LOCUS       NM_018286               1755 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 100 (TMEM100), transcript
            variant 2, mRNA.
ACCESSION   NM_018286
VERSION     NM_018286.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1755)
  AUTHORS   Nees,T.A., Wang,N., Adamek,P., Zeitzschel,N., Verkest,C., La
            Porta,C., Schaefer,I., Virnich,J., Balkaya,S., Prato,V.,
            Morelli,C., Begay,V., Lee,Y.J., Tappe-Theodor,A., Lewin,G.R.,
            Heppenstall,P.A., Taberner,F.J. and Lechner,S.G.
  TITLE     Role of TMEM100 in mechanically insensitive nociceptor un-silencing
  JOURNAL   Nat Commun 14 (1), 1899 (2023)
   PUBMED   37019973
  REMARK    GeneRIF: Role of TMEM100 in mechanically insensitive nociceptor
            un-silencing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1755)
  AUTHORS   Pan,C., Jiao,Y., Kong,D., Deng,H., Xu,S., Tang,D., Yin,W., Gao,P.,
            Yu,W., Fan,Y. and Wen,D.
  TITLE     Upregulation of DRG protein TMEM100 facilitates dry-skin-induced
            pruritus by enhancing TRPA1 channel function
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (2), 404-416 (2022)
   PUBMED   36514220
  REMARK    GeneRIF: Upregulation of DRG protein TMEM100 facilitates
            dry-skin-induced pruritus by enhancing TRPA1 channel function.
REFERENCE   3  (bases 1 to 1755)
  AUTHORS   Wang,Y., Ha,M., Li,M., Zhang,L. and Chen,Y.
  TITLE     Histone deacetylase 6-mediated downregulation of TMEM100 expedites
            the development and progression of non-small cell lung cancer
  JOURNAL   Hum Cell 35 (1), 271-285 (2022)
   PUBMED   34687431
  REMARK    GeneRIF: Histone deacetylase 6-mediated downregulation of TMEM100
            expedites the development and progression of non-small cell lung
            cancer.
REFERENCE   4  (bases 1 to 1755)
  AUTHORS   Liu,Y., Wang,Y., Lou,Y., Tian,W. and Que,K.
  TITLE     Functional expression of TRPA1 channel, TRPV1 channel and TMEM100
            in human odontoblasts
  JOURNAL   J Mol Histol 52 (5), 1105-1114 (2021)
   PUBMED   34514518
  REMARK    GeneRIF: Functional expression of TRPA1 channel, TRPV1 channel and
            TMEM100 in human odontoblasts.
REFERENCE   5  (bases 1 to 1755)
  AUTHORS   Ma,J., Yan,T., Bai,Y., Ye,M., Ma,C., Ma,X. and Zhang,L.
  TITLE     TMEM100 negatively regulated by microRNA-106b facilitates cellular
            apoptosis by suppressing survivin expression in NSCLC
  JOURNAL   Oncol Rep 46 (2) (2021)
   PUBMED   34278505
  REMARK    GeneRIF: TMEM100 negatively regulated by microRNA106b facilitates
            cellular apoptosis by suppressing survivin expression in NSCLC.
REFERENCE   6  (bases 1 to 1755)
  AUTHORS   Frullanti,E., Colombo,F., Falvella,F.S., Galvan,A., Noci,S., De
            Cecco,L., Incarbone,M., Alloisio,M., Santambrogio,L., Nosotti,M.,
            Tosi,D., Pastorino,U. and Dragani,T.A.
  TITLE     Association of lung adenocarcinoma clinical stage with gene
            expression pattern in noninvolved lung tissue
  JOURNAL   Int J Cancer 131 (5), E643-E648 (2012)
   PUBMED   22223368
  REMARK    GeneRIF: Loss of TMEM100 is associated with lung adenocarcinoma.
REFERENCE   7  (bases 1 to 1755)
  AUTHORS   Somekawa,S., Imagawa,K., Hayashi,H., Sakabe,M., Ioka,T., Sato,G.E.,
            Inada,K., Iwamoto,T., Mori,T., Uemura,S., Nakagawa,O. and Saito,Y.
  TITLE     Tmem100, an ALK1 receptor signaling-dependent gene essential for
            arterial endothelium differentiation and vascular morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 109 (30), 12064-12069 (2012)
   PUBMED   22783020
REFERENCE   8  (bases 1 to 1755)
  AUTHORS   Carty,C.L., Johnson,N.A., Hutter,C.M., Reiner,A.P., Peters,U.,
            Tang,H. and Kooperberg,C.
  TITLE     Genome-wide association study of body height in African Americans:
            the Women's Health Initiative SNP Health Association Resource
            (SHARe)
  JOURNAL   Hum Mol Genet 21 (3), 711-720 (2012)
   PUBMED   22021425
REFERENCE   9  (bases 1 to 1755)
  AUTHORS   de Krom,M., Staal,W.G., Ophoff,R.A., Hendriks,J., Buitelaar,J.,
            Franke,B., de Jonge,M.V., Bolton,P., Collier,D., Curran,S., van
            Engeland,H. and van Ree,J.M.
  TITLE     A common variant in DRD3 receptor is associated with autism
            spectrum disorder
  JOURNAL   Biol Psychiatry 65 (7), 625-630 (2009)
   PUBMED   19058789
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 1755)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA896013.1, BC010128.2 and BQ027747.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018286.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP341507.1, SRR5189667.188386.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267769 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424486.3/ ENSP00000395328.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               DA896013.1         1-150
            151-1477            BC010128.2         1-1327
            1478-1755           BQ027747.1         17-294              c
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..1755
                     /gene="TMEM100"
                     /note="transmembrane protein 100"
                     /db_xref="GeneID:55273"
                     /db_xref="HGNC:HGNC:25607"
                     /db_xref="MIM:616334"
     exon            1..246
                     /gene="TMEM100"
                     /inference="alignment:Splign:2.1.0"
     exon            247..1755
                     /gene="TMEM100"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..716
                     /gene="TMEM100"
                     /codon_start=1
                     /product="transmembrane protein 100"
                     /protein_id="NP_060756.2"
                     /db_xref="CCDS:CCDS11587.1"
                     /db_xref="GeneID:55273"
                     /db_xref="HGNC:HGNC:25607"
                     /db_xref="MIM:616334"
                     /translation="MTEEPIKEILGAPKAHMAATMEKSPKSEVVITTVPLVSEIQLMA
                     ATGGTELSCYRCIIPFAVVVFIAGIVVTAVAYSFNSHGSIISIFGLVVLSSGLFLLAS
                     SALCWKVRQRSKKAKRRESQTALVANQRSLFA"
     regulatory      1739..1744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM100"
                     /note="hexamer: ATTACA"
     polyA_site      1755
                     /gene="TMEM100"
                     /note="major polyA site"
ORIGIN      
        1 gtcatttagg aacagaggta gcctgaaaga agcaggaact ccaggatccc aaaccagagc
       61 agaccctata gtaaagtatt tttacatctt ttcctttccc cagaagagat ccctaaccta
      121 ttgttttatt gacagccttg ctgttagagg ctctttccca gaagttggac gaagaggctc
      181 aggcgttgct gtttcttgtc ttccaagtca agtggttact ctggtaatgg attgcctctc
      241 tccgagcttt caccctggtg agactgtcca gatctagtct gtaaacccag cttagaagca
      301 ctgttgtaaa aatgactgaa gagcccatca aggagatcct gggagcccca aaggctcaca
      361 tggcagcgac gatggagaag agccccaaga gtgaagttgt gatcaccaca gtccctctgg
      421 tcagtgagat tcagttgatg gctgctacag ggggtaccga gctctcctgc taccgctgca
      481 tcatcccctt tgctgtggtt gtcttcatcg ccggcatcgt ggtcaccgcg gtggcttaca
      541 gcttcaattc ccatgggtct attatctcca tctttggcct ggttgttctg tcatctggac
      601 tttttttact agcctccagt gccttgtgct ggaaagtgag acaaaggagc aagaaagcca
      661 agagacggga gagtcaaaca gctctcgtgg caaatcagag aagcttgttt gcttgagact
      721 gaatacgacc aaatgggcca ttgggcctgg aaaacgtgct ctgactttgt cacccaattc
      781 acccagaacc atggtgggag agaacagact tggcgttgga gcagactgga agaatggggg
      841 tgggagggtg gaggggcttc tcctttgtga ggaatgactc atgtcttctt taacgacaaa
      901 cttaacccta agggctactt ctgagactga aaaatcagct ttctatttac atgaaacact
      961 ttgggggtca tgggagtgca cagcattaga cagtatttgg ttcaccctgt aaagtagcca
     1021 agaaaagatg agaaaaatca agataggcct ggcacactag acatttgcct ccaaaagaaa
     1081 taacctacag tcttaagatg tatcataaaa atgttctgcc aaggatctaa attaccttgg
     1141 gtttcgcata tgtctatgaa attctgtgat aatttttttc aatacattga ttcactggcg
     1201 tctgttttca ttttatactt ttaataactc atcactggtg gtactttatc ttgaaaagta
     1261 atatttttta tattttaaca ttggacagtg ttagccagtt gtaatgatgt atcagaagta
     1321 aagaaaaacc cattaaagtt atagctaata gatgctgttg ggggttaaat taatagtaaa
     1381 ataatccaat atagcacttt tgatgatttt tatataaaag tcaactgtac atttcattca
     1441 gaataataaa tacttattgc tgctaaaact tcttaaatgg ttgtttctgc tatagttatt
     1501 tctattgcag ttccaaattg ccatcttccc ttgtctcatt tgcaagttct caattgtatt
     1561 tctctcaaat ggacaggttc cttctttact ggaggatttt tgtttttatc atattggttt
     1621 ttcattactt ctgaatagtc ttaattacgt ttactaaatt ctaaaggatt tctgtgctat
     1681 tataattagg aaatcaacgt ctttggtcag gaactttata atgtgctatt aaatgtatat
     1741 tacatttttg tggaa
//
