LOCUS       NM_001143842            1539 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 106C (TMEM106C), transcript
            variant 1, mRNA.
ACCESSION   NM_001143842
VERSION     NM_001143842.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1539)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1539)
  AUTHORS   Jiang,C., Li,F., Yang,M., Duan,J., Lai,J., Sun,S. and Fan,S.
  TITLE     LINC00238 inhibits hepatic carcinoma progression by activating
            TMEM106C-mediated apoptosis pathway
  JOURNAL   Mol Med Rep 24 (5) (2021)
   PUBMED   34476506
  REMARK    GeneRIF: LINC00238 inhibits hepatic carcinoma progression by
            activating TMEM106Cmediated apoptosis pathway.
REFERENCE   3  (bases 1 to 1539)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1539)
  AUTHORS   Duan,J., Qian,Y., Fu,X., Chen,M., Liu,K., Liu,H., Yang,J., Liu,C.
            and Chang,Y.
  TITLE     TMEM106C contributes to the malignant characteristics and poor
            prognosis of hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 13 (4), 5585-5606 (2021)
   PUBMED   33591950
  REMARK    GeneRIF: TMEM106C contributes to the malignant characteristics and
            poor prognosis of hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 1539)
  AUTHORS   Luo,X., Han,G., Lu,R., Guan,S., Wang,Y., Ju,L., Chen,L., Shao,J.
            and Bian,Z.
  TITLE     Transmembrane protein 106C promotes the development of
            hepatocellular carcinoma
  JOURNAL   J Cell Biochem 121 (11), 4484-4495 (2020)
   PUBMED   32037603
  REMARK    GeneRIF: Transmembrane protein 106C promotes the development of
            hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 1539)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA571733.1, CX763149.1, CN256547.1 and BC000854.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001143842.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            both encode isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.424922.1,
                                           SRR3476690.281170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429772.7/ ENSP00000400471.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DA571733.1         50-87
            39-109              CX763149.1         1-71
            110-751             CN256547.1         70-711
            752-1424            BC000854.2         643-1315
            1425-1539           BC000854.2         1317-1431
FEATURES             Location/Qualifiers
     source          1..1539
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..1539
                     /gene="TMEM106C"
                     /note="transmembrane protein 106C"
                     /db_xref="GeneID:79022"
                     /db_xref="HGNC:HGNC:28775"
     exon            1..109
                     /gene="TMEM106C"
                     /inference="alignment:Splign:2.1.0"
     exon            110..324
                     /gene="TMEM106C"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..890
                     /gene="TMEM106C"
                     /note="isoform a is encoded by transcript variant 1;
                     endoplasmic reticulum membrane protein overexpressed in
                     cancer"
                     /codon_start=1
                     /product="transmembrane protein 106C isoform a"
                     /protein_id="NP_001137314.1"
                     /db_xref="CCDS:CCDS8758.1"
                     /db_xref="GeneID:79022"
                     /db_xref="HGNC:HGNC:28775"
                     /translation="MGSQHSAAARPSSCRRKQEDDRDGLLAEREQEEAIAQFPYVEFT
                     GRDSITCLTCQGTGYIPTEQVNELVALIPHSDQRLRPQRTKQYVLLSILLCLLASGLV
                     VFFLFPHSVLVDDDGIKVVKVTFNKQDSLVILTIMATLKIRNSNFYTVAVTSLSSQIQ
                     YMNTVVSTYVTTNVSLIPPRSEQLVNFTGKAEMGGPFSYVYFFCTVPEILVHNIVIFM
                     RTSVKISYIGLMTQSSLETHHYVDCGGNSTAI"
     exon            325..388
                     /gene="TMEM106C"
                     /inference="alignment:Splign:2.1.0"
     exon            389..548
                     /gene="TMEM106C"
                     /inference="alignment:Splign:2.1.0"
     exon            549..689
                     /gene="TMEM106C"
                     /inference="alignment:Splign:2.1.0"
     exon            690..739
                     /gene="TMEM106C"
                     /inference="alignment:Splign:2.1.0"
     exon            740..793
                     /gene="TMEM106C"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1539
                     /gene="TMEM106C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1518..1523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM106C"
                     /note="hexamer: AATAAA"
     polyA_site      1539
                     /gene="TMEM106C"
                     /note="major polyA site"
ORIGIN      
        1 gcgctgagtg cgtgccgctc cgccgaccga agaggctggt aagtcctcaa gctggcaggt
       61 ggtcggggga gcggccggag aggagctgcc gggagttcgt gccctgcagg acatgacacc
      121 agtggcatat cacggccatg gggtctcagc attccgctgc tgctcgcccc tcctcctgca
      181 ggcgaaagca agaagatgac agggacggtt tgctggctga acgagagcag gaagaagcca
      241 ttgctcagtt cccatatgtg gaattcaccg ggagagatag catcacctgt ctcacgtgcc
      301 aggggacagg ctacattcca acagagcaag taaatgagtt ggtggctttg atcccacaca
      361 gtgatcagag attgcgccct cagcgaacta agcaatatgt cctcctgtcc atcctgcttt
      421 gtctcctggc atctggtttg gtggttttct tcctgtttcc gcattcagtc cttgtggatg
      481 atgacggcat caaagtggtg aaagtcacat ttaataagca agactccctt gtaattctca
      541 ccatcatggc caccctgaaa atcaggaact ccaacttcta cacggtggca gtgaccagcc
      601 tgtccagcca gattcagtac atgaacacag tggtcagtac atatgtgact actaacgtct
      661 cccttattcc acctcggagt gagcaactgg tgaattttac cgggaaggcc gagatgggag
      721 gaccgttttc ctatgtgtac ttcttctgca cggtacctga gatcctggtg cacaacatag
      781 tgatcttcat gcgaacttca gtgaagattt catacattgg cctcatgacc cagagctcct
      841 tggagacaca tcactatgtg gattgtggag gaaattccac agctatttaa caactgctat
      901 tggttcttcc acacagcgcc tgtagaagag agcacagcat atgttcccaa ggcctgagtt
      961 ctggacctac ccccacgtgg tgtaagcaga ggaggaattg gttcacttaa ctcccagcaa
     1021 acatcctcct gccacttagg aggaaacacc tccctatggt accatttatg tttctcagaa
     1081 ccagcagaat cagtgcctag cctgtgccca gcaaatagtt ggcactcaat aaagatttgc
     1141 agaatttaat acagatcttt tcagctgttc ttagggcatt ataaatggaa atcataacgt
     1201 ggttctaggt tatcaaacca tggagtgatg tggagctagg attgtgagtg acctgcaggc
     1261 cattatcagt gcctcatctg tgcagaagtg gcagcagaga gggaccatcc aaatacctaa
     1321 gagaaaacag acctagtcag gatatgaatt tgtttcagct gttcccaaag gcctgggagc
     1381 tttttgaaaa gaaagaaaaa agtgtgttgg cttttttttt ttttagaaag ttagaattgt
     1441 ttttaccaag agtctatgtg gggcttgatt cacccttcat ccattggctg gaacatggat
     1501 tggggatttg atagaaaaat aaaccctgct tttgattca
//
