LOCUS       NM_145041               3266 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 106A (TMEM106A), transcript
            variant 2, mRNA.
ACCESSION   NM_145041
VERSION     NM_145041.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3266)
  AUTHORS   Mao,D., Yan,F., Zhang,X. and Gao,G.
  TITLE     TMEM106A inhibits enveloped virus release from cell surface
  JOURNAL   iScience 25 (2), 103843 (2022)
   PUBMED   35198896
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3266)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3266)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3266)
  AUTHORS   Dai,H., Xu,D., Su,J., Jang,J. and Chen,Y.
  TITLE     Transmembrane protein 106a activates mouse peritoneal macrophages
            via the MAPK and NF-kappaB signaling pathways
  JOURNAL   Sci Rep 5, 12461 (2015)
   PUBMED   26215746
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3266)
  AUTHORS   Xu,D., Qu,L., Hu,J., Li,G., Lv,P., Ma,D., Guo,M. and Chen,Y.
  TITLE     Transmembrane protein 106A is silenced by promoter region
            hypermethylation and suppresses gastric cancer growth by inducing
            apoptosis
  JOURNAL   J Cell Mol Med 18 (8), 1655-1666 (2014)
   PUBMED   24975047
  REMARK    GeneRIF: Low TMEM106A expression is associated with gastric cancer.
REFERENCE   6  (bases 1 to 3266)
  AUTHORS   Garcia-Casado,Z., Romero,I., Fernandez-Serra,A., Rubio,L.,
            Llopis,F., Garcia,A., Llombart,P. and Lopez-Guerrero,J.A.
  TITLE     A de novo complete BRCA1 gene deletion identified in a Spanish
            woman with early bilateral breast cancer
  JOURNAL   BMC Med Genet 12, 134 (2011)
   PUBMED   21989022
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK056132.1, AC024051.5 and BQ013276.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145041.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.235083.1,
                                           SRR1803613.233723.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000612339.4/ ENSP00000483246.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1542              AK056132.1         1-1542
            1543-3163           AC024051.5         109611-111231       c
            3164-3266           BQ013276.1         13-115              c
FEATURES             Location/Qualifiers
     source          1..3266
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..3266
                     /gene="TMEM106A"
                     /note="transmembrane protein 106A"
                     /db_xref="GeneID:113277"
                     /db_xref="HGNC:HGNC:28288"
     exon            1..48
                     /gene="TMEM106A"
                     /inference="alignment:Splign:2.1.0"
     exon            49..216
                     /gene="TMEM106A"
                     /inference="alignment:Splign:2.1.0"
     exon            217..448
                     /gene="TMEM106A"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1026
                     /gene="TMEM106A"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transmembrane protein 106A isoform a"
                     /protein_id="NP_659478.1"
                     /db_xref="CCDS:CCDS11462.1"
                     /db_xref="GeneID:113277"
                     /db_xref="HGNC:HGNC:28288"
                     /translation="MGKTFSQLGSWREDENKSILSSKPAIGSKAVNYSSTGSSKSFCS
                     CVPCEGTADASFVTCPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLI
                     CLVTSSFIVFFLFPRSVIVQPAGLNSSTVAFDEADIYLNITNILNISNGNYYPIMVTQ
                     LTLEVLHLSLVVGQVSNNLLLHIGPLASEQMFYAVATKIRDENTYKICTWLEIKVHHV
                     LLHIQGTLTCSYLSHSEQLVFQSYEYVDCRGNASVPHQLTPHPP"
     exon            449..512
                     /gene="TMEM106A"
                     /inference="alignment:Splign:2.1.0"
     exon            513..666
                     /gene="TMEM106A"
                     /inference="alignment:Splign:2.1.0"
     exon            667..807
                     /gene="TMEM106A"
                     /inference="alignment:Splign:2.1.0"
     exon            808..851
                     /gene="TMEM106A"
                     /inference="alignment:Splign:2.1.0"
     exon            852..905
                     /gene="TMEM106A"
                     /inference="alignment:Splign:2.1.0"
     exon            906..3266
                     /gene="TMEM106A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3237..3242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM106A"
                     /note="hexamer: AATAAA"
     polyA_site      3266
                     /gene="TMEM106A"
                     /note="major polyA site"
ORIGIN      
        1 attttcgatt ccactctctt ccgtttctgt cgctgcagtc gtccgcggga ctccggccgg
       61 ttgccggccc caggcggtgc ttctccccac caccgcccag ctcagctcag cccagcccag
      121 cccactctgc ccttagaggc ccttctcccc aaagacgcac tccagaagtc tcgccctcgt
      181 gcggctgagg agcctgggat cccagacctg aacaagtgaa acccccgccc ctgaagaatg
      241 ggtaagacgt tttcccagct gggctcttgg cgggaggatg agaacaagtc aatcctgtcc
      301 tccaaaccag ccattggcag caaggctgtc aactactcca gcaccggtag cagcaagtct
      361 ttttgttcct gtgtgccttg tgaaggaact gctgatgcca gcttcgtgac ttgtcccacc
      421 tgccagggca gtggcaagat tccccaagag ctggagaagc agttggtggc tctcattccc
      481 tatggggacc agaggctgaa gcccaagcac acgaagctct ttgtgttcct ggccgtgctc
      541 atctgcctgg tgacctcctc cttcatcgtc tttttcctgt ttccccggtc cgtcattgtg
      601 cagcctgcag gcctcaactc ctccacagtg gcctttgatg aggctgatat ctacctcaac
      661 ataacgaata tcttaaacat ctccaatggc aactactacc ccattatggt gacacagctg
      721 accctcgagg ttctgcacct gtccctcgtg gtggggcagg tttccaacaa ccttctccta
      781 cacattggcc ctttggccag tgaacagatg ttttacgcag tagctaccaa gatacgggat
      841 gaaaacacat acaaaatctg tacctggctg gaaatcaaag tccaccatgt gcttttgcac
      901 atccagggca ccctgacctg ttcatacctg agccattcag agcagctggt ctttcagagc
      961 tatgaatatg tggactgccg aggaaacgca tctgtgcccc accagctgac ccctcaccca
     1021 ccatgacctg tctgctgtcc ctgtactcca ggcacctgca accctggtct atatctccca
     1081 caactccctg gtgactaagg aaggactaca gaggctttgc caaaggagaa gccctgcctc
     1141 atcacaccct tacctcccac cccctcagca caggaagctt gctttgaagt taacttcata
     1201 cacacacact catatcctcc agtttccccc agattctttc aggggctgcc atcagattct
     1261 gcccttggtt agttttttgt tttttttttg gtagagacag agtctcactg ttggtccagg
     1321 ttggttttga actcctgggc tcaagcgatc ctcccttctt ggcctcccaa agcacttgga
     1381 ttacagatgt gagcctgtgc ctggctggtc tttcttgagg aaaatctgac ctggcatttt
     1441 cttgaggcac cttagattcc ctggagtggc acctggcctt tctgtactga gcacctggtc
     1501 agtctgaagg gggcatttca ccccagctcc atcagggctg gctgtcccgt ctgaatgtgg
     1561 agagagctgt agttttatct ggcttttaaa acatggacct gccggctggg cgcagtggct
     1621 tacacctgta atcccagtac tttgggaggc cgaagtgggt ggatcacttg agggcaggag
     1681 ttcgtgacca gcctggtcaa catggtgaaa ccttgtctct actaaaaata caaaaattag
     1741 ctgggtgtgg tggcatgcgc ctgtaatccc agctactcgg gaggctgagg cagcagaatc
     1801 acttgaaacc ggaaggcaga ggttgcagtg agccaagatc gtgcaactgc actccagcct
     1861 gggcaaaaga gcaaaacttt gtctcaaaaa aagactcttt tcaagttttc taccctctga
     1921 taagaaaatt tggggatatc cagtgccatc tccaaggact ttcaggggat catagatgct
     1981 tttctgtgcc tatctgcttt gaccatgtga aaaagtgata gtctgcttct ctctggtaac
     2041 ttgtctgcca cccatctgat agtaagatta gccaaggccc tttagccctc tgtcctttct
     2101 ggttattgac tgtccctggt tcctaggaag acagagttgt tctccagcta aagcgtctcc
     2161 tctctataaa gtagttttac tattcttttc atagcaggag ccaaaatagt agaggagggg
     2221 agagaggcac ctggcactct gcgggcctgc acaggaaaaa cagagccaaa gacagaatca
     2281 ttgtataaga tatttattaa aggagagcct ctaagtccac atcctgagcc catgtgagtg
     2341 gacacaggta ggtaaaacgg tgggtccagc tgctgtcatc tgaaagcctt caggagatga
     2401 agctatcagt atccagctga aggctgctgg gttctgttcc accaccacct tagcaccagg
     2461 gccctctctg gtcccagagg cctcatctct ccttgggctt tgacaatgtg gagcagcaca
     2521 tcagcaggga ctggtctaga ccctcccttt cctgtcactt agctggagct aagctccaga
     2581 taacccctag gttcccactg gctcctagta gaaatagttt ctgtacttta gcagaacagg
     2641 aaggatattt gttcattaaa ggtggcttgg tcttacagct gggtgcagtg gtatatacct
     2701 gtagtcccag ctactcagga agctgaggtg agaggatctc tagagcccag gaattcaagt
     2761 ttaacatgag cagcaacatt agcaagaccc cgtttaaaaa aaaaaaaaga gctgggcgta
     2821 atggcgcaca cctgtaatcc cacctactca ggaggctgag gcaggagaat cacttgaacc
     2881 tgggaggcag aggttgcagt gagccaagat cgcaccactg cactccagcc tgggcaacaa
     2941 gggcgagact ctgtctcaaa aaaaaaaaaa aaaaaagatg gctgtctctt tatcattcag
     3001 acagaacgat gaacacaggt gagcagggaa agctaatttt gaagtaggat gcatggagag
     3061 ggagaagtgg tgacagaact tggtaactag ctggctgggg gaacgagggg aaggaaggag
     3121 actgctgtct ccaagctgag gtcagggtgg tgttggcaag agcgcaaaag tccagggaag
     3181 ccaggctgga gctgctgtgt atagactgcc aaatgtgaag tatttatatt gtattcaata
     3241 aactatactt aagagtgttc aaaaaa
//
