LOCUS       NM_017728               4703 bp    mRNA    linear   PRI 12-FEB-2024
DEFINITION  Homo sapiens transmembrane protein 104 (TMEM104), transcript
            variant 1, mRNA.
ACCESSION   NM_017728
VERSION     NM_017728.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4703)
  AUTHORS   Olsen,J.V., Blagoev,B., Gnad,F., Macek,B., Kumar,C., Mortensen,P.
            and Mann,M.
  TITLE     Global, in vivo, and site-specific phosphorylation dynamics in
            signaling networks
  JOURNAL   Cell 127 (3), 635-648 (2006)
   PUBMED   17081983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN999695.1, AK074029.1, AC068874.21 and CN479614.1.
            
            On Jul 1, 2019 this sequence version replaced NM_017728.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011552.1, SRR11853565.13607.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335464.10/ ENSP00000334849.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-572               DN999695.1         23-594
            573-2881            AK074029.1         549-2857
            2882-2882           AC068874.21        95195-95195         c
            2883-4700           AK074029.1         2859-4676
            4701-4703           CN479614.1         45-47               c
FEATURES             Location/Qualifiers
     source          1..4703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..4703
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /note="transmembrane protein 104"
                     /db_xref="GeneID:54868"
                     /db_xref="HGNC:HGNC:25984"
     exon            1..79
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /inference="alignment:Splign:2.1.0"
     exon            80..191
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1637
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 104 isoform 1"
                     /protein_id="NP_060198.3"
                     /db_xref="CCDS:CCDS32723.1"
                     /db_xref="GeneID:54868"
                     /db_xref="HGNC:HGNC:25984"
                     /translation="MAGEITETGELYSSYVGLVYMFNLIVGTGALTMPKAFATAGWLV
                     SLVLLVFLGFMSFVTTTFVIEAMAAANAQLHWKRMENLKEEEDDDSSTASDSDVLIRD
                     NYERAEKRPILSVQRRGSPNPFEITDRVEMGQMASMFFNKVGVNLFYFCIIVYLYGDL
                     AIYAAAVPFSLMQVTCSATGNDSCGVEADTKYNDTDRCWGPLRRVDAYRIYLAIFTLL
                     LGPFTFFDVQKTKYLQILTSLMRWIAFAVMIVLALIRIGHGQGEGHPPLADFSGVRNL
                     FGVCVYSFMCQHSLPSLITPVSSKRHLTRLVFLDYVLILAFYGLLSFTAIFCFRGDSL
                     MDMYTLNFARCDVVGLAAVRFFLGLFPVFTISTNFPIIAVTLRNNWKTLFHREGGTYP
                     WVVDRVVFPTITLVPPVLVAFCTHDLESLVGITGAYAGTGIQYVIPAFLVYHCRRDTQ
                     LAFGCGVSNKHRSPFRHTFWVGFVLLWAFSCFIFVTANIILSETKL"
     exon            192..313
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /inference="alignment:Splign:2.1.0"
     exon            314..395
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /inference="alignment:Splign:2.1.0"
     exon            396..492
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /inference="alignment:Splign:2.1.0"
     exon            493..573
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /inference="alignment:Splign:2.1.0"
     exon            574..673
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /inference="alignment:Splign:2.1.0"
     exon            674..782
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /inference="alignment:Splign:2.1.0"
     exon            783..876
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /inference="alignment:Splign:2.1.0"
     exon            877..4703
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3397..3402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /note="hexamer: ATTAAA"
     polyA_site      3432
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /note="major polyA site"
     regulatory      4684..4689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
                     /note="hexamer: AATAAA"
     polyA_site      4703
                     /gene="TMEM104"
                     /gene_synonym="SLC38A12"
ORIGIN      
        1 ggaagctggt gctggacagc tggcgccggc agcagcggac cggcgggaga cggcggcttg
       61 ggagctggct gtgctgcagg agctgcggca gccgccgtcc ttgcacctaa ggaacctctg
      121 ctgccagccc ttcctcactt ttggaaatgg cgggtgaaat tacagagacc ggggaactct
      181 actcttccta cgttgggctg gtgtacatgt ttaacctcat cgtgggcacg ggcgcactca
      241 ccatgcccaa ggcattcgcc actgccgggt ggcttgtcag cctcgtcctg ctggtgttcc
      301 tgggcttcat gagcttcgtg accaccacct ttgtgataga ggccatggct gcagccaacg
      361 cgcagctcca ctggaagagg atggagaacc tcaaggagga ggaagatgac gactcctcca
      421 cagcctcaga cagcgatgtt ctcatccggg acaactacga gcgggcagag aagcggccca
      481 tcctgtctgt gcagagacgt ggatctccca acccgtttga aatcacagac cgggtggaaa
      541 tgggacaaat ggcctccatg ttcttcaata aagtgggggt caacttgttc tatttctgca
      601 tcatcgttta cctgtatgga gacctcgcca tctatgctgc tgccgtgccc ttctccctca
      661 tgcaggtgac ctgcagcgcc actggcaatg actcctgcgg tgtggaagca gacaccaaat
      721 acaatgacac tgaccggtgc tgggggcccc tgcgccgagt ggacgcctac cgcatctact
      781 tggcgatctt cactctcctc ctcggaccgt tcaccttctt tgacgtccag aagaccaagt
      841 acctgcagat cctgacctct ctgatgagat ggatcgcttt cgccgtcatg attgtgctgg
      901 ccctgatccg catcgggcac ggacaagggg aggggcaccc gcccctggct gacttctcgg
      961 gggtccggaa cctgtttggg gtgtgcgtct actccttcat gtgccagcac tctctgccat
     1021 ccctcattac ccccgtctcc tccaagcgcc acctcacaag gctggtgttc ctggactacg
     1081 tgctgatcct ggccttctac ggcctcctct ccttcaccgc catcttctgc ttccgcggcg
     1141 acagcctcat ggacatgtac accctcaact tcgcgcgctg tgacgtcgtg ggcctggccg
     1201 ctgtgcgctt tttcctgggc ctcttccccg tcttcaccat cagcaccaac ttccccatca
     1261 ttgccgtgac cctgcgcaac aactggaaga cactcttcca ccgcgagggc ggcacgtacc
     1321 cgtgggtggt ggaccgcgtc gtgtttccca ccatcaccct ggtgccgcct gtgctggtgg
     1381 ccttctgcac ccacgacctg gagtccctgg tgggcatcac aggggcctac gcgggcaccg
     1441 gcatccagta cgtcatcccc gccttcctgg tgtaccactg ccgcagggac acccagctgg
     1501 cctttggctg tggggtcagc aacaagcaca ggtccccttt ccgccacacc ttctgggtgg
     1561 gcttcgtgct gctctgggct ttctcctgct tcattttcgt cacggccaat atcatcctca
     1621 gcgagaccaa gctctgatgg caggacaggc aggtctagtg acaggaggca taggggcccc
     1681 agccccaccc ctcgcccgca gagcccagat ttagttgctc ccaggtcttc atggggcagg
     1741 tgggactgtg gctctagggg aaaccccctg tccagctggg gttgttctcc ccacccacct
     1801 tccacccagt ctgcacctgt cctcactccc ccgggcagct ctcccaccag gtccttctgc
     1861 ctgggtgacg cgtggctgct cccaagttct aagactcatt actggaatca cacctctccc
     1921 acatcttcca acacgcttca cccccaaccc tacttccagg gcgggctact ccctgcacaa
     1981 tgggagatgc agtgctggca ctgccatcat ttgtcccaga cccatgcccc tcccctctcc
     2041 tgccccatcc tgcgtccttg tctaagaaac ctccactagc agctgctgcc tcttcagagg
     2101 cgaatcccag gctggaagta tcctagccag gtctgcctgt gacggcaggg cccaccctcc
     2161 caccaggcct gggaggcggt aggtgccacc tcagagaggg cctggctggc cccatgacaa
     2221 gaacaagaag tgctaactgg taccagagtc cccagataga gctgcgaggg ccctcgctgt
     2281 gggcgcgagc tccggagtag caggctggat ggagcatccc ttctacaggg acacagccgc
     2341 ctgccagctg ggcctaaagt ctggagcttg tctctgaaag ggaccgtctg ctgccctcgc
     2401 tgccccactg gagccctcag ggcctcctac agtgcaggtg gtcctactag agggaagcca
     2461 tccccacctg gcacctcagc ggcttggcag tgacatggca gtgggagggc tctgaggttc
     2521 ccaccctgac aatggtcagg ctgcccgtgc tcccactcca acactaaaag cggctccctt
     2581 aggggctgag cgtgggtgct cagtgttcac gctatatccc ttgggcaatg tggggttgga
     2641 tggggccccc acttccattc ccatggaagg aggccaggtc cccagccacc tcccactcag
     2701 ccatgcacgc acttgctggg ctggcctcct gggaaacaca ggtgactcga atgaactctg
     2761 cattttcaac gtgccttcta ctgcttcagg acctgggggt ccccctgacc ctcactggct
     2821 tgcccccagc cctgggcctg gccccacctg tcctggagcc cagagcccct ggcctggagc
     2881 tacctctctg gggtgggtct caggccccac ccctccctct tttgagttca gtgccttgct
     2941 cagcccctcc cctgtatctc agcgtcttca gacctctgac agagcgacga tgtagggtct
     3001 cccggggccc aaggtggtct cagggtcagg ggtgggattt gcagggaact cggggagccc
     3061 acgggctgcg ccacctctgc cctggcagct gaagcctggg agagtccctg cgtggtgtaa
     3121 ttggcctcag cccgctttct ctgtgccgtc gcacctcagt gtttctcata gcttgtcccc
     3181 acgtgtcact ttccatccac gggaaaaaca aatgcccctt ctccatctat cattgcgact
     3241 tcctcccagg aggcctctca ggttgggtag agcaggggcc tgcagtggtc aggccaagag
     3301 caaggaagac ctggctgccc cactgtggct gaaaactcaa aacatctgga actacccttc
     3361 tccaattacg ttccctcttg cttaaagaca aagctaatta aatcatcctg ccacccgagg
     3421 ctccaaacca aatcttggac gcaaattcat tagcttcata aagcccaggt tgatttatgt
     3481 gacagtctgg aaccgcccag ccatggagtc ggtggccgtg ttccctgccc tggagggaac
     3541 tggccagcag tgaccacatc gctgatgcca agtggggacc ctcaccactg ccgttgtcta
     3601 gctgctttgc tcctcagtgt cctcctgctg taagtcagat gaggtcacct tcctctccat
     3661 cgatgccagg cttctgccgc tgacggccaa tggggcttgg ggccaggggc agagaacccc
     3721 aacagcaaga gagccccagg tgatgctggc tctccacgtg catccggcac gtttcactgc
     3781 agccatcatc aacttggcaa agtaggcaag ctcagcttgt ggtttccatt ttgcagatgg
     3841 gcccccgggg tcagtgatgg gaagagcaga agaggatgcc agcccagcct ggcccaggag
     3901 caggtgtcgt tgtggaggaa agcttaaact caacagcctc tacccaacat ctgccacctg
     3961 catggcccca gatgcccccg gtgcaggcca ggtcaaggtg ggagtaaact ttctttgcct
     4021 ccctccccac agaagcacca gacccacctg agccccagag cctcatgcca gcagctcctg
     4081 gctgttcctc acctgaggct agagcagcag ctgccagctt atagatgggg cggatggcag
     4141 gtgatagact gggaagcact gctgggtggt ggaggtgggc agtggcacca tgacgggccc
     4201 ctagccacac agctgtcctc actacggggc agggagcagc ctcggcaaca ggcaaaggcc
     4261 agagtcagag tggtggggag gacaggggct gctgccccgc tcctggaaag ccactgcaga
     4321 ggggcagtgg ctggcagtgc caggcctggg ggaagtggaa gcgtcctgtc tgggggcaga
     4381 ttcccaagca agggtgaccc atggttaagg gccactggaa agctggagag agcttgggat
     4441 cccttccacc tggggccaat ggtgttgatt gcagactgga ggggtaacct ccgctgaggg
     4501 tcattatgtg ccaggcatgg cattgggtac tttctgcatt gggaccaggc agccgggcct
     4561 gccatttgag gcagcgagcc tccgtgacct gtcctccctc atttgtaaag tggggtaaca
     4621 gctatgtcac tggccagttg tggggattaa agtgctgagc ttagtgccca gcccaaaatg
     4681 ctcaataaag ctattcagtg ata
//
