., Mooser,V., Murray,J.C., Murray,S.S.,
            Nalls,M.A., Navarro,P., Nelis,M., Ness,A.R., Northstone,K.,
            Oostra,B.A., Peacock,M., Palmer,L.J., Palotie,A., Pare,G.,
            Parker,A.N., Pedersen,N.L., Peltonen,L., Pennell,C.E., Pharoah,P.,
            Polasek,O., Plump,A.S., Pouta,A., Porcu,E., Rafnar,T., Rice,J.P.,
            Ring,S.M., Rivadeneira,F., Rudan,I., Sala,C., Salomaa,V., Sanna,S.,
            Schlessinger,D., Schork,N.J., Scuteri,A., Segre,A.V.,
            Shuldiner,A.R., Soranzo,N., Sovio,U., Srinivasan,S.R.,
            Strachan,D.P., Tammesoo,M.L., Tikkanen,E., Toniolo,D., Tsui,K.,
            Tryggvadottir,L., Tyrer,J., Uda,M., van Dam,R.M., van Meurs,J.B.,
            Vollenweider,P., Waeber,G., Wareham,N.J., Waterworth,D.M.,
            Weedon,M.N., Wichmann,H.E., Willemsen,G., Wilson,J.F., Wright,A.F.,
            Young,L., Zhai,G., Zhuang,W.V., Bierut,L.J., Boomsma,D.I.,
            Boyd,H.A., Crisponi,L., Demerath,E.W., van Duijn,C.M., Econs,M.J.,
            Harris,T.B., Hunter,D.J., Loos,R.J., Metspalu,A., Montgomery,G.W.,
            Ridker,P.M., Spector,T.D., Streeten,E.A., Stefansson,K.,
            Thorsteinsdottir,U., Uitterlinden,A.G., Widen,E., Murabito,J.M.,
            Ong,K.K. and Murray,A.
  CONSRTM   GIANT Consortium
  TITLE     Thirty new loci for age at menarche identified by a meta-analysis
            of genome-wide association studies
  JOURNAL   Nat Genet 42 (12), 1077-1085 (2010)
   PUBMED   21102462
REFERENCE   5  (bases 1 to 3727)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079942.12, AC092984.3, AC018472.30 and AC055753.21.
            
            On Aug 31, 2019 this sequence version replaced NM_023943.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variant 1 and 2
            encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.657435.1,
                                           SRR14038193.2237733.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321871.11/ ENSP00000324651.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC079942.12        171311-171355
            46-164              AC092984.3         107724-107842       c
            165-250             AC018472.30        23573-23658         c
            251-1660            AC055753.21        128834-130243
            1661-1815           AC055753.21        139262-139416
            1816-3727           AC055753.21        144946-146857
FEATURES             Location/Qualifiers
     source          1..3727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..3727
                     /gene="TMEM108"
                     /gene_synonym="CT124; RTLN"
                     /note="transmembrane protein 108"
                     /db_xref="GeneID:66000"
                     /db_xref="HGNC:HGNC:28451"
                     /db_xref="MIM:617361"
     exon            1..45
                     /gene="TMEM108"
                     /gene_synonym="CT124; RTLN"
                     /inference="alignment:Splign:2.1.0"
     exon            46..164
                     /gene="TMEM108"
                     /gene_synonym="CT124; RTLN"
                     /inference="alignment:Splign:2.1.0"
     exon            165..250
                     /gene="TMEM108"
                     /gene_synonym="CT124; RTLN"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1938
                     /gene="TMEM108"
                     /gene_synonym="CT124; RTLN"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cancer/testis antigen 124; retrolinkin"
                     /codon_start=1
                     /product="transmembrane protein 108 isoform 1 precursor"
                     /protein_id="NP_076432.1"
                     /db_xref="CCDS:CCDS33858.1"
                     /db_xref="GeneID:66000"
                     /db_xref="HGNC:HGNC:28451"
                     /db_xref="MIM:617361"
                     /translation="MKRSLQALYCQLLSFLLILALTEALAFAIQEPSPRESLQVLPSG
                     TPPGTMVTAPHSSTRHTSVVMLTPNPDGPPSQAAAPMATPTPRAEGHPPTHTISTIAA
                     TVTAPHSESSLSTGPAPAAMATTSSKPEGRPRGQAAPTILLTKPPGATSRPTTAPPRT
                     TTRRPPRPPGSSRKGAGNSSRPVPPAPGGHSRSKEGQRGRNPSSTPLGQKRPLGKIFQ
                     IYKGNFTGSVEPEPSTLTPRTPLWGYSSSPQPQTVAATTVPSNTSWAPTTTSLGPAKD
                     KPGLRRAAQGGGSTFTSQGGTPDATAASGAPVSPQAAPVPSQRPHHGDPQDGPSHSDS
                     WLTVTPGTSRPLSTSSGVFTAATGPTPAAFDTSVSAPSQGIPQGASTTPQAPTHPSRV
                     SESTISGAKEETVATLTMTDRVPSPLSTVVSTATGNFLNRLVPAGTWKPGTAGNISHV
                     AEGDKPQHRATICLSKMDIAWVILAISVPISSCSVLLTVCCMKRKKKTANPENNLSYW
                     NNTITMDYFNRHAVELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLF
                     VGNDQVSEI"
     exon            251..1660
                     /gene="TMEM108"
                     /gene_synonym="CT124; RTLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1815
                     /gene="TMEM108"
                     /gene_synonym="CT124; RTLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..3727
                     /gene="TMEM108"
                     /gene_synonym="CT124; RTLN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2145..2150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM108"
                     /gene_synonym="CT124; RTLN"
                     /note="hexamer: AATAAA"
     polyA_site      2166
                     /gene="TMEM108"
                     /gene_synonym="CT124; RTLN"
                     /note="major polyA site"
     regulatory      3701..3706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM108"
                     /gene_synonym="CT124; RTLN"
                     /note="hexamer: AATAAA"
     polyA_site      3727
                     /gene="TMEM108"
                     /gene_synonym="CT124; RTLN"
ORIGIN      
        1 gctttctcct gagccgtcgg agggagccgg agcgcttctc ccgagttggt gatagattgg
       61 tggtcatcca acatgcagaa atgaatgagc agtgaaaagc agcagagccg atgggtcatg
      121 aggatgtaag tgcgtttgaa ggcttccaca ccctctactc caggacagaa tcatgaataa
      181 actggaggat aagcaggacc agatgatacc atgaagagaa gtttacaggc cctctattgc
      241 caactgttaa gtttcctgct gatcttggca ctgaccgaag cgctggcatt tgccatccag
      301 gaaccatctc ccagggaatc tcttcaggtc ctcccttcag gcactccccc gggaaccatg
      361 gtgacagcac cccacagctc taccagacat acttctgtgg tgatgctgac ccccaatccc
      421 gatggacccc cctcacaggc tgcagctccc atggcaacac cgacaccccg tgcagagggg
      481 caccctccta cgcacaccat ctccaccatc gctgcgacag taaccgcccc ccattctgaa
      541 agctccctgt ccacagggcc cgctccagca gccatggcaa ccacatcctc caagccagag
      601 ggccgccctc gagggcaggc tgcccccacc atcctgctga caaagccacc gggggccacc
      661 agccgcccca ccacagcgcc cccccgcact accacacgca ggccccccag gcccccaggc
      721 tcttcccgaa aaggggctgg taattcatca cgccctgtcc cgcctgcacc tggtggccac
      781 tccaggagta aagaaggaca gcgaggacga aatccaagct ccacacctct ggggcagaag
      841 cggcccctgg ggaaaatctt tcagatctac aagggcaact tcacagggtc tgtggaaccg
      901 gagccctcta ccctcacccc caggacccca ctctggggct actcctcttc accacagccc
      961 cagacagtgg ctgcgaccac agtgcccagc aatacctcat gggcacccac caccacctcc
     1021 ctggggcctg caaaggacaa gccaggcctt cgcagagcag cccagggggg tggttctacc
     1081 ttcaccagcc aaggagggac accagatgcc acagcagcct caggtgcccc tgtcagtcca
     1141 caagctgccc cagtgccttc tcagcgcccc caccacggtg acccacagga tggccccagc
     1201 catagtgact cttggcttac tgttacccct ggcaccagca gacctctgtc taccagctct
     1261 ggggtcttca cggctgccac ggggcccacc ccagctgcct tcgataccag tgtctcagcc
     1321 ccttcccagg ggattcctca gggagcatcc acaaccccac aagctccaac ccatccctcc
     1381 agggtctcag aaagcactat ttctggagcc aaggaggaga ctgtggccac cctcaccatg
     1441 accgaccggg tgcccagtcc tctctccaca gtggtatcca cagccacagg caatttcctc
     1501 aaccgcctgg tccccgccgg gacctggaag cctgggacag cagggaacat ctcccatgtg
     1561 gccgaggggg acaaaccgca gcacagagcc accatctgcc tgagcaagat ggatatcgcc
     1621 tgggtgatcc tggccatcag cgtgcccatc tcctcctgct ctgtcctgct gacggtgtgc
     1681 tgcatgaaga ggaagaagaa gaccgccaac ccggagaaca acctgagcta ctggaacaac
     1741 accatcacca tggactactt caacaggcat gctgtggagc tgcccaggga gatccagtcc
     1801 cttgaaacct ctgaggacca gctctcagag ccccgctccc cagccaatgg cgactataga
     1861 gacactggga tggtccttgt taaccccttc tgtcaagaaa cactgtttgt gggaaacgat
     1921 caagtatctg agatctaact acagcaggca tcactttgcc attccgtatt tttcgtctct
     1981 aaattataaa tatacaaata catatattat aaatataacc tttgtgtaac cctgacttaa
     2041 tgagaaacat tttcagcttt ttttcctatg aattgtcaac atctttttta caagtgtggt
     2101 ttaaaaaaaa aaaaaacttt acagaatgat ctgtggcttt ataaaataaa ggtatttcta
     2161 agcaaagcag ttgcattgat tgcttctctt aataactatt cttgagcacc tggggatccc
     2221 aggaaccctg gtcaggtgag gtaagagact gacctcctgt agaagctgaa tgttacagtg
     2281 caagcgcacg attctttgag tgattcttaa agctctggtt cctcttgatt tggtgtgacc
     2341 ccatttcctc ccttctcata cgcacacctg taaagggaac tggaccgcct caggggaaga
     2401 cggcagactc atgcacagag aaggaaaagg gaacatctca tcacctctga ggatgagtac
     2461 cctggagcct tatgacggca ccattggatg tcatgtttaa ttccatccaa gttgtggatg
     2521 gcaggcagga gcatggagcc ctcaggaatc catggaggac atcaaggcat cccaaggcca
     2581 tattccccta acattacttc cactgctaac aacaggactg cctttccctg gtgggaaaat
     2641 gctcccttta tgcccattcc tgtatcccct ccaacaccca catctgcatt aaacacccgt
     2701 gcctttctct tggagagggt ttagatgcag atcccggccc tggagcttta aaatgcttgc
     2761 ccttccttct tcaaggatca aatgtttatt ggggttcagc tttgttttct caaaaggcca
     2821 tggtatcgtg cccctgagga acatgtttat ctaagaagct ttgaggtagt agagcgataa
     2881 tttttgaaac cttcctcctg caatctttaa aaaagaaaaa aaagattgcc caaacaaatc
     2941 atttgggaga agacatcatt atactcctac ttggcactgc aaacctgctc gcagcaccag
     3001 ccggtggact tgccatccag ctctcagctt ccactgctcc ccttgttccc ggccggctgg
     3061 ctgcctcccc gtgctgtgtc cagcacggcc aacaacgtca gaccctcaga gacgcccaag
     3121 gggcttccag aggtggccgc ttctctattt tttcctgatt gtggctgaga gagatgatta
     3181 ctgctttgac acttcctttc tctaaaagaa aaatagtttg atagtatatt ttgaatatag
     3241 atgctcttat agtcagattg ggaattgaac ttgaatattg ggtcatatgt ttgtgttgtt
     3301 gctgtagtct atcatgactt ttttctttct gcattttcct taaaaaaaaa aaaaagatgg
     3361 ccttcaaaag tgtgttctca atgttgtatg aacctccttc acatgagttc ggttgttgtc
     3421 tctcttcaaa gactcttcaa cccacaaaga agcaactaaa tgtttctcta agtttaattt
     3481 tctagcgtgt tgttgtctta cctttttaac cttaccataa tatttctgtt aactgttaca
     3541 tttaatatac caatgtgtgt aagtatacag agaaaaatct gtttgtaaag taaaatttat
     3601 atataatata tgtaatcaaa gatacatatg ttatatatac atatgtggat gtatgactta
     3661 tttttcctta tccacagatt tcagctacca tgtatatata aataaactta ttttattagc
     3721 cagagga
//
