LOCUS       NP_003683                380 aa            linear   PRI 12-JUN-2025
DEFINITION  tomoregulin-1 precursor [Homo sapiens].
ACCESSION   NP_003683
VERSION     NP_003683.2
DBSOURCE    REFSEQ: accession NM_003692.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 380)
  AUTHORS   Chan,Y.H., Liu,Z., Bastard,P., Khobrekar,N., Hutchison,K.M.,
            Yamazaki,Y., Fan,Q., Matuozzo,D., Harschnitz,O., Kerrouche,N.,
            Nakajima,K., Amin,P., Yatim,A., Rinchai,D., Chen,J., Zhang,P.,
            Ciceri,G., Chen,J., Dobbs,K., Belkaya,S., Lee,D., Gervais,A.,
            Aydin,K., Kartal,A., Hasek,M.L., Zhao,S., Reino,E.G., Lee,Y.S.,
            Seeleuthner,Y., Chaldebas,M., Bailey,R., Vanhulle,C., Lorenzo,L.,
            Boucherit,S., Rozenberg,F., Marr,N., Mogensen,T.H., Aubart,M.,
            Cobat,A., Dulac,O., Emiroglu,M., Paludan,S.R., Abel,L.,
            Notarangelo,L., Longnecker,R., Smith,G., Studer,L., Casanova,J.L.
            and Zhang,S.Y.
  TITLE     Human TMEFF1 is a restriction factor for herpes simplex virus in
            the brain
  JOURNAL   Nature 632 (8024), 390-400 (2024)
   PUBMED   39048830
  REMARK    GeneRIF: Human TMEFF1 is a restriction factor for herpes simplex
            virus in the brain.
REFERENCE   2  (residues 1 to 380)
  AUTHORS   Dai,Y., Idorn,M., Serrero,M.C., Pan,X., Thomsen,E.A., Narita,R.,
            Maimaitili,M., Qian,X., Iversen,M.B., Reinert,L.S., Flygaard,R.K.,
            Chen,M., Ding,X., Zhang,B.C., Carter-Timofte,M.E., Lu,Q., Jiang,Z.,
            Zhong,Y., Zhang,S., Da,L., Zhu,J., Denham,M., Nissen,P.,
            Mogensen,T.H., Mikkelsen,J.G., Zhang,S.Y., Casanova,J.L., Cai,Y.
            and Paludan,S.R.
  TITLE     TMEFF1 is a neuron-specific restriction factor for herpes simplex
            virus
  JOURNAL   Nature 632 (8024), 383-389 (2024)
   PUBMED   39048823
  REMARK    GeneRIF: TMEFF1 is a neuron-specific restriction factor for herpes
            simplex virus.
REFERENCE   3  (residues 1 to 380)
  AUTHORS   Tian,J., Yang,L., Wang,Z. and Yan,H.
  TITLE     MIR503HG impeded ovarian cancer progression by interacting with
            SPI1 and preventing TMEFF1 transcription
  JOURNAL   Aging (Albany NY) 14 (13), 5390-5405 (2022)
   PUBMED   35771155
  REMARK    GeneRIF: MIR503HG impeded ovarian cancer progression by interacting
            with SPI1 and preventing TMEFF1 transcription.
REFERENCE   4  (residues 1 to 380)
  AUTHORS   Nie,X., Zheng,M., Gao,L., Hu,Y., Zhuang,Y., Li,X., Zhu,L., Liu,J.
            and Lin,B.
  TITLE     Interaction between TMEFF1 and AHNAK proteins in ovarian cancer
            cells: Implications for clinical prognosis
  JOURNAL   Int Immunopharmacol 107, 108726 (2022)
   PUBMED   35338959
  REMARK    GeneRIF: Interaction between TMEFF1 and AHNAK proteins in ovarian
            cancer cells: Implications for clinical prognosis.
REFERENCE   5  (residues 1 to 380)
  AUTHORS   Arii,J., Hirohata,Y., Kato,A. and Kawaguchi,Y.
  TITLE     Nonmuscle myosin heavy chain IIb mediates herpes simplex virus 1
            entry
  JOURNAL   J Virol 89 (3), 1879-1888 (2015)
   PUBMED   25428876
REFERENCE   6  (residues 1 to 380)
  AUTHORS   Letra,A., Menezes,R., Govil,M., Fonseca,R.F., McHenry,T.,
            Granjeiro,J.M., Castilla,E.E., Orioli,I.M., Marazita,M.L. and
            Vieira,A.R.
  TITLE     Follow-up association studies of chromosome region 9q and
            nonsyndromic cleft lip/palate
  JOURNAL   Am J Med Genet A 152A (7), 1701-1710 (2010)
   PUBMED   20583170
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (residues 1 to 380)
  AUTHORS   Harms,P.W. and Chang,C.
  TITLE     Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct
            binding to the nodal coreceptor Cripto
  JOURNAL   Genes Dev 17 (21), 2624-2629 (2003)
   PUBMED   14563676
  REMARK    GeneRIF: In Xenopus, TMEFF1 blocks nodal signaling through binding
            to the nodal coreceptor Cripto; it does not associate with either
            nodal or the type I activin receptor-like kinase (ALK) 4 receptor.
REFERENCE   8  (residues 1 to 380)
  AUTHORS   Gery,S., Yin,D., Xie,D., Black,K.L. and Koeffler,H.P.
  TITLE     TMEFF1 and brain tumors
  JOURNAL   Oncogene 22 (18), 2723-2727 (2003)
   PUBMED   12743596
  REMARK    GeneRIF: This protein may behave as a tumor suppressor gene in
            brain cancers.
REFERENCE   9  (residues 1 to 380)
  AUTHORS   Eib,D.W., Merkx,G.F., Martens,G.J. and Cremers,F.P.
  TITLE     Assignment1 of H7365 (C9orf2) to human chromosome band 9q31 by
            somatic cell hybrid analysis and fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 180-181 (1998)
   PUBMED   9730596
REFERENCE   10 (residues 1 to 380)
  AUTHORS   Eib,D.W. and Martens,G.J.
  TITLE     A novel transmembrane protein with epidermal growth factor and
            follistatin domains expressed in the hypothalamo-hypophysial axis
            of Xenopus laevis
  JOURNAL   J Neurochem 67 (3), 1047-1055 (1996)
   PUBMED   8752111
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353805.20, DN602026.1, BC035056.1, BC021991.1 and BF436262.1.
            
            On Apr 5, 2003 this sequence version replaced NP_003683.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.58274.1, BC035056.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374879.5/ ENSP00000364013.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     Protein         1..380
                     /product="tomoregulin-1 precursor"
                     /note="cancer/testis antigen family 120, member 1;
                     tomoregulin-1; transmembrane protein with EGF-like and one
                     follistatin-like domain"
                     /calculated_mol_wt=36987
     sig_peptide     1..39
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3966
     mat_peptide     40..380
                     /product="Tomoregulin-1. /id=PRO_0000286056"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IYR6.1)"
                     /calculated_mol_wt=36987
     Region          99..143
                     /region_name="KAZAL"
                     /note="Kazal type serine protease inhibitors; smart00280"
                     /db_xref="CDD:197624"
     Site            105..106
                     /site_type="other"
                     /note="Reactive bond.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00798; propagated
                     from UniProtKB/Swiss-Prot (Q8IYR6.1)"
     Region          189..235
                     /region_name="KAZAL"
                     /note="Kazal type serine protease inhibitors; smart00280"
                     /db_xref="CDD:197624"
     Site            196..197
                     /site_type="other"
                     /note="Reactive bond.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00798; propagated
                     from UniProtKB/Swiss-Prot (Q8IYR6.1)"
     Region          <275..311
                     /region_name="PHA02887"
                     /note="EGF-like protein; Provisional"
                     /db_xref="CDD:165214"
     Site            331..351
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IYR6.1)"
     Region          359..380
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IYR6.1)"
     CDS             1..380
                     /gene="TMEFF1"
                     /gene_synonym="C9orf2; CT120.1; H7365; TR-1"
                     /coded_by="NM_003692.5:397..1539"
                     /db_xref="CCDS:CCDS6750.1"
                     /db_xref="GeneID:8577"
                     /db_xref="HGNC:HGNC:11866"
                     /db_xref="MIM:603421"
ORIGIN      
        1 mgaaaaeapl rlpaapplaf ccytsvlllf afslpgsras nqppgggggs ggdcpggkgk
       61 sincselnvr esdvrvcdes sckyggvcke dgdglkcacq fqchtnyipv cgsngdtyqn
      121 ecflrraack hqkeitviar gpcysdngsg sgegeeegsg aevhrkhskc gpckykaecd
      181 edaenvgcvc nidcsgysfn pvcasdgssy nnpcfvreas cikqeqidir hlghctdtdd
      241 tsllgkkddg lqyrpdvkda sdqredvyig nhmpcpenln gycihgkcef iystqkascr
      301 cesgytgqhc ektdfsilyv vpsrqklthv liaaiigavq iaiivaivmc itrkcpknnr
      361 grrqkqnlgh ftsdtssrmv
//
